N,N-Diethylpropionamide supplier

Name
N,N-Diethylpropionamide
EINECS
CAS No. 1114-51-8
Article Data33
CAS DataBase
Density 0.87 g/cm³
Solubility
Melting Point -22oC
Formula C₇H₁₅NO
Boiling Point 194.3 °C at 760 mmHg
Molecular Weight 129.202
Flash Point 73.6 °C
Transport Information
Appearance colorless clear liquid
Safety 36
Risk Codes 20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms Propionamide,N,N-diethyl- (6CI,7CI,8CI);Diethylpropionamide;N,N-Diethylpropanamide;NSC 105;
PSA 20.31000
LogP 1.26480

Synthetic route

: 802294-64-0
propionic acid

: 109-89-7
diethylamine

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
Stage #1: propionic acid With niobium pentachloride In dichloromethane Stage #2: diethylamine In dichloromethane at 45 - 50℃; for 2.5h;	84%
With tetrachlorosilane; benzene
(i) 4-dimethylamino-but-3-yn-2-one, THF, (ii) /BRN= 605268/; Multistep reaction;

: 4231-35-0
methyl(diethylamino)acetylene

: 621-07-8
N,N-dibenzylhydroxylamine

A: 1114-51-8
N,N-diethylpropanamide

B: 100-52-7
benzaldehyde

C: 100-46-9
benzylamine

Conditions

Conditions	Yield
In tetrahydrofuran for 0.5h; Ambient temperature;	A 80% B 10% C 7%

...Expand

: 79-03-8
propionyl chloride

: 996-50-9
N,N-diethyl-1,1,1-trimethylsilanamine

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
In hexane for 5h; Ambient temperature;	71%

: 925-90-6
ethylmagnesium bromide

: C17H37NOP(1+)*Cl(1-)

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
With bis(triphenylphosphine)nickel(II) chloride In tetrahydrofuran at 20℃; for 2h;	58%

: 3555-94-0
isocyanatoethene

: 4231-35-0
methyl(diethylamino)acetylene

A: 1114-51-8
N,N-diethylpropanamide

B: 82639-26-7
4-(diethylamino)-3-methyl-2-pyridinone

C: 82639-27-8
2-(diethylamino)-3-methyl-4-pyridinone

D: 82639-25-6
N-(ethenylcarbamoyl)-4-(diethylamino)-3-methyl-2-pyridinone

Conditions

Conditions	Yield
In diethyl ether Mechanism; Product distribution; Ambient temperature; vinyl isothiocyanate, var. mol. ratio of Educts;	A 15.5% B 15.5% C 42% D 28.5%
In diethyl ether 1.) reflux, 2.) room temp., overnight;	A 15.5% B 42% C 3.7% D 28.5%

...Expand

: 79-03-8
propionyl chloride

: 109-89-7
diethylamine

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
With benzene

: 123-62-6
propionic acid anhydride

: 109-89-7
diethylamine

: 1114-51-8
N,N-diethylpropanamide

: 3553-80-8
ethyl N,N-diethylcarbamate

: 925-90-6
ethylmagnesium bromide

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
In tetrahydrofuran

: 21954-69-8
diethyl-amidosulfurous acid methyl ester

: 802294-64-0
propionic acid

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
With pyridine

: 74-85-1
ethene

: 201230-82-2
carbon monoxide

: 109-89-7
diethylamine

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
With cobalt(II) formate at 250 - 380℃;

...Expand

: 37612-61-6
1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one

: 109-89-7
diethylamine

A: 67-51-6
3,5-dimethyl-1H-pyrazole

B: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
In benzene at 29.5℃; Rate constant; other pyrazol, other amines;

...Expand

: 93702-88-6
1-diethylamino-1-(2-hydroxyethoxy)-1-propene

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
With sodium hydroxide at 80℃; for 2h;

