3-Chloropropionic acid supplier

Name
3-Chloropropionic acid
EINECS 203-534-4
CAS No. 107-94-8
Article Data98
CAS DataBase
Density 1.29 g/cm³
Solubility Soluble in water, ethanol, chloroform, miscible with ether
Melting Point 37-41 °C
Formula C₃H₅ClO₂
Boiling Point 199 °C at 760 mmHg
Molecular Weight 108.525
Flash Point 66.9 °C
Transport Information UN 3261 8/PG 2
Appearance White to beige crystalline low melting mass
Safety 26-36/37/39-45
Risk Codes 35-34-21/22
Molecular Structure
Hazard Symbols C
Synonyms Propionicacid, 3-chloro- (7CI,8CI);Propionic acid, b-chloro- (2CI);b-Monochloropropionic acid;NSC 174;NSC 2183;b-Chloropropionic acid;
PSA 37.30000
LogP 0.69990

Synthetic route

: 542-76-7
3-Chloropropionitrile

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With benzene-1,2-dicarboxylic acid for 0.75h; microwave irradiation;	91%
With benzene-1,2-dicarboxylic acid at 240℃; under 3040 Torr; for 1h;	72%
With hydrogenchloride
With water In dimethyl sulfoxide at 26℃; for 72h; pH=7; aq. phosphate buffer;	25 %Chromat.

: 625-36-5
2-chloropropionyl chloride

: 100-46-9
benzylamine

A: 107-94-8
chloropropionic acid

B: 13304-62-6
N-benzylacrylamide

C: 501-68-8
Beclamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃; for 0.0833333h; Temperature; Concentration;	A 6% B 5% C 89%

...Expand

: 625-36-5
2-chloropropionyl chloride

: 100-46-9
benzylamine

A: 107-94-8
chloropropionic acid

B: 501-68-8
Beclamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; for 0.0166667h; Time;	A 22% B 78%

...Expand

: 802294-64-0
propionic acid

A: 590-92-1
3-Bromopropionic acid

B: 107-94-8
chloropropionic acid

C: 598-72-1
2-Bromopropionic acid

D: 598-78-7
(R,S)-2-chloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride; oxygen; potassium bromide; sodium nitrite In chloroform; water at 40℃; under 760.051 Torr; for 18h; Sealed tube; Irradiation;	A 65% B n/a C 23% D n/a

...Expand

: 79-10-7
acrylic acid

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride at 65 - 70℃; for 4h;	32.3%
With hydrogenchloride
With hydrogenchloride at 12℃;

: 57-57-8
β-Propiolactone

: 6921-34-2
benzylmagnesium chloride

A: 107-94-8
chloropropionic acid

B: 1821-12-1
4-Phenylbutyric acid

...Expand

: 57-57-8
β-Propiolactone

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium chloride at 30 - 45℃;
With hydrogenchloride

: 19434-65-2
3-chloropropanaldehyde

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With nitric acid
With nitric acid

: 141-76-4
3-iodopropanoic acid

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With chlorine

: 1070-78-6
1,1,1,3-tetrachloropropane

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With sulfuric acid

: 79-03-8
propionyl chloride

: 802294-64-0
propionic acid

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
at 75 - 80℃; unter Belichtung;

: 802294-64-0
propionic acid

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With tetrachloromethane; sulfuryl dichloride; dibenzoyl peroxide
With chlorine at 400℃; in der Dampfphase;
With tetrachloromethane; sulfuryl dichloride; dibenzoyl peroxide
With chlorine at 120℃; in fluessiges Phase;
With chlorine at 30 - 60℃; unter Belichtung;

: 802294-64-0
propionic acid

A: 107-94-8
chloropropionic acid

B: 598-78-7
(R,S)-2-chloropropionic acid

Conditions

Conditions	Yield
With chlorine Irradiation.im UV-Licht;
With hydrogenchloride Electrolysis.an einer Platinanode;
With hydrogenchloride Electrolysis.an Platinanode;

