4-Iodotoluene supplier | CasNO.624-31-7

Name
4-Iodotoluene
EINECS 210-841-7
CAS No. 624-31-7
Article Data235
CAS DataBase
Density 1.706 g/cm³
Solubility insoluble in water
Melting Point 33-36 °C
Formula C₇H₇I
Boiling Point 211.5 °C at 760 mmHg
Molecular Weight 218.037
Flash Point 86.3 °C
Transport Information
Appearance white to light yellow crystalline low melting mass
Safety 24/25-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Toluene,p-iodo- (7CI,8CI);1-Iodo-4-methylbenzene;1-Methyl-4-iodobenzene;4-Iodomethylbenzene;
PSA 0.00000
LogP 2.59960

Synthetic route

: 36719-51-4
3,3-diethyl-1-(4-methylphenyl)-1-triazene

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With cation exchange resin BioRad AG 50W-X12 (H+); sodium iodide In acetonitrile at 75℃; Product distribution; further solvent: THF, DMSO;	99%
With sulfonic acid resin (H+ form, Bio-Rad AG 50W-12); sodium iodide In acetonitrile at 75℃; for 0.133333h;	90%
With chloro-trimethyl-silane; sodium iodide In acetonitrile at 60℃; for 0.0833333h;	75%

: 459-44-9
4-methylbenzenediazonium tetrafluoroborate

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With potassium iodide In water at 25℃; for 0.0833333h; Solvent; Sandmeyer Reaction;	99%
With iodine; potassium iodide In dimethyl sulfoxide at 15℃;
With trimethylsilyl iodide; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 65℃; for 2h;	98 % Chromat.
With diiodomethane; tetrabutylammonium perchlorate In methanol; N,N-dimethyl-formamide at 20℃; for 3h; Sandmeyer Reaction; Electrochemical reaction;	71 %Chromat.
With trimethylsilyl iodide at 60 - 70℃; Inert atmosphere; Ionic liquid;

: 108-88-3
toluene

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With potassium ferrate(VI); iodine In hexane for 2.33333h; Reflux; regioselective reaction;	95%
With N-iodosaccharine at 20℃; Ionic liquid; Darkness; regioselective reaction;	92%
With sodium dodecyl-sulfate; sodium iodide; Ce(OH)3OOH at 20℃; for 2h;	87%

: 106-49-0
p-toluidine

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
Stage #1: p-toluidine With potassium sulfite; phosphoric acid In water at 6 - 18℃; for 0.25h; Stage #2: With sodium iodate In water at 35℃; Temperature;	93%
Stage #1: p-toluidine With sodium nitrite Stage #2: With potassium iodide	91%
Stage #1: p-toluidine With toluene-4-sulfonic acid In water at 20℃; Stage #2: With potassium iodide In water at 20℃; for 1.25h;	91%

: 106-38-7
para-bromotoluene

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With copper(I) oxide; L-proline; potassium iodide In ethanol at 110℃; for 30h; Catalytic behavior; Reagent/catalyst; Time; Schlenk technique; Inert atmosphere; Sealed tube;	93%
With copper(l) iodide; pyrographite In neat (no solvent) at 150℃; for 36h;	90%
With copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; sodium iodide In acetonitrile at 100℃; for 1h; Buchwald's halogen exchange reaction; Inert atmosphere; Microwave irradiation;	90%

: potassium (4-methylphenyl)trifluoroborate

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With chloroamine-T; sodium iodide In tetrahydrofuran; water at 20℃; for 0.166667h;	91%

: 4-toluenediazonium o-benzenedisulfonimide

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; for 0.75h; Product distribution; Further Variations:; various reagent ratios; Substitution;	90%
With tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; for 0.75h; Substitution;	82%

: 5720-05-8
4-methylphenylboronic acid

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With sodium nitrite In acetonitrile at 80℃; for 0.5h; Reagent/catalyst; Temperature; Sealed tube;	87%
With copper(I) oxide; ammonium hydroxide; oxygen; potassium iodide In water at 25℃; for 24h;	83%
With iodine; potassium carbonate In acetonitrile at 80℃; for 10h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Schlenk technique; Sealed tube;	81%