: 75-34-3
1,1-dichloroethane

: 201230-82-2
carbon monoxide

: 109-89-7
diethylamine

A: 1114-51-8
N,N-diethylpropanamide

B: 106815-19-4
N,N-diethyl-2-diethylaminopropionamide

Conditions

Conditions	Yield
With triethylamine; dicobalt octacarbonyl at 100℃; under 38000 Torr; for 48h; Yield given. Yields of byproduct given;

...Expand

: 557-91-5
1,1-Dibromoethane

: 201230-82-2
carbon monoxide

: 109-89-7
diethylamine

A: 617-84-5
N-formyldiethylamine

B: 1114-51-8
N,N-diethylpropanamide

C: 1187-03-7
N,N,N',N'-tetraethylurea

D: 14288-05-2
N,N,N',N'-tetraethyloxamide

E: 106815-19-4
N,N-diethyl-2-diethylaminopropionamide

F: 133746-51-7
N,N,N',N'-tetraethyl-methylmalonamide

Conditions

Conditions	Yield
With triethylamine; dicobalt octacarbonyl In hexane at 100℃; under 38000 Torr; for 48h; Product distribution; K2CO3, other solvents; other catalysts; other geminal dihaloalkanes;

...Expand

: 557-91-5
1,1-Dibromoethane

: 201230-82-2
carbon monoxide

: 109-89-7
diethylamine

A: 1114-51-8
N,N-diethylpropanamide

B: 106815-19-4
N,N-diethyl-2-diethylaminopropionamide

C: 133746-51-7
N,N,N',N'-tetraethyl-methylmalonamide

Conditions

Conditions	Yield
With triethylamine; dicobalt octacarbonyl In tetrahydrofuran at 100℃; under 38000 Torr; for 48h; K2CO3, other catalysts and solvents; Yield given. Yields of byproduct given;

...Expand

: 121-44-8
triethylamine

: 292638-85-8
acrylic acid methyl ester

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
With ruthenium trichloride; triethylamine at 100℃; for 10h;

: 96439-62-2
2-((E)-1-Diethylamino-propenyl)-1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one

A: 1114-51-8
N,N-diethylpropanamide

B: 81-07-2
saccharin

Conditions

Conditions	Yield
With water

: 4231-35-0
methyl(diethylamino)acetylene

(cycloheptatrienylmethyl)carbene complex 1b: (cycloheptatrienylmethyl)carbene complex 1b

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 20.2 percent / H2SO4 / 4 h / 50 - 60 °C 2: 20percent aq. NaOH / 2 h / 80 °C View Scheme

: 123-91-1
1,4-dioxane

: 74-85-1
ethene

: 109-89-7
diethylamine

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
In water

...Expand

: 74-85-1
ethene

: 109-89-7
diethylamine

: 111-27-3
hexan-1-ol

: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
With CO

...Expand

: 201230-82-2
carbon monoxide

: 121-44-8
triethylamine

A: 685-91-6
diethylacetamide

B: 38806-26-7
N-Ethyl,N-methylacetamide

C: 1114-51-8
N,N-diethylpropanamide

Conditions

Conditions	Yield
With tertamethylammonium iodide; palladium dichloride In 1-methyl-pyrrolidin-2-one at 20 - 240℃; under 7500.75 - 48754.9 Torr; for 2.33333h; Autoclave;	A 43 %Chromat. B 12 %Chromat. C 37 %Chromat.

...Expand

: 1114-51-8
N,N-diethylpropanamide

: 54333-75-4
2-chloro-N,N-diethylpropionamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: With methyl chlorosulfate In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;	100%

: 1114-51-8
N,N-diethylpropanamide

: 95-46-5
2-methylphenyl bromide

: N,N-diethyl-2-o-tolylpropanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 2-methylphenyl bromide With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	98%

: 106-41-2
4-bromo-phenol

: 1114-51-8
N,N-diethylpropanamide

: N,N-diethyl-2-(4-hydroxyphenyl)propanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 4-bromo-phenol With {[P(t-Bu3)]PdBr}2; potassium hydride In tetrahydrofuran; cyclohexane at 20℃; for 24h;	95%