: 802294-64-0
propionic acid

A: 107-94-8
chloropropionic acid

B: 565-64-0
2,3-dichloropropanoic acid

C: 598-78-7
(R,S)-2-chloropropionic acid

Conditions

Conditions	Yield
beim Chlorieren in der fluessigen Phase unter Belichtung;

...Expand

: 107-13-1
acrylonitrile

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride bei Siedetemperatur;

: 109-78-4
3-Hydroxypropionitrile

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride
With hydrogenchloride at 100℃;
With hydrogenchloride und Kochen des Reaktionsgemisches unter weiterem Durchleiten von Chlorwasserstoff;
With hydrogenchloride; water und Kochen des Reaktionsgemisches unter weiterem Durchleiten von Chlorwasserstoff;

: 625-36-5
2-chloropropionyl chloride

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 627-30-5
1-chloro-3-hydroxypropane

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With nitric acid
With alkaline KMNO4
With nitric acid
With oxygen; sodium hydroxide In water at 60℃; under 8258.9 Torr; Kinetics; Autoclave;

: 503-66-2
3-hydroxypropionic acid

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With hydrogenchloride at 120℃;

: 590-92-1
3-Bromopropionic acid

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With lithium chloride In dimethyl sulfoxide at 100℃; for 6h;

: 40861-09-4
3-chloroperpropionic acid

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
With benzonitrile; (5,10,15,20-tetraphenylporphyrinato)manganese(III) chloride at 30℃; Rate constant;

: 86641-76-1
3,12-bis(3'-bromo-1'-oxopropyl)-3,12-diaza-6,9-diazoniadispiro<5.2.5.2>hexadecane dichloride

A: 590-92-1
3-Bromopropionic acid

B: 107-94-8
chloropropionic acid

C: 121051-82-9
3,12-bis(3'-chloro-1'-oxopropyl)-3,12-diaza-6,9-diazoniadispiro<5.2.5.2>hexadecane dibromide

D: 95461-34-0
3,12-Bisacrylyl-3,12-diaza-6,9-diazoniadispiro<5,2,5,2>hexadecane dichloride

E: 122842-21-1
3,12-bis(3'-hydroxy-1'-oxopropyl)-3,12-diaza-6,9-diazoniadispiro<5.2.5.2>hexadecane dichloride

F: 503-66-2
3-hydroxypropionic acid

Conditions

Conditions	Yield
In water at 70℃; for 5h; Product distribution; Kinetics; Rate constant; various time; other temperature;

...Expand

: 623-71-2
ethyl 3-chloropropanoate

A: 107-94-8
chloropropionic acid

B: 74-85-1
ethene

Conditions

Conditions	Yield
In gas at 360 - 420℃; under 49 - 209 Torr; Rate constant; Kinetics; Thermodynamic data; E(act);

: 5421-53-4
4,4'-Di-tert-butyldiphenyliodonium chloride

A: 107-94-8
chloropropionic acid

B: 253185-03-4, 253185-04-5
tert-butylbenzene

C: 35779-04-5
1-tert-butyl-4-iodobenzene

D: 3972-56-3
4-(tert-butyl)chlorobenzene

Conditions

Conditions	Yield
With (+)-cis-dioxolane; 2,2'-azobis(isobutyronitrile) at 75℃; for 7h; Product distribution; Quantum yield; various reaction conditions; also photochemical reaction;

...Expand

: 142-28-9
1,3-Dichloropropane

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
Product distribution; dehalogenation; P. butanovora strain ml-15; aerobic condition; other bacterium strains; other halogeno alkanes;

: 3-Chloro-propionic acid 1-phenoxy-ethyl ester

A: 107-94-8
chloropropionic acid

B: 75-07-0
acetaldehyde

C: 108-95-2
phenol

Conditions

Conditions	Yield
With water In acetonitrile Rate constant; var. pH;