: bis(4-methylphenyl)(trifluoromethanesulfonato)-λ3-iodane

: 10532-64-6
N-(4-methylphenyl)cyanamide

A: 147248-14-4
phenyl(p-tolyl)cyanamide

B: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With sodium carbonate In water at 80℃; for 2h;	A 86% B 196 mg

...Expand

: 123726-16-9
bis(4-methylphenyl)iodonium trifluoromethanesulfonate

: 75-31-0
isopropylamine

: 10532-64-6
N-(4-methylphenyl)cyanamide

A: 624-31-7
4-tolyl iodide

B: N,N-di(p-tolyl)cyanamide

C: 1-isopropyl-2,3-di-p-tolylguanidine

Conditions

Conditions	Yield
With [2,2]bipyridinyl; potassium carbonate; copper(l) chloride In toluene at 80℃; for 2h; Inert atmosphere;	A 76% B 24% C 85%

...Expand

: 33604-67-0
(4-methylphenyl)azo 4-methylphenyl sulfone

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium iodide In diethyl ether; acetonitrile for 4h; Ambient temperature;	84%

: C12H9IN2O4S2

: 594-27-4
tetramethylstannane

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
palladium diacetate In tetrahydrofuran at 40℃; for 0.75h;	83%

: 594-27-4
tetramethylstannane

: 4-Iodo-benzenediazonium; hydrogen sulfate

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
palladium diacetate In water; acetonitrile at 20℃; for 2h;	82%
With palladium diacetate In water; acetonitrile at 20℃; for 2h;	74%

: potassium 4-tolyltriolborate

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With chloroamine-T; sodium iodide In tetrahydrofuran; water at 20℃; for 0.333333h;	80%

: 380481-66-3
5,5-dimethyl-2-(4-methylphenyl)-1,3,2-dioxaborinane

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With chloroamine-T; sodium iodide In tetrahydrofuran for 0.166667h;	78%

: 106-49-0
p-toluidine

: 82113-65-3
bis(trifluoromethanesulfonyl)amide

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
Stage #1: bis(trifluoromethanesulfonyl)amide With tert.-butylnitrite; acetic acid In ethanol Cooling with ice; Stage #2: p-toluidine With tetraethylammonium iodide In water at 20℃;	78%

: N,N-diethyldithiocarbamoyl(di-p-tolyl)iodane

A: 624-31-7
4-tolyl iodide

B: 109720-10-7
diethyl dithiocarbamic acid p-tolyl ester

Conditions

Conditions	Yield
Ambient temperature;	A n/a B 75%

: 99-94-5
p-Toluic acid

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With iodine; mercury(II) oxide In nitrobenzene at 180 - 185℃; for 2h;	75%
With N-iodo-succinimide; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; iodine; caesium carbonate In 1,2-dichloro-ethane at 50℃; for 24h; Inert atmosphere; Irradiation; Sealed tube;	67%
Multi-step reaction with 2 steps 1: thionyl chloride 2: N-hydroxypyridine-2-thione sodium salt, AIBN, CH2I2 / toluene / 0.58 h / Heating View Scheme
With tris-(dibenzylideneacetone)dipalladium(0); 1-iodo-butane; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 120℃; for 16h; Sealed tube; Inert atmosphere;	31 %Chromat.

: 4,4'-dimethyldiphenyliodonium fluoroborate

: 100-52-7
benzaldehyde

A: 624-31-7
4-tolyl iodide

B: 1517-63-1
4-methylphenyl(phenyl)methanol

C: 108-88-3
toluene

Conditions

Conditions	Yield
With chromium dichloride; nickel dichloride In N,N-dimethyl-formamide at 25℃; for 5h; Arylation;	A 73 % Spectr. B 73% C 41 % Spectr.
With chromium dichloride; nickel dichloride In N,N-dimethyl-formamide for 5h; Ambient temperature;	A 73 % Chromat. B 72% C 41 % Chromat.

