Conditions | Yield |
---|---|
With potassium hydroxide In tetrahydrofuran for 16h; | 99% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h; | 92% |
Conditions | Yield |
---|---|
Stage #1: 3-Bromophenol With potassium carbonate In acetone for 0.25h; Stage #2: dimethyl sulfate In acetone for 10h; Reflux; | 95% |
With sodium hydroxide | |
With sodium hydroxide |
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In sulfolane at 220℃; for 0.166667h; | 95% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 220℃; for 0.166667h; Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
Stage #1: methanol With tetrabutyl-ammonium chloride; potassium hydroxide In cyclohexane at 55℃; for 0.0833333h; Stage #2: m-nitrobromobenzene In cyclohexane at 55 - 60℃; for 3h; Reagent/catalyst; | 83% |
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium hydroxide In n-heptane at 20 - 50℃; for 3h; Reagent/catalyst; | 82% |
3-methoxyphenyl bromide
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; copper In acetonitrile at 20℃; for 0.75h; Substitution; | 78% |
With tetrabutylammomium bromide In acetonitrile at 60℃; for 0.75h; Substitution; | 72% |
Conditions | Yield |
---|---|
Stage #1: methanol With sodium hydride In tert-butyl methyl ether; mineral oil at 20℃; for 0.25h; Inert atmosphere; Sealed tube; Stage #2: 3-bromophenyl(mesityl)iodonium bromide In tert-butyl methyl ether; mineral oil at 50℃; for 1h; Inert atmosphere; Sealed tube; chemoselective reaction; | 77% |
(2,4,6-trimethylphenyl)(3’-methoxyphenyl)iodonium triflate
3-methoxyphenyl bromide
Conditions | Yield |
---|---|
With copper(I) bromide In acetonitrile at 80℃; for 2h; | 64% |
Conditions | Yield |
---|---|
Stage #1: m-Anisidine With Bromotrichloromethane; sodium nitrite In dichloromethane; water at 23℃; for 0.0833333h; Stage #2: With acetic acid In dichloromethane; water at 23℃; for 24h; Temperature; | 28% |
With sulfuric acid; sodium nitrite anschliessend Erwaermen mit Kupfer(I)-bromid; | |
With hydrogen bromide; sodium nitrite anschliessend Erwaermen mit Kupfer-Pulver; |
Conditions | Yield |
---|---|
With potassium hydroxide |
A
bromobenzene
B
iodobenzene
C
3-methoxyphenyl bromide
D
3-methoxy-1-iodobenzene
Conditions | Yield |
---|---|
With BrNBu4 In chloroform at 55℃; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aqueous H2SO4 / Diazotization.Kochen der Diazoniumsalz-Loesung 2: aqueous NaOH View Scheme | |
Multi-step reaction with 2 steps 1: aqueous H2SO4 / Diazotization.Kochen der Diazoniumsalz-Loesung 2: aqueous KOH View Scheme |
(3-methoxyphenyl)(triphenyl-λ5-phosphanyl)gold
3-methoxyphenyl bromide
Conditions | Yield |
---|---|
With N-Bromosuccinimide In chloroform-d1 at 20℃; chemoselective reaction; | > 95 %Spectr. |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid 2: copper(I) bromide / acetonitrile / 2 h / 80 °C View Scheme |
(3-bromophenyl)boronic acid
3-methoxyphenyl bromide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C 2.1: sodium hydride / tert-butyl methyl ether; mineral oil / 0.25 h / 20 °C / Inert atmosphere; Sealed tube 2.2: 1 h / 50 °C / Inert atmosphere; Sealed tube View Scheme |
3-bromo-4-iodoanisole
3-methoxyphenyl bromide
Conditions | Yield |
---|---|
With nickel(II) iodide; 1,4-bis(dicyclohexylphosphino)butane; sodium carbonate; cesium iodide In tetrahydrofuran at 35℃; for 72h; Irradiation; |
benzophenone
3-methoxyphenyl bromide
(3-methoxyphenyl)(diphenyl)methanol
Conditions | Yield |
---|---|
Stage #1: 3-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: benzophenone In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere; | 100% |
