2,6-Dichlorophenol supplier

Name
2,6-Dichlorophenol
EINECS 201-761-3
CAS No. 87-65-0
Article Data94
CAS DataBase
Density 1.458 g/cm³
Solubility <0.1 g/100 mL at 20 °C in water
Melting Point 65 °C
Formula C₆H₄Cl₂O
Boiling Point 219 °C at 760 mmHg
Molecular Weight 163.003
Flash Point 94.9 °C
Transport Information UN 2020 6.1/PG 3
Appearance white or light purple crystals
Safety 26-27-36/37/39-37/39-45-36/37-16
Risk Codes 34-36/38-39/23/24/25-23/24/25-11
Molecular Structure
Hazard Symbols C, Xi, T, F
Synonyms Phenol,2,6-dichloro-;NSC 60647;
PSA 20.23000
LogP 2.69900

Synthetic route

: 188645-80-9
tert-butyl (2,6-dichlorophenoxy)dimethylsilane

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With lithium acetate In water; N,N-dimethyl-formamide at 70℃; for 3h; Inert atmosphere;	94%

: 95-57-8
2-monochlorophenol

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine; sulfuryl dichloride In toluene at 25℃; for 24h; Inert atmosphere; regioselective reaction;	91%
With 1,3-dichloro-5,5-dimethylhydantoin; diisopropylamine hydrochloride In toluene at 0℃; for 4h; Darkness; regioselective reaction;	78%
With tetrachloromethane; tert-butylhypochlorite

: 3336-41-2
3,5-dichloro-4-hydroxybenzoic acid

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With copper(I) oxide In quinoline at 220℃; for 6h; Autoclave;	86%
With quinoline at 190℃;
With methyllithium; calcium carbonate

: 83-38-5
2,6-dichlorobenzaldehyde

A: 87-65-0
2,6-Dichlorophenol

B: 50-30-6
2,6-dichlorobenzoic acid

Conditions

Conditions	Yield
With selenium(IV) oxide; dihydrogen peroxide In tetrahydrofuran for 52h; Heating;	A 4 % Chromat. B 86%

: 95-57-8
2-monochlorophenol

A: 87-65-0
2,6-Dichlorophenol

B: 120-83-2
2,4-dichlorophenol

Conditions

Conditions	Yield
With iron(III) chloride; diphenyl sulfide; boric acid at 40 - 80℃;	A 13.31% B 85.43%
With chloroamine In water pH=9.0; Product distribution; Further Variations:; Reagents; pH-values;	A 23% B 77%
With N-chlorobis(2-chloroethyl)amine; silica gel In tetrachloromethane at 25℃; Yield given. Yields of byproduct given;
With 2,3,4,4,5,6-hexachlorocyclohexa-2,5-dien-1-one In tetrachloromethane; N,N-dimethyl-formamide at 20℃; for 360h; other reagent; Yield given. Yields of byproduct given;
With aluminum (III) chloride; sulfuryl dichloride In neat (no solvent) at 25 - 55℃; for 3h; Reagent/catalyst; Temperature; regioselective reaction;	A 5.7 %Chromat. B 92.1 %Chromat.

: 3776-30-5
2,2,6,6-tetrachlorocyclohexanone

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With triethylamine In toluene at 80℃; for 2.5h; Reagent/catalyst; Solvent; Time;	84.4%
With triethylamine In N,N-dimethyl-formamide at 100℃; for 4h; Dehydrochlorination;	30%

: 6267-90-9
1,3-dichloro-2-(2-propenyloxy)benzene

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With 12-TPA/SBA 15 In 1,4-dioxane at 110℃;	75%

: 73852-17-2
2,6-dichlorophenylboronic acid

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With ozone In ethanol; water at 20 - 30℃; for 0.583333h;	73%

: C11H12Cl2O

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With 12-TPA/SBA 15 In 1,4-dioxane at 110℃;	70%

