4'-Methyl-2-cyanobiphenyl supplier

Name
4'-Methyl-2-cyanobiphenyl
EINECS 422-310-9
CAS No. 114772-53-1
Article Data237
CAS DataBase
Density 1.09 g/cm³
Solubility Insoluble in water
Melting Point 49 °C
Formula C₁₄H₁₁N
Boiling Point 356.8 °C at 760 mmHg
Molecular Weight 193.248
Flash Point 170.4 °C
Transport Information
Appearance white crystalline powder
Safety 22-26-36/37/39-36/37/45/57-20-36
Risk Codes 20/21/22-36/37/38-48/25/62/51/53-22
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms 2'-Cyano-4-methylbiphenyl;4-Methyl-2'-cyanobiphenyl;2-(4-Methylphenyl)benzonitrile;2-(p-Tolyl)benzonitrile;2-Cyano-4'-methyl-1,1'-biphenyl;2-Cyano-4'-methylbiphenyl;OTBN（O-Tolybenzenitrile）;
PSA 23.79000
LogP 3.53368

Synthetic route

: 873-32-5
2-Chlorobenzonitrile

: 5720-05-8
4-methylphenylboronic acid

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate In n-heptane; water at 60℃; for 1.66667h; Suzuki Coupling; Inert atmosphere;	100%
With potassium carbonate In water; isopropyl alcohol at 100℃; for 7h; Catalytic behavior; Suzuki-Miyaura Coupling; Inert atmosphere;	100%
With bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; tetra(n-butyl)ammonium hydroxide; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate In N,N-dimethyl-formamide at 130℃; for 0.666667h; Suzuki-Miyaura coupling; Microwave irradiation;	99%

: 2042-37-7
o-cyanobromobenzene

: 5720-05-8
4-methylphenylboronic acid

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In 1,4-dioxane; water at 50℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere;	100%
With potassium carbonate; [1-cyclohexyl-3-(di-pyridin-2-yl-methyl)-urea][PdCl2] In water at 100℃; for 1h; Suzuki-Miyaura coupling;	99%
With potassium carbonate; palladium dichloride In water; N,N-dimethyl-formamide at 20℃; for 0.0833333h; Suzuki cross-coupling reaction;	99%

: 4-methyl-8-(4-methylphenyl)-2,6-dioxotetrahydro[1,3,2]oxazaborolo[2,3-b][1,3,2]oxazaborol-4-ium-8-uide

: 873-32-5
2-Chlorobenzonitrile

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; TPGS-750-M; triethylamine In water at 40℃; Inert atmosphere;	99%
With potassium carbonate In ethanol; water at 120℃; for 2.5h; Suzuki-Miyaura reaction; continuous flow reactor;	54%

: 873-32-5
2-Chlorobenzonitrile

: 4294-57-9
para-methylphenylmagnesium bromide

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With C35H31BrN4NiP In tetrahydrofuran at 25℃; for 17h; Schlenk technique; Inert atmosphere;	98%
Stage #1: para-methylphenylmagnesium bromide With zinc(II) chloride In tetrahydrofuran at 20℃; for 0.333333h; Stage #2: 2-Chlorobenzonitrile With bis(tri-t-butylphosphine)palladium(0) In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 100℃; for 24h; Negishi reaction; Further stages.;	97%
With chloro(1,3-bis(pyridin-2-ylmethyl)imidazolylidene)nickel(II) hexafluorophosphate In tetrahydrofuran at 20℃; for 12h; Kumada-Corriu coupling reaction; Inert atmosphere;	85%

: 873-32-5
2-Chlorobenzonitrile

: 16927-79-0
4'-methyl-2-acetyl-1,1'-biphenyl

: 5720-05-8
4-methylphenylboronic acid

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With cesium fluoride; Pd(dba)2 In 1,4-dioxane	98%

...Expand

: 873-32-5
2-Chlorobenzonitrile

: 66117-64-4
di(p-tolyl)borinic acid

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With NiCl2(Tris-(4-methoxy-phenyl)-phosphin)2; potassium phosphate tribasic trihydrate; P(p-CH3OC6H4)3 In toluene at 110℃; for 5h; Reagent/catalyst; Inert atmosphere;	98%
With triphenyl phosphite; potassium phosphate tribasic trihydrate; N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride; palladium diacetate In tert-butyl alcohol at 80℃; for 16h; Inert atmosphere;	97%
With bis(triphenylphosphine)nickel(II) chloride; potassium phosphate tribasic trihydrate; 1-n-butyl-3-methylimidazolim bromide In toluene at 110℃; for 6h; Inert atmosphere;	97%