With magnesium 1.) ether, 2.) a) RT, 6 h, b) reflux, 1 h; Yield given. Multistep reaction; | |
With n-butyllithium |
Conditions | Yield |
---|---|
With tetraphenyldisilane; cesium fluoride In acetonitrile at 100℃; for 0.0833333h; | 100% |
With tetrakis(triphenylphosphine) palladium(0); formaldehyd; caesium carbonate In dimethyl sulfoxide at 80℃; for 12h; | 85% |
With N,N,N,N,-tetramethylethylenediamine; C39H46IrN4 In acetonitrile at 45℃; for 48h; Sealed tube; Glovebox; Inert atmosphere; | 80% |
3-methoxyphenyl bromide
3-methoxy-benzaldehyde
bis(3-methoxyphenyl)methanol
Conditions | Yield |
---|---|
With n-butyllithium In hexane; ethyl acetate | 100% |
With magnesium In diethyl ether for 1h; Ambient temperature; | 62% |
With magnesium 1.) ether, ultrasound; Yield given. Multistep reaction; | |
Stage #1: 3-methoxyphenyl bromide With magnesium In tetrahydrofuran at 0℃; Reflux; Inert atmosphere; Stage #2: 3-methoxy-benzaldehyde In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #3: With hydrogenchloride; water In tetrahydrofuran | |
Stage #1: 3-methoxyphenyl bromide With magnesium In diethyl ether at 20℃; for 2h; Inert atmosphere; Stage #2: 3-methoxy-benzaldehyde In diethyl ether at 20℃; for 2h; Inert atmosphere; |
3-methoxyphenyl bromide
Dichlorophenylphosphine
bis(3-methoxyphenyl)(phenyl)phosphine oxide
Conditions | Yield |
---|---|
Stage #1: 3-methoxyphenyl bromide With magnesium Metallation; Stage #2: Dichlorophenylphosphine Arylation; Stage #3: With water; dihydrogen peroxide In tetrahydrofuran Oxidation; Further stages.; | 100% |
With magnesium Yield given; |
Conditions | Yield |
---|---|
With potassium phosphate; 3-(2,6-diisopropylphenyl)-1-(2-diphenylphosphanylbenzyl)-3H-imidazol-1-ium chloride; bis(η3-allyl-μ-chloropalladium(II)) In 1,4-dioxane at 80℃; for 12h; Suzuki cross-coupling; | 100% |
With potassium carbonate In 5,5-dimethyl-1,3-cyclohexadiene | 100% |
With potassium phosphate; naphthidine di(radical cation)s-stabilized Pd nanoparticles In 1,4-dioxane at 80℃; for 5h; Suzuki-Miyaura cross-coupling reaction; | 99% |
3-methoxyphenyl bromide
acrylic acid n-butyl ester
(E)-n-butyl 3-(3-methoxyphenyl)acrylate
Conditions | Yield |
---|---|
With potassium carbonate; bis(dibenzylideneacetone)-palladium(0); 3-(2,6-diisopropylphenyl)-1-(2-diphenylphosphanylbenzyl)-3H-imidazol-1-ium chloride In N,N-dimethyl acetamide at 140℃; for 12h; Heck reaction; | 100% |
With di-tert-butylneopentylphosphonium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; bis(dibenzylideneacetone)-palladium(0) In N,N-dimethyl-formamide at 24℃; for 24h; Heck Reaction; Glovebox; | 98% |
With bis(1,1'-ethylene-3,3'-divinylimidazole-2,2'-diylidene)nickel(II) dibromide dihydrate; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 4h; Heck Reaction; Inert atmosphere; Schlenk technique; | 96% |
Conditions | Yield |
---|---|
With Me2Zn(TMP)Li In tetrahydrofuran at 20℃; for 12h; | 100% |
With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex In tetrahydrofuran at -78 - 20℃; for 8h; Inert atmosphere; | 84% |
Conditions | Yield |
---|---|
With caesium carbonate; diisopropyl(2-tert-butyl)phenoxyphosphine; RhCl(PPh3)3 In toluene for 18h; Heating; | 100% |
3-methoxyphenyl bromide
m-Anisidine
3-methoxy-N-(3-methoxyphenyl)benzenamine
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 110℃; for 48h; Buchwald-Hartwig amination; | 100% |
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium t-butanolate In toluene at 100℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; | 72% |
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) In toluene at 120℃; | 40% |