: 108-95-2
phenol

A: 87-65-0
2,6-Dichlorophenol

B: 106-48-9
4-chloro-phenol

C: 120-83-2
2,4-dichlorophenol

Conditions

Conditions	Yield
With hydrogenchloride; sodium chlorate In water; acetic acid at 20℃; for 72h;	A 4% B 16% C 65%

...Expand

: 108-95-2
phenol

A: 87-65-0
2,6-Dichlorophenol

B: 95-57-8
2-monochlorophenol

C: 106-48-9
4-chloro-phenol

D: 120-83-2
2,4-dichlorophenol

E: 88-06-2
2,4,6-Trichlorophenol

Conditions

Conditions	Yield
With aluminium trichloride; diphenyl sulfide; chlorine In neat (no solvent) at 35℃; for 1.5h; Product distribution; others 2-alkylphenols; var. chlorinating agent, temp., and time;	A 0.5% B 18.4% C 58.6% D 7.7% E 0.5%
With N,N'-dichloropiperazine; silica gel In tetrachloromethane at 25℃; Product distribution; further reagents;
With tert-butylhypochlorite; tris(3-pyridiniumprop-1-yl)benzene-1,3,5-tricarboxylatetrichloride In acetonitrile Product distribution; Mechanism; other tentacle reagents and variations of concentration;
With tert-butylhypochlorite; cetylpyridinium chloride In water Product distribution; other reagents and solvent;
With sulfuryl dichloride; 2-aminopyridine In toluene at 70℃; for 1h; Product distribution; chlorination catalyzed by var. amines under var. conditions;	A n/a B 32.3 % Chromat. C 60.3 % Chromat. D n/a E n/a

...Expand

: 108-95-2
phenol

A: 87-65-0
2,6-Dichlorophenol

B: 95-57-8
2-monochlorophenol

C: 106-48-9
4-chloro-phenol

D: 120-83-2
2,4-dichlorophenol

Conditions

Conditions	Yield
With chloroamine In water pH=9.0; Product distribution; Further Variations:; Reagents; pH-values;	A 9.6% B 50.5% C 23% D 16.3%
With oxygen; silica gel; copper dichloride at 200℃; Formation of xenobiotics;	A 0.004% B 4.761% C 1.149% D 0.393%
With oxygen; silica gel; copper dichloride at 225℃; Formation of xenobiotics; Further byproducts.;	A 0.008% B 3.892% C 0.998% D 0.394%

...Expand

: 14863-58-2
2,6-dichlorophenyl dimethylcarbamate

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With hydrazine hydrate at 60℃; for 2h; Sealed tube; regioselective reaction;	50%

: 108-95-2
phenol

A: 87-65-0
2,6-Dichlorophenol

B: 120-83-2
2,4-dichlorophenol

Conditions

Conditions	Yield
With hydrogenchloride; potassium permanganate In acetonitrile at 60℃;	A 44% B 44%
With alkaline sodium hypochlorite solution
With chlorine

: 1984-65-2
2,6-dichloroanisole

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With sodium methylate In N,N,N,N,N,N-hexamethylphosphoric triamide at 120℃;	33%

: 87-61-6
1,2,3-trichlorobenzene

A: 87-65-0
2,6-Dichlorophenol

B: 1984-59-4
2,3-dichloroanisole

C: 1984-65-2
2,6-dichloroanisole

Conditions

Conditions	Yield
With potassium hydroxide; Tris(3,6-dioxaheptyl)amine at 135℃; for 2h;	A 23% B 756 g C 496 g

...Expand

: 79-46-9
2-nitropropane

: 56733-60-9
2,6-dichloro-4-dimethylaminomethyl-phenol

A: 87-65-0
2,6-Dichlorophenol

B: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

C: 85628-45-1
2,6-Dichlor-4-(2-methyl-2-nitropropyl)phenol

Conditions

Conditions	Yield
potassium fluoride; tetrabutyl-ammonium chloride for 30h; Heating;	A n/a B n/a C 12%

