3-Thiophenecarboxaldehyde supplier

Name
3-Thiophenecarboxaldehyde
EINECS 207-865-5
CAS No. 498-62-4
Article Data81
CAS DataBase
Density 1.238 g/cm³
Solubility Not miscible in water.
Melting Point -30 °C
Formula C₅H₄OS
Boiling Point 190.6 °C at 760 mmHg
Molecular Weight 112.152
Flash Point 73.9 °C
Transport Information
Appearance clear yellow to light brown liquid
Safety 37-24-36-26
Risk Codes 22-43-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 3-Formylthiophene;3-Thienaldehyde;3-Thienylcarboxaldehyde;3-Thiophenealdehyde;NSC 172858;Thiophen-3-aldehyde;
PSA 45.31000
LogP 1.56060

Synthetic route

: 71637-34-8
3-hydroxymethyl-thiophene

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With silica gel; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium perchlorate In dichloromethane Ambient temperature;	96%
With oxygen In 1,3,5-trimethyl-benzene at 60℃; under 760.051 Torr; for 3h; Solvent; Reagent/catalyst;	95%
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium nitrate; europium(III) nitrate hexahydrate; acetic acid In toluene at 40℃; for 9h;	95%

: 113772-16-0
2,5-dihydro-3-thiophenecarboxaldehyde

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With sulfuryl dichloride In dichloromethane at -36 - -30℃; for 0.5h;	92%
With sulfuryl dichloride In dichloromethane at -35℃;	58.9%

: 1244041-07-3
2-(thiophen-3-yl)-1,3-dithiane

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With eosin y In water; acetonitrile at 20℃; for 3h; Irradiation;	89%

: 872-31-1
3-Bromothiophene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
Stage #1: 3-Bromothiophene With n-butyllithium In diethyl ether; hexane at -78℃; for 1h; Stage #2: N,N-dimethyl-formamide In diethyl ether; hexane at -78 - 20℃; for 1.5h;	87.8%
Stage #1: 3-Bromothiophene With n-butyllithium In diethyl ether; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: N,N-dimethyl-formamide In diethyl ether; hexane at 20℃; for 12h; Inert atmosphere;	70%

: 71637-34-8
3-hydroxymethyl-thiophene

A: 498-62-4
3-thiophene carboxaldehyde

B: 88-13-1
3-Thiophene carboxylic acid

Conditions

Conditions	Yield
With sodium hypochlorite; C8H18NPol; sodium hydrogencarbonate In water; toluene at 15 - 20℃; for 4.5h; Product distribution / selectivity;	A 87.5% B 0.1%
With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium chloride; oxygen In 1,2-dichloro-ethane at 25℃; for 48h; Schlenk technique;	A 18 %Spectr. B 65%
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate In water; toluene at 15 - 20℃; for 4.5h; Product distribution / selectivity;	A 52.3% B 2.3%

: C17H28OS2

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With triethylsilane In tetrahydrofuran for 1h; Reagent/catalyst; Fukuyama Reduction;	87%

: 10486-61-0
3-thienyl iodide

: 201230-82-2
carbon monoxide

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With triethylsilane; palladium diacetate; sodium hydrogencarbonate; sodium carbonate at 20℃; under 760.051 Torr; for 48h;	84%
With rhodium(III) chloride trihydrate; hydrogen; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 90℃; under 7500.75 Torr; for 12h; Autoclave;	68%
With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; formic acid In N,N-dimethyl-formamide at 50℃; under 760 Torr; for 5h; Electrolysis;	82 % Chromat.

