Product Name

  • Name

    2-Thiopheneethanol

  • EINECS 226-452-0
  • CAS No. 5402-55-1
  • Article Data42
  • CAS DataBase
  • Density 1.173 g/cm3
  • Solubility slightly soluble in water
  • Melting Point
  • Formula C6H8OS
  • Boiling Point 223 °C at 760 mmHg
  • Molecular Weight 128.195
  • Flash Point 101.1 °C
  • Transport Information
  • Appearance clear colorless to slightly brown liquid
  • Safety 23-24/25-36-26
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 5402-55-1 (2-Thiopheneethanol)
  • Hazard Symbols IrritantXi
  • Synonyms 2-(2-Hydroxyethyl)thiofuran;2-(2-Hydroxyethyl)thiophene;2-(2-Thienyl)-1-ethanol;2-(2-Thienyl)ethanol;2-(Thiophen-2-yl)ethanol;NSC 5136;thiophene-2- ethanol;Thiophene-2-Ethanol;
  • PSA 48.47000
  • LogP 1.28290

Synthetic route

ethyl thiophen-2-ylacetate
57382-97-5

ethyl thiophen-2-ylacetate

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
With phenylsilane; cobalt(II) diacetate tetrahydrate; sodium triethylborohydride In 1,2-dimethoxyethane; toluene at 25℃; for 15h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Schlenk technique;100%
Stage #1: ethyl thiophen-2-ylacetate With sodium tetrahydroborate In tetrahydrofuran at 70℃; for 0.25h;
Stage #2: In tetrahydrofuran; methanol at 70℃; for 0.15h;
94%
With ethylmagnesium bromide; poly(methylhydrosiloxane); bis(cyclopentadienyl)titanium dichloride In tetrahydrofuran; diethyl ether for 17.5h; Ambient temperature;89%
methyl 2-thiopheneacetate
19432-68-9

methyl 2-thiopheneacetate

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
Stage #1: methyl 2-thiopheneacetate With diethylzinc; lithium chloride In tetrahydrofuran; hexane at 20℃; for 6h; Inert atmosphere;
Stage #2: With sodium hydroxide In tetrahydrofuran; hexane; water at 20℃; for 8h; Inert atmosphere; chemoselective reaction;
98%
Stage #1: methyl 2-thiopheneacetate With sodium tetrahydroborate In tetrahydrofuran at 70℃; for 0.25h;
Stage #2: In tetrahydrofuran; methanol at 70℃; for 0.15h;
97%
With strain of the zygomycete fungus S. racemosum MUT 770 In dimethyl sulfoxide for 72h; Enzymatic reaction;96%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 6h;97%
With tricarbonyl(η(4)-cycloocta-1,5-diene)iron; phenylsilane In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; UV-irradiation; chemoselective reaction;95%
With indium(III) bromide; 1,1,3,3-Tetramethyldisiloxane In chloroform at 60℃; for 2h; Inert atmosphere;73%
oxirane
75-21-8

oxirane

2,5-dilithiothiophene
63762-35-6

2,5-dilithiothiophene

A

2-thiophenethanol
5402-55-1

2-thiophenethanol

B

2,2′-(thiophene-2,5-diyl)diethanol
131202-62-5

2,2′-(thiophene-2,5-diyl)diethanol

Conditions
ConditionsYield
In hexane 1) -10 deg C, 2 h, 2) r.t., 24 h;A 95%
B 5%
2-[2-(tert-butyldimethylsilyloxy)ethyl]thiophene
160744-11-6

2-[2-(tert-butyldimethylsilyloxy)ethyl]thiophene

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
With Povidone-Iodine In methanol at 30℃; for 1h; Solvent; Temperature;91%
2,2,2-trichloro-1-(thien-2-yl)-ethanol
35320-27-5