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 72h; Reflux; Inert atmosphere; |
3-methoxyphenyl bromide
1-(3-Bromophenyl)ethanone
1-(3-bromo-phenyl)-1-(3-methoxy-phenyl)-ethanol
Conditions | Yield |
---|---|
Stage #1: 3-methoxyphenyl bromide With bromine; magnesium In diethyl ether at 20℃; Stage #2: 1-(3-Bromophenyl)ethanone In diethyl ether for 3h; Reflux; | 100% |
3-methoxyphenyl bromide
4-methyl-3-(triisopropylsilyloxy)aniline
N-(3-methoxyphenyl)-4-methyl-3-(triisopropylsilyloxy)aniline
Conditions | Yield |
---|---|
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate In toluene at 100℃; for 31h; Buchwald-Hartwig Coupling; Inert atmosphere; | 100% |
3-methoxyphenyl bromide
Methyl 4-amino-2-methoxybenzoate
methyl 2-Methoxy-4-[(3-methoxyphenyl)amino]benzoate
Conditions | Yield |
---|---|
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate In toluene at 100℃; for 21h; Inert atmosphere; | 100% |
3-methoxyphenyl bromide
1-amino-3-methylbenzene
3-methoxy-N-(3-methylphenyl)aniline
Conditions | Yield |
---|---|
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate In toluene at 100℃; for 15h; Buchwald-Hartwig Coupling; Inert atmosphere; | 100% |
3-methoxyphenyl bromide
4-amino-2-(benzyloxy)benzonitrile
Conditions | Yield |
---|---|
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate In toluene at 100℃; for 31h; Buchwald-Hartwig Coupling; | 100% |
imidazo[1,2-a]pyridine
3-methoxyphenyl bromide
3-(3-methoxyphenyl)imidazo[1,2-a]pyridine
Conditions | Yield |
---|---|
With C27H22N4O2Pd; potassium acetate In N,N-dimethyl acetamide at 140℃; for 18h; Catalytic behavior; Schlenk technique; Inert atmosphere; | 100% |
With palladium diacetate; potassium hydroxide In water at 100℃; for 24h; Inert atmosphere; | 53% |
3-methoxyphenyl bromide
(2-cyclopropylethynyl)trimethylsilane
1-(2-cyclopropylethynyl)-3-methoxybenzene
Conditions | Yield |
---|---|
Stage #1: 3-methoxyphenyl bromide With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; cesium fluoride In water at 20℃; for 0.25h; Sealed tube; Inert atmosphere; Stage #2: (2-cyclopropylethynyl)trimethylsilane In water at 80℃; for 16h; Sealed tube; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; L-lysine at 130℃; for 5h; Microwave irradiation; | 99% |
With copper(l) iodide; N-((4-nitro-1-oxy-pyridin-2-yl)methyl)oxalamic acid; tetrabutylammomium bromide; potassium hydroxide In water at 100℃; for 36h; Schlenk technique; Inert atmosphere; Sealed tube; | 99% |
With potassium tert-butylate; copper(I) oxide In N,N-dimethyl-formamide at 130℃; for 24h; | 91% |
N-Methylformamide
3-methoxyphenyl bromide
N-methyl-N-(3-methoxyphenyl)carboxamide
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 16h; | 99% |
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 16h; Arylation; | 98% |
3-methoxyphenyl bromide
bis(pinacol)diborane
2-(3-bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1-(4,4'-di-tert-butyl-[2,2'-bipyridin]-6-yl)-2-(dimethyl(phenyl)silyl)-2,3-dihydro-1H-benzo[d][1,3,2]diazaborole Inert atmosphere; Schlenk technique; Sealed tube; | 99% |
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; cyclopentyl methyl ether; 1,1'-di(pyridin-2-yl)-1,1',3,3'-tetrahydro-2,2'-bibenzo[d][1,3,2]diazaborole at 100℃; for 16h; Schlenk technique; Inert atmosphere; | 96% |
With Pinacolborane; 4,4'-di-tert-butylbipyridine In cyclohexane at 80℃; | 77% |
3-methoxyphenyl bromide
4-methylphenylboronic acid
3-methoxy-4'-methylbiphenyl
Conditions | Yield |
---|---|
With cetyltrimethylammonim bromide; sodium hydroxide In water at 25℃; for 1h; Catalytic behavior; Suzuki Coupling; Microwave irradiation; | 99% |
