tert-Butyldimethylsilyl chloride supplier

Name
tert-Butyldimethylsilyl chloride
EINECS 242-042-4
CAS No. 18162-48-6
Article Data33
CAS DataBase
Density 0.862 g/cm³
Solubility Soluble in chloroform and ethyl acetate. Insoluble in water.
Melting Point 86-89 °C
Formula C₆H₁₅ClSi
Boiling Point 125 °C at 760 mmHg
Molecular Weight 150.724
Flash Point 22.8 °C
Transport Information UN 2925 4.1/PG 2
Appearance White solid
Safety 26-36/37/39-46-62-45-25-16-28-27-33-29-53
Risk Codes 22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25
Molecular Structure
Hazard Symbols C,F,T
Synonyms Silane,chloro-tert-butyldimethyl- (8CI);(1,1-Dimethylethyl)dimethylsilyl chloride;Chloro-tert-butyldimethylsilane;Dimethyl(1,1-dimethylethyl)chlorosilane;Dimethyl-tert-butylsilyl chloride;TBDMS chloride;TBDMS-Cl;t-Butyldimethylchlorosilane;tert-Butyl(dimethyl)silane chloride;tert-Butyldimethylchlorosilane;Tert-butyldimethylsilyl chloride ( TBMS );T-Butyldimethylsilyl chloride;tert-Butyldimethylsilyl chloride;
PSA 0.00000
LogP 3.23040

Synthetic route

: 29681-57-0
tert-butyldimethylsilane

: 563-47-3
3-Chloro-2-methylpropene

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
palladium diacetate	99.8%

: 72726-46-6
tert-butyl(dimethyl)(phenylseleno)silane

A: 1666-13-3
diphenyl diselenide

B: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
With chlorine In tetrachloromethane	A 96% B 93%

: 75-44-5
phosgene

: 75-77-4
chloro-trimethyl-silane

: 18173-64-3
tert-butyldimethylsilanol

: 107-06-2
1,2-dichloro-ethane

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide	96%

...Expand

: 75-44-5
phosgene

: 75-77-4
chloro-trimethyl-silane

: 18173-64-3
tert-butyldimethylsilanol

: 107-06-2
1,2-dichloro-ethane

: 93-61-8
N-methyl-N-phenylformamide

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
	92%

...Expand

: 29681-57-0
tert-butyldimethylsilane

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
With hexachloroethane; palladium dichloride In tetrahydrofuran at 20℃; for 2h;	89%
With tetrabutylammonium perchlorate; copper(l) chloride In 1,2-dimethoxyethane electrochemical reaction;	83%
With copper(l) iodide; copper dichloride In tetrahydrofuran; diethyl ether at 20℃; for 60h;	73%

: 18159-55-2
tri-t-butylsilane

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; palladium on activated charcoal In hexane at 25℃; for 2h;	87%

: 507-20-0
tertiary butyl chloride

: 75-78-5
dimethylsilicon dichloride

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
With magnesium In tetrahydrofuran; hexane	78%
With copper(l) cyanide; magnesium In tetrahydrofuran for 2h; Heating;	74%

: 66548-21-8
di(methyl)tert-butyl(methoxy)silane

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 20℃; for 10h;	78%
With hydrogenchloride In hexane at 0℃; for 2h;	71%
With hydrogenchloride In water at 20℃; for 5 - 10h; Product distribution / selectivity;	60%

: 594-19-4
tert.-butyl lithium

: 75-78-5
dimethylsilicon dichloride

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
In pentane for 2h; Heating;	61%

: 75-78-5
dimethylsilicon dichloride

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
With t-C4H9Li In not given	58%
With tert.-butyl lithium In not given	58%

: 66348-17-2
bis(trifluoromethyl)germanium chloride

: 80594-86-1
1,3-di-tert-butyl-1,1,3,3-tetramethyldisilatellurane

A: 112438-43-4
bistris(trifluoromethyl)germyl telluride

B: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
Ar atmosphere, heating (80°C, 2 d); protection against light; fractional sublimation; elem. anal.;	A 52% B n/a

...Expand

: 18173-64-3
tert-butyldimethylsilanol

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
With thionyl chloride In chloroform for 0.5h;	39%
With hydrogenchloride In hexane at 0℃; for 2h;	98 % Chromat.

: 2357-76-8
tert-butyldimethylfluorosilane

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
With chloro-trimethyl-silane; aluminium trichloride

: 96760-01-9
1-(tert-butyldimethylsilyloxy)-1-isopropoxycyclopropane

A: 75-29-6
isopropyl chloride

B: 18162-48-6
tert-butyldimethylsilyl chloride

C: isopropyl 3-(trichlorotitanio)propionate

D: C9H19Cl3O2SiTi

Conditions

Conditions	Yield
With titanium tetrachloride In chloroform-d1 Product distribution; Mechanism;

...Expand

: 85909-11-1
Aminodichlorphosphan

A: C6H15ClNPSi

B: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
at 319.84℃; Thermolysis;

: 18163-07-0
2-(trimethylsilyl)propene

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NH4F*HF, H2SO4 2: ClSiMe3, AlCl3 View Scheme

: 288-32-4
1H-imidazole

: 389625-48-3
7'-chloro-4'-methylfluorescein

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide

: 677-22-5
tert-butylmagnesium chloride

: 75-78-5
dimethylsilicon dichloride

: 18162-48-6
tert-butyldimethylsilyl chloride

: 288-32-4
1H-imidazole

: 192376-55-9
(2R)-4-(3-pyridyl)-1,2-butanediol

: 98-59-9
p-toluenesulfonyl chloride

A: 192376-56-0
(2R)-2-(tert-butyldimethylsilyloxy)-4-(pyridin-3-yl)-1-(4-toluenesulfonyloxy)butane

B: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
In pyridine; dichloromethane

...Expand

: 29681-57-0
tert-butyldimethylsilane

: 7681-65-4
copper(I) iodide

: 7447-39-4
copper(II) chloride

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
In tetrahydrofuran

...Expand

: 91-16-7
1,2-dimethoxybenzene

: 29681-57-0
tert-butyldimethylsilane

: 75-78-5
dimethylsilicon dichloride

A: 1066-35-9
dimethylmonochlorosilane

B: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
AlCl3	A n/a B 91% and 92%

...Expand

: 288-32-4
1H-imidazole

: 7646-93-7
potassium hydrogensulfate

: 18162-48-6
tert-butyldimethylsilyl chloride

Conditions

Conditions	Yield
In N-methyl-acetamide

: 3736-77-4
2,2'-Anhydrouridine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 55264-11-4
(2R,3R,3aS,9aR)-3-((tert-butyldimethylsilyl)oxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-3,3a-dihydro-2H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6(9aH)-one

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 2h; Inert atmosphere;	100%
With 1H-imidazole In N,N-dimethyl-formamide for 3h; Ambient temperature;	92%
With pyridine; 1H-imidazole Ambient temperature;	61%
With 1H-imidazole
With 1H-imidazole In N,N-dimethyl-formamide for 1h;

: 818-72-4
1-Octyn-3-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 60134-93-2
3-(tert-butyldimethylsilyloxy)oct-1-yne

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide for 8h; Ambient temperature;	100%
With 1H-imidazole silylation;	99%
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃; for 20h;	99%

: 79-14-1
glycolic Acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 67226-76-0
(tert-butyldimethylsiloxy) acetic acid tert-butyldimethylsilyl ester

Conditions

Conditions	Yield
With pyridine for 2h; Ambient temperature;	100%
With 1H-imidazole In N,N-dimethyl-formamide for 10h; Ambient temperature;	97%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;	95%

: 5390-04-5
pent-1-yn-5-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 61362-77-4
1-(tert-butyldimethylsilyloxy)-4-pentyne

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 25℃;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 4h; Inert atmosphere;	100%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;	100%

: 14320-38-8
cyclopent-3-enol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 68845-72-7
4-tert-butyldimethylsilyloxycyclopentene

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃;	100%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 16.5h;	100%
With 1H-imidazole In tetrahydrofuran at 0℃;	95%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 100-51-6
benzyl alcohol

: 53172-91-1
(benzyloxy)(tert-butyl)dimethylsilane

Conditions

Conditions	Yield
With P(MeN(CH3)CH2CH2)3N; triethylamine In acetonitrile at 24℃; for 2.5h;	100%
With ferric hydrogen sulphate; triethylamine In acetonitrile at 20℃; for 60h; Inert atmosphere; chemoselective reaction;	100%
With 1H-imidazole; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 20℃; for 0.5h;	99%

: 109-99-9
tetrahydrofuran

: 18162-48-6
tert-butyldimethylsilyl chloride

: 92511-12-1
1-{[dimethyl(1,1-dimethylethyl)silyl]oxy}-4-iodobutane

Conditions

Conditions	Yield
With sodium iodide In acetonitrile at 55℃; for 16h; Inert atmosphere;	100%
With sodium iodide In tetrahydrofuran; acetonitrile at 55℃; for 18h; Inert atmosphere;	100%
With sodium iodide In acetonitrile at 20℃; Inert atmosphere; Darkness;	93%

: 98-00-0
(2-furyl)methyl alcohol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 121389-55-7
tert-butyl(furan-2-ylmethoxy)dimethylsilane

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at -78 - 20℃;	100%
With 1H-imidazole In N,N-dimethyl-formamide	99%
With 1H-imidazole In N,N-dimethyl-formamide at 23℃; for 0.5h;	97%

: 4412-91-3
furan-3-methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 89861-06-3
tert-butyl (furan-3-ylmethoxy)dimethylsilane

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃; for 2h;	100%
With 1H-imidazole In dichloromethane	100%
With N-ethyl-N,N-diisopropylamine In dichloromethane for 1h; Ambient temperature;	98%

: 120-72-9
indole

: 18162-48-6
tert-butyldimethylsilyl chloride

: 40899-73-8
N-tert-butyldimethylsilylindole

Conditions

Conditions	Yield
Stage #1: indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Stage #2: tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃;	100%
Stage #1: indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Stage #2: tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h;	100%
Stage #1: indole With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.75h; Inert atmosphere; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; mineral oil at 0 - 20℃; for 12h; Inert atmosphere;	93%

: 586-95-8
pyridine-4-methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 117423-41-3
4-((tert-butyldimethylsilyloxy)methyl)pyridine

Conditions

Conditions	Yield
With 1H-imidazole In DMF (N,N-dimethyl-formamide) for 3.25h;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;	100%
Stage #1: tert-butyldimethylsilyl chloride With 1H-imidazole In dichloromethane; N,N-dimethyl-formamide for 0.166667h; Inert atmosphere; Stage #2: pyridine-4-methanol In dichloromethane; N,N-dimethyl-formamide at 20℃; for 13h; Inert atmosphere;	99%

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 18162-48-6
tert-butyldimethylsilyl chloride

: 155108-06-8
5-(((tert-butyldimethylsilyl)oxy)methyl)furan-2-carbaldehyde

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃; for 24h; Inert atmosphere;	100%
Stage #1: 5-hydroxymethyl-2-furfuraldehyde With 1H-imidazole In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: tert-butyldimethylsilyl chloride In dichloromethane at 20℃; Inert atmosphere; Darkness;	99%
With potassium carbonate In dichloromethane at 20℃; for 12h;	99%

: 62147-49-3
1,3-dihydroxyacetone dimer

: 18162-48-6
tert-butyldimethylsilyl chloride

: 127382-65-4
1,3-bis-O-(tert-butyldimethylsilyl)-1,3-dihydroxy-2-propanone

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane for 18h;	100%
With triethylamine In dichloromethane at 20℃; for 12h;	99%
With 1H-imidazole In N,N-dimethyl-formamide for 3h; Ambient temperature;	98%

: 526-55-6
2-(3-indole)-ethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 101079-48-5
3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1H-indole

Conditions

Conditions	Yield
With 1H-imidazole In tetrahydrofuran at 0 - 20℃; for 0.5h; Inert atmosphere;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;	100%
With 1H-imidazole In N,N-dimethyl-formamide for 16h; Ambient temperature;	99%

: 5631-67-4
7-hydroxychroman-2-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: 82861-23-2
7-((tert-butyldimethylsilyl)oxy)chroman-2-one

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 25℃; for 10h;	100%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	91%

: 951-78-0
2'-deoxyuridine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 64911-18-8
3',5'-O-di(tert-butyldimethylsilyl)-2'-deoxyuridine

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; for 3h;	100%
With pyridine; 1H-imidazole at 0 - 20℃;	100%
With 1H-imidazole In N,N-dimethyl-formamide Etherification;	97%

: 59-14-3
5-bromo-2'-deoxyuridine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 154925-95-8
3',5'-di-O-(tert-butyldimethylsilyl)-5-bromo-2'-deoxyuridine

Conditions

Conditions	Yield
With pyridine at 40℃; for 20h; Inert atmosphere;	100%
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 20℃; for 12h;	99%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 60h;	96%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 1.5h;	94%
With TEA In tetrahydrofuran at 75℃; for 40h;	65%

: 2408-36-8
lithium cyanide

: 108-94-1
cyclohexanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 114114-74-8
1-<(tert-butyldimethylsilyl)oxy>-1-cyanocyclohexane

Conditions

Conditions	Yield
In tetrahydrofuran for 70h; Ambient temperature;	100%

...Expand

: 961-07-9
2'-Deoxyguanosine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 51549-35-0
3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;	100%
With 1H-imidazole In N,N-dimethyl-formamide silylation;	97%
With 1H-imidazole In N,N-dimethyl-formamide; toluene for 3h; Inert atmosphere; Heating; Large scale;	97%

: 123-08-0
4-hydroxy-benzaldehyde

: 18162-48-6
tert-butyldimethylsilyl chloride

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran	100%
With dmap; triethylamine In [D3]acetonitrile at 25℃; for 0.2h;	99%
With triethylamine In dichloromethane at 20℃; for 2h;	98%

: 90-02-8
salicylaldehyde

: 18162-48-6
tert-butyldimethylsilyl chloride

: 116585-12-7
2-((tert-butyldimethylsilyl)oxy)benzaldehyde

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 1h;	100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 12h; Schlenk technique; Glovebox;	100%

: 121-33-5
vanillin

: 18162-48-6
tert-butyldimethylsilyl chloride

: 69404-94-0
O-tert-butyldimethylsilylvanillin

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃; for 2h;	100%
With 1H-imidazole; dmap In dichloromethane at 20℃; Inert atmosphere;	100%
With 1H-imidazole; dmap In dichloromethane at 20℃; for 2h;	100%

: 107-21-1
ethylene glycol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 102229-10-7
2-(tert-butyldimethylsilyloxy)ethanol

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 0.166667h; Cooling with ice;	100%
With dmap; triethylamine In dichloromethane at 0 - 20℃;	99%
With pyridine at 20℃; for 2h; Inert atmosphere;	99%

: 621-59-0
isovanillin

: 18162-48-6
tert-butyldimethylsilyl chloride

: 97315-18-9
p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃;	100%
With 2-(Dimethylamino)pyridine; triethylamine In dichloromethane at 0 - 20℃; for 12h;	100%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide Inert atmosphere;	100%

: 97-64-3, 2676-33-7
ethyl 2-hydroxypropionate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 105198-38-7
(S)-(-)-ethyl 2-(tert-butyldimethylsilyloxy)propanoate

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane a) RT, overnight, b) reflux, 10 h;	100%
With 1H-imidazole
With 1H-imidazole In dichloromethane Ambient temperature;
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h;

: 821-41-0
5-Hexen-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 85807-84-7
tert-butyl(5-hexenyloxy)dimethylsilane

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide	100%
With 1H-imidazole In tetrahydrofuran at 20℃;	100%
With 1H-imidazole In dichloromethane at 20℃; for 19h;	100%

: 1191-25-9
6-Hydroxyhexanoic acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 77744-44-6
6-(tert-butyldimethylsilyloxy)hexanoic acid

Conditions

Conditions	Yield
Stage #1: 6-Hydroxyhexanoic acid With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide at 20℃; for 0.5h;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 0.25h;	87%
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; Inert atmosphere;	86%
With 1H-imidazole In N,N-dimethyl-formamide at 50℃;	80%
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; Inert atmosphere;

: 50622-09-8
2,3-O-isopropylidene-L-threitol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 108817-96-5
[(4S,5S)-5-[(tert-butyl(dimethyl)silyl)oxymethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]methanol

Conditions

Conditions	Yield
Stage #1: 2,3-O-isopropylidene-L-threitol With sodium hydride In tetrahydrofuran at 0 - 20℃; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at 20℃; for 16h;	100%
With 1H-imidazole; dmap In dichloromethane at 20℃; for 3h; Inert atmosphere;	100%
Stage #1: 2,3-O-isopropylidene-L-threitol With sodium hydride In tetrahydrofuran at 20℃; for 0.75h; Inert atmosphere; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at 20℃; for 0.75h; Inert atmosphere;	98%

: 106-44-5
p-cresol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 62790-85-6
tert-Butyl(dimethyl)-(4-methylphenoxy)silane

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;	99%
With 1H-imidazole; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 20℃; for 2h;	97%

: 371-41-5
4-Fluorophenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 113984-68-2
4-<(dimethyl-tert-butylsilyl)oxy>fluorobenzene

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 12h;	98%
With 1H-imidazole In N,N-dimethyl-formamide at 0℃; for 1h;	91%

tert-Butyldimethylsilyl chloride Consensus Reports

Reported in EPA TSCA Inventory.

tert-Butyldimethylsilyl chloride Specification

The tert-Butyldimethylsilyl chloride, with the CAS registry number 18162-48-6,is also known as TBSCl; tert-Butylchlorodimethylsilane; t-Butyldimethylsilyl chloride; t-Butyldimethylchlorosilane. It belongs to the product categories of organosilicon compounds;Miscellaneous Reagents.Its EINECS number is 242-042-4. This chemical's molecular formula is C₆H₁₅ClSi and molecular weight is 150.72. What's more,Its systematic name is Ttert-Butylchlorodimethylsilane .It is a White solid which is Flammable, Corrosive and Moisture Sensitive.The tert-Butylchlorodimethylsilane (CAS NO.18162-48-6) is used for pharmaceutical intermediates, and is also used in organic synthesis as hydroxyl protectant.

Physical properties about tert-Butyldimethylsilyl chloride are:
(1)ACD/LogP: 2.833; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.83; (4)ACD/LogD (pH 7.4): 2.83; (5)ACD/BCF (pH 5.5): 83.82; (6)ACD/BCF (pH 7.4): 83.82; (7)ACD/KOC (pH 5.5): 828.61; (8)ACD/KOC (pH 7.4): 828.61; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.411; (13)Molar Refractivity: 43.378 cm3; (14)Molar Volume: 174.746 cm3; (15)Surface Tension: 18.7350006103516 dyne/cm; (16)Density: 0.863 g/cm3; (17)Flash Point: 22.778 °C; (18)Enthalpy of Vaporization: 34.789 kJ/mol; (19)Boiling Point: 124.999 °C at 760 mmHg; (20)Vapour Pressure: 15.0319995880127 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:Cl[Si](C(C)(C)C)(C)C;
(2)Std. InChI:InChI=1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3;
(3)Std. InChIKey:BCNZYOJHNLTNEZ-UHFFFAOYSA-N.

The toxicity data of tert-Butyldimethylsilyl chloride are as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	intraperitoneal	1gm/kg (1000mg/kg)	IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE	Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975Vol. 27MAY1975,

Product Name

tert-Butyldimethylsilyl chloride

Synthetic route

tert-Butyldimethylsilyl chloride Consensus Reports

tert-Butyldimethylsilyl chloride Specification

Related Products

Hot Products