...Expand

: 18282-51-4
4-iodo-benzyl alcohol

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With chlorocarbonylbis(triphenylphosphine)iridium(I); hydrazine hydrate; potassium hydroxide In methanol at 160℃; for 3h; Wolff-Kishner Reduction; Sealed tube;	73%
With chlorocarbonylbis(triphenylphosphine)iridium(I); hydrazine hydrate; potassium hydroxide In methanol at 160℃; for 3h; Sealed tube;	73%
With 2,4,6-trimethyl-pyridine; 4,4'-dimethoxyphenyl disulfide; iridium(lll) bis[2-(2,4-difluorophenyl)-5-methylpyridine-N,C20]-4,40-di-tert-butyl-2,20-bipyridine hexafluorophosphate; triphenylphosphine In toluene for 24h; Irradiation;	30 %Chromat.

: 108-88-3
toluene

A: 615-37-2
ortho-methylphenyl iodide

B: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With iodine; lithium perchlorate In various solvent(s) Ambient temperature; anodic oxidation;	A 30% B 70%
With dinitrogen tetraoxide; pyrographite; ferric nitrate; sodium iodide at 20℃; for 20h;	A 40% B 60%
With iodine In nitromethane at 120℃; for 1h; Sealed tube; Overall yield = 88 %; regioselective reaction;	A 41% B 47%

: 869373-61-5
1-(4-methylphenyl)-3-(2-methoxy-4-nitrophenyl)-2-triazene

A: 624-31-7
4-tolyl iodide

B: 5458-84-4
2-iodo-5-nitroanisole

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; sodium iodide In acetonitrile at 40℃; for 2h;	A 70% B n/a

: 3728-43-6
p-(trimethylsilyl)toluene

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With silver tetrafluoroborate; Iodine monochloride In methanol at 0℃; for 0.25h;	65%
With iodine; silver trifluoroacetate In methanol at 0℃; for 0.25h;	64.8%
With sulfuric acid; potassium iodide In methanol; acetonitrile at 20℃; Electrochemical reaction;	96 %Chromat.

: 67-66-3
chloroform

: 6293-70-5
4,4'-dimethyldiphenyliodonium iodide

A: 624-31-7
4-tolyl iodide

B: 99-94-5
p-Toluic acid

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide at 50℃; for 1h; Carbonylation;	A n/a B 64%

...Expand

: 104-15-4
toluene-4-sulfonic acid

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With 2-Iodobenzoic acid; iodine; 3-chloro-benzenecarboperoxoic acid In acetonitrile at 50℃; for 8h; Darkness;	61%

: 1-((4 methylphenyl)diazenyl)piperidine

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With zinc(II) iodide In acetonitrile at 20℃; for 2h;	60%

: 141-32-2
acrylic acid n-butyl ester

: 106-38-7
para-bromotoluene

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With tri-n-propylamine In neat (no solvent) at 140℃; for 18h; Heck Reaction; Green chemistry;	58%

: 159950-96-6
1-(p-methylbenzenesulfonyloxy)-1,2-benziodoxol-3(1H)-one

: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
With iodine In acetonitrile for 16h; Ambient temperature;	57%
With iodine In acetonitrile at 20 - 30℃; for 16h;	57%

: 201230-82-2
carbon monoxide

: 16825-72-2
4-iodoxy-toluene

A: 624-31-7
4-tolyl iodide

B: 99-94-5
p-Toluic acid

Conditions

Conditions	Yield
With sodium tetrachloropalladate; sodium carbonate In water at 50℃; for 10h; Yields of byproduct given;	A n/a B 55%