: 10486-61-0
3-thienyl iodide

: 64-18-6
formic acid

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; tricyclohexylphosphine In N,N-dimethyl-formamide at 60℃; for 10h; Inert atmosphere; Sealed tube;	84%
Stage #1: 3-thienyl iodide; formic acid With palladium diacetate; acetic anhydride; tricyclohexylphosphine In N,N-dimethyl-formamide at 30℃; for 1h; Inert atmosphere; Green chemistry; Stage #2: With triethylamine In N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere; Green chemistry;	65%

: 872-31-1
3-Bromothiophene

: 201230-82-2
carbon monoxide

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium diacetate; propyl di-tert-butylphosphinite In toluene at 100℃; under 3750.38 Torr; for 20h; Inert atmosphere;	82%
With 4-methoxy-N'-tetramethylethylenediamine; hydrogen; catacxium A; palladium diacetate In toluene at 100℃; under 3750.3 Torr; for 16h;	82 % Chromat.
With N,N,N,N,-tetramethylethylenediamine; hydrogen; catacxium A; palladium diacetate In toluene at 100℃; under 3750.38 Torr; for 16h;	82 % Chromat.
With N,N,N,N,-tetramethylethylenediamine; C6H6*C48H78O2P2Pd; hydrogen In toluene at 20 - 100℃; under 3750.38 Torr; Inert atmosphere; Autoclave;	87 %Chromat.

: 10486-61-0
3-thienyl iodide

: 124-38-9
carbon dioxide

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 80℃; under 7500.75 Torr; for 20h; Autoclave; Green chemistry;	82%
With rhodium(III) iodide; hydrogen; acetic anhydride; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 100℃; for 24h; Autoclave;	60%

: (CH3CNO)2(CH3CNOH)2Co(C5H5N)(OOCH2C4H3S)

A: 498-62-4
3-thiophene carboxaldehyde

B: 71637-34-8
3-hydroxymethyl-thiophene

Conditions

Conditions	Yield
In methanol decomposition of the complex by refluxing in methanol under N2 for 6-8 h; evapn. of the solvent, extn. of the organic compounds with ether, gas chromatography;	A 19% B 81%

: 872-31-1
3-Bromothiophene

: 124-38-9
carbon dioxide

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 100℃; under 7500.75 Torr; for 20h; Autoclave; Green chemistry;	80%

: 872-31-1
3-Bromothiophene

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium acetate In acetonitrile at 60℃; for 16h; Schlenk technique; Inert atmosphere;	77%

: 88-13-1
3-Thiophene carboxylic acid

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With palladium(II) acetylacetonate; hydrogen; 2,2-dimethylpropanoic anhydride; dicyclohexylphenylphosphine In tetrahydrofuran at 80℃; under 3750.38 Torr; for 20h; Inert atmosphere;	70%
With hydrogen; 2,2-dimethylpropanoic anhydride; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 80℃; under 22501.8 Torr; for 48h;	73 % Spectr.
Multi-step reaction with 2 steps 1: 88 percent / LiAlH4 / diethyl ether 2: 7.3 g / PCD / CH2Cl2 / 1.5 h View Scheme
Multi-step reaction with 3 steps 1: thionyl chloride 2: pyridine 3: phosphorus (V)-chloride; benzene / anschliessend in Aether mit Zinn(II)-chlorid und Chlorwasserstoff behandeln und Erhitzen des vom Aether befreiten Reaktionsgemisches mit Wasser View Scheme

: 872-31-1
3-Bromothiophene

: 50978-45-5
3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With triethylsilane; palladium diacetate; sodium carbonate; 1,4-di(diphenylphosphino)-butane In N,N-dimethyl-formamide at 80℃; Inert atmosphere; Sealed tube;	70%

: 35022-11-8
3-styryl-thiophene

A: 498-62-4
3-thiophene carboxaldehyde

B: 234-41-3
naphtho[1,2-b]thiophene

C: 100-52-7
benzaldehyde

D: 78604-61-2
[2,2']Bi[naphtho[1,2-b]thiophenyl]

Conditions

Conditions	Yield
With oxygen In hexane Cyclization; oxidation; Irradiation;	A 8% B 69% C 8% D 15%
With oxygen In hexane at 25℃; Cyclization; oxidation; Irradiation;	A 8% B 69% C 8% D 15%

...Expand

: 40018-26-6
1,4-dithiane-2,5-diol

: 542-78-9
Malondialdehyde

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With diethylamine at 70℃; for 6h; Temperature; Reagent/catalyst;	65%

: 1468-83-3
1-(thiophen-3-yl)-ethanone

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With copper(l) iodide; oxygen In dimethyl sulfoxide at 120℃; for 19h; chemoselective reaction;	64%