...Expand

: 95-57-8
2-monochlorophenol

A: 262-12-4
dioxin

B: 87-65-0
2,6-Dichlorophenol

C: 39227-53-7
1-chlorodibenzo-p-dioxin

D: 4,6-dichlorodibenzofuran

Conditions

Conditions	Yield
With oxygen at 600℃; for 0.000555556h; Product distribution; Further Variations:; Temperatures;	A 1.32% B 0.59% C 0.92% D 9.43%

...Expand

: 95-57-8
2-monochlorophenol

A: 262-12-4
dioxin

B: 87-65-0
2,6-Dichlorophenol

C: 39227-53-7
1-chlorodibenzo-p-dioxin

D: 120-83-2
2,4-dichlorophenol

Conditions

Conditions	Yield
With oxygen; silica gel; copper dichloride at 400℃; Product distribution; Further Variations:; Temperatures;	A 0.6915% B 0.219% C 0.7511% D 0.238%
With oxygen; silica gel; copper dichloride at 350℃; Formation of xenobiotics; Further byproducts.;	A 0.0672% B 0.229% C 0.3293% D 0.282%

...Expand

: 95-57-8
2-monochlorophenol

A: 87-65-0
2,6-Dichlorophenol

B: 120-83-2
2,4-dichlorophenol

C: 88-06-2
2,4,6-Trichlorophenol

Conditions

Conditions	Yield
With oxygen; silica gel; copper dichloride at 300℃; Formation of xenobiotics;	A 0.282% B 0.379% C 0.128%
With N-chloro-succinimide at 80℃; for 10h; regioselective reaction;	A 8 %Chromat. B 55 %Chromat. C 18 %Chromat.

...Expand

: 95-57-8
2-monochlorophenol

A: 87-65-0
2,6-Dichlorophenol

B: 39227-53-7
1-chlorodibenzo-p-dioxin

C: 120-83-2
2,4-dichlorophenol

D: 88-06-2
2,4,6-Trichlorophenol

Conditions

Conditions	Yield
With oxygen; silica gel; copper dichloride at 325℃; Formation of xenobiotics;	A 0.257% B 0.0024% C 0.312% D 0.053%

...Expand

: 91-22-5
quinoline

: 3336-41-2
3,5-dichloro-4-hydroxybenzoic acid

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
at 190 - 200℃;
at 190℃;

: 507-40-4
tert-butylhypochlorite

: 95-57-8
2-monochlorophenol

: 87-65-0
2,6-Dichlorophenol

: 3217-15-0
4-bromo-2,6-dichloro-phenol

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With palladium on activated charcoal; sodium acetate; benzene Hydrogenation.Reagens 4: Cyclohexan;
With sodium sulfite In water at 130℃; Sealed tube; Microwave irradiation; Green chemistry;	63 mg

: 34593-75-4
4-tert-butyl-2,6-dichloro-phenol

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With aluminium trichloride; xylene

: 5930-28-9
4-amino-2,6-dichlorophenol

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With sulfuric acid Diazotization.Kochen des Diazoniumsulfats mit Wasser und Soda;

: 75908-77-9
2,6-dichloro-4-tert-pentyl-phenol

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
With aluminium trichloride; xylene at 65 - 95℃;
With boron trifluoride; xylene at 60℃;

: 3336-41-2
3,5-dichloro-4-hydroxybenzoic acid

: 121-69-7
N,N-dimethyl-aniline

: 87-65-0
2,6-Dichlorophenol

Conditions

Conditions	Yield
at 190℃;

: 67-56-1
methanol

: 124-41-4
sodium methylate

: 87-61-6
1,2,3-trichlorobenzene

A: 87-65-0
2,6-Dichlorophenol

B: 1984-59-4
2,3-dichloroanisole

C: 576-24-9
2,3-dichlorophenol

Conditions

Conditions	Yield
at 180℃; im Rohr;

