3-Chloropropionyl chloride supplier

Name
3-Chloropropionyl chloride
EINECS 210-890-4
CAS No. 625-36-5
Article Data67
CAS DataBase
Density 1.296 g/cm³
Solubility reacts with water
Melting Point -32 °C
Formula C₃H₄Cl₂O
Boiling Point 144.9 °C at 760 mmHg
Molecular Weight 126.97
Flash Point 61.7 °C
Transport Information UN 3390 6.1/PG 1
Appearance Clear colorless to dark brown liquid
Safety 23-26-36/37/39-45-38-16-8
Risk Codes 14-22-26-34-35-10
Molecular Structure
Hazard Symbols T+
Synonyms Propionylchloride, 3-chloro- (6CI,7CI,8CI);(Chloromethyl)acetyl chloride;3-Chloropropanoyl chloride;3-Chloropropionic acid chloride;NSC 84180;b-Chloropropanoylchloride;b-Chloropropionic acid chloride;b-Chloropropionyl chloride;w-Chloropropanoyl chloride;w-Chloropropionyl chloride;
PSA 17.07000
LogP 1.38070

Synthetic route

: 107-94-8
chloropropionic acid

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
With bis(trichloromethyl) carbonate In toluene at 25℃; for 8h; Reagent/catalyst; Temperature;	98.5%
With thionyl chloride	63%
With phosphorus trichloride

: 57-57-8
β-Propiolactone

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
With bis(trichloromethyl) carbonate; N,N-dimethylpiperidine-4-carboxamide hydrochloride at 25℃; for 10h; Reagent/catalyst; Large scale;	98%
With phosphorus pentachloride In benzene at 20℃; for 10h; Chlorination;	87%
With tetrachloromethane; sulfuryl dichloride
With tetrachloromethane; phosphorus pentachloride
With thionyl chloride

: 79-10-7
acrylic acid

A: 814-68-6
acryloyl chloride

B: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide at 80℃; under 2068.65 Torr; for 0.416667h; Reagent/catalyst; Pressure;	A 4% B 94%
With trichlorophosphate In N,N-dimethyl-formamide at 80℃; for 0.00833333h; Reagent/catalyst; Temperature;	A 91% B 6%
With thionyl chloride; N,N-dimethyl-formamide In neat (no solvent) at 60℃; for 0.0166667h; Catalytic behavior; Reagent/catalyst; Temperature; Time; Flow reactor;

: 79-10-7
acrylic acid

A: C6H7ClO3

B: 814-68-6
acryloyl chloride

C: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide at 60℃; for 0.0166667h; Reagent/catalyst;	A 7% B 82% C 11%

...Expand

: 79-10-7
acrylic acid

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
With phosgene; N,N-dimethyl-formamide at 70℃; for 10h;	80%
With N,N-dimethyl-formamide
With phosgene In N,N-dimethyl-formamide at 70℃; for 40h;
With phosgene In N,N-dimethyl-formamide at 70℃; for 40h;	200 g
With thionyl chloride In N,N-dimethyl-formamide at 80℃; for 0.416667h; Concentration; Reagent/catalyst;

: 676-83-5
methyldichlorophosphane

: 79-10-7
acrylic acid

A: 15171-48-9
2-methyl-2,5-dioxo-1,2-oxaphospholane

B: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
In paraffin	A n/a B 76%
	A n/a B 76%

...Expand

: 23270-34-0
3-(chloro-methyl-phosphinoyl)-butyryl chloride

: 79-10-7
acrylic acid

A 2,4-Dimethyl-2,5-dioxo-1,2-phospholane: 2,4-Dimethyl-2,5-dioxo-1,2-phospholane

B: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
	A n/a B 70%

...Expand

: 15171-48-9
2-methyl-2,5-dioxo-1,2-oxaphospholane

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
	70%

: 75-44-5
phosgene

: 74-85-1
ethene

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
With aluminium trichloride; toluene
With carbon disulfide at -5 - -4℃;

: 79-03-8
propionyl chloride

A: 7623-09-8
2-chloropropionyl chloride

B: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
With chlorine at 0 - 5℃; Irradiation.unter UV-Bestrahlung;
With sulfuryl dichloride; dibenzoyl peroxide
With sulfuryl dichloride; dibenzoyl peroxide