: 2042-37-7
o-cyanobromobenzene

: potassium (4-methylphenyl)trifluoroborate

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; oxygen; potassium carbonate In ethanol; water at 80℃; for 0.416667h; Suzuki-Miyaura Coupling;	97%
With palladium diacetate; potassium carbonate In ethanol; water at 25℃; for 2h; Suzuki-Miyaura Coupling;	95%

: 84392-32-5
4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With pyridine; trichlorophosphate at 100℃; for 3h;	96%
With pyridine; trichlorophosphate at 10 - 100℃; for 3h;
Multi-step reaction with 2 steps 1: hydrogenchloride 2: thionyl chloride / water; toluene View Scheme

: 2042-37-7
o-cyanobromobenzene

: 696-61-7
4-tolylmagnesium chloride

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With 1,2-dimethoxyethane; Cl4Li2Pd; 1,3-bis-(diphenylphosphino)propane	95%
With 1,2-dimethoxyethane; lithium chloride; manganese(ll) chloride; 1,3-bis-(diphenylphosphino)propane; palladium dichloride In tetrahydrofuran at 20℃; for 1 - 3.5h;	95%
With 1,2-dimethoxyethane; 1,3-bis-(diphenylphosphino)propane; palladium diacetate	94%

: 873-32-5
2-Chlorobenzonitrile

: 824-79-3
sodium 4-methylbenzenesulfinate

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With palladium diacetate; XPhos In toluene at 120℃; for 40h; Inert atmosphere; Sealed tube;	95%

: 873-32-5
2-Chlorobenzonitrile

: 90252-89-4
p-tolylzinc(II) chloride

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine)nickel(0) Negishi-like coupling reaction;	94%
With C26H24ClN2NiP*0.1C7H8 In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Negishi Coupling; Schlenk technique; Inert atmosphere;	92%
tris(dibenzylideneacetone)dipalladium (0); tris[tert-butyl]phosphonium tetrafluoroborate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 175℃; for 0.166667h; Negishi cross-coupling; microwave irradiation;	90%
With C21H18N8Ni2O(2+)*2F6P(1-) In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 20 - 80℃; Negishi coupling reaction;	88%

: 873-32-5
2-Chlorobenzonitrile

: 106-43-4
para-chlorotoluene

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
Stage #1: para-chlorotoluene With magnesium In tetrahydrofuran at 50 - 70℃; Inert atmosphere; Stage #2: 2-Chlorobenzonitrile With magnesium chloride In tetrahydrofuran at 5 - 10℃; Inert atmosphere;	93.6%

PdCl2/dppp: PdCl2/dppp

: 2042-37-7
o-cyanobromobenzene

: 696-61-7
4-tolylmagnesium chloride

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; 1,2-dimethoxyethane	93%

...Expand

: 106-49-0
p-toluidine

: 100-47-0
benzonitrile

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
Stage #1: p-toluidine With toluene-4-sulfonic acid; sodium nitrite In water at 25℃; Stage #2: benzonitrile With copper(l) iodide; sodium acetate In water at 80℃; Solvent; Temperature; Reagent/catalyst;	92.1%
Stage #1: p-toluidine With tetrafluoroboric acid; sodium nitrite In water at 0 - 5℃; for 0.5h; Inert atmosphere; Stage #2: benzonitrile With Tetrakis(dimethylamino)ethylen; 9-methylamino-1-ethoxyphenalenium tetrafluoroborate In dimethyl sulfoxide at 20℃; for 12h; Glovebox; Inert atmosphere; regioselective reaction;	50%

: 4'-methylbiphenyl-2-carboxime

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With phosphorus pentoxide In tetrahydrofuran at 20℃; for 1h;	92%

: 4-methyl-8-(4-methylphenyl)-2,6-dioxotetrahydro[1,3,2]oxazaborolo[2,3-b][1,3,2]oxazaborol-4-ium-8-uide

