3-Bromochlorobenzene supplier

Name
1 -Bromo-3-chloro benzene
EINECS 203-575-8
CAS No. 108-37-2
Article Data54
CAS DataBase
Density 1.628 g/cm³
Solubility insoluble in water
Melting Point -21.5 °C
Formula C₆H₄BrCl
Boiling Point 194.7 °C at 760 mmHg
Molecular Weight 191.455
Flash Point 80.6 °C
Transport Information
Appearance Clear colourless to light yellow liquid
Safety 26-36-37/39
Risk Codes 36/37/38-20/22
Molecular Structure
Hazard Symbols Xn; Xi
Synonyms 1-Bromo-3-chlorobenzene;1-Chloro-3-bromobenzene;3-Bromo-1-chlorobenzene;3-Bromophenyl chloride;3-Chloro-1-bromobenzene;3-Chlorobromobenzene;3-Chlorophenyl bromide;NSC 53548;m-Bromochlorobenzene;m-Bromophenyl chloride;m-Chlorobromobenzene;
PSA 0.00000
LogP 3.10250

Synthetic route

: 456-39-3
3-chlorobenzenediazonium tetrafluoroborate

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With dibenzo-18-crown-6; potassium bromide; copper(ll) bromide; 1,10-Phenanthroline; copper(I) bromide In acetonitrile at 20℃; for 0.333333h; Sandmeyer bromination;	99%

: 31928-47-9
4-bromo-2-chloroiodobenzene

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With [Ir(2-phenylpyridine)-2-(4,4’-di-tert-butyl-2,2’-bipyridine)]PF6; N-ethyl-N,N-diisopropylamine In acetonitrile at 25℃; for 1.5h; Irradiation;	92%

: 1416277-01-4
(3-chlorophenyl)(mesityl)iodonium trifluoromethanesulfonate

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With copper(I) bromide In acetonitrile at 80℃; for 2h;	92%

: 3-bromo-benzenediazonium; tetrachloro cuprate(II)

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
In dimethyl sulfoxide Ambient temperature;	90%

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With boron tribromide; dimethyl sulfoxide at 80℃; for 1h;	90%

: C6H4ClN2(1+)*C6H4NO4S2(1-)

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With tetrabutylammomium bromide In acetonitrile at 60℃; for 0.75h; Substitution;	75%
With tetrabutylammomium bromide; copper In acetonitrile at 20℃; for 0.75h; Substitution;	71%

: 3-bromobenzenediazonium o-benzenedisulfonimide

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; copper In acetonitrile at 20℃; Substitution;	74%

: 63503-60-6
3-chlorophenylboronic acid

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With N-Bromosuccinimide In acetonitrile at 81℃; for 8h;	59%

: 108-90-7
chlorobenzene

A: 106-39-8
bromochlorobenzene

B: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With bromine trifluoride; bromine at 0 - 10℃;	A 25% B 5%

: 635305-47-4
2-(3-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With copper(ll) bromide In methanol Heating;	24%

: 59748-90-2
4-Bromo-2-chloro-benzoic Acid

: 1344681-59-9
5-bromo-3-chloro-3',5'-dimethyl-[1,1'-biphenyl]-2-carboxylic acid

A: 108-37-2
1-bromo-3-chlorobenzene

B: 1344681-53-3
3-bromo-5-chloro-3',5'-dimethyl-1,1'-biphenyl

Conditions

Conditions	Yield
With silver carbonate In dimethyl sulfoxide at 120℃; for 4h;	A 18% B 5%

...Expand

: 108-86-1
bromobenzene

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With thallium chloride at 100℃; durch Chlorieren;

: 17333-84-5
3-chlorobenzenediazonium

: 108-37-2
1-bromo-3-chlorobenzene

: 585-79-5
3-Bromonitrobenzene

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With tetrachloromethane at 270℃;

: 108-42-9
3-chloro-aniline

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid at 5 - 10℃; Einleiten von N2O3 und anschliessendes Erhitzen;
Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuBr und HBr;
Stage #1: 3-chloro-aniline With hydrogen bromide; sodium nitrite In water at 0 - 5℃; Stage #2: With hydrogen bromide; copper(I) bromide In water

: 103-84-4
Acetanilid

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
durch sukzessive Chlorierung, Bromierung, Verseifung und Behandlung mit Aethylnitrit;