: 79-03-8
propionyl chloride

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
With chlorine at 0 - 5℃; Irradiation.UV-Bestrahlung;
With sulfuryl dichloride; dibenzoyl peroxide

: 74-85-1
ethene

: 201230-82-2
carbon monoxide

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
(i) PdCl2, benzene, (ii) /BRN= 3587209/; Multistep reaction;

: 107-13-1
acrylonitrile

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
(i) aq. HCl, (ii) SOCl2; Multistep reaction;

: 7719-09-7
thionyl chloride

: 57-57-8
β-Propiolactone

: 625-36-5
2-chloropropionyl chloride

: 57-57-8
β-Propiolactone

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 625-36-5
2-chloropropionyl chloride

: 56-23-5
tetrachloromethane

: 79-03-8
propionyl chloride

A: 625-36-5
2-chloropropionyl chloride

B α-chloro-propionyl chloride: α-chloro-propionyl chloride

Conditions

Conditions	Yield
Chlorierung unter Belichtung;

...Expand

: 79-03-8
propionyl chloride

: 7782-50-5
chlorine

A: 7623-09-8
2-chloropropionyl chloride

B: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
at 0 - 5℃; UV-Bestrahlung.Irradiation;

...Expand

: 7791-25-5
sulfuryl dichloride

: 79-03-8
propionyl chloride

: 94-36-0
dibenzoyl peroxide

A: 7623-09-8
2-chloropropionyl chloride

B: 625-36-5
2-chloropropionyl chloride

...Expand

: 79-03-8
propionyl chloride

A: 625-36-5
2-chloropropionyl chloride

B α-chloro-propionic acid chloride: α-chloro-propionic acid chloride

Conditions

Conditions	Yield
With tetrachloromethane; chlorine

: 75-44-5
phosgene

: 7446-70-0
aluminium trichloride

: 74-85-1
ethene

: 108-88-3
toluene

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
at 35 - 40℃;

...Expand

: 75-44-5
phosgene

: 7446-70-0
aluminium trichloride

: 74-85-1
ethene

CS2: CS2

: 625-36-5
2-chloropropionyl chloride

Conditions

Conditions	Yield
at -7 - -2℃;

...Expand

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 625-36-5
2-chloropropionyl chloride

: 57369-31-0
1,2,6,7-tetrahydropyrido<3,2,1-i,j>quinolin-3(5H)-one

Conditions

Conditions	Yield
Stage #1: 1,2,3,4-tetrahydroisoquinoline; 2-chloropropionyl chloride In acetone for 1h; Inert atmosphere; Reflux; Stage #2: With aluminum (III) chloride; sodium chloride at 150℃; for 1h; Inert atmosphere;	100%
Stage #1: 1,2,3,4-tetrahydroisoquinoline; 2-chloropropionyl chloride In acetone for 1h; Reflux; Stage #2: With aluminum (III) chloride; sodium chloride at 150℃; for 0.5h;	88%
With acetone Erhitzen des Reaktionsprodukts mit Aluminiumchlorid;
With aluminium trichloride 1.) acetone, reflux, 2 h, 2.) heating; Multistep reaction;

: 106-49-0
p-toluidine

: 625-36-5
2-chloropropionyl chloride

: 19342-88-2
3-chloro-N-(4-methylphenyl)propionamide

Conditions

Conditions	Yield
In acetone for 1h; Acylation; Heating;	100%
In water; acetone for 6h; Reflux;	100%
With potassium carbonate In acetone at 0℃; for 1h; Condensation;	95%

: 106-47-8
4-chloro-aniline

: 625-36-5
2-chloropropionyl chloride

: 19314-16-0
3-chloro-N-(4-chlorophenyl)propanamide

Conditions

Conditions	Yield
In acetone for 1h; Acylation; Heating;	100%
In acetone for 2h; Reflux;	85%
Stage #1: 4-chloro-aniline With sodium acetate; acetic acid In water at 5℃; Stage #2: 2-chloropropionyl chloride at 0 - 20℃;	70%

: 64-04-0
phenethylamine

: 625-36-5
2-chloropropionyl chloride

: 306-20-7
3-chloro-N-(4-phenylethyl)propanamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In chloroform; water at 20℃; for 1h;	100%
With sodium hydroxide

