Pathalic acid supplier | CasNO.88-99-3

Name
Phthalic acid
EINECS 201-873-2
CAS No. 88-99-3
Article Data903
CAS DataBase
Density 1.451 g/cm³
Solubility 7 g/L (25 °C) in water
Melting Point 210-211 °C (dec.)(lit.)
Formula C₈H₆O₄
Boiling Point 378.274 °C at 760 mmHg
Molecular Weight 166.133
Flash Point 196.749 °C
Transport Information
Appearance White crystals or fine white powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Phthalicacid (8CI);NSC 5348;Sunftal 20;o-Benzenedicarboxylic acid;o-Carboxybenzoic acid;o-Dicarboxybenzene;o-Phthalic acid;1,2-Benzenedicarboxylicacid;
PSA 74.60000
LogP 1.08300

Synthetic route

: 95-47-6
o-xylene

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With zinc(II) oxide In N,N-dimethyl-formamide for 0.0833333h; microwave irradiation;	89%
With manganese(II) bromide; dihydrogen peroxide; oxygen In supercritical water at 380℃; under 172517 - 180018 Torr;	78%
With dihydrogen peroxide; sodium carbonate; acetic acid at 100℃; under 7500.75 Torr; for 12h; Reagent/catalyst; Green chemistry;	78%

: 95-47-6
o-xylene

A: 87-41-2
2-benzofuran-1(3H)-one

B: 88-99-3
benzene-1,2-dicarboxylic acid

C: 65-85-0
benzoic acid

D: 119-67-5
o-carboxybenzaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 380℃; under 172517 Torr; Product distribution / selectivity; Supercritical conditions;	A n/a B 72% C n/a D n/a
With oxygen; manganese(II) bromide; hydrogen bromide In water at 380℃; Product distribution / selectivity; Supercritical conditions;	A n/a B 65% C n/a D n/a
With dihydrogen peroxide; manganese(II) bromide In water at 380℃; under 172517 - 180018 Torr; Product distribution / selectivity; Supercritical conditions;	A n/a B 63% C n/a D n/a

...Expand

: 643-79-8
o-phthalic dicarboxaldehyde

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With selenium(IV) oxide; dihydrogen peroxide In tetrahydrofuran for 50h; Heating;	93%
With potassium hydroxide; sodium tetrahydroborate; air; palladium on activated charcoal In methanol at 20℃; for 7h;	90%
With tert.-butylhydroperoxide; copper(l) chloride In acetonitrile at 20℃; for 2.5h;	84%

: 95-47-6
o-xylene

A: 87-41-2
2-benzofuran-1(3H)-one

B: 88-99-3
benzene-1,2-dicarboxylic acid

C: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 380℃; under 172517 - 180018 Torr; Product distribution / selectivity; Supercritical conditions;	A n/a B 66% C n/a
With dihydrogen peroxide In water at 380℃; under 172517 - 180018 Torr; Product distribution / selectivity; Supercritical conditions;	A n/a B 66% C n/a
With oxygen; manganese(II) bromide; hydrogen bromide In water at 380℃; Product distribution / selectivity; Supercritical conditions;	A n/a B 66% C n/a
With oxygen; hydrogen bromide; manganese(II) acetate In water at 380℃; Product distribution / selectivity; Supercritical conditions;	A n/a B 63% C n/a

...Expand

: 95-47-6
o-xylene

A: 87-41-2
2-benzofuran-1(3H)-one

B: 529-20-4
2-methylphenyl aldehyde

C: 88-99-3
benzene-1,2-dicarboxylic acid

D: 65-85-0
benzoic acid

E: 119-67-5
o-carboxybenzaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 380℃; under 172517 Torr; Product distribution / selectivity; Supercritical conditions;	A n/a B n/a C 71% D n/a E n/a
With oxygen; hydrogen bromide; manganese(II) acetate In water at 380℃; Product distribution / selectivity; Supercritical conditions;	A n/a B n/a C 60% D n/a E n/a
With oxygen; hydrogenchloride; manganese(II) acetate In water at 380℃; Product distribution / selectivity; Supercritical conditions;	A n/a B n/a C 17% D n/a E n/a
With oxygen; manganese(II) acetate In water at 380℃; Product distribution / selectivity; Supercritical conditions;	A n/a B n/a C 8% D n/a E n/a