: 104-92-7
1-bromo-4-methoxy-benzene

: 1114-51-8
N,N-diethylpropanamide

: N,N-diethyl-2-(4-methoxyphenyl)propanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 1-bromo-4-methoxy-benzene With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	94%

Yield

Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h;
Stage #3: 1-bromo-4-methoxy-benzene With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;

94%

: 872-31-1
3-Bromothiophene

: 1114-51-8
N,N-diethylpropanamide

: N,N-diethyl-2-(thiophen-3-yl)propionamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 3-Bromothiophene With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 70℃; for 24h;	92%

: 557-93-7
2-bromoprop-1-ene

: 1114-51-8
N,N-diethylpropanamide

: 2,3-dimethylbut-3-enoic acid diethylamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 2-bromoprop-1-ene With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	92%

: 1114-51-8
N,N-diethylpropanamide

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: N,N-diethyl-2-(2-methoxynaphthalen-6-yl)propanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 2-Bromo-6-methoxynaphthalene With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	92%

Yield

Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h;
Stage #3: 2-Bromo-6-methoxynaphthalene With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;

92%

: 1114-51-8
N,N-diethylpropanamide

: 104-95-0
(4-bromophenyl)thioanisole

: N,N-diethyl-2-(4-methylsulfanylphenyl)propionamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: (4-bromophenyl)thioanisole With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	91%

Yield

Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h;
Stage #3: (4-bromophenyl)thioanisole With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;

91%

: 1114-51-8
N,N-diethylpropanamide

: 623-00-7
4-bromobenzenecarbonitrile

: 2-(4-cyanophenyl)-N,N-diethylpropanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 4-bromobenzenecarbonitrile With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	91%

Yield

Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h;
Stage #3: 4-bromobenzenecarbonitrile With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;

91%

: 1114-51-8
N,N-diethylpropanamide

: 402-43-7
p-trifluoromethylphenyl bromide

: N,N-diethyl-2-(4-(trifluoromethyl)phenyl)propanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: p-trifluoromethylphenyl bromide With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	90%

Yield

Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h;
Stage #3: p-trifluoromethylphenyl bromide With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;

90%

: 1114-51-8
N,N-diethylpropanamide

: 106-40-1
4-bromo-aniline

: 2-(4-aminophenyl)-N,N-diethylpropanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 4-bromo-aniline With {[P(t-Bu3)]PdBr}2; potassium hydride In tetrahydrofuran; cyclohexane at 20℃; for 24h;	90%

: 1271-66-5
dimethyltitanocene

: 1114-51-8
N,N-diethylpropanamide

: 816-40-0
1-Bromo-2-butanone

Conditions

Conditions	Yield
Stage #1: dimethyltitanocene; N,N-diethylpropanamide In toluene at 65℃; Schlenk technique; Inert atmosphere; Stage #2: With bromine In toluene at -78℃; for 0.0333333h; Schlenk technique; Inert atmosphere; Stage #3: With water In toluene at 20℃; for 1h; Schlenk technique; Inert atmosphere; regioselective reaction;	90%

: 1114-51-8
N,N-diethylpropanamide

: 578-57-4
2-bromoanisole

: N,N-diethyl-2-(2-methoxyphenyl)propanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 2-bromoanisole With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	88%

: 106-39-8
bromochlorobenzene

: 1114-51-8
N,N-diethylpropanamide

: 2-(4-chlorophenyl)-N,N-diethylpropanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: bromochlorobenzene With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	87%

: 1114-51-8
N,N-diethylpropanamide

: 586-78-7
para-nitrophenyl bromide

: N,N-diethyl-2-(4-nitrophenyl)propionamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: para-nitrophenyl bromide With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	87%

Yield

Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h;
Stage #3: para-nitrophenyl bromide With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;

87%

: 626-55-1
3-Bromopyridine

: 1114-51-8
N,N-diethylpropanamide

: N,N-diethyl-2-(pyridin-3-yl)propanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: 3-Bromopyridine With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 70℃; for 24h;	86%

