Product Name

  • Name

    CUMYLAMINE

  • EINECS
  • CAS No. 585-32-0
  • Article Data40
  • CAS DataBase
  • Density 0.944 g/cm3
  • Solubility Insoluble in water.
  • Melting Point 116°C (estimate)
  • Formula C9H13N
  • Boiling Point 196.499 °C at 760 mmHg
  • Molecular Weight 135.209
  • Flash Point 84.05 °C
  • Transport Information UN2735
  • Appearance Liquid. (Clear, colorless ~ yellow.)
  • Safety 26-36/37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 585-32-0 (CUMYLAMINE)
  • Hazard Symbols T
  • Synonyms Benzylamine,a,a-dimethyl- (8CI);(2-Phenyl-2-propyl)amine;1-Methyl-1-phenylethylamine;1-Phenylisopropylamine;2-Amino-2-phenylpropane;2-Phenyl-2-propanamine;Cumylamine;NSC 66156;a,a-Dimethylbenzenemethanamine;a,a-Dimethylbenzylamine;
  • PSA 26.02000
  • LogP 2.58070

Synthetic route

cumyl azide
32366-26-0

cumyl azide

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; for 18h;95%
With hydrogen In ethanol for 12h;94%
With lithium aluminium tetrahydride In diethyl ether 1.) 12 h, 2.) reflux, 1 h;68%
methyllithium
917-54-4

methyllithium

benzonitrile
100-47-0

benzonitrile

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With cerium(III) chloride90%
N-(1-methyl-1phenylethyl)acetamide
79649-68-6

N-(1-methyl-1phenylethyl)acetamide

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With ammonium bromide; ethylenediamine at 100℃; for 10h; Microwave irradiation;88%
dichloromethylcerium
94616-84-9

dichloromethylcerium

benzamide
55-21-0

benzamide

A

benzonitrile
100-47-0

benzonitrile

B

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
at -78 - 0℃; for 2h; 5.0 equival. MeCeCl2;A n/a
B 73%
α,α-dimethylbenzyl isocyanate
4747-74-4

α,α-dimethylbenzyl isocyanate

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With hydrogenchloride In water 70-80 deg C, 0.5 h; reflux, 0.5 h;72%
dichloromethylcerium
94616-84-9

dichloromethylcerium

benzenecarbothioamide
2227-79-4

benzenecarbothioamide

A

benzonitrile
100-47-0

benzonitrile

B

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
at -78 - 0℃; for 2h; 5.0 equival. MeCeCl2;A n/a
B 68%
2-bromo-2-phenylpropane
3575-19-7

2-bromo-2-phenylpropane

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With ammonia53%
With ammonia
methylmagnesium chloride
676-58-4

methylmagnesium chloride

benzonitrile
100-47-0

benzonitrile

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With titanium(IV) isopropylate In diethyl ether for 10h; Heating;44%
2-methyl-2-phenyl-propanamide
826-54-0

2-methyl-2-phenyl-propanamide

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With bromine
With alkaline aqueous sodium hypobromite
1-methyl-1-phenylethyl alcohol
617-94-7

1-methyl-1-phenylethyl alcohol

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With potassium cyanide; sulfuric acid In dibutyl ether at 60 - 80℃;
Multi-step reaction with 2 steps
1: 95 percent / LiAlH4 / diethyl ether / 18 h / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: NaN3; TFA / CHCl3 / 12 h / 20 °C
2: 19.8 g / H2 / Lindlar's catalyst / ethanol / 12 h
View Scheme
p-(2-Aminoprop-2-yl)-isopropylbenzol
17797-08-9

p-(2-Aminoprop-2-yl)-isopropylbenzol

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With hydrogenchloride; aluminium trichloride In toluene
N-formyl-α,α-dimethylbenzylamine
42044-69-9

N-formyl-α,α-dimethylbenzylamine

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With potassium hydroxide In ethylene glycol
(alkaline hydrolysis);
With sodium hydroxide In water
N-Isopropylidene-benzenesulfenamide
38206-14-3

N-Isopropylidene-benzenesulfenamide

phenyllithium
591-51-5

phenyllithium

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
(i) Et2O, (ii) H2O; Multistep reaction;
2-nitro-2-phenylpropane
3457-58-7

2-nitro-2-phenylpropane

A

dicumene
1889-67-4

dicumene

B

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With potassium hydroxide; nickel In ethanol at 20℃; pH=13; Reduction; Electrolysis;A 2 % Chromat.
B 97 % Chromat.
β-nitro-β-phenyl-propane

