m-Anisidine supplier | CasNO.536-90-3

Name
m-Anisidine
EINECS 208-651-4
CAS No. 536-90-3
Article Data222
CAS DataBase
Density 1.064 g/cm³
Solubility <0.1 g/100 mL at 19 °C in water
Melting Point ?1-1 °C(lit.)
Formula C₇H₉NO
Boiling Point 251 °C at 760 mmHg
Molecular Weight 123.155
Flash Point 109.6 °C
Transport Information UN 2431 6.1/PG 3
Appearance Pale yellow oily liquid or dark red liquid
Safety 26-60-61-45-36/37-28B
Risk Codes 22-36/37/38-50/53-51/53-33-26/27/28
Molecular Structure
Hazard Symbols T+, N, Xn
Synonyms 1-Amino-3-methoxybenzene;3-Aminoanisole;3-Methoxyaniline;3-Methoxybenzenamine;3-Methoxyphenylamine;NSC 7631;m-Aminoanisole;m-Aminomethoxybenzene;m-Anisylamine;m-Methoxyaniline;Benzenamine, 3-methoxy-;
PSA 35.25000
LogP 1.85860

Synthetic route

: 2398-37-0
3-methoxyphenyl bromide

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With bis(tri-ortho-tolylphosphine)palladium(0); (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 80℃; for 5h; Inert atmosphere;	99%
With copper(l) iodide; 2-carboxyquinoline N-oxide; potassium carbonate; ammonium hydroxide In dimethyl sulfoxide at 80℃; for 23h; Inert atmosphere;	93%
With ammonium hydroxide; copper(l) iodide; diethylenetriaminopentaacetic acid; potassium hydroxide In water at 100℃; for 12h; Sealed tube;	90%

: 2845-89-8
1-chloro-3-methoxy-benzene

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With bis(tri-ortho-tolylphosphine)palladium(0); (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 100℃; for 12h; Inert atmosphere;	99%
With C43H63ClFeNiP2; ammonia; sodium t-butanolate In 1,4-dioxane; toluene at 100℃; for 16h; Reagent/catalyst; Inert atmosphere;	91%
With ammonium sulfate; bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate at 100 - 110℃; for 12h;	88%
With bis(1,5-cyclooctadiene)nickel (0); (R)-1-[(Sp)-2-(dicyclohexylphosphanyl)ferrocenyl]ethyldicyclohexylphosphane; ammonia; sodium t-butanolate In 1,4-dioxane; toluene at 110℃; for 16h; Sealed tube;

: 616-38-6
carbonic acid dimethyl ester

: 591-27-5
m-Hydroxyaniline

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With dimanganese decacarbonyl at 180℃; for 1h;	99%

: 555-03-3
3-nitroanisole

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With isopropyl alcohol; potassium hydroxide for 0.133333h; Microwave irradiation; regioselective reaction;	98%
With hydrogen In ethanol; water at 25℃; under 11251.1 Torr; for 6h; chemoselective reaction;	98%
With nickel(II) oxide; ethanol; potassium hydroxide for 0.183333h; Microwave irradiation; sealed vessel;	97%

: 3866-16-8
3-methoxyphenyl azide

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With ammonium hydroxide at 90℃; for 0.166667h;	98%
With zinc In methanol at 20℃; for 6h;	94%
With aluminium(III) iodide In benzene for 0.166667h; Reduction; Heating;	93%

: N'-(3-methoxy-phenyl)-N,N-dimethyl-formamidine

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With hydrogen; palladium dihydroxide In water; tert-butyl alcohol at 20℃; under 3361.46 Torr; for 12h; Hydrogenolysis;	98%

: 60144-52-7
tert-butyl 3-methoxyphenylcarbamate

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
In 2,2,2-trifluoroethanol at 150℃; for 1h; microwave irradiation;	95%
With 2,2,2-trifluoroethanol at 150℃; for 1h; Product distribution / selectivity; Microwave irradiation;	95%
With 2,2,2-trifluoroethanol at 150℃; for 1h; Product distribution / selectivity; Microwave irradiation;	95%
With 1,1,1,3',3',3'-hexafluoro-propanol at 150℃; for 0.5h; Product distribution / selectivity; Microwave irradiation;	89%