...Expand

: 96-49-1
[1,3]-dioxolan-2-one

: 87-65-0
2,6-Dichlorophenol

: 42001-44-5
2-(2,6-dichlorophenoxy)ethanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 2h; Heating;	100%

: 87-65-0
2,6-Dichlorophenol

: 358-23-6
trifluoromethylsulfonic anhydride

: 133280-47-4
2,6-dichlorophenyl trifluoromethanesulphonate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	100%

: 87-65-0
2,6-Dichlorophenol

: 98-80-6
phenylboronic acid

: 2432-11-3
(1,1';3',1''-terphenyl)-2'-ol

Conditions

Conditions	Yield
With palladium diacetate; dicyclohexylphenylphosphine In water; 1,2-dichloro-ethane at 40 - 70℃; for 3h; Reagent/catalyst; Solvent; Temperature; Concentration; Suzuki Coupling; Inert atmosphere; Sealed tube;	99.3%
With C28H44N2PPd; potassium carbonate In ethanol; water at 60℃; for 6h; Suzuki coupling;	96%
With reduced graphene oxide/Pd-Fe3O4(at)polypyrrole nanocomposite In water at 70℃; for 3h; Suzuki Coupling; Sonication;	65%

: 87-65-0
2,6-Dichlorophenol

: 177489-12-2
4-(4-nitrophenyl)-1-piperazinecarbonyl chloride

: 1092069-78-7
C17H15Cl2N3O4

Conditions

Conditions	Yield
Stage #1: 2,6-Dichlorophenol With sodium hydride In tetrahydrofuran for 0.25h; Molecular sieve; Stage #2: 4-(4-nitrophenyl)-1-piperazinecarbonyl chloride In tetrahydrofuran at 20℃; for 18.5h; Heating / reflux;	99%
Stage #1: 2,6-Dichlorophenol With sodium hydride In tetrahydrofuran for 0.25h; Stage #2: 4-(4-nitrophenyl)-1-piperazinecarbonyl chloride In tetrahydrofuran at 20℃; for 19h; Heating / reflux;	99%

: 87-65-0
2,6-Dichlorophenol

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: C12H15BCl2O3

Conditions

Conditions	Yield
In [D3]acetonitrile at 20℃; Inert atmosphere;	99%

: 87-65-0
2,6-Dichlorophenol

: 618-80-4
2,6-dichloro-4-nitrophenol

Conditions

Conditions	Yield
With Zn(NO3)2*2N2O4 In dichloromethane at 20℃; for 0.0833333h;	98%
With tetra(n-butyl)ammonium dichromate(VI); sodium nitrite In dichloromethane for 23h; Reflux; chemoselective reaction;	98%
With Tetraethylene glycol; silica gel; dinitrogen tetraoxide In dichloromethane at 20℃; for 0.0833333h;	97%

: 87-65-0
2,6-Dichlorophenol

A: 92545-10-3
2,6-Dichlorophenyl sulfate

B: 3,5-Dichloro-4-sulfooxy-benzenesulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide In nitromethane-d3 at -30℃; for 0.0333333h; Product distribution; various solvents, times, temperatures, amounts of SO3;	A 98% B 2%

: 87-65-0
2,6-Dichlorophenol

: 645-45-4
hydrocinnamic acid chloride

: 2,6-dichlorophenyl 3-phenylpropanoate

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole; N,N,N,N,-tetramethylethylenediamine In acetonitrile at 0 - 5℃; for 1h;	98%

: 87-65-0
2,6-Dichlorophenol

: 31736-75-1
3-chloro-1-(4-fluorophenyl)-1-propanol

: 1037716-90-7
1-(4-fluorophenyl)-1-(2,6-dichlorophenoxy)-3-chloropropane

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 20℃; Inert atmosphere;	98%

: 87-65-0
2,6-Dichlorophenol

: 22422-27-1
3-chloro-1-(p-tolyl)propan-1-ol

: 1037716-99-6
1-(4-methylphenyl)-1-(2,6-dichlorophenoxy)-3-chloropropane

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 20℃; Inert atmosphere;	98%

: 87-65-0
2,6-Dichlorophenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 188645-80-9
tert-butyl (2,6-dichlorophenoxy)dimethylsilane