...Expand

: 91-20-3
naphthalene

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With zinc(II) oxide In N,N-dimethyl-formamide for 0.125h; microwave irradiation;	78%
With sodium hypochlorite; ruthenium(III) chloride trihydrate; sulfuric acid; tetrabutylammomium bromide In water; 1,2-dichloro-ethane at 23℃; for 0.5h; pH=9; Green chemistry;	58%
With silica gel at -196.1℃; Irradiation;	49%

: 95-47-6
o-xylene

A: 118-90-1
ortho-methylbenzoic acid

B: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
Stage #1: o-xylene With manganese(IV) oxide; C32H16N8O4Ru; C46H39CrN12O2; oxygen at 195℃; under 14251.4 Torr; for 0.2h; Stage #2: With manganese(IV) oxide; C32H16N8O4Ru; C46H39CrN12O2; oxygen; acetic acid at 150℃; under 4500.45 Torr; for 4h; Temperature; Pressure; Reagent/catalyst;	A 89.3% B 10.6%
Stage #1: o-xylene With N-acetylphthalimide; Cr(4+)4NO3(1-); C36H24N8NiO4; C52H44FeN4O8; oxygen at 120℃; under 2250.23 Torr; for 1.5h; Stage #2: With N-acetylphthalimide; Cr(4+)4NO3(1-); C36H24N8NiO4; C52H44FeN4O8; oxygen; acetic acid at 170℃; under 12001.2 Torr; for 0.6h; Temperature; Pressure; Reagent/catalyst;	A 14.4% B 85.3%
With zinc(II) oxide In N,N-dimethyl-formamide for 0.133333h; microwave irradiation;	A 80% B 5 % Spectr.

: 201230-82-2
carbon monoxide

: 2042-37-7
o-cyanobromobenzene

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 12h; Irradiation;	78%

: 5779-72-6
2,4,5-trimethylbenzaldehyde

A: 89-05-4
1,2,4,5-benzenetetracarboxylic acid

B: 34240-10-3
5-methyl-1,2,4-benzenetricarboxylic acid

C: 528-44-9
1,2,4-benzene tricarboxylic acid

D: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
Stage #1: 2,4,5-trimethylbenzaldehyde With oxygen at 210℃; under 24002.4 Torr; Stage #2: With oxygen; hydrogen bromide In water at 210℃; under 21752.2 Torr; Stage #3: With hydrogen; 0.5% Pd/C at 150℃; under 7500.75 Torr;

...Expand

: 95-47-6
o-xylene

A: 118-90-1
ortho-methylbenzoic acid

B: 87-41-2
2-benzofuran-1(3H)-one

C: 88-99-3
benzene-1,2-dicarboxylic acid

D: 65-85-0
benzoic acid

E: 119-67-5
o-carboxybenzaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 380℃; under 172517 Torr; Product distribution / selectivity; Supercritical conditions;	A n/a B n/a C 74% D n/a E n/a
With dihydrogen peroxide In water at 380℃; under 172517 Torr; Product distribution / selectivity; Supercritical conditions;	A n/a B n/a C 71% D n/a E n/a
With dihydrogen peroxide In water at 380℃; under 172517 - 180018 Torr; Product distribution / selectivity; Supercritical conditions;	A n/a B n/a C 52% D n/a E n/a
With dihydrogen peroxide; cobalt(II) bromide In water at 380℃; under 172517 - 180018 Torr; Product distribution / selectivity; Supercritical conditions;	A n/a B n/a C 51% D n/a E n/a

...Expand

: 83-33-0
inden-1-one

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen; manganese (II) acetate tetrahydrate; cobalt(II) diacetate tetrahydrate In acetic acid at 120℃; under 760.051 Torr; for 15h;	82%
With KO2; 18-crown-6 ether In N,N-dimethyl-formamide for 20h; Ambient temperature;	61 % Chromat.

: 119-67-5
o-carboxybenzaldehyde

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide; sodium tetrahydroborate; air; palladium on activated charcoal In methanol at 20℃; for 3h;	86%
With tetrakis(pyridine)silver(II) peroxodisulfate In water; acetonitrile for 5h; Ambient temperature;	80%
With potassium permanganate In water; acetonitrile

: 201230-82-2
carbon monoxide

: 583-53-9
1,2-dibromobenzene

A: 610-94-6
2-bromobenzoic acid methyl ester

B: 131-11-3
phthalic acid dimethyl ester

C: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 18h; Irradiation;	A 4% B 85% C 3%