2,2,2-trichloro-1-(thien-2-yl)-ethanol

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
With lithium borohydride; sodium hydroxide In isopropyl alcohol Temperature; Jocic Reaction; Heating; Inert atmosphere;89%
oxirane
75-21-8

oxirane

thiophene
188290-36-0

thiophene

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
Stage #1: thiophene With sodium; polyethylene; isoprene In tetrahydrofuran; toluene at -1 - 1℃; for 3.5h;
Stage #2: oxirane In tetrahydrofuran; toluene at 19 - 21℃; for 2h;
Stage #3: With water; ammonium chloride In tetrahydrofuran; toluene at 0 - 22℃; for 0.25h; Product distribution / selectivity; Cooling with ice-methanol bath;
83%
Stage #1: thiophene With cis-Octadecenoic acid; sodium; isopropenylbenzene In tetrahydrofuran; toluene at -1 - 1℃; for 3.5h;
Stage #2: oxirane In tetrahydrofuran; toluene at 19 - 21℃; for 2h;
Stage #3: With water In tetrahydrofuran; toluene at 0 - 20℃; for 0.166667 - 0.25h; Product distribution / selectivity; Cooling with ice-methanol bath;
83%
Stage #1: thiophene With cis-Octadecenoic acid; sodium; 2,3-dimethyl-buta-1,3-diene In tetrahydrofuran; toluene at -1 - 1℃; for 2h;
Stage #2: oxirane In tetrahydrofuran; toluene at 20℃; for 0.333333h;
Stage #3: With water In tetrahydrofuran; toluene at 0 - 13℃; for 0.5h; Product distribution / selectivity;
83%
With n-butyllithium In tetrahydrofuran; hexane at 0℃;68%
With n-butyllithium; diethyl ether
thiophene
188290-36-0

thiophene

ethyleneglycol sulfate
1072-53-3

ethyleneglycol sulfate

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
Stage #1: thiophene With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: ethyleneglycol sulfate In tetrahydrofuran; hexane at -78 - 20℃;
Stage #3: With sulfuric acid In tetrahydrofuran; hexane for 3h; Heating; Further stages.;
79%
thiophene-2-sulfonic acid 2-bromo-ethyl ester

thiophene-2-sulfonic acid 2-bromo-ethyl ester

A

2-thiophenethanol
5402-55-1

2-thiophenethanol

B

thiophene-2-sulfonic acid ethyl ester

thiophene-2-sulfonic acid ethyl ester

C

4,5-dihydro-6-oxa-1,7-dithia-indene 7,7-dioxide

4,5-dihydro-6-oxa-1,7-dithia-indene 7,7-dioxide

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene for 12h; Heating;A 74%
B 13%
C 9%
thiophen-2-yl-acetic acid propyl ester

thiophen-2-yl-acetic acid propyl ester

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
Stage #1: thiophen-2-yl-acetic acid propyl ester With sodium tetrahydroborate In tetrahydrofuran at 70℃; for 0.25h;
Stage #2: In tetrahydrofuran; methanol at 70℃; for 0.15h;
68%
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

1,1,3,3-Tetramethyldisiloxane
3277-26-7

1,1,3,3-Tetramethyldisiloxane

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
Stage #1: Thiophene-2-acetic acid; 1,1,3,3-Tetramethyldisiloxane With C24H23ClCrIrNO3; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate In dichloromethane at 40℃; for 15h; Schlenk technique; Glovebox; Inert atmosphere;
Stage #2: With water In dichloromethane at 25℃; for 1h;
68%
2-Chloromethylthiophene
765-50-4

2-Chloromethylthiophene

formaldehyd
50-00-0

formaldehyd

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
Stage #1: 2-Chloromethylthiophene With chloro-trimethyl-silane; ethylene dibromide; zinc In tetrahydrofuran at 70℃; for 2h; Schlenk technique; Inert atmosphere;
Stage #2: formaldehyd In tetrahydrofuran at 70℃; for 6h; Schlenk technique; Inert atmosphere;
45%
oxirane
75-21-8

oxirane

thiophene
188290-36-0

thiophene

A

2-thiophenethanol
5402-55-1

2-thiophenethanol

B

2,2′-(thiophene-2,5-diyl)diethanol
131202-62-5

2,2′-(thiophene-2,5-diyl)diethanol

Conditions
ConditionsYield
With n-butyllithium; diethyl ether
oxirane
75-21-8

oxirane

2-thienyl chloride
96-43-5

2-thienyl chloride

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
With sodium amalgam; benzene unter Stickstoff;
oxirane
75-21-8