...Expand

: 3958-63-2
lithium 2-nitropropane

: 2665-60-3
(p-methylphenyl)phenyliodonium bromide

A: 50-00-0
formaldehyd

B: 591-50-4
iodobenzene

C: 3964-18-9
2,3-dimethyl-2,3-dinitrobutane

D: 624-31-7
4-tolyl iodide

Conditions

Conditions	Yield
In methanol at 30℃; for 48h; Further byproducts given;	A 37% B 44% C 6% D 54%

...Expand

: 624-31-7
4-tolyl iodide

: 19028-26-3
4-dichloroiodanyl-toluene

Conditions

Conditions	Yield
With hydrogenchloride; sodium hypochlorite at 15℃; for 1h;	100%
With chlorine In dichloromethane at 20℃; for 1h;	96%
Stage #1: 4-tolyl iodide With urea hydrogen peroxide adduct at 85℃; for 0.25h; Stage #2: With hydrogenchloride for 1h;	96%

: 624-31-7
4-tolyl iodide

: 855-38-9
P(p-CH3OC6H4)3

: Tris-(4-methoxy-phenyl)-p-tolyl-phosphonium; iodide

Conditions

Conditions	Yield
With palladium diacetate In benzene at 120℃; for 25h;	100%

: 201230-82-2
carbon monoxide

: 624-31-7
4-tolyl iodide

: 99-94-5
p-Toluic acid

Conditions

Conditions	Yield
With potassium carbonate; palladium diacetate In water; N,N-dimethyl-formamide at 25℃; under 760 Torr; for 4h;	100%
With potassium hydroxide; amphiphilic resin-supported phosphine-palladium; water at 25℃; under 760 Torr; for 12h; Product distribution; Further Variations:; Reagents; hydroxycarbonylation;	100%
With dichloro bis(acetonitrile) palladium(II); sodium dodecyl-sulfate; potassium carbonate In water; toluene; butan-1-ol at 50℃; under 760 Torr; for 4h;	92%

: 624-31-7
4-tolyl iodide

: 292638-85-8
acrylic acid methyl ester

: 20754-20-5
3-p-tolyl-acrylic acid methyl ester

Conditions

Conditions	Yield
With triethylamine; PdCl2(4,4'-bis(n-C10F21CH2OCH2)-2,2'-bpy) In N,N-dimethyl-formamide at 140℃; for 5h; Heck reaction;	100%
With sodium acetate; 1-(2-iodophenyl)-1H-tetrazole; palladium diacetate In N,N-dimethyl-formamide at 80℃; for 6h; Product distribution; Further Variations:; Solvents; Temperatures; Heck reaction;	99%
With C18H19Cl2N2PPd; triethylamine In N,N-dimethyl-formamide at 140℃; for 2h; Catalytic behavior; Reagent/catalyst; Time; Temperature; Heck Reaction; Inert atmosphere; Schlenk technique;	99%

: 624-31-7
4-tolyl iodide

: 536-74-3
phenylacetylene

: 3287-02-3
4-(phenylethynyl)toluene

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; bis(triphenylphosphine)nickel(II) chloride In 1,4-dioxane; water for 4h; Sonogashira-Hagihara reaction; Heating;	100%
With copper(l) iodide; triethylamine; triphenylphosphine; (MeNC3H3N)(MeNC3H3NCOC4H8N)PdI2 In N,N-dimethyl-formamide at 20℃; Sonogashira coupling;	100%
With copper(l) iodide; 4-(diphenylphosphino)-benzyltrimethylammonium bromide; triethylamine; palladium dichloride at 70℃; for 3h; Sonogashira reaction; Ionic liquid; Inert atmosphere;	100%

: 624-31-7
4-tolyl iodide

: 762-04-9
phosphonic acid diethyl ester

: 1754-46-7
diethyl 4-methylphenylphosphonate

Conditions

Conditions	Yield
With Pd(PPh2)(m-C6H4SO3Na)*(H2O)4; triethylamine In water; acetonitrile for 1.5h; Ambient temperature;	100%
With triethylsilane; bis-triphenylphosphine-palladium(II) chloride; triethylamine In toluene for 0.183333h; Irradiation;	91%
With water extract of rice straw ash (WERSA) In water at 90℃; for 4h;	90%

