Dibenz[b,f]azepine-5-carbonyl chloride supplier

Name
Dibenz[b,f]azepine-5-carbonyl chloride
EINECS 412-100-5
CAS No. 33948-22-0
Article Data19
CAS DataBase
Density 1.316 g/cm³
Solubility
Melting Point 149-153 °C(lit.)
Formula C₁₅H₁₀ClNO
Boiling Point 413.7 °C at 760 mmHg
Molecular Weight 255.703
Flash Point 204 °C
Transport Information UN 3261 8/PG 2
Appearance light yellow or grey power
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms Iminostilbene carbonyl chloride;Iminostilbene-5-carbonyl chloride;5H-Dibenz[b,f]azepine-5-carbonylchloride;5-Chlorocarbonyl iminostilbene;
PSA 20.31000
LogP 4.73230

Synthetic route

: 143667-53-2
10-Brom-5-chlorcarbonyl-5H-dibenzazepin

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
With tetraethylammonium perchlorate In water; N,N-dimethyl-formamide cathode: Hg, working potential: -1.60 V, charge: 2.0-2.1 F/mol, 4-5 h;	92%

: 33948-19-5
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
With sodium bromate; N-benzyl-N,N,N-triethylammonium chloride; bromine; dibenzoyl peroxide In chlorobenzene at 92 - 97℃; for 8.5h; Temperature; Reagent/catalyst;	90.5%
Multi-step reaction with 2 steps 1: Br2 / chlorobenzene / 1.5 h / 145 - 150 °C 2: chlorobenzene / 2 h / 150 - 155 °C View Scheme
With bromine In chlorobenzene at 80℃; for 6h; Temperature; Inert atmosphere;

: 256-96-2
dibenzoazepine

: 32315-10-9
bis(trichloromethyl) carbonate

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
With pyridine In 1,2-dichloro-ethane at 75℃; for 3h; Inert atmosphere;	75%
In toluene
With pyridine In ethyl acetate n-hexane; dichloromethane

: 40421-03-2, 56875-24-2
trans-10,11-dibromo-10,11-dihydro-5H-dibenzazepine-5-carbonyl chloride

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
In various solvent(s) at 25℃; for 24h;	65%
In d7-N,N-dimethylformamide at 25℃; for 24h; Product distribution; variation of reaction solvents, reactant and time;	65%

: 41359-12-0, 66849-41-0
trans-10-bromo-10,11-dihydro-11-hydroxy-5H-dibenzazepine-5-carbonyl chloride

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; recorcinol In chloroform at 10℃; for 7h;	50%

: 41359-12-0, 66849-41-0
trans-10-bromo-10,11-dihydro-11-hydroxy-5H-dibenzazepine-5-carbonyl chloride

A: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 40421-03-2, 56875-24-2
trans-10,11-dibromo-10,11-dihydro-5H-dibenzazepine-5-carbonyl chloride

Conditions

Conditions	Yield
With hydrogen bromide In chloroform at 10℃; for 1.5h; Product distribution; variaton of solvents and reactant;	A 35% B 38%
With hydrogen bromide In chloroform at 10℃; for 1.5h;	A 35% B 38%

: 75-44-5
phosgene

: 256-96-2
dibenzoazepine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
In toluene for 0.5h;
In toluene for 5h;
In toluene; Petroleum ether; benzene
In toluene

: 41359-09-5
1a,10b-dihydro-6H-dibenzooxirenoazepine-6-carbonyl chloride

A: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 40421-03-2, 56875-24-2
trans-10,11-dibromo-10,11-dihydro-5H-dibenzazepine-5-carbonyl chloride

Conditions

Conditions	Yield
With hydrogen bromide In chloroform at 10℃; for 3h;

: 33948-20-8
10-bromo-10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
In chlorobenzene at 150 - 155℃; for 2h;

: 41359-09-5
1a,10b-dihydro-6H-dibenzooxirenoazepine-6-carbonyl chloride

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.55 g / HBr / CHCl3 / 1 h / 10 °C 2: 50 percent / BF3.Et2O, resorcinol / CHCl3 / 7 h / 10 °C View Scheme