: 2042-37-7
o-cyanobromobenzene

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With dichloro[1,1′-bis[bis(1,1-dimethylethyl)phosphino]ferrocene-P,P′]palladium; TPGS-750-M; triethylamine In water at 20℃; Inert atmosphere;	92%
With Pd/Nb2O5; potassium carbonate In ethanol; water at 120℃; for 2h; Suzuki-Miyaura cross-coupling; Microwave irradiation;

: 2-cyanophenyl 1H-imidazole-1-sulfonate

: 5720-05-8
4-methylphenylboronic acid

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With C26H16Cl6N2O2Pd2; tetrabutylammomium bromide; potassium hydroxide In methanol; water at 110℃; for 0.333333h; Suzuki coupling; Microwave irradiation;	92%

: 2042-37-7
o-cyanobromobenzene

: 31614-66-1
tributyl(p-tolyl)stannane

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; lithium chloride In N,N-dimethyl-formamide Inert atmosphere;	92%

: 4-methyl-8-(4-methylphenyl)-2,6-dioxotetrahydro[1,3,2]oxazaborolo[2,3-b][1,3,2]oxazaborol-4-ium-8-uide

: 395-46-0
2-cyanobenzene-1-sulfonyl fluoride

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; diisopropylamine In ethanol; water at 25℃; for 4h;	92%

: o-(p-tolyl)benzaldoxime

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With formic acid	91%

: 4387-36-4
2-iodobenzonitrile

: 5720-05-8
4-methylphenylboronic acid

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With potassium phosphate Reflux;	90.4%
With sodium carbonate In water; ethyl acetate; isopropyl alcohol at 50℃; for 0.00111111h; Suzuki-Miyaura coupling; Microchannel flow reactor;	99 %Chromat.
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In N,N-dimethyl-formamide for 6h; Suzuki Coupling; Inert atmosphere; Reflux;

: 873-32-5
2-Chlorobenzonitrile

: 696-61-7
4-tolylmagnesium chloride

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
Stage #1: 2-Chlorobenzonitrile With bis(triphenylphosphine)nickel(II) chloride; methoxydichlorozinc acid In tetrahydrofuran at 20℃; for 0.25h; Stage #2: 4-tolylmagnesium chloride In tetrahydrofuran at 28 - 32℃; Inert atmosphere;	90%
Stage #1: 2-Chlorobenzonitrile With chloro-trimethyl-silane; manganese(ll) chloride In tetrahydrofuran at -5 - 0℃; Inert atmosphere; Green chemistry; Stage #2: 4-tolylmagnesium chloride In tetrahydrofuran at -5 - 25℃; for 9h; Inert atmosphere; Green chemistry;	86%
With nickel; zinc(II) chloride In tetrahydrofuran at 50 - 60℃; Product distribution; various double metal catalysts, various yield of products;
With iron(III) chloride In tetrahydrofuran at 0 - 130℃; for 3h; Temperature; Grignard Reaction; Large scale;	6.93 kg

: 824-79-3
sodium 4-methylbenzenesulfinate

: 138313-23-2
2-<(trifluoromethanesulfonyl)oxy>benzonitrile

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With palladium diacetate; XPhos In toluene at 120℃; for 24h; Sealed tube; Inert atmosphere;	90%

: 2042-37-7
o-cyanobromobenzene

: 824-79-3
sodium 4-methylbenzenesulfinate

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With palladium diacetate; XPhos In toluene at 120℃; for 40h; Inert atmosphere; Sealed tube;	90%
With caesium carbonate; palladium dichloride In N,N-dimethyl-formamide at 185℃; for 20h; Inert atmosphere; Sealed tube;	54%

: 624-31-7
4-tolyl iodide

: 138642-62-3
2-Cyanophenylboronic acid

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With Ti0.97Pd0.03O1.97; potassium carbonate In water at 100℃; for 6h; Suzuki-Miyaura Coupling;	89%

NiCl2 (Ph3 P)2: NiCl2 (Ph3 P)2

: ethyl acetate n-hexane

: 106-38-7
para-bromotoluene

: 2042-37-7
o-cyanobromobenzene

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With hydrogenchloride; tert.-butyl lithium; zinc(II) chloride In tetrahydrofuran; pentane	88%
With hydrogenchloride; tert.-butyl lithium; zinc(II) chloride In tetrahydrofuran; pentane	88%
With hydrogenchloride; tert.-butyl lithium; zinc(II) chloride In tetrahydrofuran; pentane	88%