: 591-19-5
3-bromoaniline

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl;

: 56961-77-4
1-bromo-2,3-dichlorobenzene

A: 108-37-2
1-bromo-3-chlorobenzene

B: 95-50-1
1,2-dichloro-benzene

Conditions

Conditions	Yield
With hexane at 25℃; for 4h; Irradiation; relative rate of dehalogenation, other polyhalobenzenes;

: 873-38-1
4-chloro-2-bromoaniline

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With tetrafluoroboric acid; N,N-dimethyl-formamide; sodium nitrite 1) water, 0 deg C, 2 h, 2) 40 deg C, 30 min; Yield given. Multistep reaction;

: 541-73-1
1,3-Dichlorobenzene

A: 108-37-2
1-bromo-3-chlorobenzene

B: 108-36-1
1,3-dibromobenzene

Conditions

Conditions	Yield
With bromobenzene; Cu-HZSM-5 zeolite at 399.9℃; Mechanism; Product distribution;	A 11.6 % Chromat. B 3.2 % Chromat.

: 14862-52-3
1,3-dibromo-5-chlorobenzene

: 71-43-2
benzene

A: 108-37-2
1-bromo-3-chlorobenzene

B: 2051-61-8
m-chlorobiphenyl

C: 126866-35-1
3-bromo-5-chloro-1,1’-biphenyl

D: 5′-chloro-1,1′:3′,1″-terphenyl

Conditions

Conditions	Yield
at 25℃; for 20h;	A 1.0 % Chromat. B 30.3 % Chromat. C 25.2 % Chromat. D 36.1 % Chromat.

...Expand

: 3460-24-0
1,4-dibromo-2-chlorobenzene

: 71-43-2
benzene

A: 108-37-2
1-bromo-3-chlorobenzene

B: 92-66-0
4-bromo-1,1'-biphenyl

C: 91354-08-4
4-bromo-3-chloro-1,1'-biphenyl

D: 58775-86-3
2-chloro-4-bromobiphenyl

Conditions

Conditions	Yield
at 25℃; for 20h;	A 2.7 % Chromat. B 8.2 % Chromat. C 4.3 % Chromat. D 17.1 % Chromat.

...Expand

: 937-14-4
3-chloro-benzenecarboperoxoic acid

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With Bromotrichloromethane; cyclohexane In 1,2-dichloro-ethane at 65℃; for 24h; Product distribution; Mechanism;

: 7726-95-6
bromine

: 108-90-7
chlorobenzene

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
at 475℃;

3-chloro-phenyl-mercury acetate: 3-chloro-phenyl-mercury acetate

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With bromine; acetic acid

diazotized m-chloro-aniline: diazotized m-chloro-aniline

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With hydrogen bromide Behandlung mit CuBr;

m-bromo-benzenediazonium chloroplatinate: m-bromo-benzenediazonium chloroplatinate

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With sodium carbonate

silver-<3-chloro benzoate>: silver-<3-chloro benzoate>

: 108-37-2
1-bromo-3-chlorobenzene

Conditions

Conditions	Yield
With tetrachloromethane; bromine

: 108-90-7
chlorobenzene

A: 108-37-2
1-bromo-3-chlorobenzene

B 2-chloro-1-bromo-benzene; 4-chloro-1-bromo-benzene: 2-chloro-1-bromo-benzene; 4-chloro-1-bromo-benzene

Conditions

Conditions	Yield
With bromine at 475℃;

: 108-37-2
1-bromo-3-chlorobenzene

: 124-38-9
carbon dioxide

: 93224-85-2
2-bromo-6-chlorobenzoic acid

Conditions

Conditions	Yield
Stage #1: 1-bromo-3-chlorobenzene With lithium diisopropyl amide In tetrahydrofuran at -78℃; Stage #2: carbon dioxide In tetrahydrofuran at -78 - 20℃; for 2h;	100%
With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -75℃; for 2h;	94%
Stage #1: 1-bromo-3-chlorobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexanes at -78℃; for 2h; Stage #2: carbon dioxide In tetrahydrofuran; hexanes for 0.25h; Stage #3: With hydrogenchloride In tetrahydrofuran; hexanes; water Product distribution / selectivity;	85%
Stage #1: 1-bromo-3-chlorobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1.5h; Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78℃; for 0.333333h; Stage #3: With hydrogenchloride; water In tetrahydrofuran; hexane
Stage #1: 1-bromo-3-chlorobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75℃; for 4h; Inert atmosphere; Stage #2: carbon dioxide In tetrahydrofuran at -70 - 20℃; for 5.5h; Inert atmosphere;