oxirane

2-thienylmagnesium iodide
89180-57-4

2-thienylmagnesium iodide

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
With diethyl ether
oxirane
75-21-8

oxirane

thiophen-2-yl magnesium bromide
5713-61-1

thiophen-2-yl magnesium bromide

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
With diethyl ether
methyl 2-thiopheneacetate
19432-68-9

methyl 2-thiopheneacetate

A

2-thiophenethanol
5402-55-1

2-thiophenethanol

B

(E)-2,4-Di-thiophen-2-yl-but-2-en-1-ol

(E)-2,4-Di-thiophen-2-yl-but-2-en-1-ol

Conditions
ConditionsYield
With titanium(IV) isopropylate; sodium hydroxide; polymethylhydrosiloxane 1.) 65 deg C, 23 h, 2.) THF, 12 h; Yield given. Multistep reaction. Yields of byproduct given;
D-Fructose
57-48-7

D-Fructose

GLUTATHIONE
70-18-8

GLUTATHIONE

A

Thiophene-2-thiol
7774-74-5

Thiophene-2-thiol

B

Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

C

2-ethylthiophene
872-55-9

2-ethylthiophene

D

2-Methylpyrazine
109-08-0

2-Methylpyrazine

E

5-Methylfurfural
620-02-0

5-Methylfurfural

F

2-thiophenethanol
5402-55-1

2-thiophenethanol

G

1-(2-furyl)-1-ethanone
1192-62-7

1-(2-furyl)-1-ethanone

H

2-methylthiophene-3-thiol
2527-76-6

2-methylthiophene-3-thiol

I

2-Acetylpyrrole
1072-83-9

2-Acetylpyrrole

J

2-methylfuran-3-thiol
28588-74-1

2-methylfuran-3-thiol

Conditions
ConditionsYield
In water at 160℃; for 2h; pH=7.5; Maillard reaction;
Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

A

2-thienylacetaldehyde
15022-15-8

2-thienylacetaldehyde

B

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
With (2-methyl-4-phenyl-1-oxabuta-1,3-diene)tricarbonyliron(0); 1,1,3,3-tetramethyldisilazane In toluene at 50℃; for 24h; Inert atmosphere; chemoselective reaction;
2-thiophenemethanol
636-72-6

2-thiophenemethanol

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Dess-Martin periodane / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: sodium hydroxide; lithium borohydride / isopropyl alcohol / Heating; Inert atmosphere
View Scheme
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: sodium hydroxide; lithium borohydride / isopropyl alcohol / Heating; Inert atmosphere
View Scheme
oxirane
75-21-8

oxirane

2-bromothiophene
1003-09-4

2-bromothiophene

2-thiophenethanol
5402-55-1

2-thiophenethanol

Conditions
ConditionsYield
With 2-methyltetrahydrofuran; iodine; zinc for 1h;112 g
2-thiophenethanol
5402-55-1

2-thiophenethanol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

2-(thiophen-2-yl)ethyl methanesulfonate
61380-07-2

2-(thiophen-2-yl)ethyl methanesulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 10℃; for 1h;100%
With triethylamine In dichloromethane at 0℃; for 0.5h;100%
With triethylamine In dichloromethane at 25℃; for 2.25h; Cooling with ice;99%
2-thiophenethanol
5402-55-1

2-thiophenethanol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

2-[2-(tert-butyldimethylsilyloxy)ethyl]thiophene
160744-11-6

2-[2-(tert-butyldimethylsilyloxy)ethyl]thiophene

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;100%
With dmap; triethylamine In dichloromethane 1.) 0 deg C, 30 min, 2.) RT, 18 h;99%
With dmap; triethylamine In dichloromethane98%
2-thiophenethanol
5402-55-1

2-thiophenethanol

acetic anhydride
108-24-7

acetic anhydride

acetic acid-(2-[2]thienyl-ethyl ester)
94135-73-6

acetic acid-(2-[2]thienyl-ethyl ester)

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; dmap In dichloromethane at 0 - 20℃; for 3h;100%
With sulfuric acid
With dmap; triethylamine In dichloromethane at 20℃; for 0.5h;
2-thiophenethanol
5402-55-1