...Expand

: 57-57-8
β-Propiolactone

: 7732-18-5
water

NaCl: NaCl

: 107-94-8
chloropropionic acid

...Expand

: 7647-01-0
hydrogenchloride

: 107-13-1
acrylonitrile

: 107-94-8
chloropropionic acid

: 7647-01-0
hydrogenchloride

: 109-78-4
3-Hydroxypropionitrile

: 107-94-8
chloropropionic acid

Conditions

Conditions	Yield
at 100℃;
bei nachfolgenden Kochen unter weiterem Durchleiten von Chlorwasserstoff;analog verlauft die Einw. von Bromwasserstoff u Jodwasserstoff;

: 107-94-8
chloropropionic acid

: 23713-65-7, 59338-76-0, 59338-77-1, 59338-78-2, 82416-23-7, 82416-24-8, 82416-25-9, 82416-26-0, 82416-31-7, 82416-32-8, 111003-03-3, 111003-05-5, 113776-10-6, 69542-91-2
2,4-dimethylcyclohexan-1-ol

: 3-chloro-propionic acid 2,4-dimethyl-cyclohexyl ester

Conditions

Conditions	Yield
Stage #1: chloropropionic acid With (chloro-phenylthio-methylene)dimethylammonium chloride In dichloromethane at 0℃; for 0.5h; Stage #2: 2,4-dimethylcyclohexan-1-ol In dichloromethane at 20℃; for 12h;	100%

: 107-94-8
chloropropionic acid

: 77380-28-0
2,5-Difluorothiophenol

: 926232-57-7
3-((2,5-difluorophenyl)thio)propanoic acid

Conditions

Conditions	Yield
Stage #1: 2,5-Difluorothiophenol With sodium hydroxide In water at 0℃; for 0.0833333h; Stage #2: chloropropionic acid In water at 70℃; Stage #3: With hydrogenchloride In water at 0℃;	100%

: 107-94-8
chloropropionic acid

: 137757-24-5
4-(6-hydroxyhexyl)benzoic acid

: 4-{6-[(3-chloropropionyl)oxy]hexyl}benzoic acid

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane at 50℃; for 18h; Dean-Stark;	100%

: 107-94-8
chloropropionic acid

: 64-17-5
ethanol

: 623-71-2
ethyl 3-chloropropanoate

Conditions

Conditions	Yield
hydrogenchloride In water for 8h; Product distribution / selectivity;	99%
With hydrogenchloride
With sulfuric acid
With sulfuric acid

: 107-94-8
chloropropionic acid

: 20495-99-2
3-chloropropanoic anhydride

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere; Glovebox;	99%
With dicyclohexyl-carbodiimide for 0.0833333h;	65 % Spectr.

: 107-94-8
chloropropionic acid

: 887003-12-5
2-amino-4-chloro-6-methyl-10,10-dioxo-10,11-dihydro-5-oxa-10λ6-thia-dibenzo[a,d]cycloheptene-8-carboxylic acid methyl ester

: 887003-66-9
4-chloro-2-(3-chloro-propylamino)-6-methyl-10,10-dioxo-10,11-dihydro-5-oxa-10λ6-thia-dibenzo[a,d]cycloheptene-8-carboxylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: chloropropionic acid With sodium tetrahydroborate In tetrahydrofuran; benzene at 0 - 20℃; for 1h; Stage #2: 2-amino-4-chloro-6-methyl-10,10-dioxo-10,11-dihydro-5-oxa-10λ6-thia-dibenzo[a,d]cycloheptene-8-carboxylic acid methyl ester In tetrahydrofuran; benzene for 3h; Heating / reflux;	99%

: 107-94-8
chloropropionic acid

: 32943-25-2
3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine

: C17H17Cl2N*ClH

Conditions

Conditions	Yield
Stage #1: chloropropionic acid With sodium tetrahydroborate In toluene at 0 - 5℃; Stage #2: 3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepine With sodium tetrahydroborate In toluene at 25 - 80℃; for 7h; Stage #3: With hydrogenchloride In water; isopropyl alcohol	99%

