Conditions | Yield |
---|---|
montmorillonite K-10 for 0.0166667h; Solid phase reaction; desilylation; microwave irradiation; | 100% |
With Nanoporous Na+-Montmorillonite Perchloric Acid In ethanol at 20℃; for 0.0833333h; | 90% |
With hydrogenchloride In methanol Ambient temperature; Yield given; |
o-Tolyl N,N,N',N'-tetramethylphosphorodiamidate
ortho-cresol
Conditions | Yield |
---|---|
With formic acid for 1h; Product distribution; Heating; | 100% |
In formic acid for 1h; Heating; Yield given; |
2-Methylphenylboronic acid
ortho-cresol
Conditions | Yield |
---|---|
With 3,3'-dihexyloxy-1,1'-binaphthylidene-4,4'-dione; potassium hydroxide In tetrahydrofuran; water at 20℃; | 100% |
With dihydrogen peroxide at 20℃; for 0.25h; Green chemistry; | 98% |
With water; oxygen; sodium sulfite at 50℃; for 1h; Green chemistry; | 97% |
Conditions | Yield |
---|---|
With hydrogen In para-xylene at 120℃; under 750.075 Torr; for 24h; Glovebox; Sealed tube; chemoselective reaction; | 99% |
With formic acid; C18H14ClN4O2Ru(1+)*Cl(1-); sodium formate In water at 80℃; for 32h; Inert atmosphere; | 70% |
With acetic acid; zinc In ethanol at 180℃; for 0.25h; Solvent; Temperature; Microwave irradiation; | 56% |
Conditions | Yield |
---|---|
platinum; potassium oxide at 360℃; | A 98% B 2% |
platinum; potassium oxide at 360℃; Product distribution; other content of catalyst; | A 98% B 2% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; cobalt(II) chloride In ethanol at 0 - 25℃; for 10h; | 98% |
Conditions | Yield |
---|---|
With hydrogen; nickel-titanium-aluminum In various solvent(s) at 160℃; for 3h; | 97.8% |
With hydrogen; nickel-titanium-aluminum In various solvent(s) at 160℃; for 3h; Product distribution; Rate constant; Thermodynamic data; other temperatures; | 97.8% |
Conditions | Yield |
---|---|
With glycolic Acid; copper hydroxide; sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 6h; Inert atmosphere; Schlenk technique; | 97% |
With copper(l) iodide; 8-quinolinol; potassium hydroxide In water; dimethyl sulfoxide; tert-butyl alcohol at 100℃; for 48h; Inert atmosphere; | 96% |
Stage #1: ortho-methylphenyl iodide With copper(l) iodide; 8-Hydroxyquinoline-N-oxide In dimethyl sulfoxide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With cesiumhydroxide monohydrate In water; dimethyl sulfoxide at 100℃; for 24h; Inert atmosphere; | 95% |
1,1-dimethylethyl 2-methylphenyl carbonate
ortho-cresol
Conditions | Yield |
---|---|
With erbium(III) triflate In ethanol for 25h; Microwave irradiation; | 97% |
2-hydroxy-3-methylphenyl boronic acid
ortho-cresol
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 120℃; for 24h; | 96% |
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide at 20℃; for 3h; | 95% |
Conditions | Yield |
---|---|
With ammonium bicarbonate In water at 20℃; for 2h; Schlenk technique; | 95% |
Conditions | Yield |
---|---|
With pyridine; hydrogen fluoride for 1.66667h; Decomposition; Fluoro-dediazoniation; Irradiation; | A 93.8% B 1.1% |
Conditions | Yield |
---|---|
Stage #1: 2-methylphenyl bromide With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); 2-((di-adamantan-1-yl)phosphaneyl)-1-(2,6-diisopropylphenyl)-1H-imidazole In 1,4-dioxane; water at 100℃; for 20h; Inert atmosphere; Stage #2: With hydrogenchloride In 1,4-dioxane; water at 20℃; Inert atmosphere; | 93% |
With cesiumhydroxide monohydrate; bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II); 2-((di-adamantan-1-yl)phosphaneyl)-1-(2,6-diisopropylphenyl)-1H-imidazole In tetrahydrofuran at 24℃; for 20h; Inert atmosphere; | 92% |
Stage #1: 2-methylphenyl bromide With copper(l) iodide; 8-Hydroxyquinoline-N-oxide In dimethyl sulfoxide at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With cesiumhydroxide monohydrate In water; dimethyl sulfoxide at 110℃; for 18h; Inert atmosphere; | 90% |