2-thiophenethanol

1-iodo-2-(thien-2-yl)ethane
92138-63-1

1-iodo-2-(thien-2-yl)ethane

Conditions
ConditionsYield
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane Cooling with ice;99%
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane at 0 - 20℃; for 1.16667h; Inert atmosphere;96%
With 1H-imidazole; iodine; triphenylphosphine In diethyl ether; acetonitrile at 20℃; for 4h; Inert atmosphere;88%
2-thiophenethanol
5402-55-1

2-thiophenethanol

2-thienylacetaldehyde
15022-15-8

2-thienylacetaldehyde

Conditions
ConditionsYield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In acetonitrile at 80℃; for 2h;99%
With Dess-Martin periodane In dichloromethane at 0 - 20℃; for 2h;60%
With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine In dichloromethane; dimethyl sulfoxide at -15℃; for 0.5h; Parikh-Doering Oxidation; Inert atmosphere;11%
2-thiophenethanol
5402-55-1

2-thiophenethanol

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

C13H11NO3S

C13H11NO3S

Conditions
ConditionsYield
With iron(II) triflate In toluene at 70℃; for 6h; Pictet-Spengler Synthesis; Green chemistry;99%
2-thiophenethanol
5402-55-1

2-thiophenethanol

2-bromo-5-(2-hydroxyethyl)thiophene
57070-78-7

2-bromo-5-(2-hydroxyethyl)thiophene

Conditions
ConditionsYield
With N-Bromosuccinimide In toluene at -20.16℃; for 2h; Inert atmosphere; Darkness;98.5%
With N-Bromosuccinimide In toluene at -20 - 20℃;90%
With N-Bromosuccinimide In toluene at -20 - 25℃; for 12h; Inert atmosphere;90%
2-thiophenethanol
5402-55-1

2-thiophenethanol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-(2-thienyl)ethyl tosylate
40412-06-4

2-(2-thienyl)ethyl tosylate

Conditions
ConditionsYield
With triethylamine at 35℃; Cooling with ice;98%
With triethylamine In toluene at 5 - 30℃; for 20.8333h; Product distribution / selectivity;96.37%
With triethylamine In dichloromethane at -5 - 20℃; for 2h;96.5%
2-thiophenethanol
5402-55-1

2-thiophenethanol

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

diphenyl 2-(thiophen-2-yl)ethyl phosphate
1414891-49-8

diphenyl 2-(thiophen-2-yl)ethyl phosphate

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate; triethylamine In dichloromethane at 20℃; for 0.5h;97%
2-thiophenethanol
5402-55-1

2-thiophenethanol

Thiophene-2-acetic acid
1918-77-0

Thiophene-2-acetic acid

Conditions
ConditionsYield
With oxygen; triethylamine at 80℃; for 15h; Reagent/catalyst; Temperature;96.5%
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 12h;85%
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In aq. phosphate buffer; water; acetonitrile at 35℃; for 6h; Catalytic behavior; Reagent/catalyst; Temperature; Green chemistry;85%
With iridium hexafluoride; sulphate-doped anatase; potassium oxide In dichloromethane at 85℃; Temperature;
2-thiophenethanol
5402-55-1

2-thiophenethanol

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

C12H11NO3S

C12H11NO3S

Conditions
ConditionsYield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In toluene at 20℃; for 4h;96%
2-thiophenethanol
5402-55-1

2-thiophenethanol

Dimethoxymethane
109-87-5

Dimethoxymethane

2-(2-methoxymethoxyethyl)thiophene
865187-87-7

2-(2-methoxymethoxyethyl)thiophene

Conditions
ConditionsYield
With lithium chloride; toluene-4-sulfonic acid for 5h; Heating / reflux;96%
2-thiophenethanol
5402-55-1

2-thiophenethanol

6-chloroquinoline
612-57-7

6-chloroquinoline

6-(2-(thiophen-2-yl)ethoxy)quinoline
1435520-81-2

6-(2-(thiophen-2-yl)ethoxy)quinoline

Conditions
ConditionsYield
With CH3O3S(1-)*C31H49OP*C12H9NPd(1+); caesium carbonate In toluene at 90℃; for 16h; Inert atmosphere;96%
2-thiophenethanol
5402-55-1