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃;	98%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃;	98%

: 87-65-0
2,6-Dichlorophenol

: 34074-22-1
2,6-dichloro-4-iodophenol

Conditions

Conditions	Yield
Stage #1: 2,6-Dichlorophenol With ethylenediamine; sodium iodide In ethanol; water for 0.25h; Stage #2: With iodine In ethanol; water at 20℃;	97%
With dihydrogen peroxide; iodine In water for 0.75h; Sonication;	97%
With dihydrogen peroxide; iodine In water at 50℃; for 24h; regioselective reaction;	95%

: 87-65-0
2,6-Dichlorophenol

: 3217-15-0
4-bromo-2,6-dichloro-phenol

Conditions

Conditions	Yield
With bromine In acetonitrile at 0℃; for 6h;	97%
With bromine In acetonitrile at 0℃; for 2h;	95.5%
With bromine In acetonitrile at 0℃; for 2h;	94%

: 87-65-0
2,6-Dichlorophenol

: 616-38-6
carbonic acid dimethyl ester

: 1984-65-2
2,6-dichloroanisole

Conditions

Conditions	Yield
With N,N'-dimethylimidazolium-2-carboxylate In acetonitrile at 160℃; for 2h; Microwave irradiation; Green chemistry;	97%

: 87-65-0
2,6-Dichlorophenol

: 3559-26-0
(2-benzoylamino-phenyl)-acetic acid methyl ester

: C22H17Cl2NO3

Conditions

Conditions	Yield
Stage #1: (2-benzoylamino-phenyl)-acetic acid methyl ester With thionyl chloride for 3h; Reflux; Stage #2: 2,6-Dichlorophenol With potassium carbonate In toluene for 3h; Reagent/catalyst; Cooling with ice; Reflux;	97%

: 87-65-0
2,6-Dichlorophenol

: 245728-73-8
(R)-2-(4-hydroxybutan-2-yl)isoindoline-1,3-dione

: 1429187-74-5
(R)-2-(4-(2,6-dichlorophenoxy)butan-2-yl)isoindoline-1,3-dione

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;	96%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 17h;	96%

: 108-05-4
vinyl acetate

: 87-65-0
2,6-Dichlorophenol

: 28165-71-1
2,6-dichlorophenyl acetate

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In neat (no solvent) at 70 - 140℃; for 0.183333h; Microwave irradiation;	96%

: 617-86-7
triethylsilane

: 87-65-0
2,6-Dichlorophenol

: (2,6-dichlorophenoxy)triethylsilane

Conditions

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride In acetonitrile at 20℃; for 3h; Irradiation;	96%

: 87-65-0
2,6-Dichlorophenol

: 108-24-7
acetic anhydride

: 28165-71-1
2,6-dichlorophenyl acetate

Conditions

Conditions	Yield
aluminium dodecatungsten phosphate at 20℃; for 0.25h;	95%
With o-benzenedisulfonimide at 20℃; for 4h;	95%
With pentaaminechlorocobalt(III) dichloride; phosphoric acid In neat (no solvent) at 75℃; for 0.166667h; Reagent/catalyst; Green chemistry; chemoselective reaction;	90%
In 1,4-dioxane; water at 25℃; Rate constant; Anion, pH 7.50;
With pyridine

: 87-65-0
2,6-Dichlorophenol

: methyl 2-(2-(2-bromopropionamido)phenyl)acetate

: 15307-86-5
[2-(2,6-dichloroanilino)phenyl]acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 60 - 100℃; for 8h; Temperature; Reagent/catalyst;	95%

