1-Chloromethyl naphthalene supplier

Name
1-Chloromethyl naphthalene
EINECS 201-678-2
CAS No. 86-52-2
Article Data74
CAS DataBase
Density 1.167 g/cm³
Solubility Insoluble in water.
Melting Point 32 °C(lit.)
Formula C₁₁H₉Cl
Boiling Point 291.5 °C at 760 mmHg
Molecular Weight 176.645
Flash Point 129.9 °C
Transport Information UN 3261 8/PG 2
Appearance Solid
Safety 26-36/37/39-45-60-20-27
Risk Codes 21/22-34-36/37/38-36-20/21/22
Molecular Structure
Hazard Symbols C, Xn
Synonyms 1-(Chloromethyl)naphthalene;1-Naphthalenylmethyl chloride;1-Naphthalylmethyl chloride;1-Naphthylmethylchloride;a-(Chloromethyl)naphthalene;a-Naphthylmethyl chloride;
PSA 0.00000
LogP 3.57860

Synthetic route

: 4780-79-4
1-naphthalene methanol

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With thionyl chloride In toluene for 12h;	98%
With thionyl chloride In chloroform at 5 - 30℃;	98.4%
With pyridine; thionyl chloride In diethyl ether at -5 - 25℃; for 12h;	98%

: 33250-32-7
1-(dimethoxymethyl)naphthalene

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With triethylsilane; acetyl chloride; tin(ll) chloride In dichloromethane at 0℃; for 2h;	92%

: 5121-00-6
naphthalen-1-yl-acetyl chloride

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With bis(tri-ortho-tolylphosphine)palladium(0); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine In toluene at 130℃; for 20h; Inert atmosphere; Glovebox;	92%

: 4780-79-4
1-naphthalene methanol

: 98-07-7
Benzotrichlorid

A: 98-87-3
benzylidene dichloride

B: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With TOP; phenylsilane In neat (no solvent) at 100℃; for 24h; Appel Halogenation; Inert atmosphere;	A n/a B 81%

...Expand

: 113688-53-2
1-tributylstannyl-methylnaphthalene

A: 86-55-5
1-naphthalenecarboxylic acid

B: 4780-79-4
1-naphthalene methanol

C: 66-77-3
1-naphthaldehyde

D: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With C2H2Cl2F3O2V; oxygen In tert-butyl alcohol at 50℃; for 24h;	A 38% B n/a C 58% D n/a
With C2H2Cl2F3O2V; oxygen In tert-butyl alcohol at 50℃; for 24h;	A 28% B 5% C 58% D 4%

...Expand

: 50-00-0
formaldehyd

: 91-20-3
naphthalene

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With hydrogenchloride; phosphoric acid; acetic acid In water for 6h; Reflux;	56%
With hydrogenchloride; zinc(II) chloride; Petroleum ether
With hydrogenchloride at 60 - 65℃;

: 90-12-0
1-Methylnaphthalene

A: 17075-39-7
4-chloro-1-methyl-naphthalene

B: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With N-chloro-succinimide; barium(II) chloride at 102℃; under 2625.26 Torr; for 0.0666667h; Microwave irradiation; Darkness; chemoselective reaction;	A 45% B 18%
With aluminum oxide; iron(III) chloride Irradiation; Title compound not separated from byproducts;
With aluminum oxide; iron(III) chloride Irradiation; Title compound not separated from byproducts;

: 75-09-2
dichloromethane

: 61767-59-7
(naphthalene-1,8-diyl)dilithium

A: 91-20-3
naphthalene

B: 1233-36-9, 3960-21-2, 72597-92-3, 72597-93-4, 85248-67-5, 2633-10-5
1,1'-cis-ethene-1,2-diyl-bis-naphthalene

C: 1233-36-9
(E)-1,2-bis(1-naphthyl)ethene

D: 24973-91-9
1H-Cyclobutanaphthalene

E: 86-52-2
1-Chloromethylnaphthalene

F: 208-96-8
acenaphthylene

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine In diethyl ether at -100 - -60℃; Product distribution; Mechanism; var. of temp., further with CD2Cl2;	A 42% B n/a C n/a D 21% E n/a F n/a

...Expand

: 56-23-5
tetrachloromethane

: 90-12-0
1-Methylnaphthalene

A: 17180-26-6
bis-chloromethylnaphthalene

B: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
at 250℃; under 52505.3 Torr; for 7h; Inert atmosphere;	A 37% B 36%