: 107-94-8
chloropropionic acid

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
With bis(trichloromethyl) carbonate In toluene at 25℃; for 8h; Reagent/catalyst; Temperature;	98.5%
With thionyl chloride	63%
With phosphorus trichloride

: 107-94-8
chloropropionic acid

: 95-88-5
4-Chlororesorcinol

: 1202889-56-2
3-chloro-1-(5-chloro-2,4-dihydroxyphenyl)propan-1-one

Conditions

Conditions	Yield
Stage #1: 4-Chlororesorcinol With trifluorormethanesulfonic acid at 4 - 10℃; Stage #2: chloropropionic acid at 10 - 55℃; Product distribution / selectivity;	98.4%
Stage #1: 4-Chlororesorcinol With trifluorormethanesulfonic acid at 4 - 10℃; Stage #2: chloropropionic acid at 10 - 55℃; Product distribution / selectivity;	98.4%

: 616-47-7
1-methyl-1H-imidazole

: 107-94-8
chloropropionic acid

: 1-(2-hydroxycarbonyl)ethyl-3-methyl-3H-imidazolium chloride

Conditions

Conditions	Yield
at 70℃; for 50h;	98%
In toluene for 5h; Reflux; Inert atmosphere;	86%
In toluene Schlenk technique;	80%
In ethyl acetate at 70℃; for 24h;

: 107-94-8
chloropropionic acid

: 261-96-1
1-azaphenothiazine

: 10-(3-chloropropyl)-10H-benzo[b]pyrido[2,3-e][1,4]thiazine hydrochloride

Conditions

Conditions	Yield
Stage #1: chloropropionic acid With sodium tetrahydroborate In toluene at 0 - 5℃; Stage #2: 1-azaphenothiazine With sodium tetrahydroborate In toluene at 25 - 75℃; for 6h; Stage #3: With hydrogenchloride In water; isopropyl alcohol	98%

: 107-94-8
chloropropionic acid

: 106-45-6
para-thiocresol

: 13739-35-0
3-[(4-methylphenyl)thio]propionic acid

Conditions

Conditions	Yield
With sodium hydroxide In water for 0.5h; Microwave irradiation;	97%
Stage #1: chloropropionic acid; para-thiocresol With potassium hydroxide; potassium carbonate In ethanol Reflux; Stage #2: With hydrogenchloride In ethanol; water Large scale reaction;	77%
With sodium hydroxide

: 107-94-8
chloropropionic acid

: 92-84-2
10H-phenothiazine

: C15H14ClNS*ClH

Conditions

Conditions	Yield
Stage #1: chloropropionic acid With sodium tetrahydroborate In toluene at 0 - 5℃; Stage #2: 10H-phenothiazine With sodium tetrahydroborate In toluene at 25 - 80℃; for 5h; Stage #3: With hydrogenchloride In water; isopropyl alcohol	97%

: 107-94-8
chloropropionic acid

: 578-95-0
10H-acridin-9-one

: 226424-38-0
3-(9-oxo-9,10-dihydro-10-acridinyl)propanoic acid

Conditions

Conditions	Yield
With 1-ethyl-3-methylimidazolium hydroxide at 50℃; for 8h; Ionic liquid;	95.9%

: 107-94-8
chloropropionic acid

: 3-cyano-4-(dimethylformamidyl)-aniline

: 1-(3-chloropropionyl)-3-cyano-4-(dimethylformamidyl)aniline

Conditions

Conditions	Yield
With 4-methyl-morpholine In tetrahydrofuran at 0 - 5℃; for 1.75h;	95.7%

: 107-94-8
chloropropionic acid

: 637-89-8
4-sulfanylphenol

: 30512-65-3
3-[(4-hydroxyphenyl)sulfanyl]propanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 100℃; for 3h;	95%
With potassium hydroxide In water at 80℃; for 2.5h; pH=12;