2-(tert-butyldimethylsilyloxy)toluene
ortho-cresol
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol at 20℃; for 1.6h; | 93% |
With zinc tetrafluoroborate In water for 24h; Heating; | 88% |
With sodium cyanide In ethanol; water at 80℃; for 15h; chemoselective reaction; | 84.5% |
With sodium phosphate dodecahydrate In N,N-dimethyl-formamide at 20℃; for 2.5h; | 83% |
Conditions | Yield |
---|---|
With cesiumhydroxide monohydrate; bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II); 2-((di-adamantan-1-yl)phosphaneyl)-1-(2,6-diisopropylphenyl)-1H-imidazole In tetrahydrofuran at 24℃; for 20h; Inert atmosphere; | 92% |
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; tris-(dibenzylideneacetone)dipalladium(0); cesiumhydroxide monohydrate In tetrahydrofuran at 24℃; Inert atmosphere; Glovebox; Sealed tube; | 91% |
With aluminum (III) chloride; choline chloride; urea; sodium hydroxide at 180℃; for 6h; Reagent/catalyst; Green chemistry; | 86.2% |
With trans-di(μ-acetato)bis[o-(di-o-tolyl-phosphino)benzyl]dipalladium(II); C29H45Pt; potassium carbonate In water; N,N-dimethyl-formamide at 115℃; for 0.5h; Inert atmosphere; Microwave irradiation; | 63% |
ortho-cresol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In benzene at 70℃; | 91% |
3,3-diethyl-1-(o-tolyl)triaz-1-ene
ortho-cresol
Conditions | Yield |
---|---|
With water; sulfonic acid resin (H+ form) In acetonitrile for 0.166667h; Heating; | 90% |
methyl 2-methylphenoxy acetate
A
o-methylphenoxyacetic acid
B
ortho-cresol
Conditions | Yield |
---|---|
With lithium chloride In N,N-dimethyl-formamide for 22h; Heating; | A 90% B 5% |
ortho-cresol
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium hydrogencarbonate In tetrahydrofuran; methanol; water at 20℃; for 16h; Inert atmosphere; | 90% |
Conditions | Yield |
---|---|
With iodine at 20℃; | 89% |
Conditions | Yield |
---|---|
With selenium(IV) oxide; dihydrogen peroxide In tetrahydrofuran for 10h; Heating; | A 88% B 9 % Chromat. |
With dihydrogen peroxide; methyltrioctylammonium tetrakis(oxodiperoxotungsto)phosphate at 90℃; for 1.5h; | A 23% B 10% |
methanol
phenol
A
2.6-dimethylphenol
B
methoxybenzene
C
ortho-cresol
Conditions | Yield |
---|---|
zirconium(IV) oxide at 320℃; under 112509 Torr; for 1.5h; Product distribution; Kinetics; Further Variations:; Catalysts; Pressures; Temperatures; | A 87% B 0.5% C 6% |
aluminum oxide at 290℃; under 195.02 - 600.05 Torr; Kinetics; Product distribution; Rate constant; | |
samarium(III) oxide; tin(IV) oxide at 349.85℃; for 1h; Product distribution; Further Variations:; Catalysts; Alkylation; |
Conditions | Yield |
---|---|
With trimethylsilyl iodide at 105 - 114℃; for 0.25h; Microwave irradiation; Inert atmosphere; | 85% |
With pyridine hydrochloride for 0.233333h; demethylation; microwave irradiation; | 82% |
With pyridinium p-toluenesulfonate for 0.0333333h; microwave irradiation; | 70% |
With boron tribromide-dimethyl sulfide complex In 1,2-dichloro-ethane at 83.5℃; for 12h; | 67.2% |
With hydrogen In dodecane; hexane at 270℃; under 22502.3 Torr; for 8h; Autoclave; |
Conditions | Yield |
---|---|
With dipotassium peroxodisulfate; iron(III) chloride hexahydrate at 110℃; for 4h; Sealed tube; | 84% |
Conditions | Yield |
---|---|
Stage #1: o-toluidine With sulfuric acid at 20℃; Cooling with ice; Stage #2: With sodium nitrite In water Reflux; | 83% |
Stage #1: o-toluidine With sodium nitrite In water at 20℃; Milling; Green chemistry; Stage #2: With water at 60℃; for 0.416667h; Neutral conditions; Green chemistry; | 78% |
With sulfuric acid Diazotization.Verkochen des Diazoniumsulfats mit Wasser; |
Conditions | Yield |
---|---|
With hydrogen In toluene at 629.9℃; Mechanism; Kinetics; Rate constant; other temperature 760-1110 K; | A n/a B 83% |
ortho-cresol
Conditions | Yield |
---|---|
