Tetraethylene glycol supplier

Name
Bis[2-(2-hydroxyethoxy)ethyl] ether
EINECS 203-989-9
CAS No. 112-60-7
Article Data28
CAS DataBase
Density 1.125 g/cm³
Solubility Soluble in water
Melting Point -5.6 °C(lit.)
Formula C₈H₁₈O₅
Boiling Point 328 °C at 760 mmHg
Molecular Weight 194.228
Flash Point 176.7 °C
Transport Information
Appearance colorless to light yellowish liquid
Safety 24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms Tetraethyleneglycol (6CI,7CI,8CI);1,11-Dihydroxy-3,6,9-trioxaundecane;2,2'-[Oxybis(2,1-ethanediyloxy)]bisethanol;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethanol;3,6,9-Trioxaundecane-1,11-diol;Bis[2-(2-hydroxyethoxy)ethyl] ether;Hi-Dry;NSC 1262;
PSA 68.15000
LogP -0.97920

Synthetic route

: 107-21-1
ethylene glycol

: 111-44-4
3-oxa-1,5-dichloropentane

: 112-60-7
Tetraethylene glycol

Conditions

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide at 90℃; for 9h;	32%
With sodium

: 75-21-8
oxirane

: 107-21-1
ethylene glycol

: 112-60-7
Tetraethylene glycol

Conditions

Conditions	Yield
at 210℃; under 36775.4 Torr;

: 75-21-8
oxirane

: 107-21-1
ethylene glycol

A: 112-60-7
Tetraethylene glycol

B: 111-46-6
diethylene glycol

C: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Conditions

Conditions	Yield
at 130 - 210℃; unter Druck, 1 Mol Aethylenoxyd;

...Expand

: 75-21-8
oxirane

: 111-46-6
diethylene glycol

A: 112-60-7
Tetraethylene glycol

B: 4792-15-8
Pentaethylene glycol

C: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

...Expand

: 75-21-8
oxirane

: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

: 112-60-7
Tetraethylene glycol

Conditions

Conditions	Yield
unter Druck;

: 75-21-8
oxirane

: 112-60-7
Tetraethylene glycol

Conditions

Conditions	Yield
With acetic acid Verseifung das entstehenden Diacetat des Tetraaethylenglykols mit Baryt;

: 107-21-1
ethylene glycol

: 106-93-4
ethylene dibromide

: 112-60-7
Tetraethylene glycol

Conditions

Conditions	Yield
at 115 - 120℃;

: 107-21-1
ethylene glycol

: 106-93-4
ethylene dibromide

A: 112-60-7
Tetraethylene glycol

B: 4792-15-8
Pentaethylene glycol

C: 111-46-6
diethylene glycol

D: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Conditions

Conditions	Yield
at 115 - 120℃; Produkt5: Hexaaethylenglykol;

...Expand

: 7388-28-5, 10604-71-4, 24768-69-2, 26915-75-3, 50856-01-4, 92004-30-3
sodium 2-hydroxyethoxide

: 111-44-4
3-oxa-1,5-dichloropentane

: 112-60-7
Tetraethylene glycol

Conditions

Conditions	Yield
at 65℃;

: 68375-97-3
2-methyl-14-crown-5

A: 112-60-7
Tetraethylene glycol

B: 75-07-0
acetaldehyde

Conditions

Conditions	Yield
With water; hydrogenchloride In 1,4-dioxane Rate constant; Equilibrium constant; Ambient temperature; effect of alkali and alkaline earth metal chlorides and concentrations of HCl;

: 81194-61-8
2,2-diphenyl-1,3,6,9,12-pentaoxacyclotetradecane

: 112-60-7
Tetraethylene glycol

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane; water at 30℃; Rate constant; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.), var. temp.;

: 107-21-1
ethylene glycol

: 112-26-5
1,2-bis(2-chloroethoxy)ethane

A: 112-60-7
Tetraethylene glycol

B: 4792-15-8
Pentaethylene glycol

Conditions

Conditions	Yield
With potassium hydroxide at 140℃; for 120h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: C8H18O5*Li(1+)