: 100-01-6
4-nitro-aniline

: 625-36-5
2-chloropropionyl chloride

: 19313-88-3
3-chloro-N-(4-nitrophenyl)propanamide

Conditions

Conditions	Yield
at 0 - 50℃; Neat (no solvent);	100%
at 20 - 50℃;	100%
at 50℃; for 16h;	97%

: 62-53-3
aniline

: 625-36-5
2-chloropropionyl chloride

: 3460-04-6
3-chloro-N-phenylpropionamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 2h;	100%
With potassium carbonate In acetone at 0℃; for 1h; Condensation;	98%
With potassium carbonate In water; acetone at 0℃; for 1h;	98%

: 91-20-3
naphthalene

: 625-36-5
2-chloropropionyl chloride

: 22422-70-4
3-chloro-1-(naphthalen-2-yl)propan-1-one

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 20℃; Cooling with ice;	100%
With carbon disulfide; aluminium trichloride
With aluminium trichloride In nitrobenzene 1.) 5 h, room temp., 2.) 30 min, 40-45 deg C;
Stage #1: naphthalene; 2-chloropropionyl chloride With aluminum (III) chloride In nitrobenzene at 0℃; Stage #2: With hydrogenchloride In nitrobenzene

: 4235-20-5
5-chloro-2-phenylsulfanyl-aniline

: 625-36-5
2-chloropropionyl chloride

: 101096-34-8
N-(3-chloropropyl)-5-chloro-2-phenylthiophenylamine

Conditions

Conditions	Yield
With pyridine In diethyl ether at 0℃; for 0.333333h;	100%

: 625-36-5
2-chloropropionyl chloride

: 71-43-2
benzene

: 936-59-4
3-chloropropiophenone

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 0 - 20℃; Inert atmosphere;	100%
aluminium trichloride; nitromethane In carbon disulfide for 2h; Product distribution; Mechanism; Ambient temperature; further Friedel-Crafts catalysts, further arenes, further haloacid chlorides; variation of temperature and time;	88%
aluminium trichloride; nitromethane In carbon disulfide for 2h; Ambient temperature;	88%

: 188290-36-0
thiophene

: 625-36-5
2-chloropropionyl chloride

: 40570-64-7
3-chloro-1-(2-thienyl)propan-1-one

Conditions

Conditions	Yield
Stage #1: 2-chloropropionyl chloride With aluminum (III) chloride In dichloromethane at -5℃; for 0.166667h; Friedel Crafts Acylation; Stage #2: thiophene In dichloromethane at -5℃; for 1h; Friedel Crafts Acylation;	100%
Stage #1: 2-chloropropionyl chloride With aluminum (III) chloride In dichloromethane at 20℃; for 0.25h; Stage #2: thiophene In dichloromethane at 0 - 20℃; for 4h;	99%
Stage #1: 2-chloropropionyl chloride With aluminum (III) chloride In dichloromethane at 20℃; for 0.25h; Stage #2: thiophene In dichloromethane at 0 - 20℃; for 4h;	99%

: 496-15-1
1-indoline

: 625-36-5
2-chloropropionyl chloride

: 64140-62-1
N-(β-chloropropionyl)-indoline

Conditions

Conditions	Yield
In acetone at 70℃; for 3h;	100%
In acetone at 70℃; for 3h; Inert atmosphere; Sealed tube;	99%
In acetone for 1h; Reflux;	73%

: 136304-78-4
methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate

: 625-36-5
2-chloropropionyl chloride

: 136304-79-5
methyl 2-(2-chloroethyl)-1-[(2'-cyanobiphenyl-4-yl)methyl]benzimidazole-7-carboxylate

Conditions

Conditions	Yield
In dichloromethane for 2h; Ambient temperature;	100%
With hydrogenchloride In methanol; CH2 Cl2 -H2 O; dichloromethane

: 625-36-5
2-chloropropionyl chloride

: 102-56-7
2,5-dimethoxyaniline

: N-(2',5'-dimethoxyphenyl)-3-chloropropanamide

Conditions

Conditions	Yield
In benzene for 1h; Ambient temperature;	100%

: 50399-51-4, 215371-20-3
trans-1,2,3,4-tetrahydro-7-methoxy-1-naphthylamine

: 625-36-5
2-chloropropionyl chloride

: N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-3-chloropropanamide

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane	100%

: 625-36-5
2-chloropropionyl chloride

: 2039-67-0
2-(3-methoxyphenyl)-1-ethanamine

: 34164-26-6
3-chloro-N-[2-(3-methoxyphenyl)ethyl]propionamide

Conditions

Conditions	Yield
With sodium hydrogencarbonate In chloroform; water at 20℃; for 1h;	100%