: 108-37-2
1-bromo-3-chlorobenzene

: 141-32-2
acrylic acid n-butyl ester

: 131061-13-7
3-chloro-trans-cinnamic acid n-butyl ester

Conditions

Conditions	Yield
With potassium carbonate; bis(dibenzylideneacetone)-palladium(0); 3-(2,6-diisopropylphenyl)-1-(2-diphenylphosphanylbenzyl)-3H-imidazol-1-ium chloride In N,N-dimethyl acetamide at 120℃; for 5h; Heck reaction;	100%
With tetrabutylammonium acetate; palladium diacetate at 100℃; for 0.5h; Heck reaction; Air atmosphere; Ionic liquid; chemoselective reaction;

: 108-37-2
1-bromo-3-chlorobenzene

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 186790-11-4
tert-butyl 4-(3-chlorophenyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 1-bromo-3-chlorobenzene; 1-t-Butoxycarbonylpiperazine With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate In xylene at 50℃; Stage #2: With macroporous polymer-supported isocyanate In xylene at 50℃; for 24h;	100%
With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 100℃;	83%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; XPhos In 1,4-dioxane at 95℃; for 2h; Inert atmosphere;	61.2%
With bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate; DavePhos
With tris-(dibenzylideneacetone)dipalladium(0); potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 16h; Inert atmosphere; Heating;	1.5 g

: 108-37-2
1-bromo-3-chlorobenzene

: 108-43-0
3-monochlorophenol

Conditions

Conditions	Yield
With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos In 1,4-dioxane; water at 100℃; for 1h;	99%
Multi-step reaction with 2 steps 1: copper dichloride; potassium carbonate / 20 h / 130 °C / Inert atmosphere; Schlenk technique 2: potassium hydroxide / dimethyl sulfoxide / 3 h / 100 °C / Schlenk technique View Scheme
Multi-step reaction with 2 steps 1: fac-tris(2-phenylpyridinato-N,C2')iridium(III); tributyl-amine; water / acetonitrile / 36 h / 25 °C / Schlenk technique; Inert atmosphere; Sealed tube; Irradiation 2: air / 16 h / 25 °C / Inert atmosphere View Scheme
With copper(l) iodide; C20H20N4O4; caesium carbonate; Benzaldoxime In dimethyl sulfoxide at 80℃; for 18h; Inert atmosphere; Glovebox;

: 108-37-2
1-bromo-3-chlorobenzene

: 107-31-3
Methyl formate

: 2845-89-8
1-chloro-3-methoxy-benzene

Conditions

Conditions	Yield
With copper(I) bromide In methanol; sodium methylate	99%

: 108-37-2
1-bromo-3-chlorobenzene

: 24424-99-5
di-tert-butyl dicarbonate

: 16537-17-0
3-chlorobenzoic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: 1-bromo-3-chlorobenzene With n-butyllithium; butyl magnesium bromide In tetrahydrofuran; hexane; toluene at -10℃; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; hexane; toluene at -10℃; Stage #3: With citric acid In tetrahydrofuran; hexane; toluene Further stages.;	99%
Stage #1: 1-bromo-3-chlorobenzene With n-butyllithium; butyl magnesium bromide In tetrahydrofuran; hexane; toluene at -10℃; for 1h; Inert atmosphere; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; hexane; toluene at -10℃; for 2h; Inert atmosphere;	99%
Stage #1: 1-bromo-3-chlorobenzene With n-hexyllithium In 2-methyltetrahydrofuran; hexane at 0℃; for 0.000194444h; Flow reactor; Stage #2: di-tert-butyl dicarbonate In 2-methyltetrahydrofuran; hexane at 0℃; for 0.00475h; Flow reactor;	50%

: 108-37-2
1-bromo-3-chlorobenzene

: 201230-82-2
carbon monoxide

: 62-53-3
aniline

: 6832-92-4
3-chloro-N-phenylbenzamide

Conditions

Conditions	Yield
With palladium diacetate; sodium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 80℃; under 760.051 Torr; for 15h;	99%