...Expand

: 88-67-5
2-Iodobenzoic acid

: 201230-82-2
carbon monoxide

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With potassium carbonate; potassium tetrachloropalladate(II) In water at 50℃; under 760 Torr; for 20h;	95%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 583-53-9
1,2-dibromobenzene

A: 610-94-6
2-bromobenzoic acid methyl ester

B: 131-11-3
phthalic acid dimethyl ester

C: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 18h; Irradiation;	A 4% B 85% C 3%

...Expand

: 95-47-6
o-xylene

A: 118-90-1
ortho-methylbenzoic acid

B: 612-20-4
2-(hydroxymethyl)benzoic acid

C: 88-99-3
benzene-1,2-dicarboxylic acid

D: 119-67-5
o-carboxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: o-xylene With N-hydroxyphthalimide; air; cobalt(II) acetate; manganese(II) acetate In acetic acid at 150℃; under 22801.5 Torr; for 3h; Stage #2: With sodium hydroxide at 90℃; Further stages.;	A 6% B 8% C 73% D 3%

...Expand

aqueous potassium hydroxide: aqueous potassium hydroxide

: 74805-32-6
2-(2-chlorobenzyl)isoindoline-1,3-dione

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride In iced-water; water	98%

: 612-40-8
2-carboxycinnamic acid

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With Oxone In water; acetonitrile for 22h; Reflux;	85%

: 4733-52-2
phthaloyl peroxide

A: 6246-98-6, 73334-88-0, 73334-89-1
N,N'-diphenyl-1,4-phenylenediamine

B: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With N,N'-diphenyl-1,4-phenylenediamine In tetrahydrofuran at 25℃;	A 88% B 98%

: 74-31-7
N,N'-diphenyl-1,4-phenylenediamine

A: 6246-98-6, 73334-88-0, 73334-89-1
N,N'-diphenyl-1,4-phenylenediamine

B: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With monoperoxyphthalic acid In tetrahydrofuran at 25℃;	A 88% B 98%

: 95-47-6
o-xylene

: 106-42-3
para-xylene

A: 88-99-3
benzene-1,2-dicarboxylic acid

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; oxygen; manganese(II) bromide In water at 400℃; under 187519 Torr; Product distribution / selectivity;	A 46% B n/a

...Expand

: 5460-29-7
2-(3-bromopropyl)isoindole-1,3-dione

: 103-67-3
benzyl-methyl-amine

A bis(3-aminopropyl)methylbenzylammonium trihydrochloride: bis(3-aminopropyl)methylbenzylammonium trihydrochloride

B: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; hydrogenchloride	A 90% B n/a

...Expand

: 201230-82-2
carbon monoxide

: 65-85-0
benzoic acid

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With sodium acetate; palladium diacetate; silver carbonate In 1,4-dioxane at 150℃; under 760.051 Torr; for 48h;	41%

: 575-41-7
1,3-dimethylnaphthalene

A: 2089-93-2
1,3-naphthalenedicarboxylic acid

B: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen; cobalt acetate; hydrogen bromide; manganese(II) acetate In water; acetic acid at 180 - 200℃; under 12001.2 Torr; for 1.08333h; Product distribution / selectivity;	A 30% B 0.1%

: 95-47-6
o-xylene

A: 118-90-1
ortho-methylbenzoic acid

B: 87-41-2
2-benzofuran-1(3H)-one

C: 529-20-4
2-methylphenyl aldehyde

D: 88-99-3
benzene-1,2-dicarboxylic acid

E: 65-85-0
benzoic acid

F: 119-67-5
o-carboxybenzaldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 380℃; under 172517 Torr; Product distribution / selectivity; Supercritical conditions;	A n/a B n/a C n/a D 70% E n/a F n/a

...Expand

: 577-16-2, 122382-54-1
2-Methylacetophenone

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With oxygen; zirconyl acetate; manganese (II) acetate tetrahydrate; cobalt(II) diacetate tetrahydrate; acetic anhydride; 1N,3N,5N-trihydroxy-1,3,5-triazin-2,4,6[1H,3H,5H]-trione In acetic acid at 120℃; under 760.051 Torr; for 15h;	73%

: 612-14-6
phthalyl alcohol

: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With C15H27Br2CoN3; potassium hydroxide In toluene at 140℃; for 16h; Cannizzaro Reaction; Inert atmosphere; Sealed tube;	80%
With potassium permanganate

