L-Pyroglutamic acid supplier

Name
L-Pyroglutamic acid
EINECS 202-700-3
CAS No. 98-79-3
Article Data64
CAS DataBase
Density 1.38 g/cm³
Solubility 10-15 g/100 mL (20 °C) in water
Melting Point 160-163 °C(lit.)
Formula C₅H₇NO₃
Boiling Point 453.1 °C at 760 mmHg
Molecular Weight 129.115
Flash Point 227.8 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Proline, 5-oxo-;Pyrrolidonecarboxylic acid;2-Pyrrolidinone-5-carboxylic acid;Proline, 5-oxo-, L-;(S)-5-Oxo-2-pyrrolidinecarboxylic acid;2-Pyrrolidone-5-Carboxylicacid;H-PYR-OH;pGlu-OH;L-Pyr-OH;L-Pyro Glutamic Acid;L-pyroglutamate;2-Oxopyrrolidine-5-carboxylic acid;Acido pidolico [INN-Spanish];5-Pyrrolidone-2-carboxylic acid;2-Benzothiazolesulfenic acid morpholide;L-5-Oxo-2-pyrrolidinecarboxylic acid;Pidolic acid [INN];L-Glutamic acid gamma-lactam;(2R)-5-oxopyrrolidine-2-carboxylate;35255-51-7;Acidum pidolicum [INN-Latin];L-Proline, 5-oxo-;CPD-589;2-Benzothiazolesulfenemorpholide;5-Carboxy-2-pyrrolidinone;Acide pidolique [INN-French];L-5-Pyrrolidone-2-carboxylic acid;(-)-2-Pyrrolidone-5-carboxylic acid;L-5-Carboxy-2-pyrrolidinone;(S)-(-)-2-Pyrrolidone-5-carboxylic acid;5-oxo-L-proline;2-L-Pyrrolidone-5-carboxylic acid;
PSA 66.40000
LogP -0.32160

Synthetic route

: 56-86-0
L-glutamic acid

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With water for 16h; Heating;	95%
In water for 16h; Heating;	95%
With 1,1'-carbonyldiimidazole In chloroform at 55℃; for 3h; Solvent; Concentration;	76.8%

: 53100-44-0
L-N-t-butoxycarbonylpyroglutamic acid

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With silica gel In dichloromethane for 0.0166667h; Irradiation;	91%
With tin(II) trifluoromethanesulfonate In dichloromethane at 20℃; for 2h;	87%

: 91229-91-3
tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane for 0.333333h; Ambient temperature;	90%

: 1676-73-9
L-glutamic acid γ-benzyl ester

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide at 40℃; for 20h;	88.3%

: 317845-09-3
(5S)-2,2-bis(trifluoromethyl)-1-aza-3-oxabicyclo[3.3.0]octan-4,8-dione

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With water In isopropyl alcohol at 20℃;	87%

: 56-86-0
L-glutamic acid

A: 149-87-1
Pyroglutamic acid

B: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
at 175℃; under 3750.38 Torr; for 5h; Temperature; Pressure; Autoclave; Large scale;	A 15.9% B 83%

: 13726-85-7
Boc-Gln-OH

: 76-05-1
trifluoroacetic acid

A: 56-86-0
L-glutamic acid

B: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
at 20℃; for 0.25h;	A 61% B 18%

...Expand

: 220280-79-5
tert-butyl (4S,4'S,5'R)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With water for 12h; Hydrolysis; cyclization; Heating;	45%

: 1676-73-9
L-glutamic acid γ-benzyl ester

A: 100-52-7
benzaldehyde

B: 65-85-0
benzoic acid

C: 98-79-3
L-Pyroglutamic acid

D: 100-51-6
benzyl alcohol

Conditions

Conditions	Yield
With sodium hydroxide; sodium tetrachloropalladate(II) In water Product distribution; Ambient temperature; initial pH:6.8; variation of initial pH and temperature;	A 37% B 4% C n/a D 24%

...Expand

: 107930-17-6
H-Glu(OChp)-OH

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide at 40℃; for 20h;	4.1%

: 6893-26-1
D-Glutamic acid

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With water

: 1119-33-1
(S)-2-Amino-pentanedioic acid 5-ethyl ester

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With ammonium hydroxide

: 55895-85-7
diethyl 2-aminopentanedioate

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With water

: 16450-41-2
L-glutamic acid diethyl ester

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With water

: 4124-76-9
N-(benzyloxycarbonyl)-L-glutamic acid anhydride

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With palladium on activated charcoal; acetic acid Hydrogenation;