...Expand

: 90-12-0
1-Methylnaphthalene

A: 17180-26-6
bis-chloromethylnaphthalene

B: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With tetrachloromethane at 250℃; for 7h; Inert atmosphere; Autoclave;	A 37% B 36%

: 90-12-0
1-Methylnaphthalene

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With N-chloro-succinimide; N-hydroxyphthalimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 80℃; for 3h; Time; Sealed tube; Inert atmosphere;	16%
With N-hydroxyphthalimide; carbon tetrabromide; trichloroisocyanuric acid; copper(II) acetate monohydrate In dichloromethane at 25℃; for 21h;	15%
With chlorine at 260℃;
With chlorine
With sodium hypochlorite; tetrabutyl-ammonium chloride In dichloromethane at 20℃; for 12h; Catalytic behavior; Inert atmosphere; Sealed tube;	20 %Chromat.

: 128-09-6
N-chloro-succinimide

: 90-12-0
1-Methylnaphthalene

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With chlorobenzene unter Einwirkung von UV-Licht;

: 91-20-3
naphthalene

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With hydrogenchloride; formaldehyd; arsenic trichloride
With hydrogenchloride; formaldehyd; arsenic(III) trioxide

: 91-20-3
naphthalene

: 107-30-2
chloromethyl methyl ether

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With acetic acid at 65℃;

: 91-20-3
naphthalene

: 98-59-9
p-toluenesulfonyl chloride

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With hydrogenchloride; formaldehyd; acetic acid

: 91-20-3
naphthalene

: 3188-13-4
ethyl chloromethyl ether

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With diethyl ether; tin(IV) chloride

: 91-20-3
naphthalene

: 7093-91-6
chloromethyl isocyanate

A: 191855-57-9
2-naphthylmethylisocyanate

B: 61924-27-4
1-isocyanatomethyl-naphthalene

C: 86-52-2
1-Chloromethylnaphthalene

D: 2506-41-4
1-chloromethylnaphthalene

Conditions

Conditions	Yield
With iron(III) chloride at 140 - 150℃; for 2h;	A 10 % Spectr. B 85 % Spectr. C n/a D n/a
With iron(III) chloride at 40 - 150℃; for 2h;	A 10 % Spectr. B 85 % Spectr. C n/a D n/a

...Expand

: 10378-55-9
1-(diazomethyl)naphthalene

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With 1,1,2-Trichloro-1,2,2-trifluoroethane Irradiation;

di-α-menaphthyl ether: di-α-menaphthyl ether

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With phosphorus pentachloride

N-α-menaphthyl-benzamide: N-α-menaphthyl-benzamide

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With phosphorus pentachloride Destillieren des Reaktionsgemisches im Vakuum;

N.N-di-α-menaphthyl-benzamide: N.N-di-α-menaphthyl-benzamide

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With phosphorus pentachloride Destillieren des Reaktionsgemisches im Vakuum;

: 50-00-0
formaldehyd

: 91-20-3
naphthalene

: 5435-44-9, 22243-66-9
(E)-3-Ureido-but-2-enoic acid ethyl ester

petroleum ether: petroleum ether

: 86-52-2
1-Chloromethylnaphthalene

...Expand

: 91-20-3
naphthalene

: 60-29-7
diethyl ether

: 3188-13-4
ethyl chloromethyl ether

tin (II)-chloride: tin (II)-chloride

: 86-52-2
1-Chloromethylnaphthalene

...Expand

: 7647-01-0
hydrogenchloride

: 50-00-0
formaldehyd

: 91-20-3
naphthalene

: 7732-18-5
water

A: 6586-89-6
1,4-bis(chloromethyl)naphthalene

B: 1733-76-2
1,5-bis(chloromethyl)naphthalene

C: 86-52-2
1-Chloromethylnaphthalene

...Expand

: 10026-13-8, 874483-75-7
phosphorus pentachloride

: 35310-62-4
bis(α-naphthylmethyl) ether

: 86-52-2
1-Chloromethylnaphthalene

: 4780-79-4
1-naphthalene methanol

A: 35310-62-4
bis(α-naphthylmethyl) ether

B: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With hydrogenchloride In water at 120℃; under 5171.62 Torr; for 0.25h; Flow reactor;	A n/a B 90 %Spectr.