β-nitro-β-phenyl-propane

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With ethanol; acetic acid; zinc
With hydrogenchloride; tin; ethanol
11-chloro-1-isopropyl-benzene

11-chloro-1-isopropyl-benzene

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With ammonia at 20℃;
2-methyl-2-phenyl-propanamide
826-54-0

2-methyl-2-phenyl-propanamide

bromine
7726-95-6

bromine

alkali

alkali

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

2-nitro-2-phenylpropane
3457-58-7

2-nitro-2-phenylpropane

acetic acid
64-19-7

acetic acid

zinc dust

zinc dust

A

acetophenone
98-86-2

acetophenone

B

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

(1-methyl-1-phenyl-ethyl)-carbamic acid ethyl ester
1611-48-9

(1-methyl-1-phenyl-ethyl)-carbamic acid ethyl ester

ammonia
7664-41-7

ammonia

A

(1-methyl-1-phenyl-ethyl)-urea
58609-76-0

(1-methyl-1-phenyl-ethyl)-urea

B

urea
57-13-6

urea

C

urethane
51-79-6

urethane

D

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
at 180 - 185℃;
N'-[1-(1-Methyl-1-phenyl-ethylamino)-meth-(Z)-ylidene]-hydrazinecarboxylic acid methyl ester

N'-[1-(1-Methyl-1-phenyl-ethylamino)-meth-(Z)-ylidene]-hydrazinecarboxylic acid methyl ester

methanol
67-56-1

methanol

A

4-(1-methyl-1-phenyl-ethyl)-2,4-dihydro-[1,2,4]triazol-3-one

4-(1-methyl-1-phenyl-ethyl)-2,4-dihydro-[1,2,4]triazol-3-one

B

methyl (2E)-2-[1-(methyloxy)methylidene]hydrazinecarboxylate

methyl (2E)-2-[1-(methyloxy)methylidene]hydrazinecarboxylate

C

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With sodium methylate at 75℃;
phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: diethyl ether / 1 h / Ambient temperature
2: sodium azide, trifluoracetic acid / CHCl3 / 15 h / 5 - 20 °C
3: lithiumaluminium hydride / diethyl ether / 3 h / Ambient temperature
View Scheme
isopropenylbenzene
98-83-9

isopropenylbenzene

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaN3, Cl3CCOOH / CHCl3 / 2 h / Heating
2: 61.5 percent / LiAlH4 / diethyl ether / 4 h / Heating
View Scheme
Multi-step reaction with 2 steps
2: aq. NaOH / H2O
View Scheme
isopropenylbenzene
98-83-9

isopropenylbenzene

CBrCl3

CBrCl3

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. H2SO4
2: (alkaline hydrolysis)
View Scheme
Multi-step reaction with 2 steps
1: NaN3, CF3CO2H / CHCl3
2: Raney-Ni / propan-2-ol
View Scheme
1,4-bis(1-methylethyl)benzene
100-18-5

1,4-bis(1-methylethyl)benzene

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NCl3, AlCl3, tBuBr / 1,2-dichloro-ethane
2: AlCl3, HCl / toluene
View Scheme
methylmagnesium bromide
75-16-1

methylmagnesium bromide

benzonitrile
100-47-0

benzonitrile

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
Stage #1: methylmagnesium bromide; benzonitrile In tetrahydrofuran; diethyl ether at 100℃; for 0.166667h; Double Grignard addition; Microwave irradiation;
Stage #2: With titanium(IV) isopropylate In tetrahydrofuran; diethyl ether at 50℃; for 1h; Double Grignard addition; Microwave irradiation;
Stage #1: methylmagnesium bromide; benzonitrile In diethyl ether at 20℃; for 0.5h; Inert atmosphere;
Stage #2: With titanium(IV) isopropylate In diethyl ether for 10h; Inert atmosphere;
N-hydroxy-2-methyl-2-phenylpropanamide
107955-92-0

N-hydroxy-2-methyl-2-phenylpropanamide

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
Stage #1: N-hydroxy-2-methyl-2-phenylpropanamide With acetic anhydride; potassium carbonate In dimethyl sulfoxide at 50℃; for 24h; Lossen Rearrangement;
Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 0℃;
acetophenone
98-86-2

acetophenone

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium / diethyl ether / 1 h / Inert atmosphere; Reflux
1.2: 0 - 5 °C
2.1: trifluoroacetic acid; sodium azide / dichloromethane / -5 - 0 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
View Scheme
N-(1-methyl-1-phenylethyl)-N'-(tert-butoxycarbonyl)hydrazinecarboxylic acid tert-butyl ester