: 494-19-9
9,10-dihydrodibenzazepine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 90 percent / toluene / 3.5 h / 90 - 95 °C 2: Br2 / chlorobenzene / 1.5 h / 145 - 150 °C 3: chlorobenzene / 2 h / 150 - 155 °C View Scheme
Multi-step reaction with 2 steps 1: chlorobenzene / 5 h / 110 °C 2: bromine / chlorobenzene / 6 h / 80 °C / Inert atmosphere View Scheme

: 32621-46-8
diphenylamine-2,2'-dicarbonyl chloride

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: H2 / Palladium-Barium sulphate; Quinolin sulphate / xylene / 2.5 h / Heating 2: 3.8 g / Hydrazine hydrate / acetic acid / 2 h / Heating 3: toluene / 0.5 h View Scheme

: 49579-63-7
diphenylamine-2,2′-dicarboxaldehyde

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 3.8 g / Hydrazine hydrate / acetic acid / 2 h / Heating 2: toluene / 0.5 h View Scheme

: 579-92-0
Vanadox

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 11.8 g / Thionyl chloride; Pyridine / 5 h / Heating 2: H2 / Palladium-Barium sulphate; Quinolin sulphate / xylene / 2.5 h / Heating 3: 3.8 g / Hydrazine hydrate / acetic acid / 2 h / Heating 4: toluene / 0.5 h View Scheme

: 16968-19-7
2,2'-dinitrobibenzyl

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogen 2: hydrogenchloride / Heating 3: N-Bromosuccinimide 4: toluene View Scheme

: 88-72-2
1-methyl-2-nitrobenzene

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: sodium amide 2: hydrogen 3: hydrogenchloride / Heating 4: N-Bromosuccinimide 5: toluene View Scheme

: 34124-14-6
2,2'-ethylenedianiline

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / Heating 2: N-Bromosuccinimide 3: toluene View Scheme

: 591-50-4
iodobenzene

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium carbonate; copper(l) iodide; S-pyrrolidine-2-carbaldehyde / dimethyl sulfoxide / 24 h / 90 °C 2: polyphosphoric acid / 100 °C 3: triethylamine / toluene / 6 h View Scheme
Multi-step reaction with 3 steps 1: potassium carbonate; copper(l) iodide; S-pyrrolidine-2-carbaldehyde / dimethyl sulfoxide / 24 h / 90 °C 2: polyphosphoric acid / 100 °C 3: triethylamine / toluene / 8 h View Scheme

: 16096-33-6
1-phenyl-1H-indole

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: polyphosphoric acid / 100 °C 2: triethylamine / toluene / 6 h View Scheme
Multi-step reaction with 2 steps 1: polyphosphoric acid / 100 °C 2: triethylamine / toluene / 8 h View Scheme
Multi-step reaction with 2 steps 1: methanesulfonic acid; phosphorus pentoxide / toluene / 6 h / 120 °C 2: toluene / 2.5 h / Reflux; Inert atmosphere View Scheme

: 256-96-2
dibenzoazepine

: 503-38-8
trichloromethyl chloroformate

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
With triethylamine In toluene for 8h;

: 120-72-9
indole

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium carbonate; copper(l) iodide; S-pyrrolidine-2-carbaldehyde / dimethyl sulfoxide / 24 h / 90 °C 2: polyphosphoric acid / 100 °C 3: triethylamine / toluene / 6 h View Scheme
Multi-step reaction with 3 steps 1: potassium carbonate; copper(l) iodide; S-pyrrolidine-2-carbaldehyde / dimethyl sulfoxide / 24 h / 90 °C 2: polyphosphoric acid / 100 °C 3: triethylamine / toluene / 8 h View Scheme
Multi-step reaction with 3 steps 1: palladium diacetate; tri-tert-butyl phosphine / o-xylene / 110 °C 2: polyphosphoric acid / 100 °C 3: triethylamine / toluene / 6 h View Scheme
Multi-step reaction with 3 steps 1: palladium diacetate; tri-tert-butyl phosphine / o-xylene / 110 °C 2: polyphosphoric acid / 100 °C 3: triethylamine / toluene / 8 h View Scheme
Multi-step reaction with 3 steps 1: dibutyltin dilaurate / toluene / 12 h / Reflux 2: methanesulfonic acid; phosphorus pentoxide / toluene / 6 h / 120 °C 3: toluene / 2.5 h / Reflux; Inert atmosphere View Scheme