: 10486-61-0
3-thienyl iodide

: 124-38-9
carbon dioxide

A: 188290-36-0
thiophene

B: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With palladium on activated charcoal; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 80℃; for 20h; Autoclave;	A 27% B 64%

...Expand

: 872-31-1
3-Bromothiophene

: 50-00-0
formaldehyd

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With triethylsilane; dichloro bis(acetonitrile) palladium(II); sodium carbonate; 1,4-di(diphenylphosphino)-butane In N,N-dimethyl-formamide at 20 - 100℃; under 15001.5 Torr; for 20h; Inert atmosphere; Autoclave;	63%

: C10H8OS2

A: 498-62-4
3-thiophene carboxaldehyde

B: 1641-09-4
3-thiophenecarbonitrile

Conditions

Conditions	Yield
With sodium azide; copper(II) choride dihydrate; oxygen In N,N-dimethyl-formamide at 100℃; for 10h; Schlenk technique; Sealed tube;	A 47% B 53%

: 34846-44-1
3-Bromomethylthiophene

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
	28%
With chloroform; hexamethylenetetramine Erhitzen des Reaktionsprodukts mit Wasserdampf oder mit wss. Aethanol;
Multi-step reaction with 2 steps 1: chloroform 2: water / Heating View Scheme
With 4-methylmorpholine N-oxide In ethyl acetate at 50℃; for 6h; Solvent;

: 40018-26-6
1,4-dithiane-2,5-diol

: 4652-35-1
3-methoxyacrolein

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 10℃; for 2h;	23%

: 3199-44-8
3-formylthiophene diethyl acetal

: 498-62-4
3-thiophene carboxaldehyde

: 55797-29-0
N-phenyl-3-thiophene-carboxamide

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With phosphorus pentachloride; benzene anschliessend in Aether mit Zinn(II)-chlorid und Chlorwasserstoff behandeln und Erhitzen des vom Aether befreiten Reaktionsgemisches mit Wasser;

: 917-54-4
methyllithium

: 76835-01-3
thieno(3,2-d) isoselenazole

A: 498-62-4
3-thiophene carboxaldehyde

B: 2-Methylselanyl-thiophene-3-carbonitrile

C: C10H4N2S2Se

D: 76834-96-3
2-Methylselanyl-thiophene-3-carbaldehyde

Conditions

Conditions	Yield
With water In tetrahydrofuran; diethyl ether at -80℃; for 5h; Product distribution;	A 16 % Chromat. B 18 % Chromat. C 26 % Chromat. D 100 % Chromat.

...Expand

: 120361-26-4
(3-thienyl)diazomethane

: 498-62-4
3-thiophene carboxaldehyde

Conditions

Conditions	Yield
With oxygen In solid matrix at -233.2℃;

: 35022-11-8
3-styryl-thiophene

A: 498-62-4
3-thiophene carboxaldehyde

B: 100-52-7
benzaldehyde

Conditions

Conditions	Yield
With oxygen; 9,10-Dicyanoanthracene In acetonitrile at 25℃; for 3h; Oxidation; Irradiation;	A 100 % Turnov. B 100 % Turnov.

: 498-62-4
3-thiophene carboxaldehyde

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 50266-60-9
(E)-3-thiophen-3-yl-acrylic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h; Stage #2: 3-thiophene carboxaldehyde In tetrahydrofuran; mineral oil at 20℃; for 1h;	100%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Stage #2: 3-thiophene carboxaldehyde In tetrahydrofuran; mineral oil at 0 - 20℃; for 3.25h;	100%
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With potassium tert-butylate In tetrahydrofuran at 20℃; Stage #2: 3-thiophene carboxaldehyde In tetrahydrofuran at 90℃; for 0.5h;	90%

: 498-62-4
3-thiophene carboxaldehyde

: 1080-32-6
O,O-diethyl benzylphosphonate

: 78347-97-4
(E)-3-styrylthiophene

Conditions

Conditions	Yield
With sodium methylate In N,N-dimethyl-formamide at 0 - 20℃; for 1.75h;	100%