: 1-phenyl-pent-4-yn-2-ol

A: 24471-54-3
(naphtalen-1-yl)methyl iodide

B: 4-(iodomethylene)-1,2,3,4-tetrahydronaphthalen-2-ol

C: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
With Iodine monochloride In dichloromethane at 20℃; Inert atmosphere;

...Expand

: 86-87-3
naphth-1-yl acetic acid

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride; N,N-dimethyl-formamide / 4 h 2: bis(tri-ortho-tolylphosphine)palladium(0); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine / toluene / 20 h / 130 °C / Inert atmosphere; Glovebox View Scheme

: 66-77-3
1-naphthaldehyde

: 86-52-2
1-Chloromethylnaphthalene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / ethanol / 0.5 h / 0 °C 2: pyridine; thionyl chloride / diethyl ether / 12 h / -5 - 25 °C View Scheme

: 86-52-2
1-Chloromethylnaphthalene

: 122-52-1
triethyl phosphite

: 53575-08-9
diethyl 1-naphthylmethylphosphonate

Conditions

Conditions	Yield
at 160℃; for 7h; Reflux;	100%
at 150℃;

: 14062-91-0
(N-benzoyl-anilino)-phenyl-acetonitrile

: 86-52-2
1-Chloromethylnaphthalene

: 72867-71-1
N-(1-Cyano-2-naphthalen-1-yl-1-phenyl-ethyl)-N-phenyl-benzamide

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 96h;	100%

: 139157-65-6, 139157-66-7
2-<(tetrahydrofur-2-yl)methyl>propanedionate de dimethyle

: 86-52-2
1-Chloromethylnaphthalene

: 139157-68-9
2-<(naphth-1-yl)methyl>-2-<(tetrahydrofur-2-yl)methyl>propanedioate de dimethyle

Conditions

Conditions	Yield
With sodium methylate; carbonic acid dimethyl ester for 42h; Heating;	100%

: 139157-65-6, 139157-66-7
2-<(tetrahydrofur-2-yl)methyl>propanedionate de dimethyle

: 86-52-2
1-Chloromethylnaphthalene

: 139157-67-8
2-<(naphth-1-yl)methyl>-2-<(tetrahydrofur-2-yl)methyl>propanedioate de dimethyle

Conditions

Conditions	Yield
With sodium methylate; carbonic acid dimethyl ester for 42h; Heating;	100%

: 439694-11-8
O,O',O''-((2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)tris(1-mercaptopropane-3,2-diyl))tris(benzylcarbamothioate)

: 1072-43-1
propylene sulphide

: 86-52-2
1-Chloromethylnaphthalene

polymer, three-armed star-shaped, Mn 11900 Da, Mw/Mn 1.14; monomer(s): 1,3,5-tri[2-(benzylaminothiocarbonyloxy)-3-mercaptopropyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; propylene sulfide; 1-(chloromethyl)naphthalene: polymer, three-armed star-shaped, Mn 11900 Da, Mw/Mn 1.14; monomer(s): 1,3,5-tri[2-(benzylaminothiocarbonyloxy)-3-mercaptopropyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; propylene sulfide; 1-(chloromethyl)naphthalene

Conditions

Conditions	Yield
Stage #1: O,O',O''-((2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)tris(1-mercaptopropane-3,2-diyl))tris(benzylcarbamothioate) With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at -78℃; for 0.5h; Stage #2: propylene sulphide In N,N-dimethyl-formamide at 0℃; for 2h; Stage #3: 1-Chloromethylnaphthalene With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;	100%

...Expand

: 439694-11-8
O,O',O''-((2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)tris(1-mercaptopropane-3,2-diyl))tris(benzylcarbamothioate)

: 1072-43-1
propylene sulphide

: 86-52-2
1-Chloromethylnaphthalene

polymer, three-armed star-shaped, Mn 15500 Da, Mw/Mn 1.17; monomer(s): 1,3,5-tri[2-(benzylaminothiocarbonyloxy)-3-mercaptopropyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; propylene sulfide; 1-(chloromethyl)naphthalene: polymer, three-armed star-shaped, Mn 15500 Da, Mw/Mn 1.17; monomer(s): 1,3,5-tri[2-(benzylaminothiocarbonyloxy)-3-mercaptopropyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; propylene sulfide; 1-(chloromethyl)naphthalene

Conditions

Conditions	Yield
Stage #1: O,O',O''-((2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)tris(1-mercaptopropane-3,2-diyl))tris(benzylcarbamothioate) With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at -78℃; for 0.5h; Stage #2: propylene sulphide In N,N-dimethyl-formamide at 0℃; for 2h; Stage #3: 1-Chloromethylnaphthalene With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;	100%