: 6319-23-9
1,2-bis(3-methoxyphenyl)diazene

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With formic acid; zinc In methanol at 20℃; for 0.116667h;	94%
With hydrazine hydrate In ethanol Heating;	94%
With hydrazine hydrate; aluminium In ethanol Heating;	94%

: 766-85-8
3-methoxy-1-iodobenzene

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; N-((1-oxy-pyridin-2-yl)methyl)oxalamic acid; ammonia In water; dimethyl sulfoxide at 25℃; Schlenk technique; Inert atmosphere; Sealed tube; chemoselective reaction;	94%
Stage #1: 3-methoxy-1-iodobenzene With copper(l) iodide; D-glucosamine hydrochloride; potassium carbonate In water; acetone at 90℃; for 0.166667h; Stage #2: With ammonia In water; acetone at 90℃; for 24h;	90%
With copper(l) iodide; 2-carboxyquinoline N-oxide; potassium carbonate; ammonium hydroxide In dimethyl sulfoxide at 50℃; for 23h; Inert atmosphere;	90%

: 14318-66-2
3-methoxy-N-methylaniline

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III); (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine In acetonitrile at -78℃; for 24h; Reagent/catalyst; Sealed tube; Inert atmosphere; Irradiation;	94%

: N'-(3-methoxy-phenyl)-N,N-dibenzyl-formamidine

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With hydrogen; palladium dihydroxide In water; tert-butyl alcohol under 3620.04 Torr; Ambient temperature;	90%
With hydrogen; palladium dihydroxide In water; tert-butyl alcohol at 20℃; under 2844.31 Torr; for 5h; Hydrogenolysis;	90%

: 66107-33-3
3-methoxyphenyl triflate

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
Stage #1: 3-methoxyphenyl triflate With bis(bis(trimethylsilyl)amido)zinc(II); tri-tert-butyl phosphine; tetrabutylammomium bromide; lithium chloride; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 50℃; for 24h; Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether	90%

: 108429-51-2
1-(m-methoxyphenyl)-4,5-dihydro-5-hydroxy-1H-1,2,3-triazole

A: 27153-17-9
3-Methoxy-formanilid

B: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran for 1.5h; Ambient temperature;	A 89% B 10%

: 591-27-5
m-Hydroxyaniline

: 74-88-4
methyl iodide

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0 - 20℃;	87%

: 10365-98-7
3-methoxyphenylboronic acid

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With copper(I) oxide; ammonium hydroxide; air In methanol at 20℃; for 16h;	87%
With sodium hydroxide; hydroxylamine-O-sulfonic acid In water; acetonitrile at 100℃; for 0.25h; Microwave irradiation;	87%
With copper(ll) sulfate pentahydrate; ammonia; sodium hydroxide In water at 20℃; under 760.051 Torr; for 4h;	84%
With copper(I) oxide; ammonium hydroxide; oxygen; sodium hydroxide In water at 25℃; for 15h;	82%
With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 16h;	78%

: 60770-72-1
2-(3-methoxyphenoxy)propanamide

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 140℃; for 8h; Green chemistry;	87%

: 2,4,6-tri(3-methoxyphenoxy)-1,3,5-triazine

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With ammonium sulfate; bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate at 100 - 110℃; for 12h;	87%

: 108716-30-9
benzyl (3-methoxyphenyl)carbamate

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With methylmagnesium bromide; hydrogen; palladium diacetate; nickel diacetate In water at 45℃; for 16h;	85%

: 3866-16-8
3-methoxyphenyl azide

: 998-39-0
tributylgermanium hydride

A: 3-methoxy-2-tributylgermylaniline

B: 5-methoxy-2-tributylgermylaniline

C: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With thiophenol In toluene for 0.5h; Heating;	A 2% B 3% C 83%

...Expand

: 1336-21-6
ammonium hydroxide

: 2398-37-0
3-methoxyphenyl bromide

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; potassium phosphate tribasic heptahydrate; water; Sucrose In water at 90℃; for 15h; Catalytic behavior; Green chemistry;	82%

: 67-56-1
methanol

: 626-01-7
3-Iodoaniline

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate at 110℃; for 21h;	78%

: 66-71-7
1,10-Phenanthroline

: 626-01-7
3-Iodoaniline

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With CuI; caesium carbonate In methanol	78%