: 56-85-9
L-glutamine

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
at 28℃; for 840h; pH=5.5 (acetate buffer), PhCH3 on surface;
With human blood serum at 24.84℃;

: 1119-33-1
(S)-2-Amino-pentanedioic acid 5-ethyl ester

A: 64-17-5
ethanol

B: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
In water at 40℃; Rate constant; pH 7.6-10.4, μ=0.5 (KCl);

: 76712-82-8
histrelin

A: 134190-11-7
His-Trp-Ser-Tyr-(D-Nim-bzl-His)-Leu-Arg-Pro-NHEt

B: cyclo(-His-Trp)

C: 134009-09-9
Ser-Tyr-(D-Nim-bzl-His)-Leu-Arg-Pro-NHEt

D: 35925-21-4

E: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With water at 87℃; for 432h; Product distribution; degradation, var. reaction time, temperature and ph;

...Expand

: 53971-11-2
N-Acetylpyroglutamic acid

A: 53971-11-2, 56805-18-6, 89885-76-7
N-Acetyl-D-pyroglutamic acid

B: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I at 40℃; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst;

: 7149-65-7
ethyl (S)-pyroglutamate

A: 64-17-5
ethanol

B: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With water In acetonitrile at 40℃; Rate constant; pH 9.7-10.5, μ=0.5 (KCl);
With 2-(di(2-hydroxyethyl)amino)ethanesulfonic acid; lipase from Bacillus thermocatenulanatus In water at 40℃; pH=7.20; Enzyme kinetics;

inactive form: inactive form

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
With Quinine

: 56-86-0
L-glutamic acid

A: 98-79-3
L-Pyroglutamic acid

B Fmoc-Pro-Rink amide-MBHA resin: Fmoc-Pro-Rink amide-MBHA resin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 67 percent / dimethylsulfoxide / 20 °C 2: 99 percent / SOCl2; DMF / CH2Cl2 / 20 °C 3: 87 percent / H2O / propan-2-ol / 20 °C View Scheme

: 131021-88-0
(S)-[2,2-bis(trifluoromethyl)-5-oxo-1,3-oxazolidin-4-yl]propionic acid

A: 98-79-3
L-Pyroglutamic acid

B Fmoc-Pro-Rink amide-MBHA resin: Fmoc-Pro-Rink amide-MBHA resin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 99 percent / SOCl2; DMF / CH2Cl2 / 20 °C 2: 87 percent / H2O / propan-2-ol / 20 °C View Scheme

: 15761-39-4
N-Boc-L-proline

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dicyclohexylcarbodiimide, 4-dimethylaminopyridine 2: 95 percent / RuO2 hydrate, 10percent aqueous NaIO4 / ethyl acetate / 2 h / Ambient temperature 3: 90 percent / CF3COOH / CH2Cl2 / 0.33 h / Ambient temperature View Scheme

: 91237-84-2
N-BOC-proline tert-butyl ester

: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / RuO2 hydrate, 10percent aqueous NaIO4 / ethyl acetate / 2 h / Ambient temperature 2: 90 percent / CF3COOH / CH2Cl2 / 0.33 h / Ambient temperature View Scheme

: 3705-42-8
Cbz-(L)-Glu-OBn

A: 98-79-3
L-Pyroglutamic acid

B natrium carbonate: natrium carbonate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 75 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / tetrahydrofuran 2: 76 percent / H2, AcOH / Pd / methanol / 24 h 3: 4.1 percent / Et3N / dimethylformamide; H2O / 20 h / 40 °C View Scheme

: 1134188-65-0
C26H48N6O15

A: 1134188-60-5
5-O-(5-amino-5-deoxy-β-D-ribofuranosyl)-1-N-[(S)-4-amino-2-hydroxy-butanoyl]paromamine

B: 98-79-3
L-Pyroglutamic acid

Conditions

Conditions	Yield
BtrG enzyme In water at 20℃; for 24h; Product distribution / selectivity; HEPES buffer; Enzymatic reaction;