: 1072-85-1
o-fluorobromobenzene

: 1114-51-8
N,N-diethylpropanamide

: N,N-diethyl-2-(2-fluorophenyl)propanamide

Conditions

Conditions	Yield
Stage #1: N,N-diethylpropanamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h; Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h; Stage #3: o-fluorobromobenzene With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 24h;	86%

: 1114-51-8
N,N-diethylpropanamide

: 13470-20-7
uranium(IV) bromide

: UBr4*3C2H5CON(C2H5)2

Conditions

Conditions	Yield
In dichloromethane addn. of a large excess of ligand in CH2Cl2 to a suspn. of UBr4 in CH2Cl2; stirring for ca 1 h; evapn., dark green oil solidified with toluene; washed with toluene, n-pentane; dried in vac. for 10 h; elem. anal.;	84%

: 1114-51-8
N,N-diethylpropanamide

: 80312-17-0
2,4-dimethoxy-N-(phenylmethylene)benzeneamine

: C22H30N2O3

Conditions

Conditions	Yield
With potassium hexamethylsilazane; bis[(3aR,8aS)-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-2-yl]methane In tetrahydrofuran at -78℃; for 24h; Mannich Aminomethylation; Inert atmosphere; stereoselective reaction;	81%

: 1114-51-8
N,N-diethylpropanamide

: 13453-49-1
thorium tetrabromide

: 98538-71-7
{ThBr3(C2H5CON(C2H5)2)3}(1+)*Br(1-)={ThBr3(C2H5CON(C2H5)2)3}Br

Conditions

Conditions	Yield
In tetrahydrofuran an excess of C2H5CON(C2H5)2 was added to a filtered soln. of ThBr4;; after 30 min the product was separated, washed twice with THF, and once with n-pentane, and dried for 8 h in vac.; elem.anal.;;	80%

: 1114-51-8
N,N-diethylpropanamide

: 83081-29-2
5-Fluor-2-(4-fluorphenyl)-4-(trifluormethyl)oxazol

: 116672-11-8
2-<2-(4-Fluorphenyl)-4-(trifluormethyl)oxazol-5-yl>propansaeure-diethylamid

Conditions

Conditions	Yield
In hexane Heating;	75%

: thorium nitrate pentahydrate

: 1114-51-8
N,N-diethylpropanamide

: Th(4+)*4NO3(1-)*2.67H5C2CON(C2H5)2=Th(NO3)4*2.67C2H5CON(C2H5)2

Conditions

Conditions	Yield
In ethanol addn. of large excess of the ligand (in abs. ethanol) to stirred soln. (abs. ethanol); stirring (1 h);; evapn. (colorless oil); dissolving (CH2Cl2); filtrate: evapn. to dryness; solidification overnight under pentane; washing (3 times/n-pentane); drying (vac./8 h); elem. anal.;;	72%

: 1114-51-8
N,N-diethylpropanamide

: 75-56-9, 16033-71-9
methyloxirane

: 338974-34-8
4-hydroxy-2-methyl-pentanoic acid diethylamide

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran	71%

: 1114-51-8
N,N-diethylpropanamide

: 106-96-7
propargyl bromide

: 1616976-79-4
N,N-diethyl-2-methylpent-4-ynamide

Conditions

Conditions	Yield
With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; hexane; toluene at -75 - 20℃; Inert atmosphere;	71%

: 1114-51-8
N,N-diethylpropanamide

: 10026-10-5
uranium(IV) chloride

: 82739-32-0
{UCl3(N,N'-diethylpropionamide)4}{UCl5(N,N'-diethylpropionamide)}

Conditions

Conditions	Yield
In tetrahydrofuran under N2, large excess of ligand added to soln. of UCl4 in THF, stirredfor 24 h; evapd. slowly in vac.; elem. anal.;	70%

