Conditions | Yield |
---|---|
With sodium hydroxide In water in hot 5n NaOH solution; | 100% |
In water |
Conditions | Yield |
---|---|
With NaOH In water 20°C (24 h); hydrolysis; | A n/a B 99.5% C 100% |
Conditions | Yield |
---|---|
With sodium hydroxide In water in hot 5n NaOH solution; | 100% |
In water |
Conditions | Yield |
---|---|
With sodium hydroxide In water in 5n NaOH solution; | 100% |
In water |
Conditions | Yield |
---|---|
With sodium hydroxide In water in hot 5n NaOH; | 100% |
In water |
Conditions | Yield |
---|---|
at 95°C, hydrolysis; | A 60% B 39% C 99% |
Conditions | Yield |
---|---|
With NaOH In not given hydrolysis at 60-70°C (3 d); | 99% |
Conditions | Yield |
---|---|
In water hydrolysis with 10 % aq. NaOH;; | 99% |
dimethyltrifluoromethylarsenic dichloride
trifluoromethan
Conditions | Yield |
---|---|
With sodium hydroxide for 4h; Ambient temperature; hydrolysis in sealed tube; | 98.8% |
glycine
methyl (chloromethyl)(trifluoromethyl)phosphinate
A
trifluoromethan
B
N-(phosphonemethyl)glycine
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 20℃; Rate constant; | A 98% B 49% |
Conditions | Yield |
---|---|
byproducts: H2; 330°C (40 h); also formation of gray mirror; | 98% |
With NaOH In not given hydrolysis at 105°C (15 h); | 14.5% |
Conditions | Yield |
---|---|
With NaOH In water 48 h, 20°C; | 98% |
With H2O hydrolysis at 200°C, 12 h; | 46% |
ammonolysis at 20°C, 48 h; | 37% |
With H2O In water hydrolysis at 200°C;; |
Conditions | Yield |
---|---|
24 h; | A n/a B 98% |
24 h; | A n/a B 98% |
1,1,1,2-tetrafluoroethane
A
1,1,1,2,2-pentafluoroethane
B
Difluoromethane
C
trifluoromethan
D
Hexafluoroethane
Conditions | Yield |
---|---|
With fluorine at 200 - 250℃; Product distribution; Further Variations:; Reagents; | A 1.1% B 0.9% C 0.4% D 97.6% |
trifluoromethan
Conditions | Yield |
---|---|
With sodium hydroxide In sodium hydroxide hydrolysis with20 % NaOH soln.; | 97.3% |
With sodium hydroxide with 20 % NaOH; | |
With NaOH with 20 % NaOH; |
Conditions | Yield |
---|---|
With water reaction in hot water;; | 97% |
dichloromethane
A
methylene chloride
B
Difluoromethane
C
R32
D
trifluoromethan
Conditions | Yield |
---|---|
With hydrogen fluoride; antimony(III) fluoride; antimony pentafluoride at 5 - 100℃; under 12504.7 Torr; | A n/a B 96.9% C 3.08% D n/a |
antimony pentafluoride | A n/a B 96.4% C 3.56% D n/a |
methylbistrifluoromethylarsenic dichloride
trifluoromethan
Conditions | Yield |
---|---|
With sodium hydroxide at 125℃; for 20h; hydrolysis in sealed tube; | 93% |
Conditions | Yield |
---|---|
With water reaction in water in presence of Ag2O;; | 92% |
With water reaction in hot water;; | 89% |
With water reaction in cold water;; | 2% |
trifluoromethan
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In [D3]acetonitrile Reagent/catalyst; Molecular sieve; | 92% |
With tetrabutyl ammonium fluoride In acetonitrile at 20℃; Solvent; Reagent/catalyst; Molecular sieve; Sealed tube; | 89% |
Conditions | Yield |
---|---|
20°C (28 d); | 91% |
20°C (28 d); | 91% |
20°C, 28 d; | >99 |
Conditions | Yield |
---|---|
With sodium hydroxide; water hydrolysis;; | A 91% B n/a |
With NaOH; H2O hydrolysis;; | A 91% B n/a |
trifluoromethyltrimethylsilane
A
trifluoromethan
B
(trifluoromethyl)silane
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In dibutyl ether at -78℃; for 0.25h; | A n/a B 90% |
Conditions | Yield |
---|---|
With HCl In not given 100°C; concd. HCl; | A 90% B n/a |
Conditions | Yield |
---|---|
With NH3 20°C, 28 d in Carius tube; | 89% |
bis(trifluoromethyl)diethylaminophosphane
A
trifluoromethan
B
bis(trifluoromethyl)phosphinous acid
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In various solvent(s) at 20℃; for 12h; | A n/a B 88% |
bis(trifluoromethyl)phosphine
A
Poly(trifluoromethylphosphane)
B
trifluoromethan
C
Tetrakis(trifluoromethyl)cyclotetraphosphane
D
pentakis-trifluoromethyl-cyclopentaphosphane
Conditions | Yield |
---|---|