N-(1-methyl-1-phenylethyl)-N'-(tert-butoxycarbonyl)hydrazinecarboxylic acid tert-butyl ester

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane / 1 h / 20 °C
2: hydrogen / methanol / 12 h
View Scheme
C9H14N2*C2HF3O2

C9H14N2*C2HF3O2

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

Conditions
ConditionsYield
With hydrogen In methanol for 12h;
4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

4-methoxy-N-(1-methyl-1-phenylethyl)benzamide
454479-63-1

4-methoxy-N-(1-methyl-1-phenylethyl)benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃; for 18h;100%
With triethylamine In dichloromethane for 12h;87%
In tetrahydrofuran at 0℃;84%
With triethylamine In dichloromethane Acylation;
1-bromomethyl-3-methoxybenzene
874-98-6

1-bromomethyl-3-methoxybenzene

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

N-(3-methoxybenzyl)-N-(1-methyl-1-phenylethyl)amine
454479-64-2

N-(3-methoxybenzyl)-N-(1-methyl-1-phenylethyl)amine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 12h;100%
3-fluorobenzene-1-sulfonyl chloride
701-27-9

3-fluorobenzene-1-sulfonyl chloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

N-(2-phenylpropan-2-yl)-3-fluorobenzenesulfonamide
1312206-53-3

N-(2-phenylpropan-2-yl)-3-fluorobenzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;100%
3-chlorophenylsulfonyl chloride
2888-06-4

3-chlorophenylsulfonyl chloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

N-(2-phenylpropan-2-yl)-3-chloro-benzenesulfonamide
1312206-54-4

N-(2-phenylpropan-2-yl)-3-chloro-benzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;100%
4-(2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl)butanoic acid
2950-83-6

4-(2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl)butanoic acid

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-phenylpropan-2-yl)butanamide
1370293-09-6

4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-phenylpropan-2-yl)butanamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h;100%
formic acid
64-18-6

formic acid

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

N-formyl-α,α-dimethylbenzylamine
42044-69-9

N-formyl-α,α-dimethylbenzylamine

Conditions
ConditionsYield
Stage #1: formic acid With acetic acid at 25℃; for 1h;
Stage #2: 2-phenyl-2-propylamine at 0 - 25℃;
100%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

(E)-N-(2-phenylpropan-2-yl)-1-(pyridin-2-yl)methanimine

(E)-N-(2-phenylpropan-2-yl)-1-(pyridin-2-yl)methanimine

Conditions
ConditionsYield
In toluene Reflux; Inert atmosphere; Dean-Stark;100%
6-methyl-2-pyridinecarboxaldehyde
1122-72-1

6-methyl-2-pyridinecarboxaldehyde

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

(E)-1-(6-methylpyridin-2-yl)-N-(2-phenylpropan-2-yl)methanimine

(E)-1-(6-methylpyridin-2-yl)-N-(2-phenylpropan-2-yl)methanimine

Conditions
ConditionsYield
In toluene Reflux; Inert atmosphere; Dean-Stark;100%
quinoline 2-carbaldehyde
5470-96-2

quinoline 2-carbaldehyde

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

(E)-N-(2-phenylpropan-2-yl)-1-(quinolin-2-yl)methanimine

(E)-N-(2-phenylpropan-2-yl)-1-(quinolin-2-yl)methanimine

Conditions
ConditionsYield
In toluene Reflux; Inert atmosphere; Dean-Stark;100%
BOC-glycine
4530-20-5

BOC-glycine

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

[(1-methyl-1-phenylethylcarbamoyl)methyl]carbamic acid tert-butyl ester
623943-92-0

[(1-methyl-1-phenylethylcarbamoyl)methyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: BOC-glycine With benzotriazol-1-ol; dicyclohexyl-carbodiimide In chloroform at 20℃; for 0.166667h;
Stage #2: 2-phenyl-2-propylamine In chloroform at 20℃; for 18h; Further stages.;
99%
butyl glyoxylate monohydrate

butyl glyoxylate monohydrate

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

butyl (E)-2-[1-methyl-1-phenylethylimino]ethanoate

butyl (E)-2-[1-methyl-1-phenylethylimino]ethanoate

Conditions
ConditionsYield
In benzene for 2h; Reflux; Inert atmosphere;99%
1-[(4-tert-butyldiphenylsilyloxy)-5-fluoropentyl]-1H-indazole-3-carboxylic acid