: 498-62-4
3-thiophene carboxaldehyde

: 56613-80-0
(R)-Phenylglycinol

: 139437-49-3
(R)-2-Phenyl-2-{[1-thiophen-3-yl-meth-(E)-ylidene]-amino}-ethanol

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 12h;	100%
In benzene Heating;	92%

: 498-62-4
3-thiophene carboxaldehyde

: 100-46-9
benzylamine

: N-benzylthiophene-3-carbaldehyde imine

Conditions

Conditions	Yield
With aluminum oxide for 12h;	100%

: 498-62-4
3-thiophene carboxaldehyde

: 5927-18-4
trimethyl phosphonoacetate

: 75754-85-7
3-Thiophen-3-yl-acrylic Acid Methyl Ester

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0℃;	100%
Stage #1: trimethyl phosphonoacetate With sodium hydride In tetrahydrofuran for 1h; Stage #2: 3-thiophene carboxaldehyde In tetrahydrofuran at 20℃; for 18h;	94%
Stage #1: trimethyl phosphonoacetate With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 2h; Inert atmosphere; Stage #2: 3-thiophene carboxaldehyde In tetrahydrofuran; mineral oil at 20℃; Inert atmosphere;	81%

: 498-62-4
3-thiophene carboxaldehyde

: 58263-67-5
(α-chloro-benzyl)-phosphonic acid diphenyl ester

: 131423-29-5
1-phenyl-2-(3-thienyl)ethyne

Conditions

Conditions	Yield
Stage #1: 3-thiophene carboxaldehyde; (α-chloro-benzyl)-phosphonic acid diphenyl ester With potassium tert-butylate In tetrahydrofuran at 20℃; for 3h; Horner-Emmons reaction; Stage #2: With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h; Horner-Emmons reaction; Further stages.;	100%

: 498-62-4
3-thiophene carboxaldehyde

: 189099-53-4
diphenyl chloro(4-methoxycarbonylphenyl)methylphosphonate

: 1-(4-methoxyphenyl)-2-(3-thienyl)ethyne

Conditions

Conditions	Yield
Stage #1: 3-thiophene carboxaldehyde; diphenyl chloro(4-methoxycarbonylphenyl)methylphosphonate With potassium tert-butylate In tetrahydrofuran at 20℃; for 3h; Horner-Emmons reaction; Stage #2: With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h; Horner-Emmons reaction; Further stages.;	100%

: 498-62-4
3-thiophene carboxaldehyde

: 54335-03-4
diphenyl phosphonate

: C12H7NO3S

Conditions

Conditions	Yield
Stage #1: 3-thiophene carboxaldehyde; diphenyl phosphonate With potassium tert-butylate In tetrahydrofuran at 20℃; for 3h; Horner-Emmons reaction; Stage #2: With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h; Horner-Emmons reaction; Further stages.;	100%

: 498-62-4
3-thiophene carboxaldehyde

: 138517-18-7
Diphenyl 1-Chloro-1-(4-pyridyl)methanephosphonate

: 4-(thien-3-ylethynyl)pyridine

Conditions

Conditions	Yield
Stage #1: 3-thiophene carboxaldehyde; diphenyl 1-chloro-1-(4-pirydyl)methanephosphonate With potassium tert-butylate In tetrahydrofuran at 20℃; for 3h; Horner-Emmons reaction; Stage #2: With potassium tert-butylate In tetrahydrofuran at 20℃; for 1h; Horner-Emmons reaction; Further stages.;	100%

: 498-62-4
3-thiophene carboxaldehyde

: 3-thiophenecarbaldoxime hydrochloride

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium hydroxide In ethanol; water at 20℃; for 18h;	100%
With pyridine; hydroxylamine hydrochloride In ethanol at 20℃; for 2h;	90%
With pyridine; hydroxylamine hydrochloride In ethanol at 20℃; for 2h;	90%

: 498-62-4
3-thiophene carboxaldehyde

: 108-59-8
malonic acid dimethyl ester

: 1300690-47-4
dimethyl [(3-thienyl)methylene]malonate

Conditions

Conditions	Yield
With piperidine; benzoic acid for 12h; Heating / reflux;	100%
With piperidine; acetic acid In benzene for 4h; Reflux;	96%
With piperidine; acetic acid In benzene Dean-Stark; Reflux;