: 95-47-6
o-xylene

A: 88-99-3
benzene-1,2-dicarboxylic acid

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With sodium hydroxide; water; dihydrogen peroxide; manganese(II) bromide at 380℃; under 172517 Torr;	A 46% B n/a
With manganese(II) bromide; dihydrogen peroxide; oxygen; sodium bromide In supercritical water at 380℃; under 172517 - 180018 Torr;

: 95-47-6
o-xylene

: 106-42-3
para-xylene

: 108-38-3
m-xylene

A: 121-91-5
isophthalic acid

B: 100-21-0
terephthalic acid

C: 88-99-3
benzene-1,2-dicarboxylic acid

D: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; oxygen; manganese(II) bromide In water at 400℃; under 187519 Torr; Product distribution / selectivity;	A 86.3% B 66.7% C 61.5% D n/a

...Expand

: 524-38-9
N-hydroxyphthalimide

acetylacetonatocobalt(III) Co(AA)3: acetylacetonatocobalt(III) Co(AA)3

A: 118-90-1
ortho-methylbenzoic acid

B: 88-99-3
benzene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With acetic acid In o-xylene	A 71% B n/a

...Expand

: 88-99-3
benzene-1,2-dicarboxylic acid

: 85-44-9
phthalic anhydride

Conditions

Conditions	Yield
(2-(pyridin-2-yl)phenyl)boronic acid In nonane for 5.5h; Product distribution / selectivity; 3 Å Molecular sieve; Reflux;	100%
With 2,6-dimethylpyridine; tris(2,2'-bipyridyl)ruthenium dichloride; carbon tetrabromide; N,N-dimethyl-formamide at 25 - 30℃; for 12h; Inert atmosphere; Photolysis;	99%
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; triethylamine In dichloromethane at 20℃; for 1h;	98%

: 88-99-3
benzene-1,2-dicarboxylic acid

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 2078-22-0
ortho-phthalic acid bis(trimethylsilyl) ester

Conditions

Conditions	Yield
With saccharin at 125℃; for 1h; Inert atmosphere;	100%
	98%
With iodine In neat (no solvent) at 20℃; for 52h; Green chemistry;	46%

: 59565-09-2
2-(vinyloxy)ethyl isothiocyanate

: 88-99-3
benzene-1,2-dicarboxylic acid

: phthalic acid bis-[1-(2-isothiocyanato-ethoxy)-ethyl] ester

Conditions

Conditions	Yield
Stage #1: 2-(vinyloxy)ethyl isothiocyanate; benzene-1,2-dicarboxylic acid at 120℃; Stage #2: With trifluoroacetic acid at 70 - 80℃; for 1h;	100%

: 88-99-3
benzene-1,2-dicarboxylic acid

: 1608-26-0
Hexamethylphosphorous triamide

: 6329-16-4
N,N,N',N'-tetramethyl-phthalamide

Conditions

Conditions	Yield
In benzene for 0.5h; Heating;	100%

: 88-99-3
benzene-1,2-dicarboxylic acid

: 87976-26-9
3,4,5,6-tetradeuterophtaloyl dicarboxylic acid

Conditions

Conditions	Yield
With hydrogen; water-d2; platinum on activated charcoal at 180℃; for 24h;	100%
Stage #1: benzene-1,2-dicarboxylic acid With platinum on carbon; hydrogen; water-d2 at 180℃; under 3420.23 Torr; for 24h; Stage #2: With water In diethyl ether	51%

: [(η(5)-C5H5)2Co][OH]

: 88-99-3
benzene-1,2-dicarboxylic acid

: 4((C5H5)2Co)(1+)*2(C6H4COOHCOO)(1-)*C6H4(COO)2(2-) = [(C5H5)2Co]4[(C6H4COOHCOO)2][C6H4(COO)2]

Conditions

Conditions	Yield
In water mixing; filtn., solvent evpn.;	100%

: bis(benzene)chromium hydroxide

: 88-99-3
benzene-1,2-dicarboxylic acid

: ((C6H6)2Cr)(1+)*C6H4COOHCOO(1-)*C6H4(COOH)2 = [(C6H6)2Cr][(C6H4COOHCOO)][C6H4(COOH)2]

Conditions

Conditions	Yield
In water mixing; filtn., solvent evpn.;	100%

: 1093966-48-3
5-(3-chloropyridin-2-yl)-7-(2-pyridin-2-ylethoxy)-1H-indazole-3-amine