1-[(4-tert-butyldiphenylsilyloxy)-5-fluoropentyl]-1H-indazole-3-carboxylic acid

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

1-[4-(tert-butyldiphenylsilyloxy)-5-fluoropentyl]-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide

1-[4-(tert-butyldiphenylsilyloxy)-5-fluoropentyl]-N-(2-phenylpropan-2-yl)-1H-indazole-3-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;99%
3-chlorosulfonylbenzoyl dichloride
4052-92-0

3-chlorosulfonylbenzoyl dichloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

3-(1-methyl-1-phenyl-ethylcarbamoyl)-benzenesulfonyl chloride
911030-55-2

3-(1-methyl-1-phenyl-ethylcarbamoyl)-benzenesulfonyl chloride

Conditions
ConditionsYield
2,6-dimethylpyridine In dichloromethane at 0 - 20℃; for 4h;98%
chloro(9H-fluoren-9-yl)dimethylsilane
154283-78-0

chloro(9H-fluoren-9-yl)dimethylsilane

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

C24H27NSi

C24H27NSi

Conditions
ConditionsYield
Stage #1: 2-phenyl-2-propylamine With n-butyllithium In diethyl ether; hexane at 0 - 20℃; for 4h; Inert atmosphere; Schlenk technique;
Stage #2: chloro(9H-fluoren-9-yl)dimethylsilane In diethyl ether; hexane at 0 - 20℃; Inert atmosphere; Schlenk technique;
98%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

N-(2-phenylpropan-2-yl)benzenesulfonamide
66898-01-9

N-(2-phenylpropan-2-yl)benzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃;97%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;88%
With sodium hydroxide
3-phenoxybenzoic acid
3739-38-6

3-phenoxybenzoic acid

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

3-phenoxy-N-(1-methyl-1-phenylethyl)benzamide
913389-91-0

3-phenoxy-N-(1-methyl-1-phenylethyl)benzamide

Conditions
ConditionsYield
Stage #1: 3-phenoxybenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.0833333h; Cooling;
Stage #2: 2-phenyl-2-propylamine In N,N-dimethyl-formamide at 20℃; for 2h;
97%
ortho-toluoyl chloride
933-88-0

ortho-toluoyl chloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

2-methyl-N-(2-phenylpropan-2-yl)benzamide
249764-74-7

2-methyl-N-(2-phenylpropan-2-yl)benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; Schlenk technique;97%
With triethylamine In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; Schlenk technique;97%
Cyclohexyl isocyanide
931-53-3

Cyclohexyl isocyanide

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

1-cyclohexyl-3-(2-phenylpropan-2-yl)thiourea

1-cyclohexyl-3-(2-phenylpropan-2-yl)thiourea

Conditions
ConditionsYield
With sulfur at 50℃; for 16h;97%
C23H29ClSi

C23H29ClSi

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

C32H41NSi

C32H41NSi

Conditions
ConditionsYield
Stage #1: 2-phenyl-2-propylamine With n-butyllithium In diethyl ether; hexane at 0 - 20℃; for 3h; Inert atmosphere; Schlenk technique;
Stage #2: C23H29ClSi In diethyl ether; hexane at 0 - 20℃; Inert atmosphere; Schlenk technique;
97%
4-(tert-butyl)chlorobenzene
3972-56-3

4-(tert-butyl)chlorobenzene

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

4-(tert-butyl)-N-(2-phenylpropan-2-yl)aniline

4-(tert-butyl)-N-(2-phenylpropan-2-yl)aniline

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methyl-phenol; [1,3-bis(2,6-diisopentylphenyl)-4,5-dichloroimidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride; sodium hydride In 1,2-dimethoxyethane at 80℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique;97%
m-Chlorobenzoyl chloride
618-46-2

m-Chlorobenzoyl chloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

3-chloro-N-(1-methyl-1-phenylethyl)benzamide
866766-98-5

3-chloro-N-(1-methyl-1-phenylethyl)benzamide

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 3h;96%
1,4-dihydro-1-naphthoyl chloride
76966-07-9

1,4-dihydro-1-naphthoyl chloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

N-(alpha,alpha-dimethylbenzyl)-1,4-dihydro-alpha-naphthoamide
101507-17-9

N-(alpha,alpha-dimethylbenzyl)-1,4-dihydro-alpha-naphthoamide

Conditions
ConditionsYield
With triethylamine In water95.5%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