...Expand

: 108-37-2
1-bromo-3-chlorobenzene

: 1358787-39-9
C17H16N4O

: 1358787-91-3
C23H19ClN4O

Conditions

Conditions	Yield
With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 80℃;	99%

: 108-37-2
1-bromo-3-chlorobenzene

: 201230-82-2
carbon monoxide

: 100-46-9
benzylamine

: 82082-49-3
N-benzyl-(3-chloro)benzamide

Conditions

Conditions	Yield
With triethylamine In toluene at 70℃; under 760.051 Torr; for 7h; Catalytic behavior;	99%

...Expand

: 108-37-2
1-bromo-3-chlorobenzene

: 86-74-8
9H-carbazole

: 19222-81-2
9-(3-chlorophenyl)-9H-carbazole

Conditions

Conditions	Yield
Stage #1: 9H-carbazole With methylmagnesium chloride In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene at 5 - 20℃; for 0.166667h; Inert atmosphere; Stage #2: 1-bromo-3-chlorobenzene With PdCl(π-allyl)(cyclohexyl-(1-methyl-2,2-diphenylcyclopropylphophine)) In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene at 108 - 112℃; for 2h; Inert atmosphere;	99%
Stage #1: 9H-carbazole With methylmagnesium chloride In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene at 5 - 20℃; for 0.333333h; Inert atmosphere; Stage #2: 1-bromo-3-chlorobenzene With di-tert-butyl(2,2-diphenyl-1-methyl-1-cyclopropyl)phosphine; bis(η3-allyl-μ-chloropalladium(II)) In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene at 110℃; for 1h;	98.5%
With bis(di-tert-butyl(2-butenyl)phosphine)dichloropalladium; sodium t-butanolate In o-xylene at 135℃; for 9h; Reagent/catalyst; Inert atmosphere;	95%

: 108-37-2
1-bromo-3-chlorobenzene

A: 108-90-7
chlorobenzene

B: 71-43-2
benzene

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In 1,2-dimethoxyethane at 35℃; for 4h; ultrasonic acceleration of reduction;	A 98% B n/a

: 108-37-2
1-bromo-3-chlorobenzene

: 98-80-6
phenylboronic acid

: 2051-61-8
m-chlorobiphenyl

Conditions

Conditions	Yield
With 3,5-di-tert-butyl-2-hydroxybenzaldehyde; potassium carbonate; palladium dichloride In ethanol; water at 20℃; for 2h; Suzuki-Miyaura Coupling;	98%
With (BeDABCO)2Pd2Cl6; potassium carbonate In ethanol at 20℃; for 0.0166667h; Suzuki-Miyaura Coupling;	97%
With potassium phosphate; tetraphosphine N,N,N′,N′-tetra(diphenylphosphinomethyl)-pyridine-2,6-diamine; palladium dichloride In o-xylene at 90℃; for 2h; Concentration; Time; Temperature; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;	97%

: 108-37-2
1-bromo-3-chlorobenzene

: 74-89-5
methylamine

: 7006-52-2
3-chloro-N-methylaniline

Conditions

Conditions	Yield
With copper In water at 100℃; for 12h; Ullmann reaction;	98%

: 108-37-2
1-bromo-3-chlorobenzene

: 960-16-7
tributylphenylstannane

: 2051-61-8
m-chlorobiphenyl

Conditions

Conditions	Yield
With 2C13H19N2(1+)*Cl6Pd2(2+); cesium fluoride In N,N-dimethyl-formamide at 120℃; for 0.0166667h; Stille Cross Coupling; Microwave irradiation;	98%
With [Pd{C6H2-(CH2CH2NH2)-(OMe)2-3,4}Br(PPh3)]; potassium carbonate In N,N-dimethyl-formamide at 90℃; for 0.0333333h; Stille coupling; Microwave irradiation; chemoselective reaction;	92%
With [Pd{C6H4(CH2N(CH2Ph)2)}(μ-Br)]2; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 0.0666667h; Stille coupling; Microwave irradiation; chemoselective reaction;	90%
With dmap; palladium dichloride for 0.333333h; Stille Cross Coupling; Microwave irradiation;	61%

: 288-32-4
1H-imidazole

: 108-37-2
1-bromo-3-chlorobenzene

: 51581-52-3
1-(3-chlorophenyl)-1H-imidazole

Conditions

Conditions	Yield
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 120℃; for 48h; Inert atmosphere;	98%