: 88-99-3
benzene-1,2-dicarboxylic acid

: 1093966-58-5
2-[5-(3-chloropyridin-2-yl)-7-(2-pyridin-2-ylethoxy)-1H-indazol-3-yl]-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
Stage #1: 5-(3-chloropyridin-2-yl)-7-(2-pyridin-2-ylethoxy)-1H-indazole-3-amine; benzene-1,2-dicarboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20 - 50℃; for 2h; Stage #2: With sodium hydrogencarbonate In water; N,N-dimethyl-formamide	100%

: 932-52-5
5-Aminouracil

: 88-99-3
benzene-1,2-dicarboxylic acid

: 59007-52-2
5-phthalimidopyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
With pyridine at 150℃; for 0.5h; Reagent/catalyst; Temperature; Inert atmosphere; Sealed tube; Microwave irradiation;	100%

: 24544-04-5
2,6-diisopropylbenzenamine

: 88-99-3
benzene-1,2-dicarboxylic acid

: (E)-2-(((2,6-diisopropylphenyl)imino)methyl)benzoic acid

Conditions

Conditions	Yield
In methanol at 20℃; for 2h; Inert atmosphere; Reflux;	100%

: 67-56-1
methanol

: 88-99-3
benzene-1,2-dicarboxylic acid

: 131-11-3
phthalic acid dimethyl ester

Conditions

Conditions	Yield
With boron trifluoride at 95℃; for 1h; Product distribution; other reaction time: 15, 20, 30 min;	99.9%
With boron trifluoride at 95℃; for 1h;	99.9%
With sulfuric acid for 24h; Reflux;	96%

: 78-39-7
Triethyl orthoacetate

: 88-99-3
benzene-1,2-dicarboxylic acid

: 84-66-2
Diethyl phthalate

Conditions

Conditions	Yield
In various solvent(s) at 80℃; for 2h;	99%

: 4937-62-6
2-amino-4-methylbenzophenone

: 7732-18-5
water

: 88-99-3
benzene-1,2-dicarboxylic acid

: 23070-81-7
2-(N-isopropylamino)-4-methylbenzophenone

Conditions

Conditions	Yield
With sodium hydroxide; sodium borohydrid In acetone	99%

...Expand

: 75-24-1
trimethylaluminum

: 88-99-3
benzene-1,2-dicarboxylic acid

: [(AlMe2)2(μ-phthalate)]2

Conditions

Conditions	Yield
In not given addn. of AlMe3 (2 equiv.) to phthalic acid; according to J. Lewinski et al. Inorg. Chem. 1998, 37, 2575;	99%
In toluene byproducts: CH4; N2-atmosphere; addn. of 2 equiv. AlMe3 to ligand at -78°C, warming to room temp., standing for 1 h; evapn. (vac.); elem. anal.;	95%

: 159465-27-7
3-Bromo-4-methoxyphenethylamine

: 88-99-3
benzene-1,2-dicarboxylic acid

: N-(3-bromo-4-methoxy-phenethyl)-phthalimide

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide In dichloromethane at 20℃; for 12h;	99%

: 88-99-3
benzene-1,2-dicarboxylic acid

: 58088-50-9
bis(pyridin-2-yl)methylamine

: 1-(pyridin-2-yl)-3-(2-(1-(pyridin-2-yl)imidazo[1,5-a]pyridin-3-yl)phenyl)imidazo[1,5-a]pyridine

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In acetic acid butyl ester; ethyl acetate at 20℃; for 17h; Reflux;	99%

: 88-99-3
benzene-1,2-dicarboxylic acid

: 616-38-6
carbonic acid dimethyl ester

: 4376-18-5
Monomethyl phthalate

Conditions

Conditions	Yield
With 5 wt percent zeolite NaY-Bf at 180℃; for 5h; Autoclave; Green chemistry;	99%

: 10042-59-8
2-propylheptan-1-ol

: 88-99-3
benzene-1,2-dicarboxylic acid

: 53306-54-0
di(2-propylheptyl) phthalate

Conditions

Conditions	Yield
With titanium(IV) isopropylate at 170 - 220℃; under 760.051 Torr; for 4.5h; Inert atmosphere; Large scale;	99%
In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 6h; Reagent/catalyst; Solvent; Temperature;