: 624-31-7
4-tolyl iodide

: 603-35-0
triphenylphosphine

: 10111-23-6
triphenyl(p-tolyl)phosphonium iodide

Conditions

Conditions	Yield
With palladium diacetate In benzene at 120℃; for 25h;	100%
tris(dibenzylideneacetone)dipalladium (0) In o-xylene at 145℃; for 1h;	92%

: 111-26-2
hexan-1-amine

: 624-31-7
4-tolyl iodide

: 56506-60-6
N-(4-methylphenyl)hexylamine

Conditions

Conditions	Yield
With 2-(2-methyl-1-oxopropane)cyclohexanone; caesium carbonate; copper(l) iodide In N,N-dimethyl-formamide at 25℃; for 1.5h;	100%
With caesium carbonate; copper(I) bromide In dimethyl sulfoxide at 55℃; for 24h; Ullmann coupling;	87%
With tetra(n-butyl)ammonium hydroxide; copper(l) chloride In water at 80℃; for 24h; Inert atmosphere;	86%

: 624-31-7
4-tolyl iodide

: 5720-05-8
4-methylphenylboronic acid

: 613-33-2
(4,4'-dimethyl-1,1'-biphenyl)

Conditions

Conditions	Yield
With sodium carbonate In ethanol; water at 80℃; for 0.166667h; Catalytic behavior; Suzuki-Miyaura Coupling;	100%
With potassium carbonate; [PS-PEG-adppp-Pd(η3-C3H5)]Cl In water at 50℃; for 12h; Suzuki-Miyaura coupling;	99%
With potassium phosphate tribasic trihydrate In ethanol; water at 60℃; for 0.166667h; Suzuki-Miyaura cross-coupling reaction;	99%

: 624-31-7
4-tolyl iodide

: 5720-07-0
4-methoxyphenylboronic acid

: 53040-92-9
4-(4-tolyl)anisole

Conditions

Conditions	Yield
With potassium carbonate In ethanol; water at 80℃; for 0.166667h; Suzuki Coupling;	100%
With sodium carbonate In ethanol; water at 80℃; for 1h; Suzuki-Miyaura Coupling; Green chemistry;	100%
With potassium carbonate; [PS-PEG-adppp-Pd(η3-C3H5)]Cl In water at 50℃; for 12h; Suzuki-Miyaura coupling;	99%

: 624-31-7
4-tolyl iodide

: 98-80-6
phenylboronic acid

: 644-08-6
4-Methylbiphenyl

Conditions

Conditions	Yield
With potassium carbonate; copper-palladium In N,N-dimethyl-formamide at 110℃; for 2h; Suzuki cross-coupling;	100%
With sodium hydroxide; Pd-dodecanethiolate nanoparticles In tetrahydrofuran at 20℃; for 24h; Suzuki-Miyaura cross-coupling;	100%
With Br4Pd(2-)*C25H30N4O2(2+); potassium carbonate In N,N-dimethyl-formamide at 120℃; for 12h; Suzuki-Miyaura reaction; Inert atmosphere;	100%

: 1663-39-4
tert-Butyl acrylate

: 624-31-7
4-tolyl iodide

: 136053-53-7, 125951-00-0
tert-butyl 4-methylcinnamate

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; palladium dichloride at 40℃; for 3h; Heck reaction; Inert atmosphere; neat (no solvent);	100%
With triethylamine; palladium In N,N-dimethyl acetamide at 80℃; for 36h; Heck reaction;	99%
With poly(N-isopropylacerylamide)-SCS-PdCl; TEA In n-heptane; N,N-dimethyl acetamide; water at 95℃; for 10h; Heck coupling;	99%