With 6,6'-dimethyl-2,2'-bipyridine; (1,2-dimethoxyethane)dichloronickel(II); bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide; water at 30℃; for 24h; Inert atmosphere; Glovebox; Sealed tube; | 83% |
With [2,2]bipyridinyl; (1,2-dimethoxyethane)dichloronickel(II); water; bis(pinacol)diborane; lithium tert-butoxide In methanol; N,N-dimethyl acetamide at 30℃; for 24h; Schlenk technique; | 63% |
Conditions | Yield |
---|---|
at 20℃; for 0.666667h; | 100% |
With triethylamine In dichloromethane at 20℃; | 99% |
With silver trifluoromethanesulfonate at 60℃; for 0.116667h; neat (no solvent); | 99% |
Conditions | Yield |
---|---|
With benzyltriphenylphosphonium peroxodisulfate; potassium bromide In acetonitrile for 4.5h; Heating; | 100% |
With dihydrogen peroxide; vanadia; potassium bromide In chloroform; water at 24.84℃; under 760.051 Torr; | 99% |
With hydrogen bromide; acetic acid In water; dimethyl sulfoxide at 20℃; for 16h; | 99% |
Conditions | Yield |
---|---|
With (NH4)2Ce(NO3)6 on pillared bentonite In methanol at 25℃; for 48h; | 100% |
With thionyl chloride; bismuth subnitrate In dichloromethane at 20℃; for 2h; | 83% |
With cupric nitrate trihydrate supported on K 10 montmorillonite clay; nitric acid; acetic anhydride In tetrachloromethane for 1h; Ambient temperature; | 80% |
Conditions | Yield |
---|---|
With triethylamine In ethyl acetate at 0 - 20℃; for 0.166667h; Green chemistry; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; | 89% |
With pyridine | 85% |
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere; | 74% |
With pyridine |
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran | 100% |
With potassium carbonate In acetone Reflux; | 100% |
Stage #1: ortho-cresol With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 0.5h; Inert atmosphere; Stage #2: propargyl bromide In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 90% |
Conditions | Yield |
---|---|
With potassium carbonate In butanone for 5.5h; Heating; | 100% |
With potassium carbonate In acetone Ambient temperature; | 100% |
With caesium carbonate In acetonitrile at 25℃; | |
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 3h; | |
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 3h; |
methyl 3,3,3-trifluoropyruvate
ortho-cresol
Conditions | Yield |
---|---|
With triethylamine In tetrachloromethane for 24h; Ambient temperature; | 100% |
With tert-butylamine In tetrachloromethane for 3h; Ambient temperature; other substituted phenols, other polyfluorinated carbonyl compounds, other amines and solvents; nucleophilic catalysis in C-hydroxyalkylation; |
Conditions | Yield |
---|---|
With Trimethylacetic acid In toluene for 20h; Heating; | 100% |
ortho-cresol
Ethyl 2-bromopropionate
ethyl 2-(2-methylphenyl)oxypropionate
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide | 100% |
With potassium iodide In N,N-dimethyl-formamide; acetone Heating; | 83% |
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Etherification; | 100% |
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 16h; | 99% |
Stage #1: ortho-cresol With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane for 0.166667h; Stage #2: chloromethyl methyl ether In 1,2-dichloro-ethane at 20℃; for 10h; | 98% |
tert-butyldimethylsilyl chloride
ortho-cresol
2-(tert-butyldimethylsilyloxy)toluene
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide for 3h; | 100% |
With 1H-imidazole In N,N-dimethyl-formamide at 23℃; for 15h; Inert atmosphere; Schlenk technique; | 99% |
With 1H-imidazole; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 20℃; for 2h; | 98% |
ortho-cresol
ortho-nitrofluorobenzene
1-methyl-2-(2-nitrophenoxy)benzene
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 95℃; for 20h; | 100% |
Stage #1: ortho-cresol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere; Stage #2: ortho-nitrofluorobenzene In N,N-dimethyl-formamide at 20 - 50℃; for 13h; Inert atmosphere; | 93% |