400°C furnace temp., 5 h; | A n/a B 87% C n/a D n/a |
400°C furnace temp., 5 h; | A n/a B 87% C n/a D n/a |
400°C furnace temp., 4 h; | A n/a B 67% C n/a D n/a |
Conditions | Yield |
---|---|
With H2O 300°C, 48 h; | 87% |
With NaOH In not given hydrolysis with 0.05 molar NaOH soln.; 20°C, 44 h shaking; | 87% |
In not given hydrolysis with buffer soln.:80% glycine and NaCl mixture, 20% 0.1 molar NaOH (pH=9.2); | 15% |
Caesium-trans-tris(trifluormethyl)-trifluorphosphat
trifluoromethan
Conditions | Yield |
---|---|
With acid In not given | 87% |
(trifluoro methyl) difluoro iodo silane
A
trifluoromethan
B
(trifluoromethyl)silane
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In dibutyl ether at -78℃; for 0.25h; | A n/a B 85% |
Conditions | Yield |
---|---|
With phosphazene base-P4-tert-butyl In tetrahydrofuran; hexane at -40℃; for 3h; Time; Reagent/catalyst; Inert atmosphere; | 99% |
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; under 750.075 Torr; for 0.000138889h; Solvent; Pressure; Concentration; Flow reactor; | 98% |
With potassium tert-butylate at 20℃; for 6h; Schlenk technique; Cooling with liquid nitrogen; | 96% |
trifluoromethan
bis(p-methoxyphenyl)methanone
4,4'-dimethoxy-α-phenyl-α-(trifluoromethyl)benzenemethanol
Conditions | Yield |
---|---|
Stage #1: trifluoromethan; bis(p-methoxyphenyl)methanone With tris(trimethylsilyl)amine; phosphazene base-P4-tert-butyl In tetrahydrofuran at 20℃; for 14h; Schlenk technique; Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1h; Schlenk technique; | 99% |
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; under 750.075 Torr; for 0.000138889h; Flow reactor; | 74% |
trifluoromethan
(S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide
Conditions | Yield |
---|---|
Stage #1: trifluoromethan; (S)-2-methyl-propane-2-sulfinic acid 1-(4-trifluoromethyl-phenyl)-meth-(E)-ylideneamide In toluene at -78℃; for 0.25h; Glovebox; Inert atmosphere; Stage #2: With phosphazene base-P4-tert-butyl In hexane at -78℃; | 99% |
Conditions | Yield |
---|---|
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 6h; Time; Inert atmosphere; | 99% |
trifluoromethan
(2-chlorophenyl)(phenyl)methanone
2,2,2-trifluoro-1-(2-chlorophenyl)-1-phenylethanol
Conditions | Yield |
---|---|
Stage #1: trifluoromethan; (2-chlorophenyl)(phenyl)methanone With tris(trimethylsilyl)amine; phosphazene base-P4-tert-butyl In tetrahydrofuran at 20℃; for 10h; Schlenk technique; Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1h; Schlenk technique; | 98% |
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; under 750.075 Torr; for 0.000138889h; Flow reactor; | 74% |
Conditions | Yield |
---|---|
With deuteriated sodium hydroxide; water-d2 at 105℃; for 7h; | 97.6% |
With 4,4'-difluorobiphenyl; cis-[(1,3-bis(diphenylphosphino)propane)Pd(Ph)(OH)]; water-d2 In N,N-dimethyl-formamide at 23℃; for 24h; Inert atmosphere; Glovebox; | 8% |
With water-d2; potassium carbonate at 120℃; | |
With water at 20℃; Thermodynamic data; Irradiation; H/D separation factors, other temperatures; ΔH; |
trifluoromethan
Conditions | Yield |
---|---|
With phosphazene base-P4-tert-butyl In hexane; toluene at -78℃; Inert atmosphere; Glovebox; diastereoselective reaction; | 96% |
Conditions | Yield |
---|---|
With phosphazene base-P4-tert-butyl In tetrahydrofuran; hexane at 40℃; for 3h; Inert atmosphere; | 95% |
With tris(trimethylsilyl)amine; tetramethylammonium fluoride In tetrahydrofuran; N,N-dimethyl-formamide at -10 - 20℃; for 6h; | 26% |
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 6h; Time; Inert atmosphere; | 1% |
With tetrabutylammonium (2-pyrrolidonide); 1,1,1,3,3,3-hexamethyl-disilazane 1.) DMF, -10 deg C, 5 h; Yield given. Multistep reaction; |
trifluoromethan
Diphenylacetonitrile
α-difluoromethyldiphenyl acetonitrile
Conditions | Yield |
---|---|
Stage #1: Diphenylacetonitrile With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Inert atmosphere; Stage #2: trifluoromethan In tetrahydrofuran; hexane at -78℃; for 0.0166667h; Reagent/catalyst; Time; Inert atmosphere; | 95% |