: 141-32-2
acrylic acid n-butyl ester

: 624-31-7
4-tolyl iodide

: 123248-21-5
(E)-n-butyl 3-(p-tolyl)acrylate

Conditions

Conditions	Yield
With 1-tert-butyl-3-(2-(diphenylarsinyl)benzyl)-1H-imidazol-3-ium chloride; caesium carbonate; bis(dibenzylideneacetone)-palladium(0) In ISOPROPYLAMIDE at 60℃; for 20h; Heck reaction; Inert atmosphere;	100%
With triethylamine; bis(N-methylimidazol-2-yl)Pd(Cl)Me In various solvent(s) at 120℃; for 0.5h; Heck coupling;	99%
With potassium phosphate; N,N'-(1,2-ethanediylidene)bishexahydro-1H-azepin-1-amine; tetrabutylammomium bromide; dichloro bis(acetonitrile) palladium(II) In N,N-dimethyl-formamide at 130℃; for 24h; Mizoroki-Heck reaction;	99%

: 624-31-7
4-tolyl iodide

: 292638-85-8
acrylic acid methyl ester

: 7560-43-2, 20754-20-5, 50363-84-3
methyl 3-(4-methylphenyl)acrylate

Conditions

Conditions	Yield
With triethylamine at 145℃; for 6h; Catalytic behavior; Heck Reaction;	100%
With [2,6-bis(2-methyloxalol-4-yl)phenyl-κ3-NCN]bromopalladium(II); potassium acetate In 1-methyl-pyrrolidin-2-one at 120℃; for 7h; Mizoroki-Heck reaction;	99%
With potassium carbonate In water at 20℃; Heck Reaction; Green chemistry;	99%

: 292638-84-7
styrene

: 624-31-7
4-tolyl iodide

: 4714-21-0
4-methylstilbene

Conditions

Conditions	Yield
With C20H20N4O6Pd(2+)*2C2H3O2(1-); tetrabutylammomium bromide; sodium acetate In N,N-dimethyl-formamide at 110℃; for 24h; Heck Reaction; Green chemistry;	100%
With tris-(dibenzylideneacetone)dipalladium(0); 2,5-di(2,4,6-trimethylphenyl)-1,2,5-thiadiazolidine-1-oxide; triethylamine In N,N-dimethyl-formamide at 200℃; for 0.166667h; Heck reaction; Microwave irradiation;	99%
With potassium hydroxide In water at 80℃; for 20h; Heck reaction;	99%

: 624-31-7
4-tolyl iodide

: 2028-63-9
but-3-yn-2-ol

: 79756-90-4
4-(4-methylphenyl)but-3-yn-2-ol

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 5.5h; Sonogashira coupling; Inert atmosphere;	100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In dimethyl sulfoxide; triethylamine at 40 - 45℃; for 10.3h;	91%
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 7h; Sonogashira coupling;	87%

: 624-31-7
4-tolyl iodide

: 104-15-4
toluene-4-sulfonic acid

: 73177-96-5
<(hydroxy)(tosyloxy)iodo>-p-toluene

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In chloroform at 20℃; for 2h;	100%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 0.5h;	98%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane; 2,2,2-trifluoroethanol at 20℃; for 0.5h;	95%

: 624-31-7
4-tolyl iodide

: 107383-25-5
(3-benzyloxy-prop-1-ynyl)trimethylsilanebenzyl ether

: 31729-70-1
bis(iodozinc)methane

: 2-(p-tolyl)-3-trimethylsilyl-1,3-butadiene

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); trifuran-2-yl-phosphane In tetrahydrofuran at 25℃; for 14h;	100%

...Expand

: 624-31-7
4-tolyl iodide

(n-Bu)3SnCCPh: (n-Bu)3SnCCPh

: 3287-02-3
4-(phenylethynyl)toluene

Conditions

Conditions	Yield
polymer supported palladium catalyst In N,N-dimethyl-formamide at 70℃; for 8h; Stille coupling reaction;	100%