2-thiophenethanol

Diphenylphosphine oxide
4559-70-0

Diphenylphosphine oxide

2-(thiophen-2-yl)ethyl diphenylphosphinate

2-(thiophen-2-yl)ethyl diphenylphosphinate

Conditions
ConditionsYield
With 1,10-Phenanthroline; iron(II) acetylacetonate; potassium carbonate In toluene at 130℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;96%
2-thiophenethanol
5402-55-1

2-thiophenethanol

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

4,4-dimethyl-6,7-dihydro-4H-thieno[3,2-c]pyran

4,4-dimethyl-6,7-dihydro-4H-thieno[3,2-c]pyran

Conditions
ConditionsYield
With iron(II) triflate In toluene at 70℃; for 24h; Pictet-Spengler Synthesis; Green chemistry;95%
2-thiophenethanol
5402-55-1

2-thiophenethanol

2-(2-Bromoethyl)thiophene
26478-16-0

2-(2-Bromoethyl)thiophene

Conditions
ConditionsYield
With carbon tetrabromide; triphenylphosphine In tetrahydrofuran at 0℃; Schlenk technique; Inert atmosphere;94%
With bromine; triphenylphosphine In dichloromethane at 20℃;69%
64%
2-thiophenethanol
5402-55-1

2-thiophenethanol

5-bromosalicylaldehyde dimethyl acetal
501085-54-7

5-bromosalicylaldehyde dimethyl acetal

2-(2-(4-bromo-2-(dimethoxymethyl)phenoxy)ethyl)thiophene
944162-02-1

2-(2-(4-bromo-2-(dimethoxymethyl)phenoxy)ethyl)thiophene

Conditions
ConditionsYield
With diisopropyl (E)-azodicarboxylate; triphenylphosphine In benzene at 0 - 20℃; for 0.5h;93.4%
With di-isopropyl azodicarboxylate; triphenylphosphine In benzene at 0 - 20℃; for 0.5h;93.4%
2-thiophenethanol
5402-55-1

2-thiophenethanol

methyl iodide
74-88-4

methyl iodide

2-(2-Methoxyethyl)thiophen
51062-09-0

2-(2-Methoxyethyl)thiophen

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; paraffin for 1h; Ambient temperature;93%
With sodium hydride In tetrahydrofuran at 50℃; for 1h;87%
With sodium amide In diethyl ether; ammonia at -60 - -50℃; for 0.5h;69%
Stage #1: 2-thiophenethanol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: methyl iodide In DMF (N,N-dimethyl-formamide) at 20℃; for 0.5h;
2-thiophenethanol
5402-55-1

2-thiophenethanol

2-Methoxyethoxymethyl chloride
3970-21-6

2-Methoxyethoxymethyl chloride

2-(2-((2-methoxyethoxy)methoxy)ethyl)thiophene
865187-88-8

2-(2-((2-methoxyethoxy)methoxy)ethyl)thiophene

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h;93%
With diisopropylamine In dichloromethane at 0℃; for 4h; Heating / reflux;85%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2.5h; Inert atmosphere;
2-thiophenethanol
5402-55-1

2-thiophenethanol

Tetrafluorophthalonitrile
1835-65-0

Tetrafluorophthalonitrile

4-{2-(2-thienyl)ethoxy}-3,5,6-trifluorophthalonitrile

4-{2-(2-thienyl)ethoxy}-3,5,6-trifluorophthalonitrile

Conditions
ConditionsYield
Stage #1: 2-thiophenethanol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; Inert atmosphere;
Stage #2: Tetrafluorophthalonitrile In tetrahydrofuran; mineral oil at -50 - 20℃; Reagent/catalyst; Temperature; Inert atmosphere;
93%
2-thiophenethanol
5402-55-1

