cumyl azide
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; for 18h; | 95% |
With hydrogen In ethanol for 12h; | 94% |
With lithium aluminium tetrahydride In diethyl ether 1.) 12 h, 2.) reflux, 1 h; | 68% |
Conditions | Yield |
---|---|
With cerium(III) chloride | 90% |
N-(1-methyl-1phenylethyl)acetamide
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
With ammonium bromide; ethylenediamine at 100℃; for 10h; Microwave irradiation; | 88% |
dichloromethylcerium
benzamide
A
benzonitrile
B
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
at -78 - 0℃; for 2h; 5.0 equival. MeCeCl2; | A n/a B 73% |
Conditions | Yield |
---|---|
With hydrogenchloride In water 70-80 deg C, 0.5 h; reflux, 0.5 h; | 72% |
dichloromethylcerium
benzenecarbothioamide
A
benzonitrile
B
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
at -78 - 0℃; for 2h; 5.0 equival. MeCeCl2; | A n/a B 68% |
Conditions | Yield |
---|---|
With ammonia | 53% |
With ammonia |
Conditions | Yield |
---|---|
With titanium(IV) isopropylate In diethyl ether for 10h; Heating; | 44% |
Conditions | Yield |
---|---|
With bromine | |
With alkaline aqueous sodium hypobromite |
Conditions | Yield |
---|---|
With potassium cyanide; sulfuric acid In dibutyl ether at 60 - 80℃; | |
Multi-step reaction with 2 steps 1: 95 percent / LiAlH4 / diethyl ether / 18 h / 0 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: NaN3; TFA / CHCl3 / 12 h / 20 °C 2: 19.8 g / H2 / Lindlar's catalyst / ethanol / 12 h View Scheme |
p-(2-Aminoprop-2-yl)-isopropylbenzol
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
With hydrogenchloride; aluminium trichloride In toluene |
N-formyl-α,α-dimethylbenzylamine
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
With potassium hydroxide In ethylene glycol | |
(alkaline hydrolysis); | |
With sodium hydroxide In water |
N-Isopropylidene-benzenesulfenamide
phenyllithium
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
(i) Et2O, (ii) H2O; Multistep reaction; |
Conditions | Yield |
---|---|
With potassium hydroxide; nickel In ethanol at 20℃; pH=13; Reduction; Electrolysis; | A 2 % Chromat. B 97 % Chromat. |
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
With ethanol; acetic acid; zinc | |
With hydrogenchloride; tin; ethanol |
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
With ammonia at 20℃; |
2-nitro-2-phenylpropane
acetic acid
A
acetophenone
B
2-phenyl-2-propylamine
(1-methyl-1-phenyl-ethyl)-carbamic acid ethyl ester
ammonia
A
(1-methyl-1-phenyl-ethyl)-urea
B
urea
C
urethane
D
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
at 180 - 185℃; |
Conditions | Yield |
---|---|
With sodium methylate at 75℃; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: diethyl ether / 1 h / Ambient temperature 2: sodium azide, trifluoracetic acid / CHCl3 / 15 h / 5 - 20 °C 3: lithiumaluminium hydride / diethyl ether / 3 h / Ambient temperature View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaN3, Cl3CCOOH / CHCl3 / 2 h / Heating 2: 61.5 percent / LiAlH4 / diethyl ether / 4 h / Heating View Scheme | |
Multi-step reaction with 2 steps 2: aq. NaOH / H2O View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. H2SO4 2: (alkaline hydrolysis) View Scheme | |
Multi-step reaction with 2 steps 1: NaN3, CF3CO2H / CHCl3 2: Raney-Ni / propan-2-ol View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NCl3, AlCl3, tBuBr / 1,2-dichloro-ethane 2: AlCl3, HCl / toluene View Scheme |
Conditions | Yield |
---|---|
Stage #1: methylmagnesium bromide; benzonitrile In tetrahydrofuran; diethyl ether at 100℃; for 0.166667h; Double Grignard addition; Microwave irradiation; Stage #2: With titanium(IV) isopropylate In tetrahydrofuran; diethyl ether at 50℃; for 1h; Double Grignard addition; Microwave irradiation; | |
Stage #1: methylmagnesium bromide; benzonitrile In diethyl ether at 20℃; for 0.5h; Inert atmosphere; Stage #2: With titanium(IV) isopropylate In diethyl ether for 10h; Inert atmosphere; |
N-hydroxy-2-methyl-2-phenylpropanamide
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