Stage #1: Diphenylacetonitrile With potassium hydroxide In water for 0.5h; Stage #2: trifluoromethan In water; acetonitrile at 20℃; for 3h; | 30% |
Conditions | Yield |
---|---|
Stage #1: 2-(p-Chlorophenyl)-2-phenylacetonitrile With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Inert atmosphere; Stage #2: trifluoromethan In tetrahydrofuran; hexane at -78℃; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
In tetrahydrofuran at -80℃; under 1484.08 Torr; for 0.166667h; Inert atmosphere; | 95% |
trifluoromethan
Conditions | Yield |
---|---|
With phosphazene base-P4-tert-butyl In toluene at -78℃; for 12h; Schlenk technique; Inert atmosphere; diastereoselective reaction; | 94% |
Fluoroform (75-46-7) was first obtained by Maurice Meslans in the violent reaction of iodoform with dry silver fluoride in 1894.The reaction was improved by Otto Ruff by substitution of silver fluoride by a mixture of mercury fluoride and calcium fluoride.The exchange reaction works with iodoform and bromoform, and the exchange of the first two halogen atoms is vigorous by fluorine.and the first efficient synthesis method was found by Henne.According to researchers, it is the most abundant of Hydrofluorocarbons (HFCs). Its usage has been regulated since December 1997 at Kyoto climate conference. To mitigate its impact, CHF3 can be destroyed with electric plasma arc technologies or by high temperature incineration.
EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.
DOT Classification: 2.2; Label: Nonflammable Gas
The Fluoroform, with the CAS registry number 75-46-7, is also known as Carbon trifluoride. It belongs to the product categories of Refrigerants; Organics. Its EINECS registry number is 200-872-4. This chemical's molecular formula is CHF3 and molecular weight is 70.01. What's more, its IUPAC name is same with its product name. It is one of the "haloforms" and it is a potent greenhouse gas. And it is also generated biologically in small amounts apparently by decarboxylation of trifluoroacetic acid. In addition, it should be kept in a cool and ventilated place.
Physical properties about Fluoroform are: (1)ACD/LogP: 0.48; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.48; (4)ACD/LogD (pH 7.4): 0.48; (5)#H bond acceptors: 0; (6)#H bond donors: 0; (7)#Freely Rotating Bonds: 0; (8)Polar Surface Area: Å2; (9)Index of Refraction: 1.179; (10)Molar Refractivity: 7.13 cm3; (11)Molar Volume: 61.7 cm3; (12)Surface Tension: 6.2 dyne/cm; (13)Density: 1.133 g/cm3; (14)Enthalpy of Vaporization: 17.17 kJ/mol at 760 mmHg; (15)Vapour Pressure: 25200 mmHg at 25 °C.
Preparation of Fluoroform: this chemical can be prepared by Ethanol with Difluoro-fluorosulfonyl-acetic acid. This reaction needs solvent acetonitrile at temperature of 50 °C. The reaction time is 1 hour. The yield is 53 %.
Uses of Fluoroform: (1) this chemical is used in diverse niche applications and is produced as a by-product of the manufacture of Teflon. It is used in the semiconductor industry in plasma etching of silicon nitride and silicon oxide. The production is also a useful refrigerant, and is a byproduct of its manufacture; (2) this chemical is used to produce other chemicals. For example, it is used to produce Deuterio-trifluoro-methane. The reaction occurs with reagents potassium carbonate, deuterium oxide at temperature of 120 °C.
When you are dealing with this chemical, you should be very careful. This chemical may catch fire in contact with air, only need brief contact with an ignition source and have a very low flash point or evolve highly flammable gases in contact with water. In case of insufficient ventilation you should wear suitable respiratory equipment.
You can still convert the following datas into molecular structure:
(1) SMILES: FC(F)F
(2) InChI: InChI=1S/CHF3/c2-1(3)4/h1H
(3) InChIKey: XPDWGBQVDMORPB-UHFFFAOYSA-N
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View