: 108-37-2
1-bromo-3-chlorobenzene

: 1873-88-7
1,1,1,3,5,5,5-heptamethyltrisiloxan

: 3-(3-bromo-5-chlorophenyl)-1,1,1,3,5,5,5-heptamethyltrisiloxane

Conditions

Conditions	Yield
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 2.9-dimethyl-1,10-phenanthroline In 1,4-dioxane at 100℃; for 24h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; Sealed tube; regioselective reaction;	98%

: 292638-84-7
styrene

: 108-37-2
1-bromo-3-chlorobenzene

: 100-47-0
benzonitrile

: 21923-40-0
6-chloro-2,4-diphenylquinoline

Conditions

Conditions	Yield
With N-n-butyl-N-methylpiperidine bis(trifluoromethanesulfonyl)imide salt; acetylferrocene; H2SiEt2 at 60℃; for 8h; Reagent/catalyst;	97.9%

...Expand

: 108-37-2
1-bromo-3-chlorobenzene

: 383-63-1
ethyl trifluoroacetate,

: 321-31-3
1-(3-chlorophenyl)-2,2,2-trifluoroethanone

Conditions

Conditions	Yield
Stage #1: 1-bromo-3-chlorobenzene With n-butyllithium In tetrahydrofuran at -78 - -50℃; for 1h; Stage #2: ethyl trifluoroacetate, In tetrahydrofuran at -78 - 20℃; Reagent/catalyst; Solvent; Temperature;	97.3%
Stage #1: 1-bromo-3-chlorobenzene With magnesium In diethyl ether Inert atmosphere; Stage #2: ethyl trifluoroacetate, In diethyl ether at -78 - -50℃; for 3.5h; Inert atmosphere;

: 67-56-1
methanol

: 108-37-2
1-bromo-3-chlorobenzene

: 201230-82-2
carbon monoxide

: 2905-65-9
methyl 3-chlorobenzoate

Conditions

Conditions	Yield
With benzophenone; sodium methylate; cobalt(II) acetate at 40℃; under 750.075 Torr; for 15h; Irradiation;	97%
With sodium methylate; C2H5OOCCH2Co(CO)4 In diethyl ether at 25 - 35℃;	78%

...Expand

: 292638-84-7
styrene

: 108-37-2
1-bromo-3-chlorobenzene

: 14064-43-8
(E)-3-chlorostilbene

Conditions

Conditions	Yield
With potassium carbonate In methanol; water at 45℃; for 6h; Catalytic behavior; Heck Reaction; Green chemistry; stereoselective reaction;	97%
With CF3O3S(1-)*C52H46NO2P2Pd(1+); potassium carbonate In 1-methyl-pyrrolidin-2-one at 130℃; for 0.1h; Heck cross-coupling reaction; In air; Microwave irradiation; chemoselective reaction;	96%
With triethylamine In N,N-dimethyl-formamide for 0.233333h; Sonication;	95%

: 108-37-2
1-bromo-3-chlorobenzene

: 6819-41-6
sodium n-propoxide

: 51241-31-7
1-chloro-3-propoxybenzene

Conditions

Conditions	Yield
With propyl methanoate; lithium chloride; copper(I) bromide In propan-1-ol at 110℃; for 4h; Sealed tube;	97%

: 108-37-2
1-bromo-3-chlorobenzene

: 121-43-7
Trimethyl borate

: 63503-60-6
3-chlorophenylboronic acid

Conditions

Conditions	Yield
Stage #1: 1-bromo-3-chlorobenzene With n-butyllithium In tetrahydrofuran; hexane at -30℃; Inert atmosphere; Flow reactor; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -30℃; Inert atmosphere; Flow reactor;	97%
Stage #1: 1-bromo-3-chlorobenzene With isopropylmagnesium chloride; lithium chloride; 3-butyl-1-methylimidazolium acetate In tetrahydrofuran at 5 - 10℃; for 3h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran at 0℃; for 4h; Inert atmosphere; Stage #3: With hydrogenchloride In water at 5℃; for 0.5h; Inert atmosphere;	66.43 g

: 108-37-2
1-bromo-3-chlorobenzene

: 4,6-diphenyl-2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,1': 2',1"-terphenyl-3-yl]-1,3,5-triazine