: 498-62-4
3-thiophene carboxaldehyde

: 92-54-6
4-phenyl-1-piperazine

: 414887-78-8
1-phenyl-4-(thiophen-3-ylmethyl)piperazine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 18℃; for 2h; Solvent; Green chemistry;	100%

: 498-62-4
3-thiophene carboxaldehyde

: 138386-62-6
(E)-2-(buta-1,3-dien-1-yl)aniline

: C15H13NS

Conditions

Conditions	Yield
In ethanol at 80℃; Inert atmosphere;	100%

: 498-62-4
3-thiophene carboxaldehyde

: 148134-23-0
3-thiophenecarboxaldehyde oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In pyridine; water; ethyl acetate	99%
With hydroxylamine
With hydroxylamine hydrochloride; copper(II) sulfate at 90℃; for 2h;	85 % Spectr.
With hydroxylamine In methanol
With sodium chloride; hydroxylamine hydrochloride; sodium carbonate In ethanol; water

: 498-62-4
3-thiophene carboxaldehyde

: 3162-29-6
1-(benzo[d][1,3]dioxol-6-yl)ethanone

: (E)-1-benzo[1,3]dioxol-5-yl-3-thiophen-3-ylpropenone

Conditions

Conditions	Yield
Stage #1: 1-(benzo[d][1,3]dioxol-6-yl)ethanone With lithium hydroxide In ethanol at 20℃; for 0.166667h; Large scale; Stage #2: 3-thiophene carboxaldehyde In ethanol at 20℃; Large scale;	99%
With sodium hydroxide In ethanol; water

: 498-62-4
3-thiophene carboxaldehyde

: 1066-54-2
trimethylsilylacetylene

: 849769-14-8
1-(thiophen-3-yl)-3-(trimethylsilyl)prop-2-yn-1-ol

Conditions

Conditions	Yield
Stage #1: trimethylsilylacetylene With n-butyllithium In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; Stage #2: 3-thiophene carboxaldehyde In tetrahydrofuran at 0℃; for 1h;	99%
Stage #1: trimethylsilylacetylene With n-butyllithium In tetrahydrofuran at 0℃; for 1h; Stage #2: 3-thiophene carboxaldehyde In tetrahydrofuran at 0℃; for 1h;	95%
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 1h;

: 498-62-4
3-thiophene carboxaldehyde

: 614-96-0
5-methyl-1H-indole

: 3,3'-bis-(5-methyl)-indolyl-3-thienylmethane

Conditions

Conditions	Yield
With 1-hexyl-3-methylimidazolium hydrogen sulphate In ethanol at 20℃; for 1h;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 107-21-1
ethylene glycol

: 13250-82-3
2-(thiophen-3-yl)-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 165℃; for 6h;	99%
With toluene-4-sulfonic acid In benzene Heating;	97%
toluene-4-sulfonic acid In toluene for 4h; Heating / reflux;	95.9%

: 498-62-4
3-thiophene carboxaldehyde

: 111-68-2
1-Heptylamine

: N-(3-thienylmethylene)-n-heptylamine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 3h; Heating;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 75-16-1
methylmagnesium bromide

: 14861-60-0
1-(thiophen-3-yl)ethan-1-ol

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 2h;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 100-65-2
N-Phenylhydroxylamine

: (Z)-N-phenyl-1-(thiophen-3-yl)methanimine oxide

Conditions

Conditions	Yield
In ethanol at 21℃; Inert atmosphere;	99%
In ethanol Heating; sonication;	79%

: 498-62-4
3-thiophene carboxaldehyde

: 75-52-5
nitromethane

: 1040923-87-2
(S)-(+)-2-nitro-1-(thiophen-3-yl)ethanol

Conditions

Conditions	Yield
With copper(II) acetate monohydrate; N-ethyl-N,N-diisopropylamine; N-<(1S,2R,4R)-1,7,7-trimethylbicyclo<2.2.1>hept-2-yl>-1-(2-pirydyl)methanamine In ethanol at -50℃; Henry reaction; optical yield given as %ee; enantioselective reaction;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 71-00-1
D,L-histidine