: 107-94-8
chloropropionic acid

: 13451-78-0
5-fluorobenzo[d]oxazole-2-thiol

: 3-((5-fluorobenzo[d]oxazol-2-yl)thio)propanoic acid

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 100℃; for 1h; Microwave irradiation;	95%

: 107-94-8
chloropropionic acid

: 108-98-5
thiophenol

: 5219-65-8
acide phenylthio-3 propanoique

Conditions

Conditions	Yield
Stage #1: thiophenol With sodium hydroxide In water at 20℃; Stage #2: chloropropionic acid In water for 4h; Reflux; Stage #3: With hydrogenchloride In water at 20℃; pH=< 2;	94%
With potassium carbonate; potassium hydroxide In ethanol; water at 0℃; for 5h; Reflux;	70%
Stage #1: chloropropionic acid; thiophenol With potassium hydroxide; potassium carbonate In ethanol Reflux; Stage #2: With hydrogenchloride In ethanol; water	63%

: 107-94-8
chloropropionic acid

: 371-42-6
4-Fluorothiophenol

: 19543-85-2
3-(4-fluorophenylthio)propanoic acid

Conditions

Conditions	Yield
Stage #1: 4-Fluorothiophenol With potassium hydroxide In ethanol; water at 60℃; Stage #2: chloropropionic acid With potassium carbonate In ethanol; water at 20 - 96℃; for 5.5h;	94%
With potassium carbonate; potassium hydroxide In ethanol; water at 0℃; for 5h; Reflux;	92%
Stage #1: chloropropionic acid; 4-Fluorothiophenol With potassium hydroxide; potassium carbonate In ethanol Reflux; Stage #2: With hydrogenchloride In ethanol; water	90%

: 107-94-8
chloropropionic acid

: 1117-97-1
N,0-dimethylhydroxylamine

: 1062512-53-1
3-chloro-N-methoxy-N-methylpropanamide

Conditions

Conditions	Yield
Stage #1: chloropropionic acid; N,0-dimethylhydroxylamine In toluene at 0℃; for 0.166667h; Stage #2: With phosphorus trichloride In toluene at 20 - 60℃; for 0.5h;	94%

: 107-94-8
chloropropionic acid

: 603-35-0
triphenylphosphine

: 36626-29-6
(2-carboxyethyl)triphenylphosphonium chloride

Conditions

Conditions	Yield
In toluene at 110℃; for 18h;	93%
In xylene for 18h; Heating;	89%
In 5,5-dimethyl-1,3-cyclohexadiene; water for 4h; Reflux;	84%

: 107-94-8
chloropropionic acid

: 108-46-3
recorcinol

: 151884-07-0
2',4'-dihydroxy-3-chloropropiophenone

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid at 80℃; for 1h;	92%
With trifluorormethanesulfonic acid at 80℃; for 1h;	90%
With trifluorormethanesulfonic acid at 85℃; for 0.75h;	86%

: 107-94-8
chloropropionic acid

: 1062512-43-9
C6H18N3O3P

: 1062512-53-1
3-chloro-N-methoxy-N-methylpropanamide

Conditions

Conditions	Yield
In toluene at 60℃;	92%

: 107-94-8
chloropropionic acid

: 202582-35-2
N-[2-((2-S-(4-methoxybenzyl)sulfanyl)ethyl)amino]acetyl-S-(4-methoxybenzyl)-2-aminoethanethiol

: C25H34N2O5S2

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 80℃;	92%

: 107-94-8
chloropropionic acid

: 8-amino-6-(4-aminophenyl)-2-phenyl-1,2,4-triazolo[4,3-a]pyrazin-3(2H)-one

: N-(4-(8-amino-3-oxo-2-phenyl-2,3-dihydro-1,2,4-triazolo-[4,3-a]pyrazin-6-yl)phenyl)acrylamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 2h;	92%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;	22%