Stage #1: ortho-cresol With potassium tert-butylate In tetrahydrofuran for 1h; Stage #2: ortho-nitrofluorobenzene In tetrahydrofuran |
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 50℃; | 100% |
In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate | 59.1 g (94%) |
In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate | 59.1 g (94%) |
1-(tert-Butoxycarbonyl)-4-cyano-4-(methanesulfonyloxymethyl)piperidine
ortho-cresol
1-(tert-Butoxycarbonyl)-4-cyano-4-(2-methylphenoxymethyl)piperidine
Conditions | Yield |
---|---|
In water; ethyl acetate; N,N-dimethyl-formamide | 100% |
(4R)-1,2,3-oxathiazolidine-3-carboxylic acid, 4-phenyl 1,1-dimethylethyl ester-2,2-dioxide
ortho-cresol
Conditions | Yield |
---|---|
Stage #1: tert-butyl (R)-4-phenyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide; ortho-cresol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h; Inert atmosphere; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 3h; optical yield given as %ee; enantioselective reaction; | 100% |
cycl-isopropylidene malonate
ortho-cresol
3-(2-methylphenoxy)-3-oxo-propanoic acid
Conditions | Yield |
---|---|
at 110℃; for 3h; | 100% |
at 100℃; for 3h; Neat (no solvent); | |
at 110℃; for 3h; Inert atmosphere; | |
at 90℃; |
ortho-cresol
[2H]-o-cresol
Conditions | Yield |
---|---|
With perchloric acid; d(4)-methanol at 75℃; for 144h; Inert atmosphere; | 100% |
With water-d2; sodium hydroxide at 180℃; for 0.25h; Reagent/catalyst; pH-value; Microwave irradiation; regioselective reaction; | 94% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
Stage #1: ortho-cresol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.0833333h; Stage #2: C16H11I In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 12h; | 100% |
Conditions | Yield |
---|---|
With Magnesium-Aluminum layered double oxides catalyst at 149.84℃; under 760.051 Torr; for 12h; Autoclave; Inert atmosphere; Irradiation; Green chemistry; | 99.4% |
With dimanganese decacarbonyl at 180℃; for 1h; Reagent/catalyst; | 30% |
N,N,N',N'-tetrabutyl-N''-methylguanidine at 180℃; for 4.5h; | 90 % Chromat. |
ortho-cresol
2-cyanobenzyl chloride
2-(2-methylphenoxymethyl)benzonitrile
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 6h; | 99.3% |
Conditions | Yield |
---|---|
With Mo2P5-MCM-48 at 120℃; for 3h; | 99.2% |
Conditions | Yield |
---|---|
With hydrogen In water at 20℃; under 7500.75 Torr; for 6h; Autoclave; | 99.1% |
With hydrogen at 100℃; under 3750.38 Torr; for 3h; Reagent/catalyst; Pressure; Temperature; | 99% |
With nickel(II) oxide; hydrogen; palladium In hexane at 80℃; under 7500.75 Torr; for 10h; | 98% |
formaldehyd
Octanethiol
ortho-cresol
methyl iodide
2,4-bis(n-octylthiomethyl)-6-methylphenol
Conditions | Yield |
---|---|
Stage #1: formaldehyd; Octanethiol; ortho-cresol With hydrogenchloride; 2,2'-iminobis[ethanol] In water for 8h; pH=Ca. 3 - 4; Reflux; Stage #2: methyl iodide With copper(l) iodide at 95℃; for 4h; Temperature; | 99.1% |
Conditions | Yield |
---|---|
With potassium carbonate; 1-Butylimidazole; copper(l) chloride In tetradecane; toluene at 120℃; for 16h; Product distribution / selectivity; | 99% |
With 2-Picolinic acid; potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; | 95% |
With 2-Picolinic acid; potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In acetonitrile at 20℃; for 1h; | 99% |
With trifluorormethanesulfonic acid In acetonitrile at 20℃; | 96% |
at 130℃; for 3h; | 95% |
The o-Cresol, with the cas registry number 95-48-7, has the IUPAC name of 2-methylphenol. Being a kind of colorless crystal, it is sensitive to light and air, and is stable chemically while incompatible with oxidizing agents, bases. And this is insoluble in water, aqueouscaustic and other organic solvents.