: N-(2,2,2-trichloroacetyl)-5H-dibenz[b,f]azepine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium carbonate / water 2: triethylamine / toluene / 6 h View Scheme
Multi-step reaction with 2 steps 1: sodium carbonate / water 2: triethylamine / toluene / 8 h View Scheme

: 108-86-1
bromobenzene

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: palladium diacetate; tri-tert-butyl phosphine / o-xylene / 110 °C 2: polyphosphoric acid / 100 °C 3: triethylamine / toluene / 6 h View Scheme
Multi-step reaction with 3 steps 1: palladium diacetate; tri-tert-butyl phosphine / o-xylene / 110 °C 2: polyphosphoric acid / 100 °C 3: triethylamine / toluene / 8 h View Scheme
Multi-step reaction with 3 steps 1: dibutyltin dilaurate / toluene / 12 h / Reflux 2: methanesulfonic acid; phosphorus pentoxide / toluene / 6 h / 120 °C 3: toluene / 2.5 h / Reflux; Inert atmosphere View Scheme

: 110-89-4
piperidine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 313554-34-6
N-(2-phenylethyl)-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	94%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 256-96-2
dibenzoazepine

Conditions

Conditions	Yield
In acetonitrile electrolysis (Et4NClO4, Hg-dropelectrode);	92%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 124-40-3
dimethyl amine

: 1548174-88-4
N,N-dimethyl-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	88%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 109-89-7
diethylamine

: 102080-94-4
N,N-diethyl-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	86%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 116822-14-1
5-Azidocarbonyldibenzazepin

Conditions

Conditions	Yield
With sodium azide; tetra-(n-butyl)ammonium iodide In chloroform; water for 30h; Heating;	85%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 117255-42-2
5,14-Dichlorcarbonyl-9b,9c,18b,18c-tetrahydrotetrabenzocyclobuta<1,2-d;3,4-d>bisazepin

Conditions

Conditions	Yield
With benzophenone In acetone for 8h; Irradiation;	84%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 74-89-5
methylamine

: 41359-02-8
5H-dibenzazepine-5-N-methyl carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	84%

: 92-54-6
4-phenyl-1-piperazine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 1250431-00-5
(5H-dibenzo[b,f]azepin-5-yl)(4-phenylpiperazin-1-yl)methanone

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane	82%

: 55-81-2
4-Methoxyphenethylamine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 1548174-78-2
N-(2-(p-methoxyphenyl)ethyl)-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	82%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 111-42-2
2,2'-iminobis[ethanol]

: 1548175-03-6
N,N-di(2-hydroxyethyl)-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	82%

: 123-75-1
pyrrolidine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 294194-10-8
(5H-dibenzo[b,f]azepin-5-yl)(pyrrolidin-1-yl)methanone

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane	80%
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	71%

: 142-25-6
N,N',N'-trimethylenediamine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 1548174-95-3
N-[2-(dimethylamino)ethyl]-N-methyl-5H-dibenzo[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	79%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 143667-53-2
10-Brom-5-chlorcarbonyl-5H-dibenzazepin

Conditions

Conditions	Yield
With bromine In chlorobenzene at 165 - 175℃; for 1h;	78%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 143667-54-3
10,11-Dibrom-5-chlorcarbonyl-5H-dibenzazepin

Conditions

Conditions	Yield
With bromine In chlorobenzene at 170℃;	78%

: 108-91-8
cyclohexylamine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 381184-44-7
N-cyclohexyl-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	78%