: 591-50-4
iodobenzene

: 87-65-0
2,6-Dichlorophenol

: 28419-69-4
2,6-dichlorodiphenyl ether

Conditions

Conditions	Yield
With sodium hydroxide In neat (no solvent) at 90℃; for 5h; Green chemistry;	95%

: 87-65-0
2,6-Dichlorophenol

: 75-36-5
acetyl chloride

: 28165-71-1
2,6-dichlorophenyl acetate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2.5h;	94.1%
With triethylamine In dichloromethane at 0 - 20℃; for 2.5h; Inert atmosphere;	94%
With triethylamine In dichloromethane at 20℃; for 2.5h;	94%

: 87-65-0
2,6-Dichlorophenol

: 106-95-6
allyl bromide

: 6267-90-9
1,3-dichloro-2-(2-propenyloxy)benzene

Conditions

Conditions	Yield
Stage #1: 2,6-Dichlorophenol With potassium carbonate In dimethyl sulfoxide at 20℃; Inert atmosphere; Stage #2: allyl bromide In dimethyl sulfoxide at 20℃; for 2h; Inert atmosphere; regioselective reaction;	94%
With potassium carbonate; butanone
With potassium carbonate

: 87-65-0
2,6-Dichlorophenol

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 4-(1-hydroxy-1-methoxycarbonyl-2,2,2-trifluoroethyl)-2,6-dichlorophenol

Conditions

Conditions	Yield
With triethylamine In benzene for 6h; Ambient temperature;	94%

: 87-65-0
2,6-Dichlorophenol

: 14301-31-6
2-chloro-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide

: 223686-74-6
2-(2,6-dichloro-phenoxy)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 6h; Heating;	94%

: 87-65-0
2,6-Dichlorophenol

: 5460-29-7
2-(3-bromopropyl)isoindole-1,3-dione

: 1148000-14-9
2-(3-(2,6-dichlorophenoxy)propyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; caesium carbonate In tetrahydrofuran at 20 - 50℃; for 16h;	94%
With tetra-(n-butyl)ammonium iodide; caesium carbonate In tetrahydrofuran at 20 - 50℃; for 16h;	94%
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 4h;
With potassium carbonate In N,N-dimethyl-formamide at 100℃;

: 87-65-0
2,6-Dichlorophenol

: 51356-03-7
4,5-dichloro-2-chloromethyl-pyridazin-3(2H)-one

: 1174278-25-1
4-chloro-5-(2,6-dichlorophenoxy)-2-[(2,6-dichlorophenoxy)-methyl]pyridazin-3(2H)-one

Conditions

Conditions	Yield
With potassium carbonate In methanol for 5h; Reflux;	94%

: 87-65-0
2,6-Dichlorophenol

: 2170-05-0
pentaphenylantimony

: 171977-33-6
2,6-dichlorophenoxytetraphenylstiborane

Conditions

Conditions	Yield
In toluene room temperature;	93%

: 75-44-5
phosgene

: 87-65-0
2,6-Dichlorophenol

: 374568-08-8
2,6-Dichlorophenyl chloroformate

Conditions

Conditions	Yield
With N,N-dimethyl-aniline In toluene Inert atmosphere;	93%

2,6-Dichlorophenol Chemical Properties

Following is the structure of 2,6-Dichlorophenol (CAS NO.87-65-0):