...Expand

: 15715-41-0
methyldiethoxyphosphine

: 86-52-2
1-Chloromethylnaphthalene

: 936366-26-6
C14H17O2P

Conditions

Conditions	Yield
for 2.5h; Heating;	100%

: 86-52-2
1-Chloromethylnaphthalene

: 685127-04-2
C22H24N2O

Conditions

Conditions	Yield
Stage #1: N-tert-butyl-3-methylpyridine-2-carboxamide With n-butyllithium; sodium bromide In tetrahydrofuran; hexane at -40℃; for 0.5h; Stage #2: 1-Chloromethylnaphthalene In tetrahydrofuran; hexane at -40℃; for 1.5h;	100%

: 100-01-6
4-nitro-aniline

: 86-52-2
1-Chloromethylnaphthalene

: 1032373-74-2
bis(naphthalen-1-ylmethyl)(4-nitrophenyl)amine

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere;	100%

: 100-02-7
4-nitro-phenol

: 86-52-2
1-Chloromethylnaphthalene

: 115720-21-3
1-(4-nitrophenoxymethyl)naphthalene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h;	99.1%

: 86-52-2
1-Chloromethylnaphthalene

: 15374-45-5
1,2-di(1-naphthyl)ethane

Conditions

Conditions	Yield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; zinc In tetrahydrofuran at 23 - 25℃; for 5h; Irradiation; Inert atmosphere;	99%
With magnesium In tetrahydrofuran at 20℃; for 2.5h; Reflux;	96%
With copper(I) bromide In water at 20℃; for 0.416667h; under air;	88%

: 86-52-2
1-Chloromethylnaphthalene

: 55210-79-2
1-(azidomethyl)naphthalene

Conditions

Conditions	Yield
With sodium azide In acetonitrile for 16h; Reflux;	99%
With sodium azide In dimethyl sulfoxide	91%
With sodium azide In dimethyl sulfoxide	91%

: 86-52-2
1-Chloromethylnaphthalene

: N-(4-biphenylcarbonyl)-5-aminofluorescein

: 3'-O-(1-naphthyl)methyl-5-aminofluorescein

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 4h; Ambient temperature;	99%

: 288-32-4
1H-imidazole

: 86-52-2
1-Chloromethylnaphthalene

: 72459-37-1
1-(naphthalen-1-ylmethyl)-1H-imidazole

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran Heating;	99%
With potassium carbonate In acetonitrile Reflux;	90%
Stage #1: 1H-imidazole With sodium hydride In 1,2-dimethoxyethane at 0℃; for 0.75h; Stage #2: 1-Chloromethylnaphthalene In 1,2-dimethoxyethane at 20℃; for 4h; Further stages.;
In dichloromethane
Stage #1: 1H-imidazole With sodium hydride In 1,4-dioxane at 90℃; for 1h; Stage #2: 1-Chloromethylnaphthalene In 1,4-dioxane at 90℃; for 22h;

: 439694-11-8
O,O',O''-((2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)tris(1-mercaptopropane-3,2-diyl))tris(benzylcarbamothioate)

: 1072-43-1
propylene sulphide

: 86-52-2
1-Chloromethylnaphthalene

polymer, three-armed star-shaped, Mn 8500 Da, Mw/Mn 1.06; monomer(s): 1,3,5-tri[2-(benzylaminothiocarbonyloxy)-3-mercaptopropyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; propylene sulfide; 1-(chloromethyl)naphthalene: polymer, three-armed star-shaped, Mn 8500 Da, Mw/Mn 1.06; monomer(s): 1,3,5-tri[2-(benzylaminothiocarbonyloxy)-3-mercaptopropyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; propylene sulfide; 1-(chloromethyl)naphthalene

Conditions

Conditions	Yield
Stage #1: O,O',O''-((2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)tris(1-mercaptopropane-3,2-diyl))tris(benzylcarbamothioate) With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at -78℃; for 0.5h; Stage #2: propylene sulphide In N,N-dimethyl-formamide at 0℃; for 2h; Stage #3: 1-Chloromethylnaphthalene With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;	99%

...Expand

: 1074-82-4
potassium phtalimide

: 86-52-2
1-Chloromethylnaphthalene

: 6968-09-8
2-[(1-naphthyl)methyl]-1H-isoindole-1,3(2H)-dione

Conditions

Conditions	Yield
In DMF (N,N-dimethyl-formamide) at 100℃;	99%
In N,N-dimethyl-formamide	99%
In N,N-dimethyl-formamide at 20℃; for 10h; Inert atmosphere;