A: 112-60-7
Tetraethylene glycol

B: lithium cation

Conditions

Conditions	Yield
In acetonitrile at 25℃; Rate constant; Equilibrium constant; different concentrations;

: 7553-56-2
iodine

: 111-46-6
diethylene glycol

A: 112-60-7
Tetraethylene glycol

B: 4792-15-8
Pentaethylene glycol

C: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Conditions

Conditions	Yield
at 190℃;

...Expand

: 107-21-1
ethylene glycol

A: 112-60-7
Tetraethylene glycol

B diethylene glycol, triethylene glycol: diethylene glycol, triethylene glycol

Conditions

Conditions	Yield
With sulfuric acid

: 75-21-8
oxirane

: 107-21-1
ethylene glycol

A: 112-60-7
Tetraethylene glycol

B diethylene glycol, triethylene glycol: diethylene glycol, triethylene glycol

Conditions

Conditions	Yield
With sulfuric acid at 90℃;

...Expand

: 111-46-6
diethylene glycol

A: 112-60-7
Tetraethylene glycol

B triethylene glycol, pentaethylene glycol: triethylene glycol, pentaethylene glycol

Conditions

Conditions	Yield
With iodine at 190℃;

: 75-21-8
oxirane

: 111-46-6
diethylene glycol

A: 112-60-7
Tetraethylene glycol

B triethylene glycol, pentaethylene glycol: triethylene glycol, pentaethylene glycol

...Expand

: 62732-91-6
debacarb

: 111-90-0
ethoxyethoxyethanol

: 112-60-7
Tetraethylene glycol

: 2615-15-8
pentaethylene glycol

A: 64-18-6
formic acid

B: 112-60-7
Tetraethylene glycol

C: 4792-15-8
Pentaethylene glycol

D: 107-21-1
ethylene glycol

E: 64-19-7
acetic acid

F: 111-46-6
diethylene glycol

G: 112-27-6
2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Conditions

Conditions	Yield
With titanium(IV) oxide In water for 24h; Concentration; UV-irradiation;

...Expand

: 112-60-7
Tetraethylene glycol

: 98-59-9
p-toluenesulfonyl chloride

: 37860-51-8
tetraethylene glycol di(p-toluenesulfonate)

Conditions

Conditions	Yield
With potassium hydroxide In dichloromethane at 0℃; for 3h;	100%
With potassium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 3h;	100%
With potassium hydroxide In dichloromethane at 0℃; for 3h;	100%

: 112-60-7
Tetraethylene glycol

: 98-59-9
p-toluenesulfonyl chloride

: 77544-60-6
p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
Stage #1: Tetraethylene glycol With sodium hydroxide In tetrahydrofuran at 0℃; for 0.25h; Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran at 0℃; for 4h;	100%

: 112-60-7
Tetraethylene glycol

: 76-83-5
trityl chloride

: 125274-16-0
1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol

Conditions

Conditions	Yield
With pyridine at 45℃;	100%
With pyridine at 45℃; for 16h; Etherification;	99%
With pyridine at 50℃; for 1h;	89%

: 112-60-7
Tetraethylene glycol

: 39178-35-3
isonicotinoyl chloride hydrochloride

: 131366-91-1
4-pyridinecarboxylic acid tetraethylene glycol diester

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 4h; Condensation; Heating;	100%

: 112-60-7
Tetraethylene glycol

: 123436-89-5
1-(bromomethyl)-4-(dodecyloxy)benzene

: 1004269-50-4
13-[4-(dodecyloxy)phenyl]-3,6,9,12-tetraoxatridecan-1-ol

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran for 4h; Heating;	100%

: 112-60-7
Tetraethylene glycol

: 137332-64-0
(+)-(S)-6-Fluoro-3-methyl-4-(3-methyl-2-butenyl)-9-nitro-2,3,4,5-tetrahydro-1H-<1,4>benzodiazepine

: 1425581-41-4
(+)-(S)-6-(tetraethylene glycol)-3-methyl-4-(3-methyl-2-butenyl)-9-nitro-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine

Conditions

Conditions	Yield
With potassium carbonate at 80℃; for 7h; Inert atmosphere;	100%

: 112-60-7
Tetraethylene glycol

: 434-13-9
Lithocholic acid

: 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

Conditions

Conditions	Yield
With hydrogenchloride at 55℃; for 20h; pH=3; Inert atmosphere;	100%

: 112-60-7
Tetraethylene glycol

: 107023-60-9
2-(2-methacryloyloxyethyloxy)ethyl isocyanate

: 19-hydroxy-7-oxo-3,8,11,14,17-pentaoxa-6-azanonadecyl methacrylate

Conditions

Conditions	Yield
With dibutyltin dilaurate; 4-methoxy-phenol In diethyl ether at 40℃; for 12h; Flow reactor;	99.7%
With dibutyltin dilaurate; 4-methoxy-phenol In tetrahydrofuran at 75℃; for 5h;

: 112-60-7
Tetraethylene glycol

: 30674-80-7
2-Isocyanatoethyl methacrylate

: 16-hydroxy-4-oxo-5,8,11,14-tetraoxa-3-azahexadecyl methacrylate

Conditions

Conditions	Yield
With dibutyltin dilaurate; 4-methoxy-phenol In diethyl ether at 40℃; for 12h; Solvent; Flow reactor;	99.5%
With dibutyltin dilaurate; 4-methoxy-phenol In tetrahydrofuran at 75℃; for 5h;

: 112-60-7
Tetraethylene glycol

: 124-63-0
methanesulfonyl chloride

: 55400-73-2
((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 10.75h;	99%
With triethylamine In dichloromethane at 20℃; for 24h;	98%
With triethylamine In dichloromethane at -5 - 20℃;	98%

: 112-60-7
Tetraethylene glycol

: 107-13-1
acrylonitrile

: 41263-79-0
4,7,10,13,16-pentaoxanonadecane-1,14-dinitrile

Conditions

Conditions	Yield
With potassium hydroxide for 1.5h; Michael addition; Cooling with ice;	99%
With potassium hydroxide In tetrahydrofuran at 20℃; for 1.5h; Michael Addition;	99%

: 112-60-7
Tetraethylene glycol

: 935-79-5
cis-1,2,3,6-tetrahydrophthalic anhydride

: 888485-48-1
C24H34O11

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 9h;	99%
With base at 0 - 20℃; for 9h;

: 4771-80-6
1,2,5,6-tetrahydrobenzoic acid

: 112-60-7
Tetraethylene glycol

: C22H34O7

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Dean-Stark; Large scale;	99%

: 112-60-7
Tetraethylene glycol

: 93-97-0
benzoic acid anhydride

: 94-49-5
1,2-ethanediol, dibenzoate

Conditions

Conditions	Yield
With proton-exchanged montmorillonite In neat (no solvent) at 100℃; for 5h; Reagent/catalyst; Time;	99%

: 112-60-7
Tetraethylene glycol

: 32752-54-8
4-(bromomethyl)benzophenone

: 244254-30-6
(4-(13-hydroxy-2,5,8,11-tetraoxatridecyl)phenyl)(phenyl)methanone

Conditions

Conditions	Yield
Stage #1: Tetraethylene glycol With sodium hydride In tetrahydrofuran at 4 - 20℃; for 1h; Stage #2: 4-(bromomethyl)benzophenone In tetrahydrofuran at 20℃; for 16h;	98.8%
Stage #1: Tetraethylene glycol With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: 4-(bromomethyl)benzophenone In tetrahydrofuran at 0 - 20℃;	65%

: 623-24-5
1,4-bis(bromomethyl)benzene

: 112-60-7
Tetraethylene glycol

: 168211-62-9
1,4-bis(13-hydroxy-2,5,8,11-tetraoxatridecyl)benzene

Conditions

Conditions	Yield
With sodium Williamson etherification;	98%
With sodium hydride at 40℃; for 48h;	71%
With potassium carbonate In acetone for 15h; Heating;	53%
With sodium 1.) 50 deg C; 2.) 60 deg C, 18 h; Yield given. Multistep reaction;