: 288-13-1
NH-pyrazole

: 624-31-7
4-tolyl iodide

: 20518-17-6
1-(4-methylphenyl)-1H-pyrazole

Conditions

Conditions	Yield
With copper(II) acetate monohydrate; caesium carbonate In N,N-dimethyl-formamide at 110℃; for 24h; Inert atmosphere;	100%
With Cu6[1,4-bis(imidazol-1-yl)butane]3I6; caesium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere;	97%
With copper(II) acetate monohydrate; caesium carbonate In N,N-dimethyl-formamide at 110℃; for 24h; Inert atmosphere;	96%

: 928-90-5
5-hexyl-1-ol

: 624-31-7
4-tolyl iodide

: 6-(p-tolyl)hex-5-yn-1-ol

Conditions

Conditions	Yield
Stage #1: 4-tolyl iodide With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 0.166667h; Stage #2: 5-hexyl-1-ol at 20℃;	100%
With C24H28Cl2N2PPd; tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 110℃; for 6h; Sonogashira Cross-Coupling; Inert atmosphere;	96%
With potassium phosphate; copper(l) iodide; (E)-1,1-diphenyl-2-(pyridin-2-ylmethylene)hydrazine; dichloro bis(acetonitrile) palladium(II) In N,N-dimethyl-formamide at 70℃; for 5h; Sonogashira cross-coupling;	73%

: 905453-88-5
4-(trifluoromethyl)phenylbromonium bis[(trifluoromethyl)sulfonyl]methylide

: 624-31-7
4-tolyl iodide

: 1010117-79-9
p-methylphenyliodonium bis(trifluoromethylsulfonyl)methylide

Conditions

Conditions	Yield
dirhodium tetraacetate at 40℃; for 0.0833333h;	100%

: 624-31-7
4-tolyl iodide

: 5272-18-4
dimethylphenylsilanol

: 644-08-6
4-Methylbiphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammonium triphenyldifluorosilicate; silver(l) oxide In tetrahydrofuran at 70℃; for 0.5h; Hiyama-type coupling;	100%
With palladium; tetrabutyl ammonium fluoride In tetrahydrofuran at 80℃; for 48h;	76%

: 629-05-0
n-octyne

: 876621-18-0
trans-[Pt(C6H4Me-p)(SC6H4OCH3-p)(PPh3)2]

: 624-31-7
4-tolyl iodide

: 67254-06-2, 53424-02-5
trans-PtI(PPh3)2C6H4Me-p

Conditions

Conditions	Yield
With triphenylphosphine In (2)H8-toluene byproducts: p-CH3C6H4CHC(n-C6H13)SC6H4OCH3-p, p-CH3C6H4SC6H4OCH3-p; P(C6H5)3, toluene-d8, 110°C, 10 h; detected by NMR spectra;	100%

...Expand

: 624-31-7
4-tolyl iodide

: 1232692-89-5
C19H25NO2Si

: 101043-55-4
2-(4-methylphenyl)phenol

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tetrabutyl ammonium fluoride; sodium t-butanolate In tetrahydrofuran; water at 60℃; for 1h; Inert atmosphere;	100%

: 38117-54-3
cyclopentadienyl iron(II) dicarbonyl dimer

: 624-31-7
4-tolyl iodide

: 62-53-3
aniline

: 6833-18-7
4-methyl-N-phenylbenzamide

Conditions

Conditions	Yield
With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 110℃; for 1h;	100%

...Expand

: 624-31-7
4-tolyl iodide

: 696-62-8
para-iodoanisole

: 53040-92-9
4-(4-tolyl)anisole

Conditions

Conditions	Yield
Stage #1: para-iodoanisole With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); diisopropopylaminoborane; triethylamine; potassium iodide In toluene at 110℃; for 1h; Suzuki coupling; Inert atmosphere; Stage #2: 4-tolyl iodide With caesium carbonate In ethanol; water; toluene at 90℃; for 15h; Suzuki coupling; Inert atmosphere;	100%
With sodium hydroxide In methanol at 20℃; for 24h; Ullmann Condensation; Irradiation; chemoselective reaction;	95%
With palladium diacetate; caesium carbonate; 1-indene In N,N-dimethyl-formamide at 20 - 90℃; for 24h; Inert atmosphere; Sealed tube;	45%