Stage #1: N-hydroxy-2-methyl-2-phenylpropanamide With acetic anhydride; potassium carbonate In dimethyl sulfoxide at 50℃; for 24h; Lossen Rearrangement; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 0℃; |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: magnesium / diethyl ether / 1 h / Inert atmosphere; Reflux 1.2: 0 - 5 °C 2.1: trifluoroacetic acid; sodium azide / dichloromethane / -5 - 0 °C / Inert atmosphere 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme |
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dichloromethane / 1 h / 20 °C 2: hydrogen / methanol / 12 h View Scheme |
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
With hydrogen In methanol for 12h; |
4-methoxy-benzoyl chloride
2-phenyl-2-propylamine
4-methoxy-N-(1-methyl-1-phenylethyl)benzamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; for 18h; | 100% |
With triethylamine In dichloromethane for 12h; | 87% |
In tetrahydrofuran at 0℃; | 84% |
With triethylamine In dichloromethane Acylation; |
1-bromomethyl-3-methoxybenzene
2-phenyl-2-propylamine
N-(3-methoxybenzyl)-N-(1-methyl-1-phenylethyl)amine
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 12h; | 100% |
3-fluorobenzene-1-sulfonyl chloride
2-phenyl-2-propylamine
N-(2-phenylpropan-2-yl)-3-fluorobenzenesulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 100% |
3-chlorophenylsulfonyl chloride
2-phenyl-2-propylamine
N-(2-phenylpropan-2-yl)-3-chloro-benzenesulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 100% |
4-(2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl)butanoic acid
2-phenyl-2-propylamine
4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-phenylpropan-2-yl)butanamide
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h; | 100% |
Conditions | Yield |
---|---|
Stage #1: formic acid With acetic acid at 25℃; for 1h; Stage #2: 2-phenyl-2-propylamine at 0 - 25℃; | 100% |
Conditions | Yield |
---|---|
In toluene Reflux; Inert atmosphere; Dean-Stark; | 100% |
Conditions | Yield |
---|---|
In toluene Reflux; Inert atmosphere; Dean-Stark; | 100% |
Conditions | Yield |
---|---|
In toluene Reflux; Inert atmosphere; Dean-Stark; | 100% |
BOC-glycine
2-phenyl-2-propylamine
[(1-methyl-1-phenylethylcarbamoyl)methyl]carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: BOC-glycine With benzotriazol-1-ol; dicyclohexyl-carbodiimide In chloroform at 20℃; for 0.166667h; Stage #2: 2-phenyl-2-propylamine In chloroform at 20℃; for 18h; Further stages.; | 99% |
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
In benzene for 2h; Reflux; Inert atmosphere; | 99% |
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; | 99% |
3-chlorosulfonylbenzoyl dichloride
2-phenyl-2-propylamine
3-(1-methyl-1-phenyl-ethylcarbamoyl)-benzenesulfonyl chloride
Conditions | Yield |
---|---|
2,6-dimethylpyridine In dichloromethane at 0 - 20℃; for 4h; | 98% |
Conditions | Yield |
---|---|
Stage #1: 2-phenyl-2-propylamine With n-butyllithium In diethyl ether; hexane at 0 - 20℃; for 4h; Inert atmosphere; Schlenk technique; Stage #2: chloro(9H-fluoren-9-yl)dimethylsilane In diethyl ether; hexane at 0 - 20℃; Inert atmosphere; Schlenk technique; | 98% |
benzenesulfonyl chloride
2-phenyl-2-propylamine
N-(2-phenylpropan-2-yl)benzenesulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; | 97% |
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 88% |
With sodium hydroxide |
3-phenoxybenzoic acid
2-phenyl-2-propylamine
3-phenoxy-N-(1-methyl-1-phenylethyl)benzamide
Conditions | Yield |
---|---|
Stage #1: 3-phenoxybenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.0833333h; Cooling; Stage #2: 2-phenyl-2-propylamine In N,N-dimethyl-formamide at 20℃; for 2h; | 97% |
ortho-toluoyl chloride
2-phenyl-2-propylamine
2-methyl-N-(2-phenylpropan-2-yl)benzamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; Schlenk technique; | 97% |
With triethylamine In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; Schlenk technique; | 97% |
Conditions | Yield |
---|---|
With sulfur at 50℃; for 16h; | 97% |
Conditions | Yield |