IUPAC Name: 2,6-Dichlorophenol
Molecular Formula: C₆H₄Cl₂O
Molecular Weight: 163.001360 g/mol
EINECS: 201-761-3
Index of Refraction: 1.593
Molar Refractivity: 37.92 cm³
Molar Volume: 111.7 cm³
Density: 1.458 g/cm³
Flash Point: 94.9 °C
Melting Point: 65 °C
Storage temp.: 0-6 °C
Polarizability: 15.03 10^-24cm³
Surface Tension: 47.8 dyne/cm
Enthalpy of Vaporization: 47.39 kJ/mol
Boiling Point: 219 °C at 760 mmHg
Vapour Pressure: 0.0828 mmHg at 25 °C
Water Solubility: <0.1 g/100 mL at 20 °C
Appearance of 2,6-Dichlorophenol (CAS NO.87-65-0): white or light purple crystals
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides.
Product Categories: Aromatic Phenols; Phenoles and thiophenoles; Alpha sort; D; DAlphabetic; DIA - DIC; Pesticides & Metabolites; Volatiles/ Semivolatiles; Organic Building Blocks; Oxygen Compounds; Phenols
Canonical SMILES: C1=CC(=C(C(=C1)Cl)O)Cl
InChI: InChI=1S/C6H4Cl2O/c7-4-2-1-3-5(8)6(4)9/h1-3,9H
InChIKey: HOLHYSJJBXSLMV-UHFFFAOYSA-N

2,6-Dichlorophenol Uses

2,6-Dichlorophenol (CAS NO.87-65-0) is used as intermediates of medicine, pesticide, dyes and organic synthesis.

2,6-Dichlorophenol Production

2,6-Dichlorophenol (CAS NO.87-65-0) can be synthesized by 4-ethylparaben obtained.

2,6-Dichlorophenol Toxicity Data With Reference

1.	skn-rbt 500 mg/24H SEV	28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,79.
2.	eye-rbt 250 µg/24H SEV	28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,79.
3.	ipr-rat LD50:390 mg/kg	BJPCAL British Journal of Pharmacology and Chemotherapy. 13 (1958),20.
4.	orl-mus LD50:2120 mg/kg	TOLED5 Toxicology Letters. 29 (1985),39.

2,6-Dichlorophenol Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program. Chlorophenol compounds are on the Community Right-To-Know List.

2,6-Dichlorophenol Safety Profile

Hazard Codes:C ,Xi ,T ,F
Risk Statements:34-36/38-39/23/24/25-23/24/25-11
34:Causes burns
36/38:Irritating to eyes and skin
39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
23/24/25:Toxic by inhalation, in contact with skin and if swallowed
11:Highly Flammable
Safety Statements:26-27-36/37/39-37/39-45-36/37-16
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27:Take off immediately all contaminated clothing
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
37/39:Wear suitable gloves and eye/face protection
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37:Wear suitable protective clothing and gloves
16:Keep away from sources of ignition - No smoking
RIDADR:UN 2020 6.1/PG 3
WGK Germany:2
RTECS:SK8750000
Hazard Note:Harmful/Corrosive
HazardClass:6.1
PackingGroup:III
Poison by intraperitoneal route. Moderately toxic by ingestion. A severe skin and eye irritant. When heated to decomposition it emits toxic fumes of Cl⁻. See also CHLOROPHENOLS.

2,6-Dichlorophenol Specification

2,6-Dichlorophenol , its cas register number 87-65-0. It also can be called 2,6-Dichlorfenol [Czech] ; 2,6-Dichlorophenol ; BRN 1447806 ; CCRIS 2511 ; HSDB 4240 ; NSC 60647 ; and Phenol, 2,6-dichloro- . Its classification code are Skin / Eye Irritant and TSCA Flag T [Subject to the Section 4 test rule under TSCA].
2,6-Dichlorophenol (CAS NO.87-65-0) is stable. It should avoid the condition like incompatible materials. It is not compatible with incompatible materials, acid chlorides, acid anhydrides. And also prevent it to broken down into hazardous decomposition products: hydrogen chloride, carbon monoxide, carbon dioxide. However, its hazardous polymerization will not occur.

Product Name

2,6-Dichlorophenol

Synthetic route

2,6-Dichlorophenol Chemical Properties

2,6-Dichlorophenol Uses

2,6-Dichlorophenol Production

2,6-Dichlorophenol Toxicity Data With Reference

2,6-Dichlorophenol Consensus Reports

2,6-Dichlorophenol Safety Profile

2,6-Dichlorophenol Specification

Related Products

Hot Products