: 186581-53-3, 908094-01-9
diazomethane

: 98-79-3
L-Pyroglutamic acid

: 4931-66-2
methyl (S)-pyroglutamate

Conditions

Conditions	Yield
In diethyl ether	100%
With diethyl ether
In methanol; diethyl ether at 0℃; for 0.5h;

: 67-56-1
methanol

: 98-79-3
L-Pyroglutamic acid

: 4931-66-2
methyl (S)-pyroglutamate

Conditions

Conditions	Yield
With thionyl chloride at 0 - 25℃;	100%
With methanesulfonic acid In chloroform; water Reflux;	100%
With Dowex-50W (X8-200) resin Inert atmosphere; Reflux;	100%

: 540-88-5
acetic acid tert-butyl ester

: 98-79-3
L-Pyroglutamic acid

: 35418-16-7, 85136-12-5
L-t-butyl pyroglutamate

Conditions

Conditions	Yield
With perchloric acid In water at 20℃; for 18h;	100%
Stage #1: acetic acid tert-butyl ester; L-Pyroglutamic acid With perchloric acid at 20℃; for 48h; Inert atmosphere; Stage #2: With perchloric acid for 48h; Inert atmosphere;	90%
With perchloric acid at 20℃; for 96h; Inert atmosphere;	90%

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 98-79-3
L-Pyroglutamic acid

: 97717-45-8
L-trimethylsilyl pyroglutamate

Conditions

Conditions	Yield
With saccharin for 2.5h; Heating;	100%

: 100-44-7
benzyl chloride

: 98-79-3
L-Pyroglutamic acid

: 94885-52-6
benzyl (L)-pyroglutamate

Conditions

Conditions	Yield
With triethylamine In 1,2-dichloro-ethane at 60℃; for 15h; Temperature; Large scale;	100%
With triethylamine In acetone for 168h; Heating;	85%
With TEA In acetone	85%

: 763-32-6
2-methyl-1-buten-4-ol

: 98-79-3
L-Pyroglutamic acid

: 865183-91-1
(5S)-2-pyrrolidone-5-carboxylic acid 3-methyl-3-butenyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;	100%
With dmap; dicyclohexyl-carbodiimide In dichloromethane

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 98-79-3
L-Pyroglutamic acid

: 2-(trimethylsilyl)ethyl (S)-5-oxopyrrolidine-2-carboxylate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 130℃; for 2h; Dean-Stark;	100%
With toluene-4-sulfonic acid In benzene for 2h; Heating;

: 98-79-3
L-Pyroglutamic acid

: 55478-53-0
pyroglutamoyl chloride

Conditions

Conditions	Yield
Stage #1: L-Pyroglutamic acid With 1,1,1,3,3,3-hexamethyl-disilazane; saccharin for 2.5h; Heating / reflux; Stage #2: With oxalyl dichloride In dichloromethane at 20℃; Heating / reflux;	100%

: 98-59-9
p-toluenesulfonyl chloride

: 98-79-3
L-Pyroglutamic acid

: 51693-17-5
(S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester

Conditions

Conditions	Yield
Stage #1: L-Pyroglutamic acid With thionyl chloride In methanol at 20℃; for 4h; Stage #2: With sodium tetrahydroborate In ethanol at 20℃; for 15h; Stage #3: p-toluenesulfonyl chloride With dmap; triethylamine In dichloromethane at 20℃; for 16h;	100%

: 75-75-2
methanesulfonic acid

: 98-79-3
L-Pyroglutamic acid

: 4931-66-2
methyl (S)-pyroglutamate

Conditions

Conditions	Yield
In methanol; chloroform Molecular sieve; Reflux;	100%

: 124-41-4
sodium methylate

: 98-79-3
L-Pyroglutamic acid

: 5-methoxypyrrolidin-2-one

Conditions

Conditions	Yield
In methanol	100%

: 64-17-5
ethanol

: 98-79-3
L-Pyroglutamic acid

: 7149-65-7
ethyl (S)-pyroglutamate

Conditions

Conditions	Yield
With thionyl chloride at 0 - 20℃;	99%
With thionyl chloride at 0℃; for 15h;	99%
With thionyl chloride at -5 - 20℃; for 10h;	98%