: 21835-63-2
1,4-dihydro-4-(3-aminophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid,dimethyl ester

: 625-36-5
2-chloropropionyl chloride

: 1,4-Dihydro-4-[3-[[3-chloro-1-oxo-1-propyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester

Conditions

Conditions	Yield
In tetrahydrofuran; ethyl acetate	100%
In tetrahydrofuran; ethyl acetate	100%
In tetrahydrofuran; ethyl acetate	100%

: 19727-83-4
6-nitroindoline

: 625-36-5
2-chloropropionyl chloride

: 1-(3-Chloropropionyl)6-nitroindoline

Conditions

Conditions	Yield
With hydrogenchloride In acetone	100%

: 625-36-5
2-chloropropionyl chloride

: 98384-97-5
C3H4ClN3O

Conditions

Conditions	Yield
With sodium azide	100%

: 848139-78-6
6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile

: 625-36-5
2-chloropropionyl chloride

: 1233953-82-6
3-chloro-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

Conditions

Conditions	Yield
at 50℃; for 16h;	100%
at 50℃;	99%

: 1750-42-1
3-aminoisoxazole

: 625-36-5
2-chloropropionyl chloride

: 1225869-37-3
3-chloro-N-(isoxazol-3-yl)propanamide

Conditions

Conditions	Yield
Stage #1: 3-aminoisoxazole With sodium hydride In tetrahydrofuran; mineral oil for 6h; Inert atmosphere; Stage #2: 2-chloropropionyl chloride In tetrahydrofuran; mineral oil at 20℃; Inert atmosphere;	100%

: N1-(2-(dimethylamino)ethyl)-5-methoxy-N4-(2-((2-methoxy-4-(3-(methylsulfonyl)propoxy)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-N1-methylbenzene-1,2,4-triamine

: 625-36-5
2-chloropropionyl chloride

: 3-chloro-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((2-((2-methoxy-4-(3-(methylsulfonyl)propoxy)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)propanamide

Conditions

Conditions	Yield
In tetrahydrofuran; water at 25℃; for 2h;	100%

: 27407-11-0
3-bromo-4-fluorophenol

: 625-36-5
2-chloropropionyl chloride

: 3-bromo-4-fluorophenyl 3-chloropropanoate

Conditions

Conditions	Yield
With aluminum (III) chloride In dichloromethane at -50 - 20℃;	100%
With aluminum (III) chloride In dichloromethane at -50 - 20℃;	71%

: 11-aminosampangine

: 625-36-5
2-chloropropionyl chloride

: C18H12ClN3O2

Conditions

Conditions	Yield
Reflux;	100%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 625-36-5
2-chloropropionyl chloride

: 1062512-53-1
3-chloro-N-methoxy-N-methylpropanamide

Conditions

Conditions	Yield
With potassium carbonate In diethyl ether; water at 0 - 20℃; Inert atmosphere;	99.9%
With potassium carbonate In diethyl ether; water at 0 - 20℃; Inert atmosphere;	92%
With potassium carbonate In tetrahydrofuran; water at 0 - 20℃; Inert atmosphere;

: 75-64-9
tert-butylamine

: 625-36-5
2-chloropropionyl chloride

: 100859-81-2
N-tert-butyl-2-(chloromethyl)acetamide

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water at -20 - 20℃; for 2h;	99%
With sodium hydroxide; 1,2-dichloro-ethane

: 95-47-6
o-xylene

: 625-36-5
2-chloropropionyl chloride

: 22422-23-7
3-chloro-1-(3,4-dimethyl-phenyl)-propan-1-one

Conditions

Conditions	Yield
With aluminum (III) chloride; nitromethane at 19 - 22℃; under 760.051 Torr; Friedel Crafts acylation; Inert atmosphere;	99%
With aluminum (III) chloride In dichloromethane at 0 - 20℃; Friedel-Crafts acylation; Inert atmosphere;	98%
With aluminum (III) chloride In dichloromethane at 25℃; for 3h;	96%

: 100-74-3
N-ethylmorpholine;