...Expand

NiCl2 (Ph3 P)2: NiCl2 (Ph3 P)2

: 106-38-7
para-bromotoluene

: 2042-37-7
o-cyanobromobenzene

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With hydrogenchloride; tert.-butyl lithium; zinc(II) chloride In tetrahydrofuran; pentane	88%
With hydrogenchloride; tert.-butyl lithium; zinc(II) chloride In tetrahydrofuran; hexane; ethyl acetate; pentane
With hydrogenchloride; tert.-butyl lithium; zinc(II) chloride In tetrahydrofuran; hexane; ethyl acetate; pentane

...Expand

: 2042-37-7
o-cyanobromobenzene

: 696-61-7
4-tolylmagnesium chloride

: palladium dichloride

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With triphenylphosphine In tetrahydrofuran; water; toluene	88%

...Expand

: 106-38-7
para-bromotoluene

2-(cyano)halobenzene: 2-(cyano)halobenzene

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
Stage #1: para-bromotoluene With chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc In tetrahydrofuran at 25℃; for 24h; Knochel Zinc Vinyl Coupling; Inert atmosphere; Stage #2: 2-(cyano)halobenzene With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride In tetrahydrofuran at 25℃; for 1h; Knochel Zinc Vinyl Coupling; Inert atmosphere; Schlenk technique;	88%

Yield

Stage #1: para-bromotoluene With chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc In tetrahydrofuran at 25℃; for 24h; Knochel Zinc Vinyl Coupling; Inert atmosphere;
Stage #2: 2-(cyano)halobenzene With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride In tetrahydrofuran at 25℃; for 1h; Knochel Zinc Vinyl Coupling; Inert atmosphere; Schlenk technique;

88%

Pd2 (dba)3: Pd2 (dba)3

: 873-32-5
2-Chlorobenzonitrile

: 5720-05-8
4-methylphenylboronic acid

: 114772-53-1
2-Cyano-4'-methylbiphenyl

Conditions

Conditions	Yield
With cesium fluoride In 1,4-dioxane	87%

...Expand

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 120568-11-8
2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl

Conditions

Conditions	Yield
With trimethylsilylazide; tetrabutyl ammonium fluoride at 120℃; for 36h;	97%
With sodium azide; zinc(II) chloride In N,N-dimethyl-formamide for 36h; Heating;	96%
With sodium azide; triethylamine hydrochloride In N,N-dimethyl-formamide at 35℃; for 3h; Temperature; Sonication;	96%

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: methyl 2-diazo-2-(fluorosulfonyl)acetate

: 5-methoxy-2-(4'-methyl-[1,1'-biphenyl]-2-yl)oxazole-4-sulfonyl fluoride

Conditions

Conditions	Yield
Stage #1: 2-Cyano-4'-methylbiphenyl With dirhodium tetraacetate In chloroform at 70℃; Stage #2: methyl 2-diazo-2-(fluorosulfonyl)acetate In chloroform at 70℃; for 12h;	97%

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Conditions

Conditions	Yield
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane	96%
With bromine In water; 1,2-dichloro-ethane at 84℃; for 0.25h; Temperature; Solvent; Irradiation; Flow reactor;	96.3%
With bromine In 1,2-dichloro-ethane at 70℃; for 0.5h; Reagent/catalyst; Temperature; Time; Irradiation;	94%

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 120568-11-8
5-<4'-Methyl-1,1'-biphenyl-2-yl>-1H-tetrazole

Conditions

Conditions	Yield
Stage #1: 2-Cyano-4'-methylbiphenyl With sodium azide; zinc(II) chloride In N,N-dimethyl-formamide for 36h; Heating; Stage #2: With hydrogenchloride In N,N-dimethyl-formamide for 1h; cooling; Further stages.;	96%
With hydrogenchloride; sodium azide; triethylamine hydrochloride In 5,5-dimethyl-1,3-cyclohexadiene at 28 - 142℃; for 29h;	87%
Stage #1: 2-Cyano-4'-methylbiphenyl With sodium azide In N,N-dimethyl-formamide at 135℃; for 37h; Stage #2: With hydrogenchloride In water; ethyl acetate; N,N-dimethyl-formamide	82%