: 2-[3-chloro-1,1': 5',1": 2",1""-quaterphenyl-3"-yl]-4,6-diphenyl-1,3,5-triazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water for 20h; Inert atmosphere; Reflux;	97%

: 108-37-2
1-bromo-3-chlorobenzene

: 2050-67-1
PCB 11

Conditions

Conditions	Yield
With [Pd{C6H4(CH2N(CH2Ph)2)}(μ-Br)]2; potassium carbonate In 1-methyl-pyrrolidin-2-one at 130℃; for 5h; Microwave irradiation; chemoselective reaction;	96%
With [Pd{C6H2(CH2CH2NH2)-(OMe)2-2,3}(μ-Br)]2; potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 0.0666667h; Microwave irradiation;	96%
With [Pd(C6H4CH2NH2-κ2-CN)PPh3MOBPPY]OTf; potassium carbonate In N,N-dimethyl-formamide at 120℃; for 0.0333333h; Microwave irradiation; chemoselective reaction;	92%

: 108-37-2
1-bromo-3-chlorobenzene

: 363-72-4
Pentafluorobenzene

: 786-55-0
3'-chloro-2,3,4,5,6-pentafluoro-1,1'-biphenyl

Conditions

Conditions	Yield
With di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; potassium carbonate; palladium diacetate In N,N-dimethyl acetamide at 120℃;	96%

: 108-37-2
1-bromo-3-chlorobenzene

: 115-19-5
2-methyl-but-3-yn-2-ol

: 2-methyl-4-(3-chlorophenyl)-3-butyn-2-ol

Conditions

Conditions	Yield
With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; Tri(p-tolyl)phosphine In tetrahydrofuran at 80℃; for 6h; Sonogashira Cross-Coupling; Inert atmosphere; Schlenk technique;	96%
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 90℃; for 72h; Sonogashira Coupling;	94%

3-Bromochlorobenzene Specification

The Benzene,1-bromo-3-chloro-, with CAS registry number 108-37-2, belongs to the following product categories: (1)Aromatic Halides (substituted); (2)Bromine Compounds; (3)Chlorine Compounds; (4)Aryl; (5)C6; (6)Halogenated Hydrocarbons. It has the systematic name of 1-bromo-3-chlorobenzene. This chemical is a kind of clear colourless to light yellow liquid. The main use of this chemical is for organic synthesis.

Physical properties of Benzene,1-bromo-3-chloro-: (1)ACD/LogP: 3.54; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.54; (4)ACD/LogD (pH 7.4): 3.54; (5)ACD/BCF (pH 5.5): 286.19; (6)ACD/BCF (pH 7.4): 286.19; (7)ACD/KOC (pH 5.5): 1995.61; (8)ACD/KOC (pH 7.4): 1995.61; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: Å²; (13)Index of Refraction: 1.574; (14)Molar Refractivity: 38.83 cm³; (15)Molar Volume: 117.5 cm³; (16)Polarizability: 15.39×10^-24cm³; (17)Surface Tension: 38.9 dyne/cm; (18)Enthalpy of Vaporization: 41.33 kJ/mol; (19)Vapour Pressure: 0.609 mmHg at 25°C.

Uses of p-Chloropropiophenone: it can be used to produce 2-bromo-6-chloro-benzoic acid. This reaction will need reagents 2,2,6,6-tetramethylpiperidine, butyllithium and solvents tetrahydrofuran, hexane. The reaction time is 2 hour(s) with reaction temperature of -75 ℃ ℃. The yield is about 94%.

When you are using this chemical, please be cautious about it as the following:
The Benzene,1-bromo-3-chloro- irritates to eyes, respiratory system and skin. This chemical is harmful by inhalation and harmful if swallowed. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Clc1cc(Br)ccc1
(2)InChI: InChI=1/C6H4BrCl/c7-5-2-1-3-6(8)4-5/h1-4H
(3)InChIKey: JRGGUPZKKTVKOV-UHFFFAOYAS
(4)Std. InChI: InChI=1S/C6H4BrCl/c7-5-2-1-3-6(8)4-5/h1-4H
(5)Std. InChIKey: JRGGUPZKKTVKOV-UHFFFAOYSA-N

Product Name

1 -Bromo-3-chloro benzene

Synthetic route

3-Bromochlorobenzene Specification

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