: 98-79-3
L-Pyroglutamic acid

: 123-56-8
Succinimide

Conditions

Conditions	Yield
With ammonium peroxydisulfate; silver nitrate In water at 20℃; for 2h; Reagent/catalyst; Temperature;	99%
With iodosylbenzene In dichloromethane for 48h; Ambient temperature;	27%

: 107-18-6
allyl alcohol

: 98-79-3
L-Pyroglutamic acid

: 4931-79-7
(S)-allyl 5-oxopyrrolidine-2-carboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane	99%
With thionyl chloride at 20℃; for 12h;	85%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 5℃; Inert atmosphere;

: N1-(4,4-difluorocyclohexyl)-4-(3,5-dimethylisoxazol-4-yl)benzene-1,2-diamine

: 98-79-3
L-Pyroglutamic acid

: (S)-N-(2-((4,4-difluorocyclohexyl)amino)-5-(3,5-dimethylisoxazol-4-yl)phenyl)-5-oxopyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With triethylamine; HATU In N,N-dimethyl-formamide at 20℃; for 18h;	99%

: 1044642-88-7
tegaserod

: 98-79-3
L-Pyroglutamic acid

: 3-(5-methoxy-1H-indol-3-ylmethylene)-N-pentylcarbazimidamide pidolate

Conditions

Conditions	Yield
In acetone at 25 - 55℃; for 20h;	98.3%

: 67-63-0
isopropyl alcohol

: 98-79-3
L-Pyroglutamic acid

: 52989-50-1
(S)-isopropyl 5-oxopyrrolidine-2-carboxylate

Conditions

Conditions	Yield
With thionyl chloride at 15℃; for 2h;	98.1%
With toluene-4-sulfonic acid for 6h; Haller-Bauer Reaction; 4 A molecular sieve;	96%
With toluene-4-sulfonic acid for 6h; Heating / reflux;	96%

: 15356-60-2
(1S,2R,5S)-(+)-menthol

: 98-79-3
L-Pyroglutamic acid

: 139014-48-5
(S)-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl] 2-oxopyrrolidine-5-carboxylate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 23℃; for 24.5h; Inert atmosphere;	98%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 20.5h; Inert atmosphere;	86%

: 683-10-3
carboxymethyl-dodecyl-dimethyl-ammonium betaine

: 98-79-3
L-Pyroglutamic acid

: C16H34NO2(1+)*C5H6NO3(1-)

Conditions

Conditions	Yield
In ethanol at 25℃; for 0.5h;	98%

: 88150-42-9
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

: 98-79-3
L-Pyroglutamic acid

: 663180-17-4
amlodipine (R)-(+)-pyroglutamate

Conditions

Conditions	Yield
In ethanol at 5 - 20℃; for 1h;	97.1%

: 98-79-3
L-Pyroglutamic acid

LiOH: LiOH

: 38609-04-0
lithium L-pyroglutamate

Conditions

Conditions	Yield
In water for 2h; Heating;	97%

: 109745-70-2, 19757-97-2
methyl glyoxylate methyl hemi-acetal

: 98-79-3
L-Pyroglutamic acid

: 502481-82-5
methyl 2-hydroxy-2-(2-oxoprolin-1-yl)acetate

Conditions

Conditions	Yield
In acetone for 60h; Heating;	97%

: 103129-82-4
amlodipine

: 98-79-3
L-Pyroglutamic acid

: 851447-24-0
(S)-(-)-amlodipine pidolate salt

Conditions

Conditions	Yield
In ethanol at 20℃; for 1h;	97%

: 24424-99-5
di-tert-butyl dicarbonate

: 98-79-3
L-Pyroglutamic acid

: 1192500-31-4
(2S,5R)-6-(sulfoxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

Conditions

Conditions	Yield
Stage #1: L-Pyroglutamic acid With benzyl chloride; triethylamine In chloroform at 0℃; for 3.5h; Reflux; Stage #2: di-tert-butyl dicarbonate With dmap; triethylamine In ethyl acetate at -25 - 35℃; for 4.91667h; Stage #3: With pyrographite; sodium sulfate In cyclohexane; water Solvent; Temperature;	96.3%

: 115-11-7
isobutene

: 98-79-3
L-Pyroglutamic acid

: 35418-16-7, 85136-12-5
L-t-butyl pyroglutamate

Conditions

Conditions	Yield
With sulfuric acid In dichloromethane	96%
With sulfuric acid In dichloromethane at 0 - 20℃; Inert atmosphere;	78%
With sulfuric acid In dichloromethane at 25℃; for 48h;	65%