2-thiophenethanol

(E)-2-(3-(thiophen-2-yl)prop-1-enyl)thiophene
1268238-64-7

(E)-2-(3-(thiophen-2-yl)prop-1-enyl)thiophene

Conditions
ConditionsYield
With (bis[(2-diisopropylphosphino)ethyl]amine)Mn(CO)2Br; sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 145℃; for 16h; Schlenk technique; Inert atmosphere;93%
With tris(triphenylphosphine)ruthenium(II) chloride; 1,3-bis-(diphenylphosphino)propane; sodium t-butanolate In toluene at 111℃; for 24h; Inert atmosphere;56%
2-thiophenethanol
5402-55-1

2-thiophenethanol

4-cyanophenylacetic acid
5462-71-5

4-cyanophenylacetic acid

C15H13NO2S

C15H13NO2S

Conditions
ConditionsYield
Stage #1: 4-cyanophenylacetic acid With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.166667h;
Stage #2: 2-thiophenethanol In dichloromethane at 20℃;
93%
2-thiophenethanol
5402-55-1

2-thiophenethanol

2-Chloroquinoline
612-62-4

2-Chloroquinoline

2-(2-(thiophen-2-yl)ethoxy)quinoline

2-(2-(thiophen-2-yl)ethoxy)quinoline

Conditions
ConditionsYield
With C12H10N(1-)*Pd(2+)*CH3O3S(1-)*C31H49O2P; sodium t-butanolate In 1,4-dioxane at 20℃; for 12h; Sealed tube; Schlenk technique; Inert atmosphere;93%
2-thiophenethanol
5402-55-1

2-thiophenethanol

carbon monoxide
201230-82-2

carbon monoxide

methyl (2-(1-phenylvinyl)phenyl)carbamic chloride

methyl (2-(1-phenylvinyl)phenyl)carbamic chloride

C23H21NO3S

C23H21NO3S

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; palladium diacetate; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine) In chlorobenzene; acetone at 20 - 80℃; for 30h; Schlenk technique; enantioselective reaction;93%
2-thiophenethanol
5402-55-1

2-thiophenethanol

phenylacetic acid
103-82-2

phenylacetic acid

2-(thiophen-2-yl)ethyl 2-phenylacetate

2-(thiophen-2-yl)ethyl 2-phenylacetate

Conditions
ConditionsYield
With C10H10Zr(2+)*2CF3O3S(1-)*C4H8O at 80℃; for 24h; Sealed tube;91%

2-Thiopheneethanol Specification

2-Thiopheneethanol, its cas register number is 5402-55-1. It also can be called 2-(2-Hydroxyethyl)thiophene; 2-(2-Thienyl)ethanol; Ethanol, 2-(2-thienyl)-; Thiophen-2-ethanol. It is a clear colorless to slight colored liquid. It belongs to the Product Categories of Heterocycles; Thiophene&Benzothiophene; Alkohols; Heterocyclic Compounds; Thiophens.

Physical properties about 2-Thiopheneethanol are: (1)ACD/LogP: 1.237; (2)ACD/LogD (pH 5.5): 1.24; (3)ACD/LogD (pH 7.4): 1.24; (4)ACD/BCF (pH 5.5): 5.13; (5)ACD/BCF (pH 7.4): 5.13; (6)ACD/KOC (pH 5.5): 112.23; (7)ACD/KOC (pH 7.4): 112.23; (8)#H bond acceptors: 1; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.568; (12)Molar Refractivity: 35.721 cm3; (13)Molar Volume: 109.236 cm3; (14)Polarizability: 14.161 10-24cm3; (15)Surface Tension: 45.5349998474121 dyne/cm; (16)Density: 1.174 g/cm3; (17)Flash Point: 101.111 °C; (18)Enthalpy of Vaporization: 48.567 kJ/mol; (19)Boiling Point: 223.027 °C at 760 mmHg; (20)Vapour Pressure: 0.0560000017285347 mmHg at 25°C

When you are using 2-Thiopheneethanol,  please be cautious about it as the following:
1. Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer);
2. Avoid contact with skin and eyes;
3. Wear suitable protective clothing;
4. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C6H8OS/c7-4-3-6-2-1-5-8-6/h1-2,5,7H,3-4H2;
(2)InChIKey=VMJOFTHFJMLIKL-UHFFFAOYSA-N;
(3)SmilesOCCc1sccc1;

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