: 625-36-5
2-chloropropionyl chloride

: N-ethyl-N-(3-propanoyl-N-ethylmorpholinium chloride) morpholinium chloride

Conditions

Conditions	Yield
In benzene for 1h; Heating;	99%

: 1077-16-3
hexylbenzene

: 625-36-5
2-chloropropionyl chloride

: 3-chloro-1-(4-hexylphenyl)-1-propanone

Conditions

Conditions	Yield
Stage #1: 2-chloropropionyl chloride With aluminum (III) chloride In dichloromethane at 20℃; for 0.25h; Stage #2: hexylbenzene In dichloromethane at 20℃; for 24h;	99%
With aluminium trichloride In pentane at 20℃; for 1h;	67%

: 553-94-6
4-bromo-m-xylene

: 625-36-5
2-chloropropionyl chloride

: 246022-83-3
4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene

Conditions

Conditions	Yield
Stage #1: 2-chloropropionyl chloride With aluminum (III) chloride In dichloromethane for 0.25h; Schlenk technique; Inert atmosphere; Stage #2: 4-bromo-m-xylene In dichloromethane at 20℃; for 20h; Inert atmosphere;	99%
With aluminium trichloride In dichloromethane at 50℃; for 3h; Addition;	87%
With aluminum (III) chloride In carbon disulfide at 0℃; for 1h; Reflux;	61%
With aluminium trichloride In carbon disulfide at 20℃; for 16h;

: 583-70-0
1-bromo-2,4-dimethylbenzene

: 625-36-5
2-chloropropionyl chloride

: 84092-78-4
1-(5-bromo-2,4-dimethylphenyl)-3-chloropropan-1-one

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide for 0.5h; Friedel-Crafts reaction; Heating;	99%

3-Chloropropionyl chloride Chemical Properties

Molecular Structure of Propanoylchloride, 3-chloro- (CAS No.625-36-5):

Molecular Formula: C₃H₄Cl₂O
Molecular Weight: 126.9693
IUPAC Name: 3-Chloropropanoyl chloride
CAS No: 625-36-5
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 2
Polar Surface Area: 17.07 Å²
Index of Refraction: 1.437
Molar Refractivity: 25.67 cm³
Molar Volume: 97.9 cm³
Surface Tension: 32.2 dyne/cm
Density: 1.296 g/cm³
Flash Point: 61.7 °C
Enthalpy of Vaporization: 38.2 kJ/mol
Boiling Point: 144.9 °C at 760 mmHg
Vapour Pressure: 4.97 mmHg at 25°C
InChI: InChI=1/C₃H₄Cl₂O /c4-2-1-3(5)6/h1-2H2
InChIKey: INUNLMUAPJVRME-UHFFFAOYAG
Std. InChI: InChI=1S/C₃H₄Cl₂O /c4-2-1-3(5)6/h1-2H2
Std. InChIKey: INUNLMUAPJVRME-UHFFFAOYSA-N
Synonyms of Propanoylchloride, 3-chloro- (CAS No.625-36-5): .Beta.-Chloropropanoyl chloride ; .Beta.-Chloropropionoyl chloride ; .Beta.-Chloropropionyl chloride ; 3-Chloropropanoyl chloride ; 3-Chlorpropanoylchlorid ; Beta-Chloropropanoyl chloride ; Beta-Chloropropionoyl chloride ; Beta-Chloropropionyl chloride ; Chlorure de 3-chloropropanoyle ; Propanoyl chloride, 3-chloro-
Product Categories: Halogen compounds;Acid Halides;Carbonyl Compounds;Organic Building Blocks

3-Chloropropionyl chloride Safety Profile

Hazard Codes: Very T+
Risk Statements:14-22-26-34-35-10
R14:Reacts violently with water.
R22:Harmful if swallowed.
R26:Very toxic by inhalation.
R34:Causes burns.
R35:Causes severe burns.
R10:Flammable.
Safety Statements:23-26-36/37/39-45-38-16-8
S23:Do not breathe vapour.
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S38:In case of insufficient ventilation, wear suitable respiratory equipment.
S16:Keep away from sources of ignition.
S8:Keep container dry.
RIDADR:UN 3390 6.1/PG 1
WGK Germany:1
F:21
HazardClass:6.1
PackingGroup:I
HS Code:29159080

Product Name

3-Chloropropionyl chloride

Synthetic route

3-Chloropropionyl chloride Chemical Properties

3-Chloropropionyl chloride Safety Profile

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