N-(α,α-dimethylbenzyl)-p-toluenesulfonamide
66898-03-1

N-(α,α-dimethylbenzyl)-p-toluenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃;95%
With sodium hydroxide
2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

N-acetyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamide
300561-19-7

N-acetyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamide

N-(1-methyl-1phenylethyl)acetamide
79649-68-6

N-(1-methyl-1phenylethyl)acetamide

Conditions
ConditionsYield
In tetrahydrofuran at 50℃; for 36h; Acylation;95%
tert-butylsulfamyl chloride
33581-95-2

tert-butylsulfamyl chloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

N-cumyl-N'-t-butylsulfamide

N-cumyl-N'-t-butylsulfamide

Conditions
ConditionsYield
In diethyl ether; hexane at 20℃; for 1.5h;95%
2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

3-halopyridine

3-halopyridine

N-(2-phenylpropan-2-yl)pyridin-3-amine

N-(2-phenylpropan-2-yl)pyridin-3-amine

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methyl-phenol; [1,3-bis(2,6-diisopentylphenyl)-4,5-dichloroimidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride; sodium hydride In 1,2-dimethoxyethane at 80℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique;95%
phenylsulfonyl fluoride
368-43-4

phenylsulfonyl fluoride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

N-(2-phenylpropan-2-yl)benzenesulfonamide
66898-01-9

N-(2-phenylpropan-2-yl)benzenesulfonamide

Conditions
ConditionsYield
With 1,1,3,3-Tetramethyldisiloxane; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 25℃; for 24h; Sealed tube;95%
4-(tert-butyl)benzene-1-sulfonyl fluoride

4-(tert-butyl)benzene-1-sulfonyl fluoride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

4-(tert-butyl)-N-(2-phenylpropan-2-yl)benzenesulfonamide

4-(tert-butyl)-N-(2-phenylpropan-2-yl)benzenesulfonamide

Conditions
ConditionsYield
With 1,1,3,3-Tetramethyldisiloxane; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 25℃; for 24h; Sealed tube;95%
2-bromo-3,3-dimethylbutanoyl chloride
29336-30-9, 86512-66-5

2-bromo-3,3-dimethylbutanoyl chloride

2-phenyl-2-propylamine
585-32-0

2-phenyl-2-propylamine

bromobutide
74712-19-9

bromobutide

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; N,N,N,N,-tetramethylethylenediamine; potassium carbonate In chlorobenzene at 20 - 25℃; for 2h;94%
With triethylamine In benzene for 4h; Ambient temperature; Yield given;
In tetrachloromethane; dichloromethane Yield given;

2-Phenylpropan-2-amine Specification

This chemical is called 2-Phenylpropan-2-amine, and it can also be named as (Phenylisopropyl)amine. With the molecular formula of C9H13N, its molecular weight is 135.21. The CAS registry number of this chemical is 585-32-0.

Other characteristics of the 2-Phenylpropan-2-amine can be summarised as followings: (1)ACD/LogP: 2.13; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 7.4): 0.192; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 3.966; (8)#H bond acceptors: 1; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 26.02 Å2; (12)Index of Refraction: 1.52; (13)Molar Refractivity: 43.542 cm3; (14)Molar Volume: 143.292 cm3; (15)Polarizability: 17.262×10-24cm3; (16)Surface Tension: 33.434 dyne/cm; (17)Density: 0.944 g/cm3; (18)Flash Point: 84.05 °C; (19)Enthalpy of Vaporization: 43.27 kJ/mol; (20)Boiling Point: 196.499 °C at 760 mmHg; (21)Vapour Pressure: 0.397 mmHg at 25°C.

Production method of this chemical: The 2-Phenylpropan-2-amine could be obtained by the reactant of 2-azido-2-phenylpropane. This reaction needs the reagent of LiAlH4, and the solvent of diethyl ether. The other condition is heating.

Uses of this chemical: The (a-nitro-isopropyl)-benzene could be obtained by the reactant of 2-Phenylpropan-2-amine. This reaction needs the reagent of KMnO4.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing when you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure: 
1.SMILES: CC(C)(c1ccccc1)N
2.InChI: InChI=1/C9H13N/c1-9(2,10)8-6-4-3-5-7-8/h3-7H,10H2,1-2H3
3.InChIKey: KDFDOINBXBEOLZ-UHFFFAOYAK

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