: 86-52-2
1-Chloromethylnaphthalene

: 4407-36-7
(2E)-3-phenyl-2-propen-1-ol

: 98977-56-1
(E)-3-phenyl-2-propenyl 1-naphthylmethyl ether

Conditions

Conditions	Yield
Stage #1: (2E)-3-phenyl-2-propen-1-ol With tetra-(n-butyl)ammonium iodide; sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h; Stage #2: 1-Chloromethylnaphthalene In tetrahydrofuran at 20℃; for 24h;	99%

: 1353761-69-9
(S)-4-benzyl-1-(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazole

: 86-52-2
1-Chloromethylnaphthalene

: 1450713-41-3
(S)-4-benzyl-1-(2,6-diisopropylphenyl)-3-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazol-3-ium chloride

Conditions

Conditions	Yield
In acetonitrile at 110℃; for 5h;	99%

: 617-84-5
N-formyldiethylamine

: 86-52-2
1-Chloromethylnaphthalene

: 35693-45-9
1-<(N,N-diethylamino)methyl>naphthalene

Conditions

Conditions	Yield
With NHC-Pd(II)-Im; sodium hydroxide In water at 50℃; for 3h; Inert atmosphere; Schlenk technique;	99%
With potassium hydroxide In water at 50℃; for 3h; Green chemistry;	85%

: 541-16-2
t-butyl malonate

: 86-52-2
1-Chloromethylnaphthalene

: 188822-17-5
di-t-butyl (1-naphthylmethyl)malonate

Conditions

Conditions	Yield
In tetrahydrofuran; ethyl acetate	98.4%

: 603-35-0
triphenylphosphine

: 86-52-2
1-Chloromethylnaphthalene

: 23277-00-1
1-naphthylmethyltriphenylphosphonium chloride

Conditions

Conditions	Yield
In toluene Reflux;	98%
In acetonitrile for 8h; Heating;	94%
In N,N-dimethyl-formamide for 5h; Heating;	91%

: 86-52-2
1-Chloromethylnaphthalene

: 75-50-3
trimethylamine

: 1930-16-1
N,N,N-trimethyl-1-(naphthalene-1-yl)methanaminium chloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60℃; for 12h;	98%
In ethanol	80%

: 86-52-2
1-Chloromethylnaphthalene

: 118-31-0
(naphth-1-yl)methylamine

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; ammonium hydroxide In PEG1000-DIL; methyl cyclohexane at 60℃; for 3h;	98%
With ammonia fluess. Ammoniak;
With hydrogenchloride; hexamethylenetetramine 1) CH2Cl2, 12 h, 2) ethanol; Yield given. Multistep reaction;
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 10 h / 20 °C / Inert atmosphere 2: hydrazine hydrate / ethanol / 4 h / Inert atmosphere; Reflux View Scheme

: 86-52-2
1-Chloromethylnaphthalene

: 90-12-0
1-Methylnaphthalene

Conditions

Conditions	Yield
With potassium formate; PdCl22 In benzene at 60℃; for 4h;	98%
With potassium formate; PdCl22 In benzene at 60℃; for 4h; Product distribution; further catalyst, reagent; solid or aqueous solution of reagent;	98%
With sodium tetrahydroborate; water In methanol at 20℃; for 0.333333h;	94%

: 439694-11-8
O,O',O''-((2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)tris(1-mercaptopropane-3,2-diyl))tris(benzylcarbamothioate)

: 1072-43-1
propylene sulphide

: 86-52-2
1-Chloromethylnaphthalene

polymer, three-armed star-shaped, Mn 5700 Da, Mw/Mn 1.10; monomer(s): 1,3,5-tri[2-(benzylaminothiocarbonyloxy)-3-mercaptopropyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; propylene sulfide; 1-(chloromethyl)naphthalene: polymer, three-armed star-shaped, Mn 5700 Da, Mw/Mn 1.10; monomer(s): 1,3,5-tri[2-(benzylaminothiocarbonyloxy)-3-mercaptopropyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; propylene sulfide; 1-(chloromethyl)naphthalene

Conditions

Conditions	Yield
Stage #1: O,O',O''-((2,4,6-trioxo-1,3,5-triazinane-1,3,5-triyl)tris(1-mercaptopropane-3,2-diyl))tris(benzylcarbamothioate) With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at -78℃; for 0.5h; Stage #2: propylene sulphide In N,N-dimethyl-formamide at 0℃; for 2h; Stage #3: 1-Chloromethylnaphthalene With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;	98%