: 107-94-8
chloropropionic acid

: 2-((trifluoromethyl)thio)benzo[d]isothiazol-3(2H)-one 1,1-dioxide

: 110-83-8
cyclohexene

: 2-((trifluoromethyl)thio)cyclohexyl 3-chloropropanoate

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; bis(4-methoxyphenyl)selenide In hexane at 20℃; for 24h; Sealed tube;	91%

...Expand

: 110-86-1
pyridine

: 107-94-8
chloropropionic acid

: 15168-37-3
1-(2-carboxy-ethyl)-pyridinium; chloride

Conditions

Conditions	Yield
at 70 - 80℃;	90%

: 107-94-8
chloropropionic acid

: 4559-70-0
Diphenylphosphine oxide

: 29874-10-0
3-(diphenyl-phosphinoyl)-propionic acid

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 50℃; for 1h;	90%
(i) NaOEt, EtOH, (ii) /BRN= 1098495/; Multistep reaction;

3-Chloropropionic acid Consensus Reports

Reported in EPA TSCA Inventory.

3-Chloropropionic acid Specification

The 3-Chloropropionic acid with CAS registry number of 107-94-8 is also known as Propanoic acid,3-chloro-. The IUPAC name and product name are the same. It belongs to product categories of omega-Chlorocarboxylic Acids; omega-Functional Alkanols, Carboxylic Acids, Amines & Halides; C1 to C5; Carbonyl Compounds; Carboxylic Acids. Its EINECS registry number is 203-534-4. In addition, the formula is C₃H₅ClO₂ and the molecular weight is 108.52. This chemical is a white to beige crystalline low melting mass that soluble in water. It may destroy living tissue on contact and should be sealed in ventilated, cool room away from fire, heat. What's more, this chemical is used as intermediate in organic synthesis and also can be used for production of anti-epilepsy drugs.

Physical properties about 3-Chloropropionic acid are: (1)ACD/LogP: 0.41; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.1; (4)ACD/LogD (pH 7.4): -2.83; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.23; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.444; (13)Molar Refractivity: 22.36 cm³; (14)Molar Volume: 84 cm³; (15)Surface Tension: 40.2 dyne/cm; (16)Density: 1.29 g/cm³; (17)Flash Point: 66.9 °C; (18)Enthalpy of Vaporization: 47.97 kJ/mol; (19)Boiling Point: 199 °C at 760 mmHg; (20)Vapour Pressure: 0.147 mmHg at 25 °C.

Preparation of 3-Chloropropionic acid: it is prepared by reaction of acrylic acid. The reaction needs reagent conc. aq. HCl at the temperature of 65 - 70 °C for 4 hours. The yield is about 32.3 %.

3-Chloropropionic acid is prepared by reaction of acrylic acid.

Uses of 3-Chloropropionic acid: it is used to produce 3-diphenylphosphinylpropionsaeure by reaction with diphenylphosphane oxide. The reaction occurs with reagent aq. KOH and solvent dimethylsulfoxide at the temperature of 50 °C for 1 hour. The yield is about 90 %.

3-Chloropropionic acid is used to produce 3-diphenylphosphinylpropionsaeure by reaction with diphenylphosphane oxide.

When you are using this chemical, please be cautious about it. As a chemical, it is harmful in contact with skin and if swallowed. Furthermore, it causes severe burns. During using it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C(CCl)C(=O)O
2. InChI: InChI=1S/C3H5ClO2/c4-2-1-3(5)6/h1-2H2,(H,5,6)
3. InChIKey: QEYMMOKECZBKAC-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	skin	1040mg/kg (1040mg/kg)		Cancer Research. Vol. 28, Pg. 653, 1968.

Product Name

3-Chloropropionic acid

Synthetic route

3-Chloropropionic acid Consensus Reports

3-Chloropropionic acid Specification

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