---|---|
Stage #1: 2-phenyl-2-propylamine With n-butyllithium In diethyl ether; hexane at 0 - 20℃; for 3h; Inert atmosphere; Schlenk technique; Stage #2: C23H29ClSi In diethyl ether; hexane at 0 - 20℃; Inert atmosphere; Schlenk technique; | 97% |
Conditions | Yield |
---|---|
With 2,6-di-tert-butyl-4-methyl-phenol; [1,3-bis(2,6-diisopentylphenyl)-4,5-dichloroimidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride; sodium hydride In 1,2-dimethoxyethane at 80℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique; | 97% |
m-Chlorobenzoyl chloride
2-phenyl-2-propylamine
3-chloro-N-(1-methyl-1-phenylethyl)benzamide
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 3h; | 96% |
1,4-dihydro-1-naphthoyl chloride
2-phenyl-2-propylamine
N-(alpha,alpha-dimethylbenzyl)-1,4-dihydro-alpha-naphthoamide
Conditions | Yield |
---|---|
With triethylamine In water | 95.5% |
p-toluenesulfonyl chloride
2-phenyl-2-propylamine
N-(α,α-dimethylbenzyl)-p-toluenesulfonamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; | 95% |
With sodium hydroxide |
2-phenyl-2-propylamine
N-acetyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamide
N-(1-methyl-1phenylethyl)acetamide
Conditions | Yield |
---|---|
In tetrahydrofuran at 50℃; for 36h; Acylation; | 95% |
Conditions | Yield |
---|---|
In diethyl ether; hexane at 20℃; for 1.5h; | 95% |
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
With 2,6-di-tert-butyl-4-methyl-phenol; [1,3-bis(2,6-diisopentylphenyl)-4,5-dichloroimidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride; sodium hydride In 1,2-dimethoxyethane at 80℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique; | 95% |
phenylsulfonyl fluoride
2-phenyl-2-propylamine
N-(2-phenylpropan-2-yl)benzenesulfonamide
Conditions | Yield |
---|---|
With 1,1,3,3-Tetramethyldisiloxane; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 25℃; for 24h; Sealed tube; | 95% |
2-phenyl-2-propylamine
Conditions | Yield |
---|---|
With 1,1,3,3-Tetramethyldisiloxane; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 25℃; for 24h; Sealed tube; | 95% |
2-bromo-3,3-dimethylbutanoyl chloride
2-phenyl-2-propylamine
bromobutide
Conditions | Yield |
---|---|
With 1-methyl-1H-imidazole; N,N,N,N,-tetramethylethylenediamine; potassium carbonate In chlorobenzene at 20 - 25℃; for 2h; | 94% |
With triethylamine In benzene for 4h; Ambient temperature; Yield given; | |
In tetrachloromethane; dichloromethane Yield given; |
This chemical is called 2-Phenylpropan-2-amine, and it can also be named as (Phenylisopropyl)amine. With the molecular formula of C9H13N, its molecular weight is 135.21. The CAS registry number of this chemical is 585-32-0.
Other characteristics of the 2-Phenylpropan-2-amine can be summarised as followings: (1)ACD/LogP: 2.13; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 7.4): 0.192; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 3.966; (8)#H bond acceptors: 1; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 26.02 Å2; (12)Index of Refraction: 1.52; (13)Molar Refractivity: 43.542 cm3; (14)Molar Volume: 143.292 cm3; (15)Polarizability: 17.262×10-24cm3; (16)Surface Tension: 33.434 dyne/cm; (17)Density: 0.944 g/cm3; (18)Flash Point: 84.05 °C; (19)Enthalpy of Vaporization: 43.27 kJ/mol; (20)Boiling Point: 196.499 °C at 760 mmHg; (21)Vapour Pressure: 0.397 mmHg at 25°C.
Production method of this chemical: The 2-Phenylpropan-2-amine could be obtained by the reactant of 2-azido-2-phenylpropane. This reaction needs the reagent of LiAlH4, and the solvent of diethyl ether. The other condition is heating.
Uses of this chemical: The (a-nitro-isopropyl)-benzene could be obtained by the reactant of 2-Phenylpropan-2-amine. This reaction needs the reagent of KMnO4.
When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing when you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
1.SMILES: CC(C)(c1ccccc1)N
2.InChI: InChI=1/C9H13N/c1-9(2,10)8-6-4-3-5-7-8/h3-7H,10H2,1-2H3
3.InChIKey: KDFDOINBXBEOLZ-UHFFFAOYAK
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