: 624-31-7
4-tolyl iodide

: [1,4'-bipiperidin]-1'-yl(4-amino-3-chlorophenyl)methanone

: [1,4'-bipiperidin]-1'-yl(3-chloro-4-(p-tolylamino)phenyl)methanone

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; XPhos In 1,4-dioxane for 4h; Inert atmosphere; Reflux;	100%

: 624-31-7
4-tolyl iodide

(1-pentyl)zinc(II) bromide: (1-pentyl)zinc(II) bromide

: 1595-09-1
1-methyl-4-n-pentylbenzene

Conditions

Conditions	Yield
With [NiBr(2,4,6-trimethylphenyl)(2,2'-bipyridine)] In tetrahydrofuran at 20℃; for 12h; Reagent/catalyst; Negishi Coupling;	100%

: 624-31-7
4-tolyl iodide

: (±)-4,4,5,5-tetramethyl-2-[2-methyl-3-phenylcyclopropyl]-1,3,2-dioxaborolane

: (±)-4-((1R,2S,3R)-2-methyl-3-phenylcyclopropyl)toluene

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium tert-butylate; bis(dibenzylideneacetone)-palladium(0) In Dimethyl ether; tert-butyl alcohol at 80℃; for 20h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere; stereoselective reaction;	100%

4-Iodotoluene Chemical Properties

IUPAC Name: 1-Iodo-4-methylbenzene
Synonyms of 4-Iodotoluene (CAS NO.624-31-7): 1-Methyl-4-iodobenzene ; p-Iodotoluene ; p-Methyliodobenzene ; p-Tolyl iodide
CAS NO: 624-31-7
Molecular Formula: C₇H₇I
Molecular Weight: 109.13
Molecular Structure:
EINECS: 210-841-7
H bond acceptors: 0
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 0 Å²
Index of Refraction: 1.604
Molar Refractivity: 43.98 cm³
Molar Volume: 127.7 cm³
Surface Tension: 39.5 dyne/cm
Density: 1.706 g/cm³
Flash Point: 86.3 °C
Enthalpy of Vaporization: 42.95 kJ/mol
Boiling Point: 211.5 °C at 760 mmHg
Vapour Pressure: 0.264 mmHg at 25°C
Melting point: 33-36°C
Water solubility: insoluble
Sensitive: Light Sensitive
Appearance: white to light yellow crystalline
SMILES: Ic1ccc(cc1)C
InChI: InChI=1/C7H7I/c1-6-2-4-7(8)5-3-6/h2-5H,1H3
InChIKey: UDHAWRUAECEBHC-UHFFFAOYAY
Std. InChI: InChI=1S/C7H7I/c1-6-2-4-7(8)5-3-6/h2-5H,1H3
Std. InChIKey: UDHAWRUAECEBHC-UHFFFAOYSA-N
Product Categories of 4-Iodotoluene (CAS NO.624-31-7): Aromatic Hydrocarbons (substituted) & Derivatives;Halogen toluene;Iodine Compounds;Pharmaceutical Intermediate

4-Iodotoluene Uses

4-Iodotoluene (CAS NO.624-31-7) is mainly used for bio-pharmaceutical.

4-Iodotoluene Safety Profile

The Hazard Codes: Xi
The Risk Statements information:
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
24/25: Avoid contact with skin and eyes
WGK Germany: 3
TSCA: T
Hazard Note: Irritant
Explodes when heated above 200°C. Upon decomposition it emits toxic fumes of I−. See also IODIDES.

4-Iodotoluene Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.

Product Name

4-Iodotoluene

Synthetic route

4-Iodotoluene Chemical Properties

4-Iodotoluene Uses

4-Iodotoluene Safety Profile

4-Iodotoluene Specification

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