: 32570-19-7
1-(3-methoxyphenyl)-2,5-dimethyl-1 H-pyrrole

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; triethylamine In ethanol at 80℃; for 16h;	76%

: 921-01-7, 3374-22-9, 4371-52-2, 40143-64-4, 40143-66-6, 40143-69-9, 52-90-4
rac-cysteine

: N-(3-methoxyphenyl)-2,4-dinitrobenzenesulfonamide

A: 3165-76-2
S-(2,4-Dinitrophenyl)-cystein

B: 7446-09-5
sulfur dioxide

C: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
In aq. phosphate buffer for 0.5h; pH=7.4;	A n/a B 76% C n/a

...Expand

: potassium 3-methoxyphenyltrifluoroborate

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With sodium hydroxide; hydroxylamine-O-sulfonic acid In water; acetonitrile at 100℃; for 0.25h; Microwave irradiation;	76%

: 150-19-6
O-methylresorcine

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
Stage #1: O-methylresorcine With Nonafluorobutanesulfonyl fluoride; tris(trimethylsilyl)amine; potassium hexamethylsilazane In tetrahydrofuran at 60℃; for 5h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; for 0.0833333h; pH=3 - 4;	75%
Multi-step reaction with 2 steps 1.1: 81 percent / K3PO4 / toluene; H2O / 0 - 20 °C 2.1: P(t-Bu)3; Zn[N(SiMe3)2]2; Bu4NBr / Pd(dba)2; LiCl / tetrahydrofuran / 24 h / 50 °C 2.2: 90 percent / aq. HCl / tetrahydrofuran; diethyl ether View Scheme

: 90-05-1
2-methoxy-phenol

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
Stage #1: 2-methoxy-phenol With Nonafluorobutanesulfonyl fluoride; tris(trimethylsilyl)amine; potassium hexamethylsilazane In tetrahydrofuran at 60℃; for 5h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; for 0.0833333h; pH=3 - 4;	72%

: 139-77-5
1-(3-methoxyphenyl)urea

: 65-85-0
benzoic acid

A: 37528-30-6
1-benzoyl-3-(3-methoxyphenyl)urea

B: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With ethyl phosphate; ethyl polyphosphate (ppe) at 100 - 105℃; for 1.5h;	A 71% B 4%

...Expand

: 15384-39-1
(3-methoxyphenyl)hydrazine

: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With titanium tetrachloride; magnesium In tetrahydrofuran at 20℃; Inert atmosphere;	71%

: 108-24-7
acetic anhydride

: 536-90-3
m-Anisidine

: 588-16-9
m-methoxyacetanilide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	100%
With cadmium(II) oxide at 80℃; for 0.0833333h; Neat (no solvent); Microwave irradiation;	97%
With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate In neat (no solvent) at 50℃; for 0.5h; Green chemistry;	96%

: 536-90-3
m-Anisidine

: 98-59-9
p-toluenesulfonyl chloride

: 58750-87-1
N-tosyl-m-anisidine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 28h;	100%
With triethylamine In dichloromethane at 4℃;	100%
With triethylamine In tetrahydrofuran at 20℃; for 15h;	95%

: 536-90-3
m-Anisidine

: 130-15-4
[1,4]naphthoquinone

: 64505-63-1
2-(3-methoxyphenylamino)naphthalene-1,4-dione

Conditions

Conditions	Yield
In ethanol at 20℃; Reagent/catalyst;	100%
With copper(II) acetate monohydrate; acetic acid at 60 - 70℃; for 0.5h; Under air;	93%
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 2h;	76%

: 536-90-3
m-Anisidine

: 3866-16-8
3-methoxyphenyl azide

Conditions

Conditions	Yield
With tert.-butylnitrite; trimethylsilylazide In acetonitrile at 0 - 20℃; for 1h;	100%
With tert.-butylnitrite; trimethylsilylazide In acetonitrile at 0 - 20℃; for 3h; Inert atmosphere;	99%
Stage #1: m-Anisidine With sulfuric acid; sodium nitrite In water; acetic acid at 0 - 5℃; for 0.166667h; Stage #2: With sodium azide In water; acetic acid at 0 - 5℃; for 3h;	94%