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 147403-93-8
4-Methylbiphenyl-2'-carboxamidoxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In methanol; dimethyl sulfoxide	96%
With hydroxylamine hydrochloride; triethylamine In dimethyl sulfoxide at 80 - 85℃; for 24h; Reagent/catalyst; Solvent;	89.6%

aqueous hydrochloric acid(pH 1): aqueous hydrochloric acid(pH 1)

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 120568-11-8
2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl

Conditions

Conditions	Yield
Zinc chloride In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; N,N-dimethyl-formamide	94%

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 1536169-09-1
o-(p-tolyl)-benzylamine hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-Cyano-4'-methylbiphenyl With C46H178O41Si42; titanium(IV)isopropoxide In toluene at 60℃; for 9h; Inert atmosphere; Stage #2: With hydrogenchloride; water In toluene at 20℃; for 9h; Inert atmosphere;	94%

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 7148-03-0
o-tolylbenzoic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethylene glycol at 170℃; for 48h;	93%
With sodium hydroxide In methanol; water at 80℃; for 10h; Temperature; Large scale;	91.06%
Stage #1: 2-Cyano-4'-methylbiphenyl With sodium hydroxide In ethylene glycol at 170℃; for 8h; Stage #2: With hydrogenchloride In water; toluene	90.4%

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 162356-74-3
4-methyl-2'-thiocarboxamido-1,1'-biphenyl

Conditions

Conditions	Yield
With hydrogenchloride In methanol	92%
Stage #1: 2-Cyano-4'-methylbiphenyl With magnesium(II) chloride hexahydrate; sodium monohydrogensulphide hydrate In water; N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: With hydrogenchloride In water for 0.333333h;	92.1%

4'-Methyl-2-cyanobiphenyl Chemical Properties

Molecular structure of 4'-Methyl-2-cyanobiphenyl (CAS NO.114772-53-1) is:

Product Name: 4'-Methyl-2-cyanobiphenyl
CAS Registry Number: 114772-53-1
IUPAC Name: 2-(4-methylphenyl)benzonitrile
Molecular Weight: 193.24384 [g/mol]
Molecular Formula: C₁₄H₁₁N
XLogP3: 3.8
H-Bond Donor: 0
H-Bond Acceptor: 1
EINECS: 422-310-9
Melting Point: 49 °C
Surface Tension: 47.7 dyne/cm
Density: 1.09 g/cm³
Flash Point: 170.4 °C
Enthalpy of Vaporization: 60.21 kJ/mol
Boiling Point: 356.8 °C at 760 mmHg
Vapour Pressure: 2.86E-05 mmHg at 25°C
Product Categories: Starting Raw Materials & Intermediates;Biphenyl derivatives;Intermediatesof;Biphenyl & Diphenyl ether;(intermediate of telmisartan);(intermediate of sartan);(intermediate of sartan s product);Losartan Potassium;Chiral Compound;Hypertension;Building block;Liquid Crystals;Organic Electronics and Photonics

4'-Methyl-2-cyanobiphenyl Uses

4'-Methyl-2-cyanobiphenyl (CAS NO.114772-53-1) is used for pharmaceutical intermediates .

4'-Methyl-2-cyanobiphenyl Safety Profile

Hazard Codes: Harmful

Xn,Xi
Risk Statements: 20/21/22-36/37/38-48/25/62/51/53-22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R48/25/62/51/53:Danger of serious damage to health by prolonged exposure, Toxic if swallowed, Risk of impaired fertility and Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R22:Harmful if swallowed.
Safety Statements: 22-26-36/37/39-36/37/45/57-20-36
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S36/37/45/57:Wear suitable protective clothing and gloves ,In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) ,Use appropriate container to avoid environmental contamination.
S20:When using, do not eat or drink.
S36:Wear suitable protective clothing.
RIDADR: 3276
Hazard Note: Irritant
HazardClass: 9
PackingGroup: III

4'-Methyl-2-cyanobiphenyl Specification

4'-Methyl-2-cyanobiphenyl , its cas register number is 114772-53-1. It also can be called 4'-Methylbiphenyl-2-carbonitrile ; 2-Cyano-4'-methylbiphenyl .It is a white crystalline powder.It insoluble in water.

Product Name

4'-Methyl-2-cyanobiphenyl

Synthetic route

4'-Methyl-2-cyanobiphenyl Chemical Properties

4'-Methyl-2-cyanobiphenyl Uses

4'-Methyl-2-cyanobiphenyl Safety Profile

4'-Methyl-2-cyanobiphenyl Specification

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