: 1135901-64-2
C11H11N3O2S

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 80℃; for 24h; Molecular sieve;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 71699-33-7
5-hydroxy-4,6-dimethyl-3-heptanone

: thiophene-3-carboxylic acid (1SR,2SR,3SR)-3-hydroxy-1-isopropyl-2-methylpentyl ester

Conditions

Conditions	Yield
With samarium diiodide; benzaldehyde In tetrahydrofuran at -15℃; for 1h; Evans-Tishchenko coupling reaction; Inert atmosphere; optical yield given as %de; diastereoselective reaction;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 7507-86-0
2-bromo-5-methoxy-benzaldehyde

: 1431656-04-0
2-bromo-5-methoxybenzyl thiophene-3-carboxylate

Conditions

Conditions	Yield
With 4-tert-butylbenzyl mercaptan; dibutylmagnesium In tetrahydrofuran at 65℃; for 24h; Tishchenko-Claisen Dismutation; Inert atmosphere; chemoselective reaction;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 615-36-1
2-bromoaniline

: C11H10BrNS

Conditions

Conditions	Yield
In toluene at 130℃; Solvent; Temperature; Inert atmosphere; Molecular sieve;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 23534-97-6
1,1,3‐tribromo‐2,2‐dimethylcyclopropane

: (3,3-dimethylcycloprop-1-en-1-yl)(thiophen-3-yl)methanol

Conditions

Conditions	Yield
Stage #1: 1,1,3‐tribromo‐2,2‐dimethylcyclopropane With n-butyllithium In diethyl ether; hexane at -78 - -10℃; for 1h; Inert atmosphere; Stage #2: 3-thiophene carboxaldehyde In diethyl ether; hexane at -50 - -10℃; for 0.25h; Inert atmosphere;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 61-54-1
tryptamine

: 1-(thiophen-3-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride

Conditions

Conditions	Yield
Stage #1: 3-thiophene carboxaldehyde; tryptamine With trifluoroacetic acid In 1,2-dichloro-ethane at 110℃; for 0.0333333h; Pictet-Spengler Synthesis; Sealed tube; Microwave irradiation; Stage #2: With hydrogenchloride In ethyl acetate at 20℃;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: C11H17BO3S

Conditions

Conditions	Yield
With FeBr2*2THF; C30H46N4Si2(2+) In acetonitrile at 20℃; for 12h; Glovebox; Inert atmosphere; Sealed tube;	99%

: 498-62-4
3-thiophene carboxaldehyde

: 933-52-8
2,2,4,4-tetramethyl-1,3-cyclobutanedione

: 6-(3’-thienyl)-3,3,5,5-tetramethyloxane-2,4-dione

Conditions

Conditions	Yield
With potassium ethoxide In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;	99%

3-Thiophenecarboxaldehyde Chemical Properties

MF: C₅H₄OS
MW: 112.15
EINECS: 207-865-5
mp -30 °C
bp 194-196 °C(lit.)
Fp 165 °F
storage temp. 2-8°C
density 1.28 g/mL at 25 °C(lit.)
vapor pressure 0.31 mm Hg ( 20 °C)
refractive index n20/D 1.583(lit.)
Sensitive Air Sensitive
BRN 105889
NIST Chemistry Reference 498-62-4_NIST
EPA Substance Registry System 498-62-4_EPA Substance

3-Thiophenecarboxaldehyde Uses

3-Thiophenecarboxaldehyde is used as pharmaceutical intermediates.

3-Thiophenecarboxaldehyde Toxicity Data With Reference

TSCA T

3-Thiophenecarboxaldehyde Safety Profile

Hazard Codes Xn,Xi
Risk Statements 22-43-36/37/38
Safety Statements 37-24-36-26
WGK Germany 3
Hazard Note Irritant

Product Name

3-Thiophenecarboxaldehyde

Synthetic route

3-Thiophenecarboxaldehyde Chemical Properties

3-Thiophenecarboxaldehyde Uses

3-Thiophenecarboxaldehyde Toxicity Data With Reference

3-Thiophenecarboxaldehyde Safety Profile

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