...Expand

: 86-52-2
1-Chloromethylnaphthalene

: 121-88-0
2-Amino-5-nitrophenol

: 930797-61-8
2-(α-naphthylmethoxy)-4-nitroaniline

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	98%

: 22323-82-6
(S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol

: 86-52-2
1-Chloromethylnaphthalene

: 868635-31-8
(R)-1-O-(1-naphthylmethyl)glycerol

Conditions

Conditions	Yield
Stage #1: (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol; 1-Chloromethylnaphthalene With potassium hydroxide In 1,4-dioxane; toluene for 2h; Heating; Stage #2: With acetic acid at 20℃; for 6h; Further stages.;	98%
Stage #1: (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol; 1-Chloromethylnaphthalene With potassium hydroxide In 1,4-dioxane; toluene at 120℃; for 2h; Stage #2: With water; acetic acid at 20℃; for 6h;	98%

: 75-15-0
carbon disulfide

: 107-11-9
1-amino-2-propene

: 86-52-2
1-Chloromethylnaphthalene

: 1448156-38-4
2-(naphthalen-1-yl)methyl N-allylcarbamodithioate

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; for 3h;	98%

...Expand

: 4394-85-8
4-morpholinecarboxaldehyde

: 86-52-2
1-Chloromethylnaphthalene

: 2862-82-0
4-(naphthalene-1-ylmethyl)morpholine

Conditions

Conditions	Yield
With NHC-Pd(II)-Im; sodium hydroxide In water at 50℃; for 3h; Inert atmosphere; Schlenk technique;	98%
With potassium hydroxide In water at 80℃; for 3h; Temperature; Green chemistry;	87%

1-Chloromethyl naphthalene Chemical Properties

Molecular Structure of 1-Chloromethyl naphthalene (CAS NO.86-52-2):

IUPAC Name: 1-(chloromethyl)naphthalene
Empirical Formula: C₁₁H₉Cl
Molecular Weight: 176.6422
H bond acceptors: 0
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 0Å²
Index of Refraction: 1.63
Molar Refractivity: 53.86 cm³
Molar Volume: 151.2 cm³
Surface Tension: 42.5 dyne/cm
Density: 1.167 g/cm³
Flash Point: 129.9 °C
Enthalpy of Vaporization: 50.97 kJ/mol
Boiling Point: 291.5 °C at 760 mmHg
Vapour Pressure: 0.00339 mmHg at 25°C
EINECS: 201-678-2
Melting point: 32 °C(lit.)
Storage temp: Refrigerator
InChI
InChI=1/C11H9Cl/c12-8-10-6-3-5-9-4-1-2-7-11(9)10/h1-7H,8H2
Smiles
c12c(cccc1CCl)cccc2
Product Categories: Naphthalene derivatives; API intermediates; Naphthalene series

1-Chloromethyl naphthalene Toxicity Data With Reference

1.		orl-rat LD50:890 mg/kg		IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. 6 (1967),1.
2.		skn-rbt LD50:2000 mg/kg		IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. 6 (1967),1.

1-Chloromethyl naphthalene Consensus Reports

Reported in EPA TSCA Inventory.

1-Chloromethyl naphthalene Safety Profile

Moderately toxic by ingestion and skin contact. See also CHLORINATED HYDROCARBONS, AROMATIC. Combustible when exposed to heat or flame. To fight fire, use dry chemical, spray or mist, CO₂. When heated to decomposition it emits toxic fumes of Cl⁻.
The Hazard Codes of 1-Chloromethyl naphthalene (CAS NO.86-52-2): C, Xn
HazardClass: 8
The Risk Statements information:
34: Causes burns
20/21: Harmful by inhalation and in contact with skin
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information:
20: When using, do not eat or drink
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
60: This material and/or its container must be disposed of as hazardous waste
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR: UN 3261 8/PG 2
WGK Germany: 3

1-Chloromethyl naphthalene Specification

1-Chloromethyl naphthalene , with CAS number of 86-52-2, can be called 1-(Chloromethyl)naphthalene ; 1-Naphthalenylmethyl chloride ; 1-Naphthylmethylchloride ; a-Naphthylmethyl chloride .

Product Name

1-Chloromethyl naphthalene

Synthetic route

1-Chloromethyl naphthalene Chemical Properties

1-Chloromethyl naphthalene Toxicity Data With Reference

1-Chloromethyl naphthalene Consensus Reports

1-Chloromethyl naphthalene Safety Profile

1-Chloromethyl naphthalene Specification

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