: 98-79-3
L-Pyroglutamic acid

: 100-51-6
benzyl alcohol

: 94885-52-6
benzyl (L)-pyroglutamate

Conditions

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide for 15h; Ambient temperature;	96%
With thionyl chloride at 0 - 20℃;	96%
With thionyl chloride; N,N-dimethyl-formamide at 20℃;	90%

: 1189587-53-8
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

: 98-79-3
L-Pyroglutamic acid

: 1189587-54-9
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methyl-2-((S)-5-oxopyrrolilidine-2-carboxamido)pentanamido)-4-methylpentanamido)-3-methylbutanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 0℃; for 8h;	96%

: febuxostat

: 98-79-3
L-Pyroglutamic acid

: febuxostat hemipidolate salt

Conditions

Conditions	Yield
In acetone at 20 - 25℃; for 4h; Solvent;	96%

: 508233-74-7
vortioxetine

: 98-79-3
L-Pyroglutamic acid

: 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine L-pyroglutamate

Conditions

Conditions	Yield
In isopropyl alcohol at 20 - 60℃; for 2h;	96%

: 113994-41-5
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

: 98-79-3
L-Pyroglutamic acid

: amlodipine (S)-(-)-pyroglutamate

Conditions

Conditions	Yield
In ethyl acetate at 25℃; for 1h;	95.3%
In ethyl acetate at 25℃; for 1h;	95.3%

L-Pyroglutamic acid Specification

The IUPAC name of L-Pyroglutamic acid is (2S)-5-oxopyrrolidine-2-carboxylic acid. With the CAS registry number 98-79-3, it is also named as 2-Benzothiazolesulfenemorpholide. The product's categories are Heterocycles; Pyrrolidine Series; Chiral; Pyroglutamic Acid [Pyr, pGu]; Unusual Amino Acids; Amino Acids; Biochemistry; Biological-modified Amino Acids; for Resolution of Bases; Optical Resolution; Synthetic Organic Chemistry; Amino Acids; Nutraceuticals, and the other registry numbers are 16891-48-8; 29222-42-2; 312618-42-1; 35255-51-7; 498-91-9; 6886-28-8; 87430-62-4. Besides, it is white to light yellow crystal powder, which should be stored in a cool, dry, well ventilated warehouse away from fire and heat source. And the packaging must be sealed and not damp. In addition, this chemical is stable, and incompatible with bases, acids, strong oxidizing agents.

Physical properties about L-Pyroglutamic acid are: (1)ACD/LogP: -1.348; (2)ACD/LogD (pH 5.5): -3.38; (3)ACD/LogD (pH 7.4): -4.88; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 4; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Index of Refraction: 1.512 ; (12)Molar Refractivity: 28.033 cm³; (13)Molar Volume: 93.496 cm³; (14)Polarizability: 11.113 10-24cm³; (15)Surface Tension: 54.6319999694824 dyne/cm; (16)Density: 1.381 g/cm³; (17)Flash Point: 227.848 °C; (18)Enthalpy of Vaporization: 78.09 kJ/mol; (19)Boiling Point: 453.134 °C at 760 mmHg

Preparation and Uses of L-Pyroglutamic acid: Please heat 42 % Glutamic acid solution for 3 hours at 140 °C. And you will obtain the reaction liquid that is the main component of L-Pyroglutamic acid. After decompression and concentration, crystallization, washing, drying, you will get the product. The yield is 94 %. Furthermore, this chemical is used as intermediate of organic synthesis, food additives. It is also used in biochemical study, medicine, cosmetics and other industries. Additionally, it is used as resolving agent.

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing, gloves and eye/face protection. Moreover, in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1;
(2)InChIKey=ODHCTXKNWHHXJC-VKHMYHEASA-N;
(3)Smiles[C@@H]1(NC(=O)CC1)C(=O)O

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	oral	> 1gm/kg (1000mg/kg)		United States Patent Document. Vol. #4882359,
rat	LD50	subcutaneous	> 2gm/kg (2000mg/kg)		United States Patent Document. Vol. #4882359,

Product Name

L-Pyroglutamic acid

Synthetic route

L-Pyroglutamic acid Specification

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