: 64-04-0
phenethylamine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 1548174-81-7
N-(2-phenylethyl)-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	78%

: 951010-97-2
5,10-bis(2-nitrobenzenesulfonyl)-5,10-diaza-1,14-tetradecanediamine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: C39H45N7O9S2

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 2h;	76%
In dichloromethane at 20℃;

: 5382-16-1
4-HYDROXYPIPERIDINE

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 1548175-06-9
5H-dibenz[b,f]azepin-5-yl-(4-hydroxypiperidin-1-yl)-methanone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	76%

: 110-91-8
morpholine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 334500-64-0
5H-dibenz[b,f]azepin-5-yl-4-morpholinyl-methanone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	75%

: 142-84-7
di-n-propylamine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 1548174-92-0
N,N-dipropyl-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	74%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 62-53-3
aniline

: 401581-13-3
N-phenyl-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In toluene for 2h; Reflux;	74%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 75-64-9
tert-butylamine

: 1548174-98-6
N-tert-butyl-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	72%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 100-46-9
benzylamine

: 41359-01-7
N-(phenylmethyl)-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	71%

: 1942-46-7
5-decyne

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 1235712-80-7
C25H27NO

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; cyclo-octa-1,5-diene In o-xylene for 20h; Inert atmosphere; Reflux;	70%

: 6850-65-3
p-hydroxycyclohexylamine

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 1548175-08-1
N-(4-hydroxycyclohexyl)-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	70%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 109-73-9
N-butylamine

: 1548174-90-8
N-n-butyl-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	69%

: 33948-22-0
5H-dibenz[b,f]azepine-5-carbonylchloride

: 75-31-0
isopropylamine

: 1548174-75-9
N-(isopropyl)-5H-dibenz[b,f]azepine-5-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	67%

Dibenz[b,f]azepine-5-carbonyl chloride Chemical Properties

Molecular Structure:

Molecular Formula: C₁₅H₁₀ClNO
Molecular Weight: 255.699
IUPAC Name: Benzo[b][1]benzazepine-11-carbonyl chloride
Synonyms of Dibenz[b,f]azepine-5-carbonyl chloride (CAS NO.33948-22-0): Chlorocarbonyl liminostilben ; Iminostilbene-5-carbonyl chloride ; Iminostilbene carbonyl chloride ; 5-chlorocarbonyl iminostilbene ; 5H-Dibenz[b,f]azepine-5-carbonyl chloride ; 5-(Chlorocarbonyl)-5H-dibenzo[b,f]azepine ; N-Chlorocarbonyliminostilbene
CAS NO: 33948-22-0
Product Categories: Heterocyclic Building Blocks ; N-Containing ; Others
Melting point: 149-153 °C
Index of Refraction: 1.651
Molar Refractivity: 70.99 cm3
Molar Volume: 194.2 cm3
Surface Tension: 52.3 dyne/cm
Density: 1.316 g/cm3
Flash Point: 204 °C
Enthalpy of Vaporization: 66.66 kJ/mol
Boiling Point: 413.7 °C at 760 mmHg
Vapour Pressure: 4.69E-07 mmHg at 25°C

Dibenz[b,f]azepine-5-carbonyl chloride Uses

Dibenz[b,f]azepine-5-carbonyl chloride (CAS NO.33948-22-0) is used as a pharmaceutical intermediates, it is also used for the synthesis of Kama West equal drugs.

Dibenz[b,f]azepine-5-carbonyl chloride Safety Profile

Hazard Codes of Dibenz[b,f]azepine-5-carbonyl chloride (CAS NO.33948-22-0): Corrosive C
Risk Statements: 34
R34: Causes burns.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3261 8/PG 2
WGK Germany: 3

Product Name

Dibenz[b,f]azepine-5-carbonyl chloride

Synthetic route

Dibenz[b,f]azepine-5-carbonyl chloride Chemical Properties

Dibenz[b,f]azepine-5-carbonyl chloride Uses

Dibenz[b,f]azepine-5-carbonyl chloride Safety Profile

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