The characteristics of o-Cresol are as follows:
(1)ACD/LogP: 1.94; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.94; (4)ACD/LogD (pH 7.4): 1.94; (5)ACD/BCF (pH 5.5): 17.62; (6)ACD/BCF (pH 7.4): 17.6; (7)ACD/KOC (pH 5.5): 271.31; (8)ACD/KOC (pH 7.4): 270.98; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 20.23; (13)Index of Refraction: 1.545; (14)Molar Refractivity: 32.95 cm3; (15)Molar Volume: 104.1 cm3; (16)Polarizability: 13.06 ×10-24 cm3; (17)Surface Tension: 38.8 dyne/cm; (18)Density: 1.038 g/cm3; (19)Flash Point: 77.1 °C; (20)Enthalpy of Vaporization: 44.47 kJ/mol; (21)Boiling Point: 191 °C at 760 mmHg; (22)Vapour Pressure: 0.379 mmHg at 25°C; (23)Exact Mass: 108.057515; (24)MonoIsotopic Mass: 108.057515; (25)Topological Polar Surface Area: 20.2; (26)Heavy Atom Count: 8; (27)Complexity: 70.8.
The production methods of o-Cresol are as below:
The first way: prepare the carbolic acid and then react with the alkylating agent of carbinol and the catalytic agent to produce o-Cresol; The second way: diazotize and then hydrolyze the Ortho Toluidine to produce o-Cresol; The third way: prepare the material of phenol and carbinol and then have the methylation with the manometer pressure of 4.14MPa and existence of aluminium oxide to get this chemical.
Uses of o-Cresol:
As to its usage, it is widely applied in many ways. It could be used as the intermediate of pesticide and herbicide, disinfectant, preservative and diluent and also in synthesis of coumarin ; It could be also used in organic synthesis and analysis reagent.
Safety Information of o-Cresol:
When you are dealing with this chemical, you should be very careful and then take some measures to protect yourself. This is a kind of toxic chemical which could at low levels cause damage to health. And it has the danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. Therefore, you should wear suitable protective clothing, gloves and eye/face protection, and if in case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
Additionally, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: CC1=CC=CC=C1O
(2)InChI: InChI=1S/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3
(3)InChIKey: QWVGKYWNOKOFNN-UHFFFAOYSA-N
Below are the toxicity information of o-Cresol:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | subcutaneous | 55mg/kg (55mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. | |
dog | LDLo | intravenous | 80mg/kg (80mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 57, 1959. | |
frog | LDLo | subcutaneous | 200mg/kg (200mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935. | |
guinea pig | LDLo | intraperitoneal | 720mg/kg (720mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935. | |
guinea pig | LDLo | subcutaneous | 35mg/kg (35mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BEHAVIORAL: EXCITEMENT | Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895. |
mouse | LC50 | inhalation | 179mg/m3/2H (179mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 40, 1982. | |
mouse | LD50 | oral | 344mg/kg (344mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974. | |
mouse | LDLo | intraperitoneal | 200mg/kg (200mg/kg) | Revue Belge de Pathologie et de Medecine Experimentale. Vol. 22, Pg. 1, 1952. | |
mouse | LDLo | subcutaneous | 410mg/kg (410mg/kg) | Zeitschrift fuer Hygiene und Infektionskrankheiten. Vol. 64, Pg. 113, 1909. | |
rabbit | LD50 | skin | 890mg/kg (890mg/kg) | Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977. | |
rabbit | LDLo | intravenous | 180mg/kg (180mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. | |
rabbit | LDLo | oral | 940mg/kg (940mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944. | |
rabbit | LDLo | subcutaneous | 450mg/kg (450mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935. | |
rat | LC50 | inhalation | > 1220mg/m3/1H (1220mg/m3) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 4-5/1969, |
rat | LD50 | oral | 121mg/kg (121mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 4-5/1969, |
rat | LD50 | skin | 620mg/kg (620mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974. | |
rat | LDLo | subcutaneous | 65mg/kg (65mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA | Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895 |
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