: zinc(II) nitrate hexahydrate

: 1114-51-8
N,N-diethylpropanamide

: 554-95-0
benzene-1,3,5-tricarboxylic acid

: 11Zn(2+)*6C9H3O6(3-)*4NO3(1-)*8C7H15NO

Conditions

Conditions	Yield
at 120℃; for 24h;	65%

...Expand

: 1114-51-8
N,N-diethylpropanamide

: 4458-31-5
N,N-diethylpropylamine

Conditions

Conditions	Yield
With hydrogen; hexarhodium hexadecacarbonyl; decacarbonyldirhenium(0) In 1,2-dimethoxyethane at 160℃; under 76000 Torr; for 36h;	62%
With dodecacarbonyl-triangulo-triruthenium; hydrogen; molybdenum hexacarbonyl In 1,2-dimethoxyethane at 160℃; under 75007.5 Torr; for 16h; Inert atmosphere;
With hydrogen In 1,2-dimethoxyethane at 160℃; under 22502.3 Torr; for 20h; Inert atmosphere; Autoclave; Molecular sieve;
With [(SIMes)PFMe2][B(C6F5)4]2; phenylsilane at 100℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique; Glovebox;

N,N-Diethylpropionamide Consensus Reports

Reported in EPA TSCA Inventory.

N,N-Diethylpropionamide Specification

The N,N-Diethylpropionamide is an organic compound with the formula C₇H₁₅NO. The IUPAC name of this chemical is N,N-diethylpropanamide. With the CAS registry number 1114-51-8, it is also named as Diethylamide of propionic acid. The product's categories are Amides; Carbonyl Compounds; Organic Building Blocks. Besides, it should be stored in a closed cool and dry place.

Physical properties about N,N-Diethylpropionamide are: (1)ACD/LogP: 0.85; (2)ACD/LogD (pH 5.5): 0.85; (3)ACD/LogD (pH 7.4): 0.85; (4)ACD/BCF (pH 5.5): 2.6; (5)ACD/BCF (pH 7.4): 2.6; (6)ACD/KOC (pH 5.5): 68.89; (7)ACD/KOC (pH 7.4): 68.89; (8)#H bond acceptors: 2 ; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 20.31 Å²; (11)Index of Refraction: 1.428; (12)Molar Refractivity: 38.22 cm³; (13)Molar Volume: 148.4 cm³; (14)Polarizability: 15.15×10^-24cm³; (15)Surface Tension: 27.9 dyne/cm; (16)Density: 0.87 g/cm³; (17)Flash Point: 73.6 °C; (18)Enthalpy of Vaporization: 43.05 kJ/mol; (19)Boiling Point: 194.3 °C at 760 mmHg; (20)Vapour Pressure: 0.444 mmHg at 25°C.

Preparation: this chemical can be prepared by propionyl chloride and diethyl-trimethylsilanyl-amine. This reaction will need solvent hexane. The reaction time is 5 hours at ambient temperature. The yield is about 71%.

Uses of N,N-Diethylpropionamide: it can be used to produce diethyl-propyl-amine at temperature of 160 °C. It will need reagent H₂, catalyst Rh₆(CO)₁₆, Re₂(CO)₁₀ and solvent 1,2-dimethoxy-ethane with reaction time of 36 hours. The yield is about 62%.

When you are using this chemical, please be cautious about it as the following:
It is harmful by inhalation, in contact with skin and if swallowed. When you are using it, wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(N(CC)CC)CC
(2)InChI: InChI=1/C7H15NO/c1-4-7(9)8(5-2)6-3/h4-6H2,1-3H3
(3)InChIKey: YKOQQFDCCBKROY-UHFFFAOYAD
(4)Std. InChI: InChI=1S/C7H15NO/c1-4-7(9)8(5-2)6-3/h4-6H2,1-3H3
(5)Std. InChIKey: YKOQQFDCCBKROY-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	770mg/kg (770mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 18, Pg. 245, 1966.

Product Name

N,N-Diethylpropionamide

Synthetic route

N,N-Diethylpropionamide Consensus Reports

N,N-Diethylpropionamide Specification

Related Products

Hot Products