: 536-90-3
m-Anisidine

: 124-63-0
methanesulfonyl chloride

: 7022-24-4
N-(3-methoxyphenyl)methanesulfonamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; Cooling with ice;	100%
With pyridine In dichloromethane Ambient temperature;	89%
With pyridine In dichloromethane at 20℃; for 12h;	52.6%

: 536-90-3
m-Anisidine

: 407-25-0
trifluoroacetic anhydride

: 14818-55-4
N-(3-methoxyphenyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h;	100%
In diethyl ether
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
With triethylamine
at 20℃; for 3h; Inert atmosphere;

: 98-01-1
furfural

: 536-90-3
m-Anisidine

: 95124-20-2
N-(furan-2-ylmethylene)-3-methoxyaniline

Conditions

Conditions	Yield
In methanol at 20℃; for 24h;	100%
for 2h; Yield given;
With magnesium sulfate In ethanol at 20℃;

: 3282-30-2
pivaloyl chloride

: 536-90-3
m-Anisidine

: 56619-93-3
N-(3-methoxyphenyl)pivalamide

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 0℃; for 1h;	100%
With sodium carbonate monohydrate In water; ethyl acetate at 0℃; for 1h; Inert atmosphere;	99.5%
With sodium carbonate monohydrate In water; ethyl acetate at 0℃; for 1h; Inert atmosphere;	99.5%

: 24424-99-5
di-tert-butyl dicarbonate

: 536-90-3
m-Anisidine

: 60144-52-7
tert-butyl 3-methoxyphenylcarbamate

Conditions

Conditions	Yield
copper(II) bis(tetrafluoroborate) at 30 - 33℃; for 0.166667h;	100%
In tetrahydrofuran at 20℃;	100%
With zinc(II) perchlorate In tert-butyl alcohol at 20℃; for 10h;	99%

: 536-90-3
m-Anisidine

: 100-52-7
benzaldehyde

: 5877-59-8
N-benzylidene-m-anisidine

Conditions

Conditions	Yield
In ethanol for 1h; Sonication;	100%
In toluene for 0.5h; Heating;	85%
In ethanol for 1h; Heating;

: 536-90-3
m-Anisidine

: 109768-45-8
2-isothiocyanatobenzylpyridinium bromide

: 109768-50-5
1-{2-[3-(3-Methoxy-phenyl)-thioureido]-benzyl}-pyridinium; bromide

Conditions

Conditions	Yield
In methanol for 5h;	100%

: 536-90-3
m-Anisidine

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 56881-19-7
Diethyl 2-<(3-methoxyphenylamino)methylene>malonate

Conditions

Conditions	Yield
at 90 - 110℃; for 1h;	100%
at 125℃; for 3h;	99%
In neat (no solvent) at 120℃; for 0.75h;	98%

: 536-90-3
m-Anisidine

: trifluoromethyl dihydro-1,4-dioxin-3-carbonyl chloride

: 5,6-dihydro-N-(3-methoxy)phenyl-2-trifluoromethyl-1,4-dioxin-3-carboxamide

Conditions

Conditions	Yield
Stage #1: trifluoromethyl dihydro-1,4-dioxin-3-carbonyl chloride With pyridine; polystyrene-bound 4-hydroxy-3-nitrobenzophenone In dichloromethane at 20℃; for 24h; Acylation; Stage #2: m-Anisidine With triethylamine In acetonitrile for 2.5h; Acylation; Heating;	100%

: 32315-10-9
bis(trichloromethyl) carbonate

: 536-90-3
m-Anisidine

: 18908-07-1
3-methoxyphenyl isocyanate

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%
In dichloromethane at 20℃; for 1.5h;
In toluene at 100℃; Cooling with ice;

: 536-90-3
m-Anisidine

: 851520-56-4
3-tert-butyl-4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide

: 3-tert-butyl-4-[(3-methoxyphenyl)amino]-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

Conditions

Conditions	Yield
In 1,4-dioxane Heating;	100%

: 536-90-3
m-Anisidine

: 851520-97-3
4-chloro-1-cyclohexyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid amide

: 1-cyclohexyl-4-[(3-methoxyphenyl)amino]-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

Conditions

Conditions	Yield
In 1,4-dioxane Heating;	100%

: 109-74-0
propyl cyanide

: 536-90-3
m-Anisidine

: 31084-55-6
butyl-(3-methoxy-phenyl)amine

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol; water at 20℃; for 4.5h;	100%

: 536-90-3
m-Anisidine

: 107-12-0
propiononitrile

A: 31084-54-5
3‐methoxy‐N‐propylaniline

B: 35666-61-6
2-methoxy-N,N-dipropylaniline

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol; water at 20℃; for 3h;	A 100% B n/a

...Expand

: 2398-37-0
3-methoxyphenyl bromide

: 536-90-3
m-Anisidine

: 92248-06-1
3-methoxy-N-(3-methoxyphenyl)benzenamine

Conditions

Conditions	Yield
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110℃; for 48h; Buchwald-Hartwig amination;	100%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium t-butanolate In toluene at 100℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere;	72%
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) In toluene at 120℃;	40%
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 72h; Reflux; Inert atmosphere;

: 108-36-1
1,3-dibromobenzene

: 536-90-3
m-Anisidine

: 202127-21-7
N,N'-bis(3-methoxyphenyl)-1,3-benzenediamine

Conditions

Conditions	Yield
With sodium t-butanolate; palladium diacetate; bis(diphenylphosphinyl)ferrocene In toluene at 100 - 110℃; for 12h;	100%
With [(π-cinnamyl)Pd(tBuXPhos)]OTf In water at 45℃; for 36h;	91%

: 106-38-7
para-bromotoluene

: 536-90-3
m-Anisidine

: 123017-90-3
3-methoxy-N-(4-methylphenyl)aniline

Conditions

Conditions	Yield
With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate In toluene for 16h; Buchwald-Hartwig amination; Heating;	100%
With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate In toluene	100%
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 16h; Buchwald-Hartwig Coupling; Reflux; Inert atmosphere;	100%

: 15568-85-1
5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione

: 536-90-3
m-Anisidine

: 213699-52-6
5-(((3-methoxyphenyl)amino)methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.25h;	100%
In isopropyl alcohol Heating;	96%
In isopropyl alcohol at 70℃; for 1h;	44%

: 403-45-2
6-fluoronicotinic acid

: 536-90-3
m-Anisidine

: 945400-81-7
6-fluoro-N-(3-methoxy-phenyl)-nicotinamide

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide; dmap In dichloromethane at 0 - 20℃; for 1h;	100%

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 536-90-3
m-Anisidine

: 1111734-31-6
N-(3-methoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamide

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 1h;	100%

: 104-88-1
4-chlorobenzaldehyde

: 536-90-3
m-Anisidine

: 940363-85-9
4-chloro-N-(3-methoxybenzyl)aniline

Conditions

Conditions	Yield
With sodium tetrahydroborate; triethylamine In methanol	100%

: N-benzylaminomethyl resin

: 536-90-3
m-Anisidine

: C15H16N3OPol

Conditions

Conditions	Yield
Stage #1: m-Anisidine With boron trifluoride diethyl etherate; isopentyl nitrite In tetrahydrofuran at -20℃; for 2h; Stage #2: N-benzylaminomethyl resin In tetrahydrofuran; pyridine; acetonitrile at 20℃; Cooling; solid phase reaction;	100%
Stage #1: m-Anisidine With boron trifluoride diethyl etherate; isopentyl nitrite In tetrahydrofuran at -20℃; for 2h; Stage #2: N-benzylaminomethyl resin With pyridine In tetrahydrofuran at -20 - 20℃; solid phase reaction;	100%
Stage #1: m-Anisidine With boron trifluoride diethyl etherate; isopentyl nitrite In tetrahydrofuran at -20℃; for 2h; Stage #2: N-benzylaminomethyl resin With pyridine In tetrahydrofuran; acetonitrile at -20 - 20℃;

: 536-90-3
m-Anisidine

: 123-11-5
4-methoxy-benzaldehyde

: 99497-93-5
(4-methoxybenzylidene)(3-methoxyphenyl)amine

Conditions

Conditions	Yield
With acetic acid In N,N-dimethyl-formamide for 1h;	100%
With TiO2 nanotubes at 20℃; for 3h; Neat (no solvent); Sunlight;	98%
In methanol for 12h; Reflux;

: 536-90-3
m-Anisidine

: 141-75-3
butyryl chloride

: 132118-40-2
N-(3-methoxyphenyl)butanamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 18h; Inert atmosphere;	100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;	82%
In dichloromethane
Stage #1: m-Anisidine With triethylamine In tetrahydrofuran at 0℃; for 0.333333h; Stage #2: butyryl chloride In tetrahydrofuran at 20℃; for 13h;
Stage #1: m-Anisidine With triethylamine In tetrahydrofuran at 25℃; for 0.166667h; Stage #2: butyryl chloride In tetrahydrofuran at 25℃; for 3h; Sealed tube;

: 18179-39-0
methyl 4-iodosalicylate

: 536-90-3
m-Anisidine

: 1644060-64-9
methyl 2-hydroxy-4-(3-methoxyphenylamino)benzoate

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate In toluene at 100℃; for 15.25h; Buchwald-Hartwig Coupling; Inert atmosphere;	100%

: 696-62-8
para-iodoanisole

: 536-90-3
m-Anisidine

: 3661-49-2
3-methoxy-N-(4-methoxyphenyl)benzenamine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 100℃; for 20h; Inert atmosphere;	100%
Stage #1: para-iodoanisole With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 0.75h; Inert atmosphere; Stage #2: m-Anisidine In toluene at 90℃; for 14h; Inert atmosphere;	81%
With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate In toluene at 100℃; for 12h; Inert atmosphere;	77.7%
With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate In toluene at 100℃; for 23h; Inert atmosphere;

m-Anisidine Chemical Properties

IUPAC Name: 3-Methoxyaniline
Molecular Weight: 123.15246 [g/mol]
Molecular Formula: C₇H₉NO
XLogP3: 0.9
H-Bond Donor: 1
H-Bond Acceptor: 2
EINECS: 208-651-4
Product Categories: Anilines, Aromatic Amines and Nitro Compounds; Aniline
Water Solubility: <0.1 g/100 mL at 19 ºC
Index of Refraction: 1.555
Molar Refractivity: 37.16 cm³
Molar Volume: 115.7 cm³
Surface Tension: 39.3 dyne/cm
Density: 1.064 g/cm³
Flash Point: 109.6 °C
Enthalpy of Vaporization: 48.83 kJ/mol
Boiling Point: 251 °C at 760 mmHg
Vapour Pressure: 0.021 mmHg at 25 °C
Appearance: Pale yellow oily liquid or dark red liquid.
Melting Point: -1-1 °C(lit.)
Classification Code of m-Anisidine (CAS NO.536-90-3): Mutation data

m-Anisidine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	562mg/kg (562mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
quail	LD50	oral	562mg/kg (562mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

m-Anisidine Safety Profile

Hazard Codes: Harmful Xn, Dangerous N, Very T+
Risk Statements: 22-36/37/38-50/53-51/53-33-26/27/28
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R33:Danger of cumulative effects.
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-60-61-45-36/37-28B
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37:Wear suitable protective clothing and gloves.
S28:After contact with skin, wash immediately with plenty of soap-suds.
RIDADR: UN 2431 6.1/PG 3
WGK Germany: 1
RTECS: BZ5408000
HazardClass: 6.1
PackingGroup: III

m-Anisidine Specification

m-Anisidine (CAS NO.536-90-3), its Synonyms are 1-Amino-3-methoxybenzene ; 3-Aminoanisole ; 3-Methoxyaniline ; 3-Methoxybenzenamine ; m-Anisylamine ; m-Aminoanisole ; 3-Anisidine ; m-Methoxyaniline ; Benzenamine, 3-methoxy- . It is very poisonous for the blood leading to pink coloration of the skin and inner suffocation. Additionally its vapors are irritanting to eyes, mucous membranes, the respiratory system and skin.

Product Name

m-Anisidine

Synthetic route

m-Anisidine Chemical Properties

m-Anisidine Toxicity Data With Reference

m-Anisidine Safety Profile

m-Anisidine Specification

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