: 1-ethyl-2,3-dimethylimidazolin-3-ium methyl carbonate

: 88-99-3
benzene-1,2-dicarboxylic acid

: 1-ethyl-2,3-dimethylimidazolinium hydrogen phthalate salt

Conditions

Conditions	Yield
In methanol at 20 - 30℃; for 4h;	99%

: 1153-05-5, 856568-31-5
triphenylarsineoxide

: 88-99-3
benzene-1,2-dicarboxylic acid

: 2C18H15AsO*C8H6O4

Conditions

Conditions	Yield
In benzene Heating;	98%

: 88-99-3
benzene-1,2-dicarboxylic acid

: 100-46-9
benzylamine

: 38228-99-8
N,N'-dibenzylphthalamide

Conditions

Conditions	Yield
In xylene for 7.5h; Heating;	98%

: 95-54-5
1,2-diamino-benzene

: 88-99-3
benzene-1,2-dicarboxylic acid

: 16529-06-9
2-(2-carboxyphenyl)benzimidazole

Conditions

Conditions	Yield
at 200℃; under 187519 Torr; for 3h; Temperature; Autoclave; Inert atmosphere;	98%
With hydrogenchloride at 80℃; for 4h;	79%
at 150℃; for 2h;	75%
With polyphosphoric acid at 250℃; for 4h;	71%

: 13328-67-1, 51017-91-5
penta(p-tolyl)antimony(V)

: 88-99-3
benzene-1,2-dicarboxylic acid

: 127948-08-7
tetraphenylantimony monophthalate

Conditions

Conditions	Yield
In 1,4-dioxane; toluene sealed evacuated ampoule, soln. of Sb-compd. in toluene addn. to soln. of acid in dioxane, heating (90°C, 1 h); cooling, filtration, residue drying;	98%

: 2170-05-0
pentaphenylantimony

: 88-99-3
benzene-1,2-dicarboxylic acid

: 127948-08-7
tetraphenylantimony phthalate

Conditions

Conditions	Yield
In toluene byproducts: benzene; room temp., 0.5-1 h; elem. anal.;	98%

Pathalic acid Consensus Reports

Reported in EPA TSCA Inventory.

Pathalic acid Specification

The IUPAC name of this chemical is phthalic acid. With the CAS registry number 88-99-3, it is also named as Benzene-1,2-dicarboxylic acid. The product's categorie is Phthalic Acids, Esters and Derivatives. It is white crystals or fine white powder which is soluble in methanol and ethanol, slightly soluble in water and ether, insoluble in chloroform. In addition, this chemical is stable, combustible and incompatible with strong oxidizing agents. Furthermore, it should be sealed in the container.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.88; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 4; (8)#H bond donors: 2; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.618; (11)Molar Refractivity: 40.113 cm³; (12)Molar Volume: 114.493 cm³; (13)Polarizability: 15.902×10^-24 cm³; (14)Surface Tension: 70.304 dyne/cm; (15)Enthalpy of Vaporization: 66.051 kJ/mol; (16)Vapour Pressure: 0 mmHg at 25°C; (17)Rotatable Bond Count: 2; (18)Exact Mass: 166.026609; (19)MonoIsotopic Mass: 166.026609; (20)Topological Polar Surface Area: 74.6; (21)Heavy Atom Count: 12; (22)Complexity: 177.

Preparation of Phthalic acid: It can be obtained by the hydrolysis of phthalic anhydride. Adding phthalic anhydride to the 60 °C water, and stirring while adding ammonia to the ph value of 8. After bleaching filtered and acidified with hydrochloric acid, we can get the product by washing. Reactive process:

Uses of Phthalic acid: It is used in the preparation of standard solution, dyes, polyester resin, polyester, plasticizers and drugs. And it is also used as analytical reagent. Furthermore, this chemical can react with 2-chloro-6-methyl-aniline to get N-(2-chloro-6-methyl-phenyl)-phthalimide. The temperature is 190 - 220 °C and the yield is 64%.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
1. SMILES:c1ccc(c(c1)C(=O)O)C(=O)O
2. InChI:InChI=1/C8H6O4/c9-7(10)5-3-1-2-4-6(5)8(11)12/h1-4H,(H,9,10)(H,11,12)

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	550mg/kg (550mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 49, Pg. 471, 1942.
mouse	LD50	oral	2530mg/kg (2530mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 711, 1992.
rat	LD50	unreported	1100mg/kg (1100mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(8), Pg. 12, 1967.

Product Name

Phthalic acid

Synthetic route

Pathalic acid Consensus Reports

Pathalic acid Specification

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