: 112-60-7
Tetraethylene glycol

: 106-96-7
propargyl bromide

: 159428-42-9
1,11-bis(2-propyn-1-oxy)-3,6,9-trioxaundecane

Conditions

Conditions	Yield
With tetrabutylammomium bromide; water; sodium hydroxide In toluene at 45 - 60℃; for 7h; Inert atmosphere;	98%
Stage #1: Tetraethylene glycol With sodium hydride In tetrahydrofuran; mineral oil for 1h; Inert atmosphere; Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 23℃; for 48h; Inert atmosphere;	94%
Stage #1: Tetraethylene glycol With sodium hydride In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: propargyl bromide In tetrahydrofuran; hexane at -78 - 20℃; for 6h;	79%

: 112-60-7
Tetraethylene glycol

: 577794-93-5
1,11-bis(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-3,6,9-trioxaundecane-1,11-dione

: 1,4,7,10,1,18,21,24-octaoxacyclooctacosane-14,16,26,28-tetraone

Conditions

Conditions	Yield
In chlorobenzene Heating;	98%

: 768-90-1
1-Adamantyl bromide

: 112-60-7
Tetraethylene glycol

: 2-(2-(2-(2-(((3s,5s,7s)-adamantan-1-yl)oxy)ethoxy)ethoxy)ethoxy)ethan-1-ol

Conditions

Conditions	Yield
With triethylamine at 180℃; for 23h;	98%
With triethylamine	93%
With triethylamine In dichloromethane at 180℃;	91%

: 112-60-7
Tetraethylene glycol

: 85-42-7
1,2-Cyclohexanedicarboxylic acid-anhydride

: C24H38O11

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 9h;	98%

: 112-60-7
Tetraethylene glycol

: 98-59-9
p-toluenesulfonyl chloride

: ((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl)bis(4-methylbenzenesulfonate)

Conditions

Conditions	Yield
With potassium hydroxide In dichloromethane at 0 - 20℃; for 3h;	98%

: 112-60-7
Tetraethylene glycol

: C7H4FNO4S

: 13-(N-4-fluorophenoxysulfonylamino)-13-oxo-3,6,9,12-tetraoxatridec-1-yl-N-(4-fluorophenoxysulfonyl)carbamate

Conditions

Conditions	Yield
at 20℃; for 0.5h;	97%

: 112-60-7
Tetraethylene glycol

: 929-75-9
2-[2-[2-[2-aminoethoxy]ethoxy]ethoxy]ethylamine

Conditions

Conditions	Yield
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In tert-Amyl alcohol at 140℃; for 20h; Inert atmosphere; Cooling;	97%
Multi-step reaction with 3 steps 1: 44 percent / PBr3, pyridine 2: 66 percent / dimethylformamide 3: 48 percent / 1) hydrazine hydrate, 2) 6N aq. HCl / Heating View Scheme
Multi-step reaction with 3 steps 1: 85 percent / Ph3P, CBr4 / acetonitrile / 18 h / 40 °C 2: 93 percent / NaN3 / dimethylformamide / 100 h / 100 °C 3: 93 percent / H2 / Pd/BaSO4 / ethanol; H2O / 30 h / 760 Torr View Scheme

: 112-60-7
Tetraethylene glycol

: 104-15-4
toluene-4-sulfonic acid

: 77544-60-6
p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 4h;	97%
With pyridine In dichloromethane at 25℃; for 20h;	81%
With pyridine at 20℃; for 6h;	30%

: 768-90-1
1-Adamantyl bromide

: 112-60-7
Tetraethylene glycol

: C18H32O5

Conditions

Conditions	Yield
With triethylamine at 180℃; for 18h;	97%

: 112-60-7
Tetraethylene glycol

: 141-78-6
ethyl acetate

: 22790-12-1
bis-[2-(2-acetoxy-ethoxy)-ethyl]-ether

Conditions

Conditions	Yield
With C16H25N3O2S for 36h; Molecular sieve; Reflux;	97%
With C16H25N3O2S for 36h; Reflux; Molecular sieve;	97%

: 34846-44-1
3-Bromomethylthiophene

: 112-60-7
Tetraethylene glycol

: 1,15-di(thiophen-3-Yl)-2,5,8,11,14-pentaoxapentadecane

Conditions

Conditions	Yield
With sodium hydride; potassium iodide In tetrahydrofuran at 50℃; for 11h; Williamson Ether Synthesis; Cooling with ice; Inert atmosphere;	96%
With sodium hydride In tetrahydrofuran Heating;	57%
With sodium hydride; potassium iodide In tetrahydrofuran Reflux;

: 112-60-7
Tetraethylene glycol

: 173280-04-1, 738599-63-8
7-chloromethylhinokitiol

: 2-Hydroxy-7-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxymethyl)-4-isopropyl-cyclohepta-2,4,6-trienone

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane Ambient temperature;	96%

: 112-60-7
Tetraethylene glycol

: 29311-53-3
(E)-3-hexene-1,6-dioic acid

poly(tetraethylene glycol hydromuconoate), polycondensation, Mn = 5600 g/mol (GPC), PDI = 1.8 (GPC); monomer(s): trans-β-hydromuconic acid; tetraethylene glycol: poly(tetraethylene glycol hydromuconoate), polycondensation, Mn = 5600 g/mol (GPC), PDI = 1.8 (GPC); monomer(s): trans-β-hydromuconic acid; tetraethylene glycol

Conditions

Conditions	Yield
stannous octoate under 20 Torr; for 24h;	96%

: 112-60-7
Tetraethylene glycol

: 124-63-0
methanesulfonyl chloride

: 477781-69-4
1-phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -30 - 0℃; for 3h;	96%

Tetraethylene glycol Consensus Reports

Reported in EPA TSCA Inventory.

Tetraethylene glycol Specification

The Tetraethylene glycol, with the CAS registry number 112-60-7, is also known as Bis[2-(2-hydroxyethoxy)ethyl] ether. It belongs to the product categories of Ethylene Glycols; Ethylene Glycols & Monofunctional Ethylene Glycols. Its EINECS registry number is 203-989-9. This chemical's molecular formula is C₈H₁₈O₅ and molecular weight is 194.23. Its IUPAC name is called 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol. This chemical's classification codes are Mutation data; Skin / Eye Irritant. It is colorless to straw-colored liquid. In addition, it should be stored in a cool, ventilated warehouse and kept away from fire and heat.

Physical properties of Tetraethylene glycol: (1)ACD/LogP: -2.23; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.23; (4)ACD/LogD (pH 7.4): -2.23; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.46; (8)ACD/KOC (pH 7.4): 1.46; (9)#H bond acceptors: 5; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 12; (12)Index of Refraction: 1.455; (13)Molar Refractivity: 47.41 cm³; (14)Molar Volume: 174.6 cm³; (15)Surface Tension: 41.3 dyne/cm; (16)Density: 1.111 g/cm³; (17)Flash Point: 176.7 °C; (18)Enthalpy of Vaporization: 66.1 kJ/mol; (19)Boiling Point: 328 °C at 760 mmHg; (20)Vapour Pressure: 1.47E-05 mmHg at 25°C.

Uses of Tetraethylene glycol: it can be used in organic synthesis as a solvent, hot carrier and gas chromatography stationary phase. Besides, it can be used with drying solvents, moisturizing agents, softening agents, nitro spray, etc.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. You should avoid contacting it with skin and eyes.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(COCCOCCOCCO)O
(2)InChI: InChI=1S/C8H18O5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h9-10H,1-8H2
(3)InChIKey: UWHCKJMYHZGTIT-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LD50	skin	> 20gm/kg (20000mg/kg)		Union Carbide Data Sheet. Vol. 3, Pg. 3, 1969.
rat	LD50	oral	28900uL/kg (28.9mL/kg)		Union Carbide Data Sheet. Vol. 3/3/1969,

Product Name

Bis[2-(2-hydroxyethoxy)ethyl] ether

Synthetic route

Tetraethylene glycol Consensus Reports

Tetraethylene glycol Specification

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