With caesium carbonate; [PdCl(NNCNHC-nBu)]BF4 In water; N,N-dimethyl-formamide at 80℃; for 2h; Suzuki-Miyaura reaction; | 95% |
With potassium phosphate; N-[(4-diphenylphosphinophenyl)methyl] D-gluconamide; PdCl2(GLCAphos)2 In water at 80℃; for 16h; | 93% |
Conditions | Yield |
---|---|
With [Pd(N,N'-bis(2,6-bis(di-p-tolylmethyl)-4-methylphenyl)-imidazol-2-ylidene)(acetylacetonate)Cl]; lithium hexamethyldisilazane In 1,4-dioxane at 110℃; for 3h; Buchwald-Hartwig Coupling; Inert atmosphere; Sealed tube; | 99% |
With sodium t-butanolate; palladium diacetate In toluene at 80℃; for 0.5h; Buchwald-Hartwig amination; | 98% |
With C27H34N5P; sodium hydroxide; bis(dibenzylideneacetone)-palladium(0) In tert-Amyl alcohol at 100℃; Inert atmosphere; | 97.77% |
3-methoxyphenyl bromide
1-Naphthylboronic acid
1-(3-methoxybiphenyl)naphthalene
Conditions | Yield |
---|---|
With potassium fluoride; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 100℃; for 18h; Suzuki coupling; | 99% |
With KF; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In 1,2-dioxacyclohexane | 99% |
With potassium phosphate In ethanol; water at 20℃; for 1h; Suzuki-Miyaura Coupling; Inert atmosphere; Green chemistry; | 98% |
With ethyl 2-hydroxypropionate; palladium diacetate; potassium carbonate In water at 80℃; for 2h; Suzuki-Miyaura Coupling; Green chemistry; | 50% |
With Br(1-)*C25H29BrN5O6(1+); potassium carbonate In water at 100℃; for 2h; Suzuki-Miyaura coupling; | > 99 %Spectr. |
3-methoxyphenyl bromide
2-Methylphenylboronic acid
3'-methoxy-2-methyl-1,1'-biphenyl
Conditions | Yield |
---|---|
With cetyltrimethylammonim bromide; sodium hydroxide In water at 30℃; for 2h; Catalytic behavior; Temperature; Time; Suzuki Coupling; Microwave irradiation; | 99% |
With C20H12N2O8PdS2(2-)*2Na(1+); sodium hydroxide In water at 100℃; for 3h; | 95% |
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water for 24h; Heating; | 90% |
Conditions | Yield |
---|---|
With sodium azide In ethylene glycol at 100℃; for 3h; Green chemistry; | 99% |
With copper(l) iodide; sodium azide; sodium L-ascorbate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane In ethanol for 0.666667h; Heating; | 95% |
With copper(l) iodide; sodium azide; L-proline; sodium hydroxide In ethanol at 95℃; for 24h; | 92% |
Conditions | Yield |
---|---|
With copper(l) iodide; potassium carbonate; L-proline In dimethyl sulfoxide at 90℃; for 31h; | 99% |
With potassium phosphate; copper(l) iodide; N-((1-oxy-pyridin-2-yl)methyl)oxalamic acid In dimethyl sulfoxide at 80℃; for 48h; Schlenk technique; Inert atmosphere; Sealed tube; chemoselective reaction; | 71% |
With 8-Hydroxyquinoline-N-oxide; caesium carbonate; copper(I) bromide In dimethyl sulfoxide at 50℃; for 60h; Ullmann coupling; Inert atmosphere; Sealed tube; chemoselective reaction; |
3-methoxyphenyl bromide
phenylacetylene
1-methoxy-3-(phenylethynyl)benzene
Conditions | Yield |
---|---|
With copper(l) iodide; ethanolamine; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran; water at 60℃; for 26h; Sonogashira coupling; | 99% |
With UC Pd; potassium carbonate; XPhos In ethanol; water at 50℃; for 5h; Sonogashira coupling; Inert atmosphere; | 95% |
With potassium phosphate; bis(η3-allyl-μ-chloropalladium(II)); N,N,N′,N′-tetra(diphenylphosphinomethyl)-1,2-ethylenediamine In 1,4-dioxane at 105℃; for 20h; Sonogashira coupling; Inert atmosphere; | 94% |
3-methoxyphenyl bromide
Pentafluorobenzene
2,3,4,5,6-pentafluoro-3'-methoxy-1,1'-biphenyl
Conditions | Yield |
---|---|
With potassium phosphate; chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium (II); Trimethylacetic acid In N,N-dimethyl acetamide at 80℃; Glovebox; | 99% |
With potassium phosphate; chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)] palladium(II); Trimethylacetic acid In N,N-dimethyl acetamide at 80℃; for 2 - 4h; | 98% |
With [Pd(trifluoroacetato)2(1,3-diisopropylbenzimidazolin-2-ylidene)(C2N3CH2Ph3)]; potassium carbonate In N,N-dimethyl acetamide at 120℃; for 24h; | 95% |
Conditions | Yield |
---|---|
With C34H52Cl2N2Pd; potassium carbonate; Trimethylacetic acid In N,N-dimethyl acetamide at 120℃; for 16h; Reagent/catalyst; | 99% |
With pentamethylcyclopentadienyltricarbonylrhenium for 2.5h; Schlenk technique; Inert atmosphere; UV-irradiation; | 92% |
With potassium tert-butylate at 100℃; for 24h; Inert atmosphere; | 89% |
Conditions | Yield |
---|---|
With bis(tri-ortho-tolylphosphine)palladium(0); (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; ammonia; sodium t-butanolate In 1,4-dioxane at 80℃; for 5h; Inert atmosphere; | 99% |
With copper(l) iodide; 2-carboxyquinoline N-oxide; potassium carbonate; ammonium hydroxide In dimethyl sulfoxide at 80℃; for 23h; Inert atmosphere; | 93% |
With ammonium hydroxide; copper(l) iodide; diethylenetriaminopentaacetic acid; potassium hydroxide In water at 100℃; for 12h; Sealed tube; | 90% |
1. Introduction of 3-Bromoanisole
3-Bromoanisole is also named as 1-Bromo-3-methoxybenzene; 3-Methoxy-1-bromobenzene; 3-Methoxybromobenzene; NSC 82293; m-Bromoanisole; m-Bromomethoxybenzene; m-Bromophenyl methyl ether; m-Methoxybromobenzene. 3-Bromoanisole is colorless clear liquid.
2. Properties of 3-Bromoanisole
Melting Point: 2 °C
Boiling Point: 210.5 °C at 760 mmHg
Flash Point: 93.3 °C
Index of Refraction: 1.539
Molar Refractivity: 40.62 cm3
Molar Volume: 129.6 cm3
Surface Tension: 34.6 dyne/cm
Enthalpy of Vaporization: 42.86 kJ/mol
Vapour Pressure: 0.278 mmHg at 25 °C
XLogP3: 3
H-Bond Acceptor: 1
Rotatable Bond Count: 1
Exact Mass: 185.968027
MonoIsotopic Mass: 185.968027
Topological Polar Surface Area: 9.2
Heavy Atom Count: 9
3. Structure Descriptors of 3-Bromoanisole
Canonical SMILES: COC1=CC(=CC=C1)Br
InChI: InChI=1S/C7H7BrO/c1-9-7-4-2-3-6(8)5-7/h2-5H,1H3
InChIKey: PLDWAJLZAAHOGG-UHFFFAOYSA-N
4. Safety Information of 3-Bromoanisole
Hazard Codes: Xi
Safety Statements: 23-24/25
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
F: 8
Hazard Note: Irritant
TSCA: T
HS Code: 29093038
5. Use of 3-Bromoanisole
3-Bromoanisole is used in organic synthesis.
6. Preparation of 3-bromoanisole
Comprising methoxydenitrating 3-bromonitrobenzene in the presence of a phase-transfer catalyst (PTC), and the preparation of 3-bromonirtobenzene by the bromination of nitrobenzene with bromine in oleum. The methoxydenitration reagent in an alkali metal methoxide, which is selected from sodium methoxide and potassium methoxide. The amount of methoxide used is 1-1.5 mol per mol of 3-bromonitrobenzene. The alkali methoxide can be a pre-prepared solid or it can be prepared in situ, by the reaction of the corresponding alkali hydroxide and methanol. In the case when pre-prepared solid methoxide is used, the effective amount of alkali hydroxide is between 1.2-1.7 mol per mol of 3-bromonitrobenzebe. The reaction temperatures are between about 40 to 80° C., with preference to reaction temperatures of 50 to 55° C. In the case in which methoxide is prepared in situ, the effective amount of alkali hydroxide is between 2.2-2.4 mol per mol of 3-bromonitrobenzene. The reaction temperatures are between about 50 to 80° C. with preference to